The Effect of Ginkgo Biloba Leaf Dropping Pill Combined with Butylphthalide Capsule on Cognitive Dysfunction in Patients after Acute Ischemic Stroke and Its Impact on Serum Cytokines

Objective: To investigate the therapeutic effect of Ginkgo biloba extract dropping pills combined with butylphthalide capsules on cognitive dysfunction in patients after acute ischemic stroke (AIS) and its impact on serum cytokines CRP, IL-6, and Hcy. Methods: This study selected 76 patients with cognitive dysfunction after ischemic stroke who were hospitalized at Zhuji People’s Hospital from January 2023 to January 2024. The patients were divided into two groups. The control group was treated with butylphthalide capsules, while the combination group received Ginkgo biloba extract dropping pills in addition to the treatment given to the control group. The neurological function, cognitive function, activities of daily living, and levels of serum cytokines CRP, IL-6, and Hcy were compared between the two groups after 1 month and 3 months of treatment. Results: The NIHSS scores, MMSE scores, ADL scores, and levels of CRP, IL-6, and Hcy in both groups showed statistically significant differences compared to before treatment (P Conclusion: The combination of Ginkgo biloba extract dropping pills and butylphthalide capsules has a better therapeutic effect on cognitive dysfunction in patients after ischemic stroke. It can improve the neurological function and cognitive function of patients, enhance their ability to perform daily activities, and reduce inflammatory responses.

Basic Research on the Burden of Dropping off and Picking up Children: Differences by Employment Type and Gender in the Tokyo Metropolitan Area

There is a need to reduce the burden of child drop-off and pick-up for child-rearing generations, but most studies on the actual situation in Japan are based on survey results. In this study, we analyzed differences in child drop-off and pick-up by employment type and gender, utilizing the “Metropolitan Area Person Trip Survey,” which is a statistical data set. The study targeted households in which both spouses were between 30 and 49 years old, had children under the age of 6, and included the following three groups. 1) Dual-income Group 1 (both spouses employed/on contract/temporary);2) Dual-income Group 2 (husband employed/on contract/temporary, wife part-time);3) Full-time housewife group (husband employed, wife unemployed). The analysis revealed that a) wives are almost always responsible for dropping off and picking up their children;b) husbands drop off and pick up their children less frequently in dual-income households;and c) households with children raising within 10 to 30 km of Tokyo Station have longer commuting times and need to reduce the burden of dropping off and picking up their children.

A data-driven model of drop size prediction based on artificial neural networks using small-scale data sets

An artificial neural network(ANN)method is introduced to predict drop size in two kinds of pulsed columns with small-scale data sets.After training,the deviation between calculate and experimental results are 3.8%and 9.3%,respectively.Through ANN model,the influence of interfacial tension and pulsation intensity on the droplet diameter has been developed.Droplet size gradually increases with the increase of interfacial tension,and decreases with the increase of pulse intensity.It can be seen that the accuracy of ANN model in predicting droplet size outside the training set range is reach the same level as the accuracy of correlation obtained based on experiments within this range.For two kinds of columns,the drop size prediction deviations of ANN model are 9.6%and 18.5%and the deviations in correlations are 11%and 15%.

Buckling Properties of Water-Drop-Shaped Pressure Hulls with Various Shape Indices Under Hydrostatic External Pressure

The water-drop-shaped pressure hull has a good streamline,which has good application prospect in the underwater observatory.Therefore,this study conducted analytical,experimental and numerical investigation of the buckling properties of water-drop-shaped pressure hulls under hydrostatic pressure.A water-drop experiment was conducted to design water-drop-shaped pressure hulls with various shape indices.The critical loads for the water-drop-shaped pressure hulls were resolved by using Mushtari’s formula.Several numerical simulations including linear buckling analysis and nonlinear buckling analysis including eigenmode imperfections were performed.The results indicated that the critical loads resolved by Mushtari's formula were in good agreement with the linear buckling loads from the numerical simulations.This formula can be extended to estimate the buckling capacity of water-drop-shaped pressure hulls.In addition,three groups of pressure hulls were fabricated by using stereolithography,a rapid prototyping technique.Subsequently,three groups of the pressure hulls were subjected to ultrasonic measurements,optical scanning,hydrostatic testing and numerical analysis.The experimental results were consistent with the numerical results.The results indicate that the sharp end of the water-drop-shaped pressure hulls exhibited instability compared with the blunt end.This paper provides a new solution to the limitations of experimental studies on the water-drop-shaped pressure hulls as well as a new configuration and evaluation method for underwater observatories.

