The present study used electroencephalography to examine mu rhythm suppression （a putative index of human mirror neuron system activation） at frontal sites （F3, Fz and F4）, central sites （C3, Cz and C4）, parieta...The present study used electroencephalography to examine mu rhythm suppression （a putative index of human mirror neuron system activation） at frontal sites （F3, Fz and F4）, central sites （C3, Cz and C4）, parietal sites （P3, Pz and P4） and occipital sites （O1 and O2）, while subjects observed real hand motion （real hand motion condition） and illustrative depictions of hand motion （drawn hand motion condition）. Experimental data revealed that mu rhythm suppression was exhibited in the mirror neuron system when subjects observed both real and drawn hand motion. Moreover, the mu rhythm recorded at the F3, Fz, F4, and Pz poles was significantly suppressed while observing both stimulus types, but no obvious mu suppression occurred at the O1, 02 and 03 poles. These results suggest that the observation of drawings of human hand actions can activate the human mirror neuron system. This evidence supports the hypothesis that the mirror neuron system may be involved in intransitively abstract action understanding.展开更多
When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate tha...When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. The patients were divided into three groups where they underwent hand-action observation and repetition, dynamic-object observation and repetition, or conventional speech therapy. Training took place 5 days per week, 35 minutes per day, for 2 weeks. We assessed language function via picture naming tests for objects and actions and the Western Aphasia Battery. Among the participants, one patient, his wife and four healthy student volunteers underwent functional magnetic resonance imaging to analyze changes in brain activation during hand-action observation and dynamic-object observation. Results demonstrated that, compared with dynamic-object observation, hand-action observation led to greater performance with respect to the aphasia quotient and affiliated naming sub-tests and a greater Western Aphasia Battery test score. The overall effect was similar to that of conventional aphasia training, yet hand-action observation had advantages compared with conventional training in terms of vocabulary extraction and spontaneous speech. Thus, hand-action observation appears to more strongly activate the mirror neuron system compared with dynamic-object observation. The activated areas included Broca's area, Wernicke's area, and the supramarginal gyrus. These results suggest that hand-action observation combined with repetition might better improve language function in aphasia patients compared with dynamic-object observation combined with repetition. The therapeutic mechanism of this intervention may be associated with activation of additional mirror neuron systems, and may have implications for the possible repair and remodeling of damaged nerve networks. The study protocol was approved by the Ethical Committee of Nanjing Medical University, China(approval number: 2011-SRFA-086) on March 11, 2011. This trial has been registered in the ISRCTN Registry(ISRCTN84827527).展开更多
Congenital mirror movements retard typical hand functions, but no definite therapeutic modality is available to treat such movements. We report an 8-year-old boy with severe mirror movements of both hands. His mirror ...Congenital mirror movements retard typical hand functions, but no definite therapeutic modality is available to treat such movements. We report an 8-year-old boy with severe mirror movements of both hands. His mirror movements were assessed using the Woods and Teuber grading scale and his fine motor skills were also evaluated by the Purdue Pegboard Test. A 2-week regimen of repetitive transcranial magnetic stimulation produced markedly diminished mirror