Equivalent source layer (ESL) imaging is an important kind of high-resolution electro- encephalogram (EEG) imaging. It consists of two categories: equivalent dipole layer (EDL) and equivalent charge layer (ECL...Equivalent source layer (ESL) imaging is an important kind of high-resolution electro- encephalogram (EEG) imaging. It consists of two categories: equivalent dipole layer (EDL) and equivalent charge layer (ECL). Both of them are assumed to be located on or near the cortical surface and have been proposed as high-resolution imaging modalities or as intermediate steps to estimate the epicortical potential. Here, EDL and ECL based on a realistic head model are presented, both simulations and real data experiment are done to compare these two models. The results show that ECL can provide higher spatial resolution about source location than EDL does.展开更多
Modeling Light propagation within human head to deduce spatial sensitivity distribution(SSD)is important for Near-infrared spectroscopy(NIRS)/imaging(NIRI)and diffuse correlation tomography.Lots of head models have be...Modeling Light propagation within human head to deduce spatial sensitivity distribution(SSD)is important for Near-infrared spectroscopy(NIRS)/imaging(NIRI)and diffuse correlation tomography.Lots of head models have been used on this issue,including layered head model,artificial simplified head model,MRI slices described head model,and visible human head model.Hereinto,visible Chinese human(VCH)head model is considered to be a most faithful presentation of anatomical structure,and has been highlighted to be employed in modeling light propagation.However,it is not practical for all researchers to use VCH head models and actually increasing number of people are using magnet resonance imaging(MRI)head models.Here,all the above head models were simulated and compared,and we focused on the effect of using di®erent head models on predictions of SSD.Our results were in line with the previous reports on the effect of cerebral cortex folding geometry.Moreover,the in fluence on SSD increases with thefidelity of head models.And surprisingly,the SSD percentages in scalp and gray matter(region of interest)in MRI head model were found to be 80%and 125%higher than in VCH head model.MRI head models induced nonignorable discrepancy in SSD estimation when compared with VCH head model.This study,as we believe,is the first to focus on comparison among full serials of head model on estimating SSD,and provided quantitative evidence for MRI head model users to calibrate their SSD estimation.展开更多
Invasive techniques are becoming increasingly important in the presurgical evaluation of epilepsy.Adopting the electrophysiological source imaging(ESI)of interictal scalp electroencephalography(EEG)to localize the epi...Invasive techniques are becoming increasingly important in the presurgical evaluation of epilepsy.Adopting the electrophysiological source imaging(ESI)of interictal scalp electroencephalography(EEG)to localize the epileptogenic zone remains a challenge.The accuracy of the preoperative localization of the epileptogenic zone is key to curing epilepsy.The T1 MRI and the boundary element method were used to build the realistic head model.To solve the inverse problem,the distributed inverse solution and equivalent current dipole(ECD)methods were employed to locate the epileptogenic zone.Furthermore,a combination of inverse solution algorithms and Granger causality connectivity measures was evaluated.The ECD method exhibited excellent focalization in lateralization and localization,achieving a coincidence rate of 99.02%(p<0.05)with the stereo electroencephalogram.The combination of ECD and the directed transfer function led to excellent matching between the information flow obtained from intracranial and scalp EEG recordings.The ECD inverse solution method showed the highest performance and could extract the discharge information at the cortex level from noninvasive low-density EEG data.Thus,the accurate preoperative localization of the epileptogenic zone could reduce the number of intracranial electrode implantations required.展开更多
The difficulty in establishing the finite element model of head and cervical spine is interpreted in the study. A head-neck 3D model is constructed accurately and quickly by the technology of CT scan,the automatically...The difficulty in establishing the finite element model of head and cervical spine is interpreted in the study. A head-neck 3D model is constructed accurately and quickly by the technology of CT scan,the automatically modeling of Mimics software and the RE technology of Geomagic software. Then the finite element model of the head-neck which is close to the real one is set up by the preprocessor of the FEM soft ware ANSYS. After the transient finite element analysis is performed on the model,the historical response of the displacement of the head is obtained. The result is validated by the result of the existed experiment. The stress,as well as the deformation,of nodes in the head and the cervical spine at any time benefits a lot to the clinic study on the injure to the head and neck caused by the impacts. And all the analysis is done by limited computer available.展开更多
According to the characteristics of spiral mining head for deep seabed cobalt-rich crust, the kinematic model, cutting loads model, quantity of cutting picks model of mining head, granularity distribution model and en...According to the characteristics of spiral mining head for deep seabed cobalt-rich crust, the kinematic model, cutting loads model, quantity of cutting picks model of mining head, granularity distribution model and energy consumption model were constructed. Based on these models, computer simulation program of cutting loads was developed with VB software. The mechanical parameters of mining head were obtained in the cutting depth range of 5160 mm. Making use of the simulation results, the effect of cutting depth of spiral mining head on the mining process was studied. The results show that the maximum force of single pick is 4.7051kN, the maximum force and torque of spiral drum of mining head are respectively 34.1668kN and 3.8795kN·m at the cutting depth of 160mm.展开更多