基于MacBERT和R-Drop的地质命名实体识别

地质命名实体识别中常用的基于BERT预训练模型的深度学习方法是基于字的方法,没有利用词信息,且神经网络中的Dropout机制会导致训练阶段和推理阶段之间存在不一致性。针对该问题,提出了一种基于MacBERT和R-Drop的地质命名实体识别模型MBCR。首先,通过MacBERT学习文本特征表示,充分利用字词信息;其次,运用BiGRU编码上下文特征,有效提取完整的语义信息;最后,采用CRF获取标签间的依赖关系,生成最优标签序列。此外,在训练过程中引入R-Drop,进一步提升模型的泛化能力。结果表明:与BiLSTM-CRF、BERTBiLSTM-CRF等模型相比,所提MBCR模型在NERdata数据集上的F1值提高了2.08百分点~4.62百分点,在Boson数据集上的F1值提高了1.26百分点~17.54百分点。

Evaluation of frictional pressure drop correlations for air-water and air-oil two-phase flow in pipeline-riser system

Accurate prediction of the frictional pressure drop is important for the design and operation of subsea oil and gas transporting system considering the length of the pipeline. The applicability of the correlations to pipeline-riser flow needs evaluation since the flow condition in pipeline-riser is quite different from the original data where they were derived from. In the present study, a comprehensive evaluation of 24prevailing correlation in predicting frictional pressure drop is carried out based on experimentally measured data of air-water and air-oil two-phase flows in pipeline-riser. Experiments are performed in a system having different configuration of pipeline-riser with the inclination of the downcomer varied from-2°to-5°to investigated the effect of the elbow on the frictional pressure drop in the riser. The inlet gas velocity ranges from 0.03 to 6.2 m/s, and liquid velocity varies from 0.02 to 1.3 m/s. A total of885 experimental data points including 782 on air-water flows and 103 on air-oil flows are obtained and used to access the prediction ability of the correlations. Comparison of the predicted results with the measured data indicate that a majority of the investigated correlations under-predict the pressure drop on severe slugging. The result of this study highlights the requirement of new method considering the effect of pipe layout on the frictional pressure drop.

基于drop-off ddPCR方法检测急性髓系白血病C-KIT基因N822位点突变及其临床应用

目的:建立急性髓系白血病(acute myeloid leukemia, AML)患者C-KIT基因N822位点突变的drop-off微滴式数字PCR(droplet digital PCR,ddPCR)定量检测方法,并评价其临床应用价值。方法:针对C-KIT基因第17外显子设计一对引物及探针,优化drop-off ddPCR反应条件及体系,评价该方法的特异性、灵敏度、重复性,使用所建立的方法对140例已行Sanger测序的AML初诊患者骨髓标本进行检测,并用二代测序(next generation sequencing, NGS)验证结果;用drop-off ddPCR对3例阳性患者化疗后C-KIT突变频率进行动态监测。结果:drop-off ddPCR检测C-KIT基因N822位点突变的最适退火温度为54℃,空白检测限为1.62拷贝数/μL,最低检测下限为10.12拷贝数/μL,线性良好。140例AML初诊患者样本中Sanger测序检出2例阳性(1.4%),而ddPCR共检出突变7例(5.0%),突变频率为0.29%~7.41%;进一步应用常规NGS方法对ddPCR阳性样本进行验证,共检出阳性3例(2.1%),等位基因频率为1.26%~8.00%。动态监测3例阳性患者C-KIT突变频率,结果显示治疗达完全缓解时C-KIT突变频率明显下降甚至降低至0。结论:本研究建立了检测C-KIT基因N822位点突变的drop-off ddPCR技术,具有良好的方法学检测性能,其灵敏度高于Sanger测序和NGS,有望用于阳性患者缓解后的可检测残留疾病监测及治疗指导。

