Objective: To evaluate the prevalence of hand osteoarthritis (hOA) in a population with knee osteoarthritis (KOA) at baseline and one year following the administration of a multi-professional OA educational program co...Objective: To evaluate the prevalence of hand osteoarthritis (hOA) in a population with knee osteoarthritis (KOA) at baseline and one year following the administration of a multi-professional OA educational program correlating symptoms and changes in BMI with function questionnaires of the upper limbs and direct grip strength measurements. Design: Epidemiological study of the prevalence of hand OA in patients with knee osteoarthritis. The Stanford Health Assessment Questionnaire instruments (HAQ);Disabilities of the Arm, Shoulder and Hand* (DASH);grip strength;and finger pinch were utilized, and the upper limbs symptoms were verified at baseline and one year following the educational program. Results: The prevalence of hOA was 23.7% at baseline and 47.4% at one year (incidence of 31.8% per year). The HAQ indicated that patients who did not alter or increased their BMI experienced worsened global strength, whereas patients who reduced BMI improved global strength (p = 0.041). Patients with higher initial BMIs experienced less improvement in the HAQ (r = -0.148, p = 0.041). The DASH results improved, but the right and left tripod grip worsened in all patients, irrespective of BMI change (p < 0.05) or symptoms at baseline and reassessment (p < 0.05). Pinch strength (right and left tripod and left pulp-pulp) was higher in patients without symptoms at baseline (p = 0.048, p = 0.045 and 0.033, respectively). Conclusions: The prevalence of hand OA increased for patients with OA undergoing an educational program irrespective of improved upper function and regardless of BMI change. Patients who decreased their BMI improved their global strength.展开更多
Background: Since the minimum grip span of a standard Smedley hand dynamometer is 4 cm, the handgrip strength (HGS) value at a less than 4 cm grip span has not been reported. Objective: The present study examined the ...Background: Since the minimum grip span of a standard Smedley hand dynamometer is 4 cm, the handgrip strength (HGS) value at a less than 4 cm grip span has not been reported. Objective: The present study examined the impact of grip span on handgrip strength (HGS) in young children using a dynamometer ranging from 2 to 4.5 cm of grip span. Methods: A total of 93 (39 girls and 54 boys) children were recruited from a local kindergarten with the cooperation of their parents. Each participant performed one test trial and then five maximal trials using different grip spans (2.0, 3.0, 3.5, 4.0, and 4.5 cm) in random order and allowing a 1-minute rest between measures. Results: There was a statistically significant difference in HGS depending on which grip span was used, χ<sup>2</sup>(4) = 211.5 (p Conclusion: Our results recommended that the target grip span for measuring maximal HGS in young children is about 4 cm (4 ± 0.5 cm).展开更多
目的探究握力与认知功能的关联是否存在性别差异。方法利用2011—2014年美国国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)数据库开展横断面研究,评估即时记忆、延迟记忆、言语流畅性和注意力4个认知...目的探究握力与认知功能的关联是否存在性别差异。方法利用2011—2014年美国国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)数据库开展横断面研究,评估即时记忆、延迟记忆、言语流畅性和注意力4个认知领域。采用加权线性回归、加权Logistic回归、相乘模型进行分析。结果回归分析显示,在男性,与握力最低组的研究对象相比,握力最高组研究对象有更低的整体认知功能降低(OR=0.377,95%CI:0.182~0.781)和即时记忆降低(OR=0.409,95%CI:0.221~0.759)的风险。在女性,握力与整体认知功能降低(OR=0.405,95%CI:0.224~0.733)、言语流畅性降低(OR=0.567,95%CI:0.356~0.902)以及注意力降低(OR=0.357,95%CI:0.211~0.607)的风险呈显著负相关关系。同时,性别和握力在整体认知功能、言语流畅性和注意力均存在显著交互作用,但是即时记忆、延迟回忆2个认知领域未检测到显著的交互作用。结论握力对整体认知功能和不同认知领域的影响存在性别差异。因此,提高握力水平,特别是女性,有利于预防认知功能下降。展开更多
BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced fibrosis.Sarcopenia,characterized by decreased muscle strength and mass,shares common pat...BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced fibrosis.Sarcopenia,characterized by decreased muscle strength and mass,shares common pathophysiological traits with NAFLD.An association exists between sarcopenia and increased NAFLD prevalence.However,data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain inconsistent.AIM To analyze the prevalence and outcomes of sarcopenia in patients with NAFLD.METHODS We conducted a comprehensive search for relevant studies in MEDLINE,Embase,and Scopus from their inception to June 2023.We included studies that focused on patients with NAFLD,reported the prevalence of sarcopenia as the primary outcome,and examined secondary outcomes,such as liver fibrosis and other adverse events.We also used the Newcastle-Ottawa scale for quality assessment.RESULTS Of the 29 studies included,the prevalence of sarcopenia in NAFLD varied widely(1.6%to 63.0%),with 20 studies reporting a prevalence of more than 10.0%.Substantial heterogeneity was noted in the measurement modalities for sarcopenia.Sarcopenia was associated with a higher risk of advanced fibrosis(odd ratio:1.97,95%confidence interval:1.44-2.70).Increased odds were consistently observed in fibrosis assessment through biopsy,NAFLD fibrosis score/body mass index,aspartate aminotransferase to alanine aminotransferase ratio,diabetes(BARD)score,and transient elastography,whereas the fibrosis-4 score showed no such association.Sarcopenia in NAFLD was associated with a higher risk of steatohepatitis,insulin resistance,cardiovascular risks,and mortality.CONCLUSION This systematic review highlights the critical need for standardized diagnostic criteria and measurement methods for sarcopenia in NAFLD patients.The variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent findings.This review demonstrates the multidimensional impact of sarcopenia on NAFLD,indicating its importance beyond liver-related events to include cardiovascular risks,mortality,and metabolic complications.展开更多
Aim: Assess upper and lower limb functions in elderly with heart failure (HF) and evaluate its relation to HF severity. Methods: Handgrip strength (HGS) in kilograms (kgs.) of both hands using handle mechanical dynamo...Aim: Assess upper and lower limb functions in elderly with heart failure (HF) and evaluate its relation to HF severity. Methods: Handgrip strength (HGS) in kilograms (kgs.) of both hands using handle mechanical dynamometer and counting the repetitions (rep.) of stand and sit on a chair during 30 seconds [the 30 seconds chair-stand test (CST)] were used in 71 elderly (≥65 years old) patients with clinically stable HF and other matched 32 healthy elderly as a control. HF was diagnosed clinically, by plasma B-Type natriuretic peptide (BNP) and by echocardiography. The New York Heart Association (NYHA) functional classification of HF was used to obtain two groups: NYHA class I-II (33 patients), and NYHA class III (38 patients). Results: Showed significant decrease in both HGS and CST score in all HF patients (9.7 ± 4.4 kgs., 8.8 ± 3.1 rep., respectively) compared to controls (77.8 ± 11 kgs., 13.5 ± 1.1 rep., respectively, p Conclusion: Upper and lower limb muscles?strength, assessed by two easy andinexpensive tests (HGS and CST), may reflect clinical severity of HF in elderly patients who cannot usually perform exercise tests. Its prognostic value requires further follow-up studies to verify.展开更多
Background: Test-retest strength reliability of the Electronic Push/Pull Dynamometer (EPPD) in the measurement of the extensor and flexor muscles on a new constructed chair. The objective of the study was to assess re...Background: Test-retest strength reliability of the Electronic Push/Pull Dynamometer (EPPD) in the measurement of the extensor and flexor muscles on a new constructed chair. The objective of the study was to assess reliability of Electronic Push/Pull Dynamometer in the measurement of the knee flexion and extension at 90° and 60° on a new constructed chair. The aims of the author: To assess reliability of Electronic Push/Pull Dynamometer in the measurement of the knee flexion and extension at 90° and 60° on a new constructed chair. Design: A test-retest reliability study. Subjects: One hundred healthy students male and female (mean age, 21y). Methods: Maximum isometric strength of the quadriceps and hamstring muscle groups was measured using the EPPD were recorded at 60° and 90° for 3 trials on 2 occasions. Reliability was assessed with the Intraclass correlation coefficient (ICC), mean and standard deviation (SD) of measurements, and smallest real differences were calculated for the maximum and for the mean and work of the 3 repetitions. Results: Mean strength ranged from 50.44 kg for knee flexion to 55.76 kg for knee extension 50.44 kg to 61.98 kg at 90° hip flexion. Test-retest reliability Intraclass correlation coefficients (ICCs) ranged from 0.85 to 0.99. ICCs for test-retest reliability ranged from 0.780 to 0.998. Conclusions: The results of the reliability study indicate that the EPPD in reliable dynamometer to use in determining lower limb muscle force production. It can be used to measure disease progression and to evaluate changes in knee extension and flexion strength at the individual patient level.展开更多