movement symptoms and increased the fine motor skills of both hands. Two weeks after the completion of the regimen, mirror movement grades had improved from grade 4 to 1 in both hands and the Purdue Pegboard Test results of the right and left hands also improved from 12 to 14 or 13. These improvements were maintained for 1 month after the 2-week repetitive transcranial magnetic stimulation regimen. After 18 months, the mirror movement grade was maintained and the Purdue Pegboard test score had improved to 15 for the right hand while the left hand score was maintained at 13. This occurred without any additional repetitive transcranial magnetic stimulation or other treatment. These findings suggest that repetitive transcranial magnetic stimulation for this patient had a therapeutic and long-term effect on mirror movements.展开更多
目的探讨基于镜像理论指导下的运动处方对断指再植术后患者再植断指恢复的影响。方法选取郑州市骨科医院2021年7月至2023年7月收治的89例断指再植术术后患者,使用信封随机抽取住院号方式分为两组。对照组44例患者给予常规康复训练运动处...目的探讨基于镜像理论指导下的运动处方对断指再植术后患者再植断指恢复的影响。方法选取郑州市骨科医院2021年7月至2023年7月收治的89例断指再植术术后患者,使用信封随机抽取住院号方式分为两组。对照组44例患者给予常规康复训练运动处方,研究组45例患者给予基于镜像理论指导下的运动处方,两组患者均干预12周。比较两组患者干预前后手指活动度[手指关节总主动活动度(total angle of motion,TAM)]、手功能[Michigan手功能评估量表(Michigan hand outcomes questionnaire,MHQ)]、断指再植功能(中华医学会手外科学会断指再植功能评定试用标准)、断指感觉功能[静态两点辨别觉(static two-point discrimination,S2PD)]及生活质量[Barthel评分(Barthel index,BI)]。结果两组患者干预前MHQ、TAM、S2PD评分及BI评分差异无统计学意义(P>0.05),干预后两组患者均有不同程度改善。研究组患者工作能力评分(72.41±5.26)分、整体手功能评分(79.63±3.81)分、日常活动评分(81.19±4.72)分、对手功能的满意度评分(73.69±5.38)分、外观评分(63.48±6.32)分,均高于对照组患者工作能力评分(61.28±6.38)分、整体手功能评分(74.35±4.68)分、日常活动评分(76.47±5.69)分、对手功能的满意度评分(67.35±5.64)分、外观评分(56.37±6.57)分,研究组疼痛评分(48.34±7.88)分低于对照组(54.48±7.61)分(P<0.05)。研究组患者干预后TAM评分(151.64±10.96)分、BI评分(77.58±5.48)分,高于对照组患者TAM评分(139.19±10.37)分、BI评分(73.49±5.36)分;研究组S2PD(9.56±2.14)mm低于对照组(12.69±2.43)mm(P<0.05)。两组患者干预前断指功能评分差异无统计学意义(P>0.05),干预后两组患者均有提升,研究组患者断指功能评分(82.68±6.51)分、干预后断指再植功能优秀率24.44%,高于对照组患者断指功能评分(75.39±6.34)分、干预后断指再植功能优秀率6.82%(P<0.05)。结论基于镜像理论指导下的运动处方可有效提升断指再植术后患者手指关节活动度及感觉功能,促进再植断指功能恢复,改善患者生活质量。展开更多
目的 观察智能镜像手套任务导向性训练联合低频重复经颅磁刺激(rTMS)对脑卒中患者手功能恢复的效果。方法 2022年10月1日至2023年6月30日,选择苏北人民医院脑卒中患者136例,随机分为对照组、镜像组、rTMS组和联合组,每组34例。各组均给...目的 观察智能镜像手套任务导向性训练联合低频重复经颅磁刺激(rTMS)对脑卒中患者手功能恢复的效果。方法 2022年10月1日至2023年6月30日,选择苏北人民医院脑卒中患者136例,随机分为对照组、镜像组、rTMS组和联合组,每组34例。各组均给予常规康复治疗,镜像组增加智能镜像手套任务导向性训练治疗,rTMS组增加低频rTMS治疗,联合组增加智能镜像手套任务导向性训练与低频rTMS治疗,共4周。比较治疗前后Fugl-Meyer评定量表上肢部分(FMA-UE)评分、Wolf运动功能测定量表(WMFT)评分和前臂伸肌群、屈肌群表面肌电均方根值(RMS)患侧/健侧比值;比较rTMS组和联合组治疗前后经颅磁刺激运动诱发电位(MEP)的差异。结果 对照组4例、镜像组7例、rTMS组5例、联合组6例脱落。4组FMA-UE、WMFT评分和前臂伸肌、屈肌群RMS比的组内效应(F> 996.656, P <0.001)、组间效应(F> 20.333, P <0.001)和交互效应(F> 72.796, P <0.001)均显著,且联合组最优。治疗后,rTMS组和联合组MEP的振幅均增加(|t|> 3.842, P <0.05),联合组明显高于rTMS组(t=-3.060, P <0.01)。结论 智能镜像手套任务导向性训练联合低频rTMS可有效促进脑卒中患者手功能恢复。展开更多
基金the Grants from the National Natural Science Foundation of China, No. 60775019, 60970062the Shanghai Pujiang Program, No. 09PJ1410200the Project-sponsored by SRF for ROCS, SEM
文摘The present study used electroencephalography to examine mu rhythm suppression （a putative index of human mirror neuron system activation） at frontal sites （F3, Fz and F4）, central sites （C3, Cz and C4）, parietal sites （P3, Pz and P4） and occipital sites （O1 and O2）, while subjects observed real hand motion （real hand motion condition） and illustrative depictions of hand motion （drawn hand motion condition）. Experimental data revealed that mu rhythm suppression was exhibited in the mirror neuron system when subjects observed both real and drawn hand motion. Moreover, the mu rhythm recorded at the F3, Fz, F4, and Pz poles was significantly suppressed while observing both stimulus types, but no obvious mu suppression occurred at the O1, 02 and 03 poles. These results suggest that the observation of drawings of human hand actions can activate the human mirror neuron system. This evidence supports the hypothesis that the mirror neuron system may be involved in intransitively abstract action understanding.
