目的分析血小板相关指标与急性缺血性卒中后抑郁(post-stroke depression,PSD)的关系。方法选取2021年9月至2022年5月在华北理工大学附属唐山市工人医院治疗的急性缺血性卒中病人235例,记录其一般临床资料,根据17项汉密顿抑郁量表(Hamil...目的分析血小板相关指标与急性缺血性卒中后抑郁(post-stroke depression,PSD)的关系。方法选取2021年9月至2022年5月在华北理工大学附属唐山市工人医院治疗的急性缺血性卒中病人235例,记录其一般临床资料,根据17项汉密顿抑郁量表(Hamilton depression rating scale,17 item,HAMD-17)评分将病人分为PSD组和非PSD组;测定各组病人血小板相关指标(血小板计数、血小板平均体积、血小板比容、血小板分布宽度);使用美国国立卫生院卒中量表(national institute of health stroke scale,NIHSS)、日常生活活动能力量表(activity of daily living,ADL)分别评估病人神经功能缺损情况和日常生活能力;采用多因素二元logistic回归模型分析与PSD相关的独立危险因素。结果研究共纳入缺血性脑卒中病人235例,PSD组病人85例,非PSD组病人150例。PSD组身体质量指数、NIHSS评分高于非PSD组,PSD组ADL评分低于非PSD组(P<0.05)。两组血小板计数和平均血小板体积分级分布上均差异有统计学差意义(P<0.05);PSD组血小板计数≤183×10^(9)/L、(>183~<257)×10^(9)/L、≥257×10^(9)/L分别有11例(12.9%)、47例(55.3%)、27例(31.8%),非PSD组分别有47例(31.3%)、72例(48.0%)、31例(20.7%)。多因素二元logistic回归分析结果显示,较高水平血小板计数、身体质量指数及NIHSS评分是PSD的独立危险因素(P<0.05)。结论较高水平的血小板计数是PSD发生的独立危险因素。展开更多
目的:分析重复经颅磁刺激(rTMS)在合并睡眠障碍抑郁症患者治疗中的应用效果。方法:选取2022年4月至2023年12月泉州市第三医院收治的抑郁症合并睡眠障碍患者78例作为研究对象,按照随机数字表法分为对照组和观察组,每组39例。对照组采用...目的:分析重复经颅磁刺激(rTMS)在合并睡眠障碍抑郁症患者治疗中的应用效果。方法:选取2022年4月至2023年12月泉州市第三医院收治的抑郁症合并睡眠障碍患者78例作为研究对象,按照随机数字表法分为对照组和观察组,每组39例。对照组采用药物治疗,观察组采用药物治疗+低频rTMS治疗。比较2组治疗后抑郁症状、睡眠质量与心率变异性。抑郁症状采用汉密顿抑郁量表(HAMD)评价,睡眠质量采用匹兹堡睡眠质量指数(PSQI)评价。结果:观察组在4周、8周后HAMD低于对照组,差异有统计学意义(P<0.05),PSQI与睡眠障碍发生率均显著较低,差异有统计学意义(P<0.05)。观察组4周后正常窦性心搏RR间期的标准差(SDNN)、24 h内每5 min RR间期平均值的标准差(SDANN)、总功率(TP)、高频(HF)、低频(LF)高于对照组,差异有统计学意义(P<0.05)。结论:低频rTMS可改善抑郁症合并睡眠障碍患者自主神经功能,减轻抑郁症状,减少睡眠障碍。展开更多
Electroencephalography is a sensitive indicator for measuring brain condition, and can reflect early changes in brain function and severity of cerebral ischemia. However, it is not yet known whether electroencephalogr...Electroencephalography is a sensitive indicator for measuring brain condition, and can reflect early changes in brain function and severity of cerebral ischemia. However, it is not yet known whether electroencephalography can predict development of post-cerebral infarc- tion depression. A total of 321 patients with ischemic stroke underwent electroencephalography and Hamilton Depression Rating Scale assessment to analyze the relationship between electroencephalography and post-cerebral infarction depression. Our results show that electroencephalograms of ischemic stroke patients with depression exhibit low-amplitude alpha activity and slow theta activity. In con- trast, electroencephalograms of ischemic stroke patients without depression show fast beta activity and slow delta activity. ＂Ihese findings confirm that low-amplitude alpha activity and slow theta activity can be considered as independent predictors for post-cerebral infarction depression.展开更多
