When febrile illnesses develop a rash in children, parents are very concerned about a serious disease. Many rashes associated with fever are caused by infectious diseases. Rashes are generally nonspecific and play a s...When febrile illnesses develop a rash in children, parents are very concerned about a serious disease. Many rashes associated with fever are caused by infectious diseases. Rashes are generally nonspecific and play a supportive role in differential diagnosis, but for some diseases, the appearance of the rash is essential in making a diagnosis. Here is presented the case of a 4-year-old boy with high fever, headache, abdominal pain, vomiting, diarrhea, and a generalized maculo-papular rash including palms and soles. On physical examination were found a black eschar, cervical lymphadenopathy, and hepatosplenomegaly. Laboratory findings resulted in moderate leukocytosis and moderate involvement of the liver and renal function. Based on this finding, a diagnosis of Mediterranean Spotted Fever was performed. The child recovered after medication with azithromycin. Because there is no reliable test that can confirm MSF in its early stages, the diagnosis is commonly made on the basis of clinical findings, so a high index of suspicion should be maintained while evaluating a child with fever and rash.展开更多
Coronavirus disease 2019 (COVID-19) is an illness caused by the novel coronavirus designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first identified in Wuhan, China, in December 2019, ...Coronavirus disease 2019 (COVID-19) is an illness caused by the novel coronavirus designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first identified in Wuhan, China, in December 2019, and soon spread all over the world causing a global pandemic. Since the beginning of the pandemic, fewer cases of COVID-19 have been reported in children than in adults. Most cases have been mild and only a small proportion of infected children needed hospitalization. As the pandemic evolved, it was soon evident that immune dysregulation inflicted by the virus, posed children at risk for their lives. It is still hard to predict its effects on children health and well-being. Here are reported a series of cases of muco-cutaneous changes following COVID-19 infection in children. Children ranged from 8 months to ten years. They had a history of a recent COVID-19 infection (1 - 3 months ago), with a RT-PCR for COVID-19 negative, SARS-CoV-2 IgM negative and a positive SARS-Cov-2 IgG. Their presentation was consistent with a late reaction to COVID-19 reaction with muco-cutaneous changes dominating the scenery.展开更多
文摘When febrile illnesses develop a rash in children, parents are very concerned about a serious disease. Many rashes associated with fever are caused by infectious diseases. Rashes are generally nonspecific and play a supportive role in differential diagnosis, but for some diseases, the appearance of the rash is essential in making a diagnosis. Here is presented the case of a 4-year-old boy with high fever, headache, abdominal pain, vomiting, diarrhea, and a generalized maculo-papular rash including palms and soles. On physical examination were found a black eschar, cervical lymphadenopathy, and hepatosplenomegaly. Laboratory findings resulted in moderate leukocytosis and moderate involvement of the liver and renal function. Based on this finding, a diagnosis of Mediterranean Spotted Fever was performed. The child recovered after medication with azithromycin. Because there is no reliable test that can confirm MSF in its early stages, the diagnosis is commonly made on the basis of clinical findings, so a high index of suspicion should be maintained while evaluating a child with fever and rash.
文摘Coronavirus disease 2019 (COVID-19) is an illness caused by the novel coronavirus designated as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It was first identified in Wuhan, China, in December 2019, and soon spread all over the world causing a global pandemic. Since the beginning of the pandemic, fewer cases of COVID-19 have been reported in children than in adults. Most cases have been mild and only a small proportion of infected children needed hospitalization. As the pandemic evolved, it was soon evident that immune dysregulation inflicted by the virus, posed children at risk for their lives. It is still hard to predict its effects on children health and well-being. Here are reported a series of cases of muco-cutaneous changes following COVID-19 infection in children. Children ranged from 8 months to ten years. They had a history of a recent COVID-19 infection (1 - 3 months ago), with a RT-PCR for COVID-19 negative, SARS-CoV-2 IgM negative and a positive SARS-Cov-2 IgG. Their presentation was consistent with a late reaction to COVID-19 reaction with muco-cutaneous changes dominating the scenery.
