BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counselin...BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the observation group exhibited superior serum inflammatory factors compared to the control group(70.12±10.32 vs 102.24±20.21,t=11.840;19.35±2.46 vs 22.27±2.13,t=7.508;32.25±4.6 vs 39.42±4.23,t=9.565;P both<0.001).Moreover,the observation group exhibited significantly improved quality of life scores compared to the control group(Social function:19.25±2.76 vs 16.23±2.34;Emotions:18.54±2.83 vs 12.28±2.16;Environment:18.49±2.48 vs 16.56±3.44;Physical health:19.53±2.39 vs 16.62±3.46;P both<0.001)after treatment.CONCLUSION MBSR combined with NET effectively alleviates depression,lowers inflammation(IL-2,IL-1β,and IL-6),reduces suicidal thoughts,enhances sleep,and improves the quality of life of individuals with depression.展开更多
BACKGROUND Psychological factors such as anxiety and depression will not only aggravate the symptoms of chronic obstructive pulmonary disease(COPD)patients and reduce the quality of life of patients,but also affect th...BACKGROUND Psychological factors such as anxiety and depression will not only aggravate the symptoms of chronic obstructive pulmonary disease(COPD)patients and reduce the quality of life of patients,but also affect the treatment effect and long-term prognosis.Therefore,it is of great significance to explore the clinical application of senile comprehensive assessment in the treatment of COPD and its influence on psychological factors such as anxiety and depression.AIM To explore the clinical application of comprehensive geriatric assessment in COPD care and its impact on anxiety and depression in elderly patents.METHODS In this retrospective study,60 patients with COPD who were hospitalized in our hospital from 2019 to 2020 were randomly divided into two groups with 30 patients in each group.The control group was given routine nursing,and the observation group was given comprehensive assessment.Clinical symptoms,quality of life[COPD assessment test(CAT)score],anxiety and depression Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)were compared between the two groups.RESULTS CAT scores in the observation group decreased from an average of 24.5 points at admission to an average of 18.3 points at discharge,and in the control group from an average of 24.7 points at admission to an average of 18.3 points at discharge.The average score was 22.1(P<0.05).In the observation group,HAMA scores decreased from 14.2 points at admission to 8.6 points at discharge,and HAMD scores decreased from 13.8 points at admission to 7.4 points at discharge.The mean HAMD scores in the control group decreased from an average of 14.5 at admission to an average of 12.3 at discharge,and from an average of 14.1 at admission to an average of 11.8 at discharge.CONCLUSION The application of comprehensive geriatric assessment in COPD care has a significant effect on improving patients'clinical symptoms and quality of life,and can effectively reduce patients'anxiety and depression.展开更多