A combined computational/experimental study of anode-concerned voltage drop in aqueous primary Mg-air batteries

The voltage drop appearing at Mg anode-electrolyte interface is a critical issue for the battery power and energy density of aqueous primary Mg-air batteries.The respective voltage loss is typically assigned to the deposits layer forming on the anode surface during discharge.In this work,we experimentally and computationally investigate the critical factors affecting the voltage drop at Mg anode towards a deeper understanding of the contribution of deposit and its growth.A two-dimensional(2D)mathematical model is proposed to compute the voltage drop of Mg-0.15Ca wt.%alloy(Mg-0.15Ca)by means of a semi-empirical formulas and experiments-based modification model,considering the effect of discharge current density,the negative difference effect(NDE)and surface deposits layer itself.This model is utilized to simulate the discharge potential of the anode at predefined experimental current densities.The computed voltage drop(half-cell voltage)is in good agreement with the experimental value.The applicability of the mathematical model is successfully validated on the second material(namely high-purity Mg).

Flow Rate Measurement of Gravity Infusion Set and Functional Evaluation of Drop Counter: A Pilot Study

Developing a novel drop counter by introducing the Internet of Things concept has been vigorously conducted in recent years. Understanding the newly introduced drop counter’s flow rate control accuracy and flow rate count feature is essential for improving safety in infusion management. This study aimed to verify if the new drop counters could secure accurate flow rate and drip count by conducting actual flow rate measurements using gravimetry and functional evaluation. A drop counter was attached to each drip chamber of the infusion set, and an IV drip was conducted at the 100 ml/h flow rate. The weight of discharged physiological saline was measured to plot trumpet curves. Next, three different types of drop counters were evaluated to determine if they maintained drip count accuracy according to the changes in their position angles. The flow rate errors in all conditions indicated trumpet-like curves, exhibiting an overall error range within ±10% in all observation windows. Although every drop counter successfully detected and measured dripping, it was challenging in some counters to detect dripping when the drip chamber was tilted. In comparing adult and pediatric IV sets, the adult IV set was found to be less likely to detect dripping in the angled position. No significant differences in results were confirmed between high and low flow rates, suggesting that the drop count function would not be affected by the flow rate in the ranges of typical infusion practices. Doppler sensors have a wide range of measurements and high sensitivity;the dripping was detected successfully even when the drip chamber was tilted, probably due to the advantages of these sensors. In contrast, miscounts occurred in those equipped with infrared sensors, which could not detect light intensity changes in tilted positions. Understanding the tendencies in flow rate errors in infusion can be valuable information for infusion management.

Efficacy of recombinant human epidermal growth factor plus sodium hyaluronate eye drops in diabetic dry eye post-cataract surgery

BACKGROUND Dry eye syndrome(DES)after diabetic cataract surgery can seriously affect the patient’s quality of life.Therefore,effective alleviation of symptoms in patients with this disease has important clinical significance.AIM To explore the clinical effect of recombinant human epidermal growth factor(rhEGF)plus sodium hyaluronate(SH)eye drops on DES after cataract surgery in patients with diabetes.METHODS We retrospectively evaluated 82 patients with diabetes who experienced DES after cataract surgery at Tianjin Beichen Hospital,Affiliated Hospital of Nankai University between April 2021 and April 2023.They were classified into an observation group(42 cases,rhEGF+SH eye drops)and a control group(40 cases,SH eye drops alone),depending on the different treatment schemes.The therapeutic efficacy,dry eye symptom score,tear film breakup time(TFBUT),basic tear secretion score[assessed using Schirmer I test(SIt)],corneal fluorescein staining(FL)score,tear inflammatory markers,adverse reactions during treat-ment,and treatment satisfaction were compared between the two groups.RESULTS Therapeutic efficacy was higher in the observation group compared with the control group.Both groups showed improved TFBUT and dry eye,as well as improved SIt and FL scores after treatment,with a more pronounced improvement in the observation group.Although no marked differences in adverse reactions were observed between the two groups,treatment satisfaction was higher in the observation group.CONCLUSION rhEGF+SH eye drops rendered clinical benefits to patients by effectively ameliorating dry eye and visual impairment with favorable efficacy,fewer adverse reactions,and high safety levels.Thus,this treatment should be promoted in clinical practice.