基金supported by the National Natural Science Foundation of China,No.81472163,81874035(to CLS)the General Project of University Philosophy and Social Science Research of China,No.2016SJB740015(to QY)+1 种基金the Science and Technology Plan Project of Zhangjiagang city of China in 2016,No.ZKS1615(to WLC)the Youth Science and Technology Project of Suzhou Health Development through Scientific Research and Education in 2018,No.KJXW2018059(to WLC)
文摘When watching someone performs an action, mirror neurons are activated in a way that is very similar to the activation that occurs when actually performing that action. Previous single-sample case studies indicate that hand-action observation training may lead to activation and remodeling of mirror neuron systems, which include important language centers, and may improve language function in aphasia patients. In this randomized-block-design experiment, we recruited 24 aphasia patients from, Zhongda Hospital, Southeast University, China. The patients were divided into three groups where they underwent hand-action observation and repetition, dynamic-object observation and repetition, or conventional speech therapy. Training took place 5 days per week, 35 minutes per day, for 2 weeks. We assessed language function via picture naming tests for objects and actions and the Western Aphasia Battery. Among the participants, one patient, his wife and four healthy student volunteers underwent functional magnetic resonance imaging to analyze changes in brain activation during hand-action observation and dynamic-object observation. Results demonstrated that, compared with dynamic-object observation, hand-action observation led to greater performance with respect to the aphasia quotient and affiliated naming sub-tests and a greater Western Aphasia Battery test score. The overall effect was similar to that of conventional aphasia training, yet hand-action observation had advantages compared with conventional training in terms of vocabulary extraction and spontaneous speech. Thus, hand-action observation appears to more strongly activate the mirror neuron system compared with dynamic-object observation. The activated areas included Broca's area, Wernicke's area, and the supramarginal gyrus. These results suggest that hand-action observation combined with repetition might better improve language function in aphasia patients compared with dynamic-object observation combined with repetition. The therapeutic mechanism of this intervention may be associated with activation of additional mirror neuron systems, and may have implications for the possible repair and remodeling of damaged nerve networks. The study protocol was approved by the Ethical Committee of Nanjing Medical University, China(approval number: 2011-SRFA-086) on March 11, 2011. This trial has been registered in the ISRCTN Registry(ISRCTN84827527).
基金supported by Yeungnam University research grants in 2010
文摘Congenital mirror movements retard typical hand functions, but no definite therapeutic modality is available to treat such movements. We report an 8-year-old boy with severe mirror movements of both hands. His mirror movements were assessed using the Woods and Teuber grading scale and his fine motor skills were also evaluated by the Purdue Pegboard Test. A 2-week regimen of repetitive transcranial magnetic stimulation produced markedly diminished mirror movement symptoms and increased the fine motor skills of both hands. Two weeks after the completion of the regimen, mirror movement grades had improved from grade 4 to 1 in both hands and the Purdue Pegboard Test results of the right and left hands also improved from 12 to 14 or 13. These improvements were maintained for 1 month after the 2-week repetitive transcranial magnetic stimulation regimen. After 18 months, the mirror movement grade was maintained and the Purdue Pegboard test score had improved to 15 for the right hand while the left hand score was maintained at 13. This occurred without any additional repetitive transcranial magnetic stimulation or other treatment. These findings suggest that repetitive transcranial magnetic stimulation for this patient had a therapeutic and long-term effect on mirror movements.