导管相关性血栓形成是外周置入中心静脉导管(peripherally inserted central catheter,PICC)留置期间最常见的并发症之一,严重时可导致非计划性拔管而影响患者的治疗进程,甚至威胁患者的生命安全。握力训练作为预防PICC相关性血栓形成...导管相关性血栓形成是外周置入中心静脉导管(peripherally inserted central catheter,PICC)留置期间最常见的并发症之一,严重时可导致非计划性拔管而影响患者的治疗进程,甚至威胁患者的生命安全。握力训练作为预防PICC相关性血栓形成的常用干预方法之一,具有有效性和实用性,但在临床实践中由于缺乏科学化、规范化、精准化训练方案的指导,患者训练依从性及其干预效果参差不齐。该文对PICC相关性血栓形成的发生机制、常用握力训练方法及局限性进行总结分析,以期为临床更好地实施握力训练干预提供参考。展开更多
为解决当前竞技二打一比赛中存在的赛制冗长、存在作弊隐患的问题,设计一种牌力评估与同等牌力生成系统。对大量人类打牌数据使用二阶聚类算法进行聚类分析,得到手牌牌力分类的标注数据集;构建基于注意力机制的长短期记忆网络(long shor...为解决当前竞技二打一比赛中存在的赛制冗长、存在作弊隐患的问题,设计一种牌力评估与同等牌力生成系统。对大量人类打牌数据使用二阶聚类算法进行聚类分析,得到手牌牌力分类的标注数据集;构建基于注意力机制的长短期记忆网络(long short term memory network,LSTM)模型,针对手牌序列与手牌牌力进行训练,并通过生成同等牌力手牌借助AI机器人进行对打实验。实验结果表明:生成的不同牌力手牌在胜率上具有显著区别,可正确生成对应牌力手牌,具有可行性。展开更多
BACKGROUND Observational studies have suggested that depression is associated with sarcopenia.However,the causal relationship between depression and sarcopenia remains unclear.AIM To investigate the causal relationshi...BACKGROUND Observational studies have suggested that depression is associated with sarcopenia.However,the causal relationship between depression and sarcopenia remains unclear.AIM To investigate the causal relationship between depression and sarcopenia.METHODS We performed a Mendelian randomization(MR)analysis to identify the bidirectional relationship between depression and sarcopenia-related traits.Summarylevel data and independent variants used as instrumental variables came from large genome-wide association studies of depression(414055 cases and 892299 controls),of appendicular lean mass(ALM,450243 participants),and of hand grip strength(exposure:360000 participants;outcome:334925 participants).RESULTS We identified a negative association of depression with lower ALM[odds ratio(OR):0.932,95%confidence interval(95%CI):0.889-0.979,P=0.005].In the reverse MR analysis,we also observed an inverse association of hand grip strength with depression(OR:0.200,95%CI:0.108-0.370,P<0.001).Similar results were obtained in sensitivity analyses.CONCLUSION Depression was causally related to decreased muscle mass,and declined muscle strength might lead to a higher risk of depression.展开更多
文摘Objective: To evaluate the prevalence of hand osteoarthritis (hOA) in a population with knee osteoarthritis (KOA) at baseline and one year following the administration of a multi-professional OA educational program correlating symptoms and changes in BMI with function questionnaires of the upper limbs and direct grip strength measurements. Design: Epidemiological study of the prevalence of hand OA in patients with knee osteoarthritis. The Stanford Health Assessment Questionnaire instruments (HAQ);Disabilities of the Arm, Shoulder and Hand* (DASH);grip strength;and finger pinch were utilized, and the upper limbs symptoms were verified at baseline and one year following the educational program. Results: The prevalence of hOA was 23.7% at baseline and 47.4% at one year (incidence of 31.8% per year). The HAQ indicated that patients who did not alter or increased their BMI experienced worsened global strength, whereas patients who reduced BMI improved global strength (p = 0.041). Patients with higher initial BMIs experienced less improvement in the HAQ (r = -0.148, p = 0.041). The DASH results improved, but the right and left tripod grip worsened in all patients, irrespective of BMI change (p < 0.05) or symptoms at baseline and reassessment (p < 0.05). Pinch strength (right and left tripod and left pulp-pulp) was higher in patients without symptoms at baseline (p = 0.048, p = 0.045 and 0.033, respectively). Conclusions: The prevalence of hand OA increased for patients with OA undergoing an educational program irrespective of improved upper function and regardless of BMI change. Patients who decreased their BMI improved their global strength.