Improvement of Temperature Drop Model Parameters for 4200mm/3500mm Rolling of Baosteel Medium and Thick Plate

Based on the temperature situation during the rolling process of 4200 mm/3500 mm medium and thick plates at Baosteel,this article analyzes the influencing factors of temperature changes during the rolling process from the perspective of heat transfer theory and the temperature change law during the rolling process.The temperature loss during the four rolling processes is tracked on site,and the temperature drop model parameters during the rolling process of 4200mm/3500mm medium and thick plates at Baosteel are quantitatively provided.It is applied to actual rolling production and has achieved good results.

电磁脉冲攻击下片上配电网络IR Drop分析方法

电磁脉冲攻击对集成电路的安全具有很强的威胁性.为了有效地抵御电磁脉冲攻击,针对片上配电网络易受电磁脉冲影响的问题,提出了一种电磁脉冲攻击下片上配电网络IRdrop分布的分析方法.首先,在集成电路布局规划阶段,基于有限元仿真构建片上配电网络模型和电磁脉冲攻击模型,仿真获得电磁脉冲下配电网络上感应电流密度的分布并计算感应电流,然后将感应电流加载到配电网络模型上,使用IR分析工具分析IRdrop分布.基于TSMC180 nm工艺版图的IR drop分析结果显示,电磁脉冲攻击能够在电源和地网络中引入2.3 V以上的IR drop.与现有基于电流分布理论值的分析方法相比,该分析方法能够更准确地获取电磁脉冲下配电网络中的IR drop分布.该分析方法可用于指导改进配电网络的设计,提升抗电磁脉冲攻击能力.实验结果显示,增加一组供电端口后,电源和地网络中的最大IR drop分别降低了28%和24%.

A 50-years record of dichloro-diphenyl-trichloroethanes and hexachloro-cyclohexanes in lake sediments and penguin droppings on King George Island, Maritime Antarctic

Since the ban on the use of organochlorine pesticides （OCPs） such as dichloro-diphenyl-trichloroethane （DDT） and hexachlorocyclohexane（HCH） in agriculture, their levels have generally dropped. In a number of cases, however, the levels of these OCPs were found to be unchanging or even increasing after the ban. With the aim to unveil the possible causes of these exceptions, we collected two lake cores from King George Island, West Antarctica, and determined their accumulation flux profiles and temporal trends of these OCPs. In the lake core sediments with glacier meltwater input, the accumulation flux of DDT shows an abnormal peak around 1980s in addition to the expected one in 1960s. In the lake core sediments without glacier meltwater input, the accumulation flux of DDT shows a gradual decline trend after the peak in 1960s. This striking difference in the DDT flux profiles between the two lake cores is most likely caused by the regional climate warming and the resulted discharge of the DDT stored in the Antarctic ice cap into the lakes in the Antarctic glacier frontier. Furthermore, to investigate the change of OCPs loadings in the Antarctic coastal ecosystem, we reconstructed the HCH and DDT concentration profiles in penguin droppings and observed a gradual increase for the former and a continuous decrease for the latter during the past 50 years. The increase of HCH seems to be due to the regional warming from the early 1970s and the resulted HCH discharge to the coastal ecosystem by glaciers＇ meltwater and the illegal use of HCH in the Southern Hemisphere in the recent decade. The different temporal trends of HCH and DDT accumulation rate in the lake core with glacier meltwater input and the aged penguin droppings can be explained by their different water-soluble property.

The sediments of lake on the Ardley Island, Antarctica: Identification of penguin-dropping soil

During CHINARE 15(Dec. 1998 Mar. 1999), a lake core 67.5 cm in length, was sampled in Y2 lake, which is located on the Ardley Island, Antarctica. The concentrations of some chemical elements in Y2 lake sediments were analyzed. According to comparative research on elementary characters of sediments in Antarctic West Lake, fresh penguin dropping as well as guano soil on the Ardley Island and Pacific Island in South China Sea, it presents that the Y2 lake sediments were ameliorated by penguin dropping. The result of element cluster analysis shows that the type elements in the sediment impacted by penguin dropping include Sr,F,S,P,Ca,Se,Cu,Zn and Ba. This can provide a base for further interpreting the climatic and environmental event recorded in the sediment.