Bipolar disorder presents significant challenges in clinical management, characterized by recurrent episodes of depression and mania often accompanied by impairment in functioning. This study investigates the efficacy...Bipolar disorder presents significant challenges in clinical management, characterized by recurrent episodes of depression and mania often accompanied by impairment in functioning. This study investigates the efficacy of pharmacological interventions and rehabilitation strategies to improve patient outcomes and quality of life. Utilizing a randomized controlled trial with multiple treatment arms, participants will receive pharmacotherapy, polypharmacotherapy, rehabilitation interventions, or combination treatments. Outcome measures will be assessed using standardized scales, including the Hamilton Depression Scale, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Mania Scale. Preliminary data suggest improvements in symptom severity and functional outcomes with combination treatments. This research aims to inform clinical practice, guide treatment decisions, and ultimately enhance the quality of care for individuals living with bipolar disorder. Findings will be disseminated through peer-reviewed journals and scientific conferences to advance knowledge in this field.展开更多
目的分析血小板相关指标与急性缺血性卒中后抑郁(post-stroke depression,PSD)的关系。方法选取2021年9月至2022年5月在华北理工大学附属唐山市工人医院治疗的急性缺血性卒中病人235例,记录其一般临床资料,根据17项汉密顿抑郁量表(Hamil...目的分析血小板相关指标与急性缺血性卒中后抑郁(post-stroke depression,PSD)的关系。方法选取2021年9月至2022年5月在华北理工大学附属唐山市工人医院治疗的急性缺血性卒中病人235例,记录其一般临床资料,根据17项汉密顿抑郁量表(Hamilton depression rating scale,17 item,HAMD-17)评分将病人分为PSD组和非PSD组;测定各组病人血小板相关指标(血小板计数、血小板平均体积、血小板比容、血小板分布宽度);使用美国国立卫生院卒中量表(national institute of health stroke scale,NIHSS)、日常生活活动能力量表(activity of daily living,ADL)分别评估病人神经功能缺损情况和日常生活能力;采用多因素二元logistic回归模型分析与PSD相关的独立危险因素。结果研究共纳入缺血性脑卒中病人235例,PSD组病人85例,非PSD组病人150例。PSD组身体质量指数、NIHSS评分高于非PSD组,PSD组ADL评分低于非PSD组(P<0.05)。两组血小板计数和平均血小板体积分级分布上均差异有统计学差意义(P<0.05);PSD组血小板计数≤183×10^(9)/L、(>183~<257)×10^(9)/L、≥257×10^(9)/L分别有11例(12.9%)、47例(55.3%)、27例(31.8%),非PSD组分别有47例(31.3%)、72例(48.0%)、31例(20.7%)。多因素二元logistic回归分析结果显示,较高水平血小板计数、身体质量指数及NIHSS评分是PSD的独立危险因素(P<0.05)。结论较高水平的血小板计数是PSD发生的独立危险因素。展开更多
目的观察穴位贴敷配合他达拉非治疗勃起功能障碍合并抑郁的临床疗效。方法将102例勃起功能障碍合并抑郁患者随机分为治疗组(52例)和对照组(50例)。治疗组采用穴位贴敷配合口服他达拉非治疗,对照组采用单纯口服他达拉非治疗。观察两组治...目的观察穴位贴敷配合他达拉非治疗勃起功能障碍合并抑郁的临床疗效。方法将102例勃起功能障碍合并抑郁患者随机分为治疗组(52例)和对照组(50例)。治疗组采用穴位贴敷配合口服他达拉非治疗,对照组采用单纯口服他达拉非治疗。观察两组治疗前后国际勃起功能指数(the international index of erectile function-5,IIEF-5)评分、RigiScan AVSS各项监测数据(勃起总时间、根部≥60%勃起时间、头部≥60%勃起时间)及汉密尔顿抑郁量表(Hamiltondepression scale,HAMD)评分、健康状况调查问卷(36-itemshort-form,SF-36)评分的变化情况。比较两组临床疗效。结果治疗组总有效率为86.5%,明显高于对照组的74.0%(P<0.05)。两组治疗后IIFE-5评分、RigiScan AVSS各项监测数据均明显高于同组治疗前(P<0.05)。治疗组治疗后HAMD评分较同组治疗前显著下降,SF-36评分显著上升,差异均具有统计学意义(P<0.05);对照组治疗后仅SF-36评分较同组治疗前上升(P<0.05)。治疗组治疗后IIFE-5评分、RigiScan AVSS各项监测数据及SF-36评分均明显高于对照组,差异均有统计学意义(P<0.05)。结论穴位贴敷配合他达拉非是一种治疗勃起功能障碍合并抑郁的有效方法,能改善HAMD评分,提高患者生活质量。展开更多
基金Supported by Guangdong Provincial Medical Scientific Research Fund Project,No.B2016109.