文摘Background: Since the minimum grip span of a standard Smedley hand dynamometer is 4 cm, the handgrip strength (HGS) value at a less than 4 cm grip span has not been reported. Objective: The present study examined the impact of grip span on handgrip strength (HGS) in young children using a dynamometer ranging from 2 to 4.5 cm of grip span. Methods: A total of 93 (39 girls and 54 boys) children were recruited from a local kindergarten with the cooperation of their parents. Each participant performed one test trial and then five maximal trials using different grip spans (2.0, 3.0, 3.5, 4.0, and 4.5 cm) in random order and allowing a 1-minute rest between measures. Results: There was a statistically significant difference in HGS depending on which grip span was used, χ<sup>2</sup>(4) = 211.5 (p Conclusion: Our results recommended that the target grip span for measuring maximal HGS in young children is about 4 cm (4 ± 0.5 cm).
文摘目的探究握力与认知功能的关联是否存在性别差异。方法利用2011—2014年美国国家健康与营养调查(National Health and Nutrition Examination Survey,NHANES)数据库开展横断面研究,评估即时记忆、延迟记忆、言语流畅性和注意力4个认知领域。采用加权线性回归、加权Logistic回归、相乘模型进行分析。结果回归分析显示,在男性,与握力最低组的研究对象相比,握力最高组研究对象有更低的整体认知功能降低(OR=0.377,95%CI:0.182~0.781)和即时记忆降低(OR=0.409,95%CI:0.221~0.759)的风险。在女性,握力与整体认知功能降低(OR=0.405,95%CI:0.224~0.733)、言语流畅性降低(OR=0.567,95%CI:0.356~0.902)以及注意力降低(OR=0.357,95%CI:0.211~0.607)的风险呈显著负相关关系。同时,性别和握力在整体认知功能、言语流畅性和注意力均存在显著交互作用,但是即时记忆、延迟回忆2个认知领域未检测到显著的交互作用。结论握力对整体认知功能和不同认知领域的影响存在性别差异。因此,提高握力水平,特别是女性,有利于预防认知功能下降。
文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)includes a spectrum of conditions,progressing from mild steatosis to advanced fibrosis.Sarcopenia,characterized by decreased muscle strength and mass,shares common pathophysiological traits with NAFLD.An association exists between sarcopenia and increased NAFLD prevalence.However,data on the prevalence of sarcopenia in NAFLD and its impact on the outcomes of NAFLD remain inconsistent.AIM To analyze the prevalence and outcomes of sarcopenia in patients with NAFLD.METHODS We conducted a comprehensive search for relevant studies in MEDLINE,Embase,and Scopus from their inception to June 2023.We included studies that focused on patients with NAFLD,reported the prevalence of sarcopenia as the primary outcome,and examined secondary outcomes,such as liver fibrosis and other adverse events.We also used the Newcastle-Ottawa scale for quality assessment.RESULTS Of the 29 studies included,the prevalence of sarcopenia in NAFLD varied widely(1.6%to 63.0%),with 20 studies reporting a prevalence of more than 10.0%.Substantial heterogeneity was noted in the measurement modalities for sarcopenia.Sarcopenia was associated with a higher risk of advanced fibrosis(odd ratio:1.97,95%confidence interval:1.44-2.70).Increased odds were consistently observed in fibrosis assessment through biopsy,NAFLD fibrosis score/body mass index,aspartate aminotransferase to alanine aminotransferase ratio,diabetes(BARD)score,and transient elastography,whereas the fibrosis-4 score showed no such association.Sarcopenia in NAFLD was associated with a higher risk of steatohepatitis,insulin resistance,cardiovascular risks,and mortality.CONCLUSION This systematic review highlights the critical need for standardized diagnostic criteria and measurement methods for sarcopenia in NAFLD patients.The variability in study designs and assessment methods for sarcopenia and liver fibrosis may account for the inconsistent findings.This review demonstrates the multidimensional impact of sarcopenia on NAFLD,indicating its importance beyond liver-related events to include cardiovascular risks,mortality,and metabolic complications.