Observer-based H_∞ control over packet dropping networks

A new controller design problem of networked control systems with packet dropping is proposed. Depending on the place that the observer is put in the system, the network control systems with packet dropping are modeled as stochastic systems with the random variables satisfying the Bernoulli random binary distribution. The observer-based controller is designed to stabilize the networked system in the sense of mean square, and the prescribed H∞ disturbance attenuation level is achieved. The controller design problem is formulated as the feasibility of the convex optimization problem, which can be solved by a linear matrix inequality （LMI） approach. Numerical examples illustrate the effectiveness of the proposed methods.

Rate-distortion optimized frame dropping and scheduling for multi-user conversational and streaming video

We propose a Rate-Distortion (RD) optimized strategy for frame-dropping and scheduling of multi-user conversa- tional and streaming videos. We consider a scenario where conversational and streaming videos share the forwarding resources at a network node. Two buffers are setup on the node to temporarily store the packets for these two types of video applications. For streaming video, a big buffer is used as the associated delay constraint of the application is moderate and a very small buffer is used for conversational video to ensure that the forwarding delay of every packet is limited. A scheduler is located behind these two buffers that dynamically assigns transmission slots on the outgoing link to the two buffers. Rate-distortion side information is used to perform RD-optimized frame dropping in case of node overload. Sharing the data rate on the outgoing link between the con- versational and the streaming videos is done either based on the fullness of the two associated buffers or on the mean incoming rates of the respective videos. Simulation results showed that our proposed RD-optimized frame dropping and scheduling ap- proach provides significant improvements in performance over the popular priority-based random dropping (PRD) technique.

Neuroprotective effects of Ginkgo biloba dropping pills in Parkinson's disease

Parkinson's disease(PD) is the second most common neurodegenerative disease in the world;however,it lacks effective and safe treatments. Ginkgo biloba dropping pill(GBDP), a unique Chinese G. biloba leaf extract preparation, exhibits antioxidant and neuroprotective effects and has a potential as an alternative therapy for PD. Thus, the aims of this study were to evaluate the effects of GBDP in in vitro and in vivo PD models and to compare the chemical constituents and pharmacological activities of GBDP and the G. biloba extract EGb 761. Using liquid chromatography tandem-mass spectrometry, 46 GBDP constituents were identified. Principal component analysis identified differences in the chemical profiles of GBDP and EGb 761. A quantitative analysis of 12 constituents showed that GBDP had higher levels of several flavonoids and terpene trilactones than EGb 761, whereas EGb 761 had higher levels of organic acids.Moreover, we found that GBDP prevented 6-hydroxydopamine-induced dopaminergic neuron loss in zebrafish and improved cognitive impairment and neuronal damage in methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced PD mice. Although similar effects were observed after EGb 761 treatment,the neuroprotective effects were greater after GBDP treatment on several endpoints. In addition, in vitro results suggested that the Akt/GSK3β pathway may be involved in the neuroprotective effects of GBDP.These findings demonstrated that GBDP have potential neuroprotective effects in the treatment of PD.

A-DROP评分对老年社区获得性肺炎临床结局的预测价值

目的探讨A-DROP评分对老年社区获得性肺炎临床结局的预测价值。方法回顾性分析2019年1月~2020年12月本院呼吸与危重症医学科收治的老年社区获得性肺炎患者(CAP)临床资料,入院后24 h内完成血常规、生化等检测,并完成A-DROP、PSI、CURB-65评分,根据28 d结局分为死亡及存活组,通过比较受试者工作特征曲线(ROC)分析A-DROP、PSI、CURB-65对患者28 d死亡率的预测效能。结果共纳入137例老年CAP患者,其中死亡组23例,存活组114例,A-DROP、PSI、CURB-65评分在死亡组中更高(P<0.0001);A-DROP、CURB-65、PSI危险分层预测老年CAP患者28 d死亡率的AUC值分别为0.759、0.732、0.755,A-DROP的截断值为极严重组,其敏感性为82.61%,特异性为65.79%;依据A-DROP进行危险分层,极严重组患者中位生存时间为22.638天(95%CI:20.096~25.180),极严重组患者死亡风险是中度组患者8.56倍(95%CI 3.3~22.21),是严重组患者的4.28倍(95%CI:1.32~13.9)。结论A-DROP评分系统对老年CAP患者死亡率具有一定预测价值,与PSI、CURB-65的预测效能相当。