Background: Fluvoxamine, a selective serotonin reuptake inhibitor is widely used in the treatment of depression, one of the most common disorders prevalent in Russia. However, studies demonstrating its efficacy and sa...Background: Fluvoxamine, a selective serotonin reuptake inhibitor is widely used in the treatment of depression, one of the most common disorders prevalent in Russia. However, studies demonstrating its efficacy and safety in routine settings in Russia are scarce. Methods: This prospective, uncontrolled, open-label study was conducted at 11 centers in Russia. Total 293 patients (aged ≥ 18 years), meeting DSM-IV criteria for depression and scoring ≥ 17 on 17-item Hamilton Rating Scale of Depression (HAMD-17) received fluvoxamine 50 - 300 mg for 6 weeks. Primary efficacy measures included change from baseline in the HAMD-17 and Clinical Global Impression (CGI) scores. Secondary efficacy measure was evaluation of sleep quality changes on HAMD-17 subscale. Safety was assessed by monitoring of adverse drug reactions (ADRs). Results: Mean age of patients was 42.7 years and the majority of them were women (72%). At the end of treatment (day 42), clinically significant reduction was observed in mean HAMD-17, CGI-severity of illness and HAMD-17 sleep sub-score from 23.1, 4.5 and 3.9 at baseline to day 42;change from baseline (Δ) was: Δ-17.3 [95% CI: -18.0;-16.7]), Δ-2.1 and Δ-3.4 [95% CI: -3.53;-3.20]), respectively. At day 42, 20.8% patients reported as normal (not at all ill) on the CGI-severity scale and 85% patients reported as “much improved” or “very much improved” on the CGI-change in severity and quality of life scores. Nausea (12.6%) and somnolence (5.1%) were the most frequently reported ADRs. No deaths or serious ADRs were reported but eight patients discontinued treatment due to ADRs. Conclusion: Treatment with fluvoxamine under routine settings showed marked improvement in Russian patients with depression as measured by HAMD-17 and CGI ratings and was thus efficacious as well as safe and well-tolerated.展开更多
文摘目的分析血小板相关指标与急性缺血性卒中后抑郁(post-stroke depression,PSD)的关系。方法选取2021年9月至2022年5月在华北理工大学附属唐山市工人医院治疗的急性缺血性卒中病人235例,记录其一般临床资料,根据17项汉密顿抑郁量表(Hamilton depression rating scale,17 item,HAMD-17)评分将病人分为PSD组和非PSD组;测定各组病人血小板相关指标(血小板计数、血小板平均体积、血小板比容、血小板分布宽度);使用美国国立卫生院卒中量表(national institute of health stroke scale,NIHSS)、日常生活活动能力量表(activity of daily living,ADL)分别评估病人神经功能缺损情况和日常生活能力;采用多因素二元logistic回归模型分析与PSD相关的独立危险因素。结果研究共纳入缺血性脑卒中病人235例,PSD组病人85例,非PSD组病人150例。PSD组身体质量指数、NIHSS评分高于非PSD组,PSD组ADL评分低于非PSD组(P<0.05)。两组血小板计数和平均血小板体积分级分布上均差异有统计学差意义(P<0.05);PSD组血小板计数≤183×10^(9)/L、(>183~<257)×10^(9)/L、≥257×10^(9)/L分别有11例(12.9%)、47例(55.3%)、27例(31.8%),非PSD组分别有47例(31.3%)、72例(48.0%)、31例(20.7%)。多因素二元logistic回归分析结果显示,较高水平血小板计数、身体质量指数及NIHSS评分是PSD的独立危险因素(P<0.05)。结论较高水平的血小板计数是PSD发生的独立危险因素。
文摘目的:分析重复经颅磁刺激(rTMS)在合并睡眠障碍抑郁症患者治疗中的应用效果。方法:选取2022年4月至2023年12月泉州市第三医院收治的抑郁症合并睡眠障碍患者78例作为研究对象,按照随机数字表法分为对照组和观察组,每组39例。对照组采用药物治疗,观察组采用药物治疗+低频rTMS治疗。比较2组治疗后抑郁症状、睡眠质量与心率变异性。抑郁症状采用汉密顿抑郁量表(HAMD)评价,睡眠质量采用匹兹堡睡眠质量指数(PSQI)评价。结果:观察组在4周、8周后HAMD低于对照组,差异有统计学意义(P<0.05),PSQI与睡眠障碍发生率均显著较低,差异有统计学意义(P<0.05)。观察组4周后正常窦性心搏RR间期的标准差(SDNN)、24 h内每5 min RR间期平均值的标准差(SDANN)、总功率(TP)、高频(HF)、低频(LF)高于对照组,差异有统计学意义(P<0.05)。结论:低频rTMS可改善抑郁症合并睡眠障碍患者自主神经功能,减轻抑郁症状,减少睡眠障碍。