文摘Aim: Assess upper and lower limb functions in elderly with heart failure (HF) and evaluate its relation to HF severity. Methods: Handgrip strength (HGS) in kilograms (kgs.) of both hands using handle mechanical dynamometer and counting the repetitions (rep.) of stand and sit on a chair during 30 seconds [the 30 seconds chair-stand test (CST)] were used in 71 elderly (≥65 years old) patients with clinically stable HF and other matched 32 healthy elderly as a control. HF was diagnosed clinically, by plasma B-Type natriuretic peptide (BNP) and by echocardiography. The New York Heart Association (NYHA) functional classification of HF was used to obtain two groups: NYHA class I-II (33 patients), and NYHA class III (38 patients). Results: Showed significant decrease in both HGS and CST score in all HF patients (9.7 ± 4.4 kgs., 8.8 ± 3.1 rep., respectively) compared to controls (77.8 ± 11 kgs., 13.5 ± 1.1 rep., respectively, p Conclusion: Upper and lower limb muscles?strength, assessed by two easy andinexpensive tests (HGS and CST), may reflect clinical severity of HF in elderly patients who cannot usually perform exercise tests. Its prognostic value requires further follow-up studies to verify.
文摘Background: Test-retest strength reliability of the Electronic Push/Pull Dynamometer (EPPD) in the measurement of the extensor and flexor muscles on a new constructed chair. The objective of the study was to assess reliability of Electronic Push/Pull Dynamometer in the measurement of the knee flexion and extension at 90° and 60° on a new constructed chair. The aims of the author: To assess reliability of Electronic Push/Pull Dynamometer in the measurement of the knee flexion and extension at 90° and 60° on a new constructed chair. Design: A test-retest reliability study. Subjects: One hundred healthy students male and female (mean age, 21y). Methods: Maximum isometric strength of the quadriceps and hamstring muscle groups was measured using the EPPD were recorded at 60° and 90° for 3 trials on 2 occasions. Reliability was assessed with the Intraclass correlation coefficient (ICC), mean and standard deviation (SD) of measurements, and smallest real differences were calculated for the maximum and for the mean and work of the 3 repetitions. Results: Mean strength ranged from 50.44 kg for knee flexion to 55.76 kg for knee extension 50.44 kg to 61.98 kg at 90° hip flexion. Test-retest reliability Intraclass correlation coefficients (ICCs) ranged from 0.85 to 0.99. ICCs for test-retest reliability ranged from 0.780 to 0.998. Conclusions: The results of the reliability study indicate that the EPPD in reliable dynamometer to use in determining lower limb muscle force production. It can be used to measure disease progression and to evaluate changes in knee extension and flexion strength at the individual patient level.
文摘导管相关性血栓形成是外周置入中心静脉导管(peripherally inserted central catheter,PICC)留置期间最常见的并发症之一,严重时可导致非计划性拔管而影响患者的治疗进程,甚至威胁患者的生命安全。握力训练作为预防PICC相关性血栓形成的常用干预方法之一,具有有效性和实用性,但在临床实践中由于缺乏科学化、规范化、精准化训练方案的指导,患者训练依从性及其干预效果参差不齐。该文对PICC相关性血栓形成的发生机制、常用握力训练方法及局限性进行总结分析,以期为临床更好地实施握力训练干预提供参考。
文摘为解决当前竞技二打一比赛中存在的赛制冗长、存在作弊隐患的问题,设计一种牌力评估与同等牌力生成系统。对大量人类打牌数据使用二阶聚类算法进行聚类分析,得到手牌牌力分类的标注数据集;构建基于注意力机制的长短期记忆网络(long short term memory network,LSTM)模型,针对手牌序列与手牌牌力进行训练,并通过生成同等牌力手牌借助AI机器人进行对打实验。实验结果表明:生成的不同牌力手牌在胜率上具有显著区别,可正确生成对应牌力手牌,具有可行性。
基金Zhejiang Province Traditional Chinese Medicine Science and Technology Project,No.2023ZR075.
文摘BACKGROUND Observational studies have suggested that depression is associated with sarcopenia.However,the causal relationship between depression and sarcopenia remains unclear.AIM To investigate the causal relationship between depression and sarcopenia.METHODS We performed a Mendelian randomization(MR)analysis to identify the bidirectional relationship between depression and sarcopenia-related traits.Summarylevel data and independent variants used as instrumental variables came from large genome-wide association studies of depression(414055 cases and 892299 controls),of appendicular lean mass(ALM,450243 participants),and of hand grip strength(exposure:360000 participants;outcome:334925 participants).RESULTS We identified a negative association of depression with lower ALM[odds ratio(OR):0.932,95%confidence interval(95%CI):0.889-0.979,P=0.005].In the reverse MR analysis,we also observed an inverse association of hand grip strength with depression(OR:0.200,95%CI:0.108-0.370,P<0.001).Similar results were obtained in sensitivity analyses.CONCLUSION Depression was causally related to decreased muscle mass,and declined muscle strength might lead to a higher risk of depression.
