Objective:To investigate the clinical effects of combining decitabine with a half-dose priming regimen in the treatment of elderly patients with acute myeloid leukemia.Methods:This study was conducted in Shaanxi Provi...Objective:To investigate the clinical effects of combining decitabine with a half-dose priming regimen in the treatment of elderly patients with acute myeloid leukemia.Methods:This study was conducted in Shaanxi Provincial People's Hospital from January 2019 to January 2022.Sxty patients were recruited as the research subects.The patients received different treatments and were randomly divided into two groups,with 30 cases in each group,one of which was treated with conventional priming regimen(control group),and the other was treated with decitabine combined with a half-dose priming regimen(study group).The two groups were compared and analyzed in terms of the effectiveness of treatment.Results:The rate of symptom relief in the study group was 96.67%,which was significantly higher than that in the control group(76.67%)(p<0.05).Before treatment,there was no significant difference in the quality-of-life scores between the two groups,with p>0.05.The patients in the study group had sigificantly longer discase free survival and overall survival than those in the control group,with p<0.05.The effectiveness of treatment in the study group was also better.Conclusion:The use of decitabine im combination with a half dose priming regimen for the treatment of elderly patients with acute myeloid lcukemia is effective in improving patients'quality of life,relieving symptoms.and prolonging their survival.展开更多
Using a photosensitizer(PS),light,and oxygen,photodynamic therapy creates cytotoxic reactive oxygen species,such as singlet oxygen(1O2),that kill cancer cells.Many cancer cell lines have up to 300 times more folic aci...Using a photosensitizer(PS),light,and oxygen,photodynamic therapy creates cytotoxic reactive oxygen species,such as singlet oxygen(1O2),that kill cancer cells.Many cancer cell lines have up to 300 times more folic acid receptors than healthy cells.Therefore,folic acid is often used to improve selectivity of PSs.Photobleaching poses a disadvantage for PSs.In this paper,we have studied the photoinduced changes of meso-substituted cationic pyridyl porphyrins in the presence of folic acid using uorescence and absorption spectroscopy.In this work,it was demonstrated that L-histidine,which is a 1O2 quencher,and D-mannitol,which is a hydroxyl radical quencher,can reduce photobleaching of cationic porphyrins and their interaction products with FA.This implies both singlet oxygen and hydroxyl radicals are involved in photobleaching.Additionally,our study revealed certain important features of the photobleaching of cationic porphyrins in the presence of folic acid.展开更多
BACKGROUND Whether hyperbaric oxygen therapy(HBOT)can cause paradoxical herniation is still unclear.CASE SUMMARY A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradua...BACKGROUND Whether hyperbaric oxygen therapy(HBOT)can cause paradoxical herniation is still unclear.CASE SUMMARY A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradually regained consciousness after surgery.HBOT was administered 22 d after surgery due to speech impairment.Paradoxical herniation appeared on the second day after treatment,and the patient’s condition worsened after receiving mannitol treatment at the rehabilitation hospital.After timely skull repair,the paradoxical herniation was resolved,and the patient regained consciousness and had a good recovery as observed at the follow-up visit.CONCLUSION Paradoxical herniation is rare and may be caused by HBOT.However,the underlying mechanism is unknown,and the understanding of this phenomenon is insufficient.The use of mannitol may worsen this condition.Timely skull repair can treat paradoxical herniation and prevent serious complications.展开更多
基金Basic Research of Natural Science in Shaanxi Province(Grant Number:2021JM-548)SPPH Incubator Fund for Development of Science and Technology(Grant Number:2021YJY-19)。
文摘Objective:To investigate the clinical effects of combining decitabine with a half-dose priming regimen in the treatment of elderly patients with acute myeloid leukemia.Methods:This study was conducted in Shaanxi Provincial People's Hospital from January 2019 to January 2022.Sxty patients were recruited as the research subects.The patients received different treatments and were randomly divided into two groups,with 30 cases in each group,one of which was treated with conventional priming regimen(control group),and the other was treated with decitabine combined with a half-dose priming regimen(study group).The two groups were compared and analyzed in terms of the effectiveness of treatment.Results:The rate of symptom relief in the study group was 96.67%,which was significantly higher than that in the control group(76.67%)(p<0.05).Before treatment,there was no significant difference in the quality-of-life scores between the two groups,with p>0.05.The patients in the study group had sigificantly longer discase free survival and overall survival than those in the control group,with p<0.05.The effectiveness of treatment in the study group was also better.Conclusion:The use of decitabine im combination with a half dose priming regimen for the treatment of elderly patients with acute myeloid lcukemia is effective in improving patients'quality of life,relieving symptoms.and prolonging their survival.
基金supported by the RA MESCS Science Committee and Belarusian Republican Foundation for Fundamental Research in the frames of the joint research project SC No.21SC-BRFFR-1F007 and BRFFR Grant No.21ARM-014 accordingly,as well as from the Ministry of Science and Higher Education of Russian Federation within the framework of a state assignment(project No.FSRR-2023-0007)。
文摘Using a photosensitizer(PS),light,and oxygen,photodynamic therapy creates cytotoxic reactive oxygen species,such as singlet oxygen(1O2),that kill cancer cells.Many cancer cell lines have up to 300 times more folic acid receptors than healthy cells.Therefore,folic acid is often used to improve selectivity of PSs.Photobleaching poses a disadvantage for PSs.In this paper,we have studied the photoinduced changes of meso-substituted cationic pyridyl porphyrins in the presence of folic acid using uorescence and absorption spectroscopy.In this work,it was demonstrated that L-histidine,which is a 1O2 quencher,and D-mannitol,which is a hydroxyl radical quencher,can reduce photobleaching of cationic porphyrins and their interaction products with FA.This implies both singlet oxygen and hydroxyl radicals are involved in photobleaching.Additionally,our study revealed certain important features of the photobleaching of cationic porphyrins in the presence of folic acid.
文摘BACKGROUND Whether hyperbaric oxygen therapy(HBOT)can cause paradoxical herniation is still unclear.CASE SUMMARY A 65-year-old patient who was comatose due to brain trauma underwent decompressive craniotomy and gradually regained consciousness after surgery.HBOT was administered 22 d after surgery due to speech impairment.Paradoxical herniation appeared on the second day after treatment,and the patient’s condition worsened after receiving mannitol treatment at the rehabilitation hospital.After timely skull repair,the paradoxical herniation was resolved,and the patient regained consciousness and had a good recovery as observed at the follow-up visit.CONCLUSION Paradoxical herniation is rare and may be caused by HBOT.However,the underlying mechanism is unknown,and the understanding of this phenomenon is insufficient.The use of mannitol may worsen this condition.Timely skull repair can treat paradoxical herniation and prevent serious complications.