基金supported by the National Natural Science Foundation of China,No.81372919the Natural Science Foundation of Guangdong Province of China,No.2014A030313016+1 种基金the Basic Key Research Project Fund of Shenzhen City of China,No.JCYJ20150324140036853the Science and Technology Program Fund of Shenzhen City of China,No.JCYJ20140418181958477
文摘Electroencephalography is a sensitive indicator for measuring brain condition, and can reflect early changes in brain function and severity of cerebral ischemia. However, it is not yet known whether electroencephalography can predict development of post-cerebral infarc- tion depression. A total of 321 patients with ischemic stroke underwent electroencephalography and Hamilton Depression Rating Scale assessment to analyze the relationship between electroencephalography and post-cerebral infarction depression. Our results show that electroencephalograms of ischemic stroke patients with depression exhibit low-amplitude alpha activity and slow theta activity. In con- trast, electroencephalograms of ischemic stroke patients without depression show fast beta activity and slow delta activity. ＂Ihese findings confirm that low-amplitude alpha activity and slow theta activity can be considered as independent predictors for post-cerebral infarction depression.
文摘Background: Fluvoxamine, a selective serotonin reuptake inhibitor is widely used in the treatment of depression, one of the most common disorders prevalent in Russia. However, studies demonstrating its efficacy and safety in routine settings in Russia are scarce. Methods: This prospective, uncontrolled, open-label study was conducted at 11 centers in Russia. Total 293 patients (aged ≥ 18 years), meeting DSM-IV criteria for depression and scoring ≥ 17 on 17-item Hamilton Rating Scale of Depression (HAMD-17) received fluvoxamine 50 - 300 mg for 6 weeks. Primary efficacy measures included change from baseline in the HAMD-17 and Clinical Global Impression (CGI) scores. Secondary efficacy measure was evaluation of sleep quality changes on HAMD-17 subscale. Safety was assessed by monitoring of adverse drug reactions (ADRs). Results: Mean age of patients was 42.7 years and the majority of them were women (72%). At the end of treatment (day 42), clinically significant reduction was observed in mean HAMD-17, CGI-severity of illness and HAMD-17 sleep sub-score from 23.1, 4.5 and 3.9 at baseline to day 42;change from baseline (Δ) was: Δ-17.3 [95% CI: -18.0;-16.7]), Δ-2.1 and Δ-3.4 [95% CI: -3.53;-3.20]), respectively. At day 42, 20.8% patients reported as normal (not at all ill) on the CGI-severity scale and 85% patients reported as “much improved” or “very much improved” on the CGI-change in severity and quality of life scores. Nausea (12.6%) and somnolence (5.1%) were the most frequently reported ADRs. No deaths or serious ADRs were reported but eight patients discontinued treatment due to ADRs. Conclusion: Treatment with fluvoxamine under routine settings showed marked improvement in Russian patients with depression as measured by HAMD-17 and CGI ratings and was thus efficacious as well as safe and well-tolerated.