文摘BACKGROUND Depression is a common and serious psychological condition,which seriously affects individual well-being and functional ability.Traditional treatment methods include drug therapy and psychological counseling;however,these methods have different degrees of side effects and limitations.In recent years,nonconvulsive electrotherapy(NET)has attracted increasing attention as a noninvasive treatment method.However,the clinical efficacy and potential mechanism of NET on depression are still unclear.We hypothesized that NET has a positive clinical effect in the treatment of depression,and may have a regulatory effect on serum inflammatory factors during treatment.AIM To assess the effects of NET on depression and analyze changes in serum inflammatory factors.METHODS This retrospective study enrolled 140 patients undergoing treatment for depression between May 2017 and June 2022,the observation group that received a combination of mindfulness-based stress reduction(MBSR)and NET treatment(n=70)and the control group that only received MBSR therapy(n=70).The clinical effectiveness of the treatment was evaluated by assessing various factors,including the Hamilton Depression Scale(HAMD)-17,self-rating idea of suicide scale(SSIOS),Pittsburgh Sleep Quality Index(PSQI),and levels of serum inflammatory factors before and after 8 wk of treatment.The quality of life scores between the two groups were compared.Comparisons were made using t and χ^(2) tests.RESULTS After 8 wk of treatment,the observation group exhibited a 91.43%overall effectiveness rate which was higher than that of the control group which was 74.29%(64 vs 52,χ^(2)=7.241;P<0.05).The HAMD,SSIOS,and PSQI scores showed a significant decrease in both groups.Moreover,the observation group had lower scores than the control group(10.37±2.04 vs 14.02±2.16,t=10.280;1.67±0.28 vs 0.87±0.12,t=21.970;5.29±1.33 vs 7.94±1.35,t=11.700;P both<0.001).Additionally,there was a notable decrease in the IL-2,IL-1β,and IL-6 in both groups after treatment.Furthermore,the observation group exhibited superior serum inflammatory factors compared to the control group(70.12±10.32 vs 102.24±20.21,t=11.840;19.35±2.46 vs 22.27±2.13,t=7.508;32.25±4.6 vs 39.42±4.23,t=9.565;P both<0.001).Moreover,the observation group exhibited significantly improved quality of life scores compared to the control group(Social function:19.25±2.76 vs 16.23±2.34;Emotions:18.54±2.83 vs 12.28±2.16;Environment:18.49±2.48 vs 16.56±3.44;Physical health:19.53±2.39 vs 16.62±3.46;P both<0.001)after treatment.CONCLUSION MBSR combined with NET effectively alleviates depression,lowers inflammation(IL-2,IL-1β,and IL-6),reduces suicidal thoughts,enhances sleep,and improves the quality of life of individuals with depression.
文摘BACKGROUND Psychological factors such as anxiety and depression will not only aggravate the symptoms of chronic obstructive pulmonary disease(COPD)patients and reduce the quality of life of patients,but also affect the treatment effect and long-term prognosis.Therefore,it is of great significance to explore the clinical application of senile comprehensive assessment in the treatment of COPD and its influence on psychological factors such as anxiety and depression.AIM To explore the clinical application of comprehensive geriatric assessment in COPD care and its impact on anxiety and depression in elderly patents.METHODS In this retrospective study,60 patients with COPD who were hospitalized in our hospital from 2019 to 2020 were randomly divided into two groups with 30 patients in each group.The control group was given routine nursing,and the observation group was given comprehensive assessment.Clinical symptoms,quality of life[COPD assessment test(CAT)score],anxiety and depression Hamilton Anxiety Rating Scale(HAMA)and Hamilton Depression Rating Scale(HAMD)were compared between the two groups.RESULTS CAT scores in the observation group decreased from an average of 24.5 points at admission to an average of 18.3 points at discharge,and in the control group from an average of 24.7 points at admission to an average of 18.3 points at discharge.The average score was 22.1(P<0.05).In the observation group,HAMA scores decreased from 14.2 points at admission to 8.6 points at discharge,and HAMD scores decreased from 13.8 points at admission to 7.4 points at discharge.The mean HAMD scores in the control group decreased from an average of 14.5 at admission to an average of 12.3 at discharge,and from an average of 14.1 at admission to an average of 11.8 at discharge.CONCLUSION The application of comprehensive geriatric assessment in COPD care has a significant effect on improving patients'clinical symptoms and quality of life,and can effectively reduce patients'anxiety and depression.
