AIM To investigate the relationship between the onsets of multikinase inhibitor(MKI)-associated hand-foot skin reaction(HFSR) and prognosis under intervention by pharmacists after the introduction of sorafenib.METHODS...AIM To investigate the relationship between the onsets of multikinase inhibitor(MKI)-associated hand-foot skin reaction(HFSR) and prognosis under intervention by pharmacists after the introduction of sorafenib.METHODS We conducted a retrospective study involving 40 patients treated with sorafenib. Intervention by pharmacists began at the time of treatment introduction and continued until the appearance of symptomatic exacerbation or non-permissible adverse reactions. We examined the relationship between MKI-associated HFSR and overall survival(OS) after the initiation of treatment.RESULTS The median OS was 10.9 mo in the MKI-associated HFSR group and 3.4 mo in the no HFSR group, showing a significant difference in multivariate analysis. A multivariate analysis of the time to treatment failure indicated that the intervention by pharmacists and MKI-associated HFSR were significant factors. The median cumulative dose and the mean medication possession ratio were significantly higher in the intervention group than in the non-intervention group. A borderline significant difference was observed in terms of OS in this group.CONCLUSION Intervention by pharmacists increased drug adherence. Under increased adherence, MKI-associated HFSR was an advantageous surrogate marker. Intervention by healthcare providers needs to be performed for adequate sorafenib treatment.展开更多
目的:探讨皮瓣综合护理对手部软组织缺损术后功能恢复及外观满意度的影响。方法:选取2019年8月-2023年8月在笔者医院行手部皮瓣移植术的患者96例作为研究对象,按照随机数表法分为观察组和对照组,各48例。对照组采用常规护理干预,观察组...目的:探讨皮瓣综合护理对手部软组织缺损术后功能恢复及外观满意度的影响。方法:选取2019年8月-2023年8月在笔者医院行手部皮瓣移植术的患者96例作为研究对象,按照随机数表法分为观察组和对照组,各48例。对照组采用常规护理干预,观察组在对照组的基础上采用皮瓣综合护理干预,比较两组手部功能恢复[采用总主动活动度(Total active motion,TAM)系统评价]、术后并发症、日常生活能力[采用Barthel指数评定量表(Barthel index,BI)评估]和外形满意度。结果:干预2周后,观察组TAM优良率高于对照组,术后并发症总发生率低于对照组,BI评分高于对照组,患者对皮瓣外形的满意度评分高于对照组,差异均有统计学意义(P<0.05)。结论:皮瓣综合护理可有效加快手部软组织缺损术后功能快速恢复,减少并发症发生,提高日常生活能力和外形满意度。展开更多
文摘AIM To investigate the relationship between the onsets of multikinase inhibitor(MKI)-associated hand-foot skin reaction(HFSR) and prognosis under intervention by pharmacists after the introduction of sorafenib.METHODS We conducted a retrospective study involving 40 patients treated with sorafenib. Intervention by pharmacists began at the time of treatment introduction and continued until the appearance of symptomatic exacerbation or non-permissible adverse reactions. We examined the relationship between MKI-associated HFSR and overall survival(OS) after the initiation of treatment.RESULTS The median OS was 10.9 mo in the MKI-associated HFSR group and 3.4 mo in the no HFSR group, showing a significant difference in multivariate analysis. A multivariate analysis of the time to treatment failure indicated that the intervention by pharmacists and MKI-associated HFSR were significant factors. The median cumulative dose and the mean medication possession ratio were significantly higher in the intervention group than in the non-intervention group. A borderline significant difference was observed in terms of OS in this group.CONCLUSION Intervention by pharmacists increased drug adherence. Under increased adherence, MKI-associated HFSR was an advantageous surrogate marker. Intervention by healthcare providers needs to be performed for adequate sorafenib treatment.
文摘目的:探讨皮瓣综合护理对手部软组织缺损术后功能恢复及外观满意度的影响。方法:选取2019年8月-2023年8月在笔者医院行手部皮瓣移植术的患者96例作为研究对象,按照随机数表法分为观察组和对照组,各48例。对照组采用常规护理干预,观察组在对照组的基础上采用皮瓣综合护理干预,比较两组手部功能恢复[采用总主动活动度(Total active motion,TAM)系统评价]、术后并发症、日常生活能力[采用Barthel指数评定量表(Barthel index,BI)评估]和外形满意度。结果:干预2周后,观察组TAM优良率高于对照组,术后并发症总发生率低于对照组,BI评分高于对照组,患者对皮瓣外形的满意度评分高于对照组,差异均有统计学意义(P<0.05)。结论:皮瓣综合护理可有效加快手部软组织缺损术后功能快速恢复,减少并发症发生,提高日常生活能力和外形满意度。
