Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellu...Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.展开更多
AIM: To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients.METHODS: Eighty-five patients with chronic h...AIM: To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients.METHODS: Eighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group Ⅰ were treated with He Jie Tang (HJT) and 35 patients in group Ⅱ were treated with combined medication. The levels of T-lymphocyte subsets (CD3+,CD4+, CD8+), NK cell activity, cytokines (TNF-α, IL-8,sIL-2R) were observed before and after the treatment.Another 20 normal persons served as group 3.RESULTS: The level of CD4+ cells and NK cell activity were lower, whereas the level of CD8+ cells in patients was higher than that in normal persons (t = 2.685,3.172, and 2.754 respectively; P＜0.01). The levels of TNF-α, IL-8, and sIL-2R in chronic hepatitis B patients were higher than those in normal persons (t = 3.526,3.170, and 2.876 respectively; P＜0.01). After 6 months of treatment, ALT, AST, and TB levels in the two groups were obviously decreased (t = 3.421, 3.106, and 2.857respectively; P＜0.01). The level of CD4+ cells and NK cell activity were increased whereas the level of CD8+ cells decreased (t = 2.179, 2.423, and 2.677 respectively;P＜0.05) in group I. The levels of TNF-α, IL-8, and sIL-2R in group Ⅰ were decreased significantly after the treatment (t = 2.611, 2.275, and 2.480 respectively;P＜0.05) but had no significant difference in group Ⅱ after the treatment (t = 1.906, 1.833, and 2.029respectively; P＞0.05). The total effective rate had no significant difference between the two groups (x2 = 2.882,P＞0.05) but the markedly effective rate wass ignificantly different between the two groups (x2 = 5.340, P＜0.05).CONCLUSION: HJT is effective in treating chronic hepatitis B. HJT seems to exert its effect by improving the cellular immune function and decreasing inflammatory cytokines in chronic hepatitis B patients.The function of HJT in protecting liver function in the process of eliminating virus needs to be further studied.展开更多
According to the characteristics of prose,"aesthetic qualities"are the most important and difficult elements for translators to surmount. Generally speaking,the "beauty"of prose is mainly embodied ...According to the characteristics of prose,"aesthetic qualities"are the most important and difficult elements for translators to surmount. Generally speaking,the "beauty"of prose is mainly embodied in its formal and nor-formal systems, and the ideal for prose translation is, of course, to realize the"aesthetic elements"at both levels. This thesis will take the prose He Tang Yue Se(paragraph three) an example to analyze this by contrasting the two versions by Zhu Chunshen(Zhu) and Yang Xianyi and Dai Naidie(Yang/Dai).展开更多
基金Hubei Chen Xiaoping Science and Technology Development Foundation Special Fund Project (No.CXPJJH12000002-2020010)Education Science Research Project,Beijing University of Chinese Medicine (No.XJY21056)Beijing University of Chinese Medicine New Teachers Start-up Fund Project (No.2022-BUCMXJKY010)。
文摘Objective:To observe the clinical effect of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in the treatment of granulomatous lobular mastitis in the mass stage and the effect on cellular pyroptosis-related proteins.Methods:Forty patients with granulomatous lobular mastitis were randomly divided into 20 cases in the observation group and 20 cases in the control group.Both groups were given dexamethasone ointment for treatment,and the observation group was treated with external application of Zi Cao Yang He Tang on the basis of the control group.Breast lump vol-ume changes,breast pain and pus symptoms,pathology and histology and immunohistochemistry,cellular death-related indicators expression were compared between the two groups.Results:After treatment,the difference in mass volume of the observation group was significantly greater than that of the control group(16.7±21.5 in the control group and 32.9±27.4 in the experimental group)and the difference between the two groups was statistically significant(P<0.05);the objective remission rate of the patients in the observation group(ORR=85%)was significantly higher than that of the treatment group(ORR=50%,P<0.05).In terms of pus formation rate and pain level,the breast pain score of the observation group was significantly lower than that of the control group after two weeks or three weeks of treatment(P<0.05);the pus formation rate of the observation group was 30%,and the pus formation rate of the control group was 20%,and the difference was not statistically significant(P>0.05).The immunohistochemical expression levels of caspase-1 and GSDMD in the observation group were significantly lower than those in the control group(P<0.05);and in terms of the expression of cellular pyroptosis-related indexes,the expression of GSDMD,cas-pase-1,and NLRP3 in the observation group was significantly lower compared with that in the control group(P<0.05).Conclusion:The efficacy of external application of Zi Cao Yang He Tang combined with dexamethasone ointment in treating granulomatous lobular mastitis in the mass stage is remarkable,which can effectively reduce breast pain,reduce the size of the mass,de-crease the expression of cellular pyroptosisrelated indexes,and have a good anti-inflammatory effect.
基金Supported by the Administrative Bureau of TCM and Chinese Drugs of Guangdong Province, No. 98374 and No. 100108
文摘AIM: To explore the effect of He Jie Tang (decoction for medication) on serum levels of T lymphocyte subsets, NK cell activity and cytokines in chronic hepatitis B patients.METHODS: Eighty-five patients with chronic hepatitis B were divided randomly into two groups. Fifty patients in group Ⅰ were treated with He Jie Tang (HJT) and 35 patients in group Ⅱ were treated with combined medication. The levels of T-lymphocyte subsets (CD3+,CD4+, CD8+), NK cell activity, cytokines (TNF-α, IL-8,sIL-2R) were observed before and after the treatment.Another 20 normal persons served as group 3.RESULTS: The level of CD4+ cells and NK cell activity were lower, whereas the level of CD8+ cells in patients was higher than that in normal persons (t = 2.685,3.172, and 2.754 respectively; P＜0.01). The levels of TNF-α, IL-8, and sIL-2R in chronic hepatitis B patients were higher than those in normal persons (t = 3.526,3.170, and 2.876 respectively; P＜0.01). After 6 months of treatment, ALT, AST, and TB levels in the two groups were obviously decreased (t = 3.421, 3.106, and 2.857respectively; P＜0.01). The level of CD4+ cells and NK cell activity were increased whereas the level of CD8+ cells decreased (t = 2.179, 2.423, and 2.677 respectively;P＜0.05) in group I. The levels of TNF-α, IL-8, and sIL-2R in group Ⅰ were decreased significantly after the treatment (t = 2.611, 2.275, and 2.480 respectively;P＜0.05) but had no significant difference in group Ⅱ after the treatment (t = 1.906, 1.833, and 2.029respectively; P＞0.05). The total effective rate had no significant difference between the two groups (x2 = 2.882,P＞0.05) but the markedly effective rate wass ignificantly different between the two groups (x2 = 5.340, P＜0.05).CONCLUSION: HJT is effective in treating chronic hepatitis B. HJT seems to exert its effect by improving the cellular immune function and decreasing inflammatory cytokines in chronic hepatitis B patients.The function of HJT in protecting liver function in the process of eliminating virus needs to be further studied.
文摘According to the characteristics of prose,"aesthetic qualities"are the most important and difficult elements for translators to surmount. Generally speaking,the "beauty"of prose is mainly embodied in its formal and nor-formal systems, and the ideal for prose translation is, of course, to realize the"aesthetic elements"at both levels. This thesis will take the prose He Tang Yue Se(paragraph three) an example to analyze this by contrasting the two versions by Zhu Chunshen(Zhu) and Yang Xianyi and Dai Naidie(Yang/Dai).