文摘Bipolar disorder presents significant challenges in clinical management, characterized by recurrent episodes of depression and mania often accompanied by impairment in functioning. This study investigates the efficacy of pharmacological interventions and rehabilitation strategies to improve patient outcomes and quality of life. Utilizing a randomized controlled trial with multiple treatment arms, participants will receive pharmacotherapy, polypharmacotherapy, rehabilitation interventions, or combination treatments. Outcome measures will be assessed using standardized scales, including the Hamilton Depression Scale, Yale-Brown Obsessive Compulsive Scale (Y-BOCS), and Mania Scale. Preliminary data suggest improvements in symptom severity and functional outcomes with combination treatments. This research aims to inform clinical practice, guide treatment decisions, and ultimately enhance the quality of care for individuals living with bipolar disorder. Findings will be disseminated through peer-reviewed journals and scientific conferences to advance knowledge in this field.
文摘目的分析血小板相关指标与急性缺血性卒中后抑郁(post-stroke depression,PSD)的关系。方法选取2021年9月至2022年5月在华北理工大学附属唐山市工人医院治疗的急性缺血性卒中病人235例,记录其一般临床资料,根据17项汉密顿抑郁量表(Hamilton depression rating scale,17 item,HAMD-17)评分将病人分为PSD组和非PSD组;测定各组病人血小板相关指标(血小板计数、血小板平均体积、血小板比容、血小板分布宽度);使用美国国立卫生院卒中量表(national institute of health stroke scale,NIHSS)、日常生活活动能力量表(activity of daily living,ADL)分别评估病人神经功能缺损情况和日常生活能力;采用多因素二元logistic回归模型分析与PSD相关的独立危险因素。结果研究共纳入缺血性脑卒中病人235例,PSD组病人85例,非PSD组病人150例。PSD组身体质量指数、NIHSS评分高于非PSD组,PSD组ADL评分低于非PSD组(P<0.05)。两组血小板计数和平均血小板体积分级分布上均差异有统计学差意义(P<0.05);PSD组血小板计数≤183×10^(9)/L、(>183~<257)×10^(9)/L、≥257×10^(9)/L分别有11例(12.9%)、47例(55.3%)、27例(31.8%),非PSD组分别有47例(31.3%)、72例(48.0%)、31例(20.7%)。多因素二元logistic回归分析结果显示,较高水平血小板计数、身体质量指数及NIHSS评分是PSD的独立危险因素(P<0.05)。结论较高水平的血小板计数是PSD发生的独立危险因素。
文摘目的观察穴位贴敷配合他达拉非治疗勃起功能障碍合并抑郁的临床疗效。方法将102例勃起功能障碍合并抑郁患者随机分为治疗组(52例)和对照组(50例)。治疗组采用穴位贴敷配合口服他达拉非治疗,对照组采用单纯口服他达拉非治疗。观察两组治疗前后国际勃起功能指数(the international index of erectile function-5,IIEF-5)评分、RigiScan AVSS各项监测数据(勃起总时间、根部≥60%勃起时间、头部≥60%勃起时间)及汉密尔顿抑郁量表(Hamiltondepression scale,HAMD)评分、健康状况调查问卷(36-itemshort-form,SF-36)评分的变化情况。比较两组临床疗效。结果治疗组总有效率为86.5%,明显高于对照组的74.0%(P<0.05)。两组治疗后IIFE-5评分、RigiScan AVSS各项监测数据均明显高于同组治疗前(P<0.05)。治疗组治疗后HAMD评分较同组治疗前显著下降,SF-36评分显著上升,差异均具有统计学意义(P<0.05);对照组治疗后仅SF-36评分较同组治疗前上升(P<0.05)。治疗组治疗后IIFE-5评分、RigiScan AVSS各项监测数据及SF-36评分均明显高于对照组,差异均有统计学意义(P<0.05)。结论穴位贴敷配合他达拉非是一种治疗勃起功能障碍合并抑郁的有效方法,能改善HAMD评分,提高患者生活质量。