Spherical silicon solar cell with reflector cup fabricated by decompression dropping method

A spherical Si solar cell with a reflector cup was successfully fabricated by a dropping method at decompression state. In the dropping method, melted Si droplets were instilled at decompression state (0.5×105 Pa) to reduce crystal growth rate, dominating crystal quality such as dislocation density in crystal grains. Spherical Si solar cells were fabricated using the spherical Si crystals with a diameter of 1 mm and then mounted on a reflector cup. The current-voltage measurement of the solar cell shows an energy conversion efficiency of 11.1% (short-circuit current density (Jsc): 24.7 mA·cm-2, open-circuit voltage: 601 mV, fill factor: 74.6%). Minority carrier diffusion length determined by surface photovoltage method was 98 μm. This value can be enhanced by the improvement of crystal quality of spherical Si crystals. These results demonstrate that spherical Si crystals fabricated by the dropping method has a great potential for substrate material of high-efficiency and low-cost solar cells.

Effect of relative humidity at either acute or chronic moderate temperature on growth performance and droppings' corticosterone metabolites of broilers

The present study aimed to investigate the effect of relative humidity(RH) at either acute or chronic moderate ambient temperature(Ta) on growth performance and droppings' corticosterone metabolites of broilers.Two experiments were conducted: effect of RH(35,60 or 85%) on average daily feed intake(ADFI) and droppings' corticosterone metabolites at acute(1 d: 20–26 or 31–20°C,26 or 31°C for 6 h d–1 at 10:00–16:00) moderate Ta(experiment 1) and effect of RH(35,60 or 85%) on growth performance and droppings' corticosterone metabolites at chronic(step-wisely increasing temperature by 3°C every 3 d from 20 to 32°C within 15 d: 20–23–26–29–32°C) moderate Ta(experiment 2).Droppings were collected at the 2,4,6,8,and 22 h after Ta-RH controlled in experiment 1 and at the 2,4,6,and 22 h after Ta controlled to 32°C in experiment 2.The results showed that: 1) In experiment 1,85% RH increased(P<0.05) the droppings' corticosterone metabolites at the 2,6,8,and 22 h and 35% RH increased(P<0.05) it at the 2 and 22 h compared to the 60% RH.Moreover,85% RH further increased(P<0.05) it compared to the 35% RH,however,no difference(P>0.05) was found in ADFI among the three RH groups at acute moderate 26°C; 35 and 85% RH increased(P<0.05) droppings' corticosterone metabolites at the 2,6,8 and 22 h and decreased(P<0.05) ADFI compared to the 60% RH,moreover,85% RH further increased(P<0.05) droppings' corticosterone metabolites and further decreased(P<0.05) ADFI compared to the 35% RH at acute moderate 31°C; and the average of droppings' corticosterone metabolites in the whole period had a negative correlation(P<0.02) with the ADFI.2) In experiment 2,85% RH increased(P<0.01) droppings' corticosterone metabolites only at the 2 h and decreased(P<0.02) ADFI and average daily gain(ADG) compared to the 60% RH,no difference(P>0.05) in droppings' corticosterone metabolites was found between the 35 and 60% RH,however,35% RH decreased(P<0.01) ADG compared to the 60% RH,and the average of droppings' corticosterone metabolites in the whole period also had a negative correlation(P<0.02) with ADFI and ADG.In conclusion,droppings' corticosterone metabolites could be used as a RH stress index and low and high RH,especially high RH,reduced growth performance possibly through inducing RH stress at moderate temperature.