文摘目的探讨基于镜像理论指导下的运动处方对断指再植术后患者再植断指恢复的影响。方法选取郑州市骨科医院2021年7月至2023年7月收治的89例断指再植术术后患者,使用信封随机抽取住院号方式分为两组。对照组44例患者给予常规康复训练运动处方,研究组45例患者给予基于镜像理论指导下的运动处方,两组患者均干预12周。比较两组患者干预前后手指活动度[手指关节总主动活动度(total angle of motion,TAM)]、手功能[Michigan手功能评估量表(Michigan hand outcomes questionnaire,MHQ)]、断指再植功能(中华医学会手外科学会断指再植功能评定试用标准)、断指感觉功能[静态两点辨别觉(static two-point discrimination,S2PD)]及生活质量[Barthel评分(Barthel index,BI)]。结果两组患者干预前MHQ、TAM、S2PD评分及BI评分差异无统计学意义(P>0.05),干预后两组患者均有不同程度改善。研究组患者工作能力评分(72.41±5.26)分、整体手功能评分(79.63±3.81)分、日常活动评分(81.19±4.72)分、对手功能的满意度评分(73.69±5.38)分、外观评分(63.48±6.32)分,均高于对照组患者工作能力评分(61.28±6.38)分、整体手功能评分(74.35±4.68)分、日常活动评分(76.47±5.69)分、对手功能的满意度评分(67.35±5.64)分、外观评分(56.37±6.57)分,研究组疼痛评分(48.34±7.88)分低于对照组(54.48±7.61)分(P<0.05)。研究组患者干预后TAM评分(151.64±10.96)分、BI评分(77.58±5.48)分,高于对照组患者TAM评分(139.19±10.37)分、BI评分(73.49±5.36)分;研究组S2PD(9.56±2.14)mm低于对照组(12.69±2.43)mm(P<0.05)。两组患者干预前断指功能评分差异无统计学意义(P>0.05),干预后两组患者均有提升,研究组患者断指功能评分(82.68±6.51)分、干预后断指再植功能优秀率24.44%,高于对照组患者断指功能评分(75.39±6.34)分、干预后断指再植功能优秀率6.82%(P<0.05)。结论基于镜像理论指导下的运动处方可有效提升断指再植术后患者手指关节活动度及感觉功能,促进再植断指功能恢复,改善患者生活质量。
文摘目的 观察智能镜像手套任务导向性训练联合低频重复经颅磁刺激(rTMS)对脑卒中患者手功能恢复的效果。方法 2022年10月1日至2023年6月30日,选择苏北人民医院脑卒中患者136例,随机分为对照组、镜像组、rTMS组和联合组,每组34例。各组均给予常规康复治疗,镜像组增加智能镜像手套任务导向性训练治疗,rTMS组增加低频rTMS治疗,联合组增加智能镜像手套任务导向性训练与低频rTMS治疗,共4周。比较治疗前后Fugl-Meyer评定量表上肢部分(FMA-UE)评分、Wolf运动功能测定量表(WMFT)评分和前臂伸肌群、屈肌群表面肌电均方根值(RMS)患侧/健侧比值;比较rTMS组和联合组治疗前后经颅磁刺激运动诱发电位(MEP)的差异。结果 对照组4例、镜像组7例、rTMS组5例、联合组6例脱落。4组FMA-UE、WMFT评分和前臂伸肌、屈肌群RMS比的组内效应(F> 996.656, P <0.001)、组间效应(F> 20.333, P <0.001)和交互效应(F> 72.796, P <0.001)均显著,且联合组最优。治疗后,rTMS组和联合组MEP的振幅均增加(|t|> 3.842, P <0.05),联合组明显高于rTMS组(t=-3.060, P <0.01)。结论 智能镜像手套任务导向性训练联合低频rTMS可有效促进脑卒中患者手功能恢复。