Objective To establish an experimental model of early stage avascular necrosis of the femoral head (ANFH) caused by corticosteroid in adult rabbits and to observe the pathological changes with various imaging techni...Objective To establish an experimental model of early stage avascular necrosis of the femoral head (ANFH) caused by corticosteroid in adult rabbits and to observe the pathological changes with various imaging techniques. Methods ANFH was induced by a combination of hypersensitivity vasculitis caused by injection of horse serum and subsequent administration of a high dose of corticosteroid. The pathological changes were detected with digital radiography (DR), computed tomography (CT), magnetic resonance imaging (MRI), ink artery infusion angiography, hematoxylin-eosin staining, and immunohistochemistry. Results The imageological and pathological changes corresponded to the clinical characteristics of early stage ANFH. DR showed bilaterally increased bone density, an unclear epiphyseal line, and blurred texture of cancellous bone. CT showed spot-like low-density imaging of cancellous bone, thinner cortical bone, osteoporosis, and an unclear epiphyseal line. MR! showed bone marrow edema and spot-like high signals in T2-weighted imaging in cancellous bone. Ink artery infusion angiography showed fewer obstructed blood vessels in the femoral head. HE staining of pathological sections showed fewer trabeculae and thin bone, an increased proportion of empty osteocyte lacunae, decreased hematopoiesis, thrombosis, and fat cell hypertrophy. Immunohistochemistry showed attenuated expression of vascular endothelial growth factor in osteoblasts and chondrocytes, and on the inner membrane of blood vessels. Conclusion Experimental rabbit model of early stage ANFH caused by corticosteroid can be successfully established and provide the foundation for developing effective methods to treat early stage ANFH.展开更多
Full face rock tunnel boring machine(TBM) has been widely used in hard rock tunnels, however, there are few published theory about cutter-head design, and the design criteria of cutter-head under complex geological ...Full face rock tunnel boring machine(TBM) has been widely used in hard rock tunnels, however, there are few published theory about cutter-head design, and the design criteria of cutter-head under complex geological is not clear yet. To deal with the complex relationship among geological parameters, cutter parameters, and operating parameters during tunneling processes, a cutter-head load model is established by using CSM(Colorado school of mines) prediction model. Force distribution on cutter-head under a certain geology is calculated with the new established load model, and result shows that inner cutters bear more force than outer cutters, combining with disc cutters abrasion; a general principle of disc cutters' layout design is proposed. Within the model, the relationship among rock uniaxial compressive strength(UCS), penetration and thrust on cutter-head are analyzed, and the results shows that with increasing penetration, cutter thrust increases, but the growth rate slows and higher penetration makes lower special energy(SE). Finally, a fitting mathematical model of ZT(ratio of cutter-head torque and thrust) and penetration is established, and verified by TB880 E, which can be used to direct how to set thrust and torque on cutter-head. When penetration is small, the cutter-head thrust is the main limiting factor in tunneling; when the penetration is large, cutter-head torque is the major limiting factor in tunneling. Based on the new cutter-head load model, thrust and torque characteristics of TBM further are researched and a new way for cutter-head layout design and TBM tunneling operations is proposed.展开更多
In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landfor...In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landform development and evolution of its drainage system to some extent. In this study, the geomorphic meaning, basic characteristics, morphological structure and the basic types of loess gully heads were systematically analysed. Then, the loess gully head′s conceptual model was established, and an extraction method based on Digital Elevation Model(DEM) for loess gully head features and elements was proposed. Through analysing the achieved statistics of loess gully head features, loess gully heads have apparently similar and different characteristics depending on the different loess landforms where they are found. The loess head characteristics reflect their growth period and evolution tendency to a certain degree, and they indirectly represent evolutionary mechanisms. In addition, the loess gully developmental stages and the evolutionary processes can be deduced by using loess gully head characteristics. This study is of great significance for development and improvement of the theoretical system for describing loess gully landforms.展开更多
Immobilization devices may be a valuable aid to ensure the improved effectiveness of radiotherapy treatments where constraining the movements of specific anatomical segments is crucial. This need is also present in ot...Immobilization devices may be a valuable aid to ensure the improved effectiveness of radiotherapy treatments where constraining the movements of specific anatomical segments is crucial. This need is also present in other situations, specifically when the superposition of various medical images is required for fine identification and characterization of some pathologies. Because of their structural characteristics, existing head immobilization systems may be claustrophobic and very uncomfortable for patients, during both the modeling and usage stages. Because of this, it is important to minimize all the discomforts related to the mask to alleviate patients’ distress and to simultaneously guarantee and maximize the restraint effectiveness of the mask. In the present work, various head immobilization mask models are proposed based on geometrical information extracted from computerized tomography images and from 3D laser scanning point clouds. These models also consider the corresponding connection to a radiotherapy table, as this connection is easily altered to accommodate various manufacturers’ solutions. A set of materials used in the radiotherapy field is considered to allow the assessment of the stiffness and strength of the masks when submitted to typical loadings.展开更多
背景:由身体接触性运动或交通事故造成的脑震荡远比人们想象的更为严重与常见,近年来引起了媒体、医学界及体育界的广泛关注与高度重视。目的:采用文献计量学方法对有限元方法在脑震荡领域的研究热点与趋势进行可视化分析,从而为中国在...背景:由身体接触性运动或交通事故造成的脑震荡远比人们想象的更为严重与常见,近年来引起了媒体、医学界及体育界的广泛关注与高度重视。目的:采用文献计量学方法对有限元方法在脑震荡领域的研究热点与趋势进行可视化分析,从而为中国在该领域的研究提供一定的参考。方法:基于Web of Science核心集数据库进行文献检索,检索主题词策略为(TS=(Concussion)) AND TS=(Finite element),利用CiteSpace 6.2.R4可视化工具对纳入文献的作者、国家、机构、关键词及被引文献等进行可视化分析。结果与结论:(1)共计纳入215篇文献,发文量与被引量总体上呈上升趋势;学科分布涉及生物医学工程、生物物理学、运动科学、临床神经学及神经科学等学科,呈现多学科交叉融合的趋势;发文量最多的作者是来自爱尔兰都柏林大学的Gilchrist M,发文量最多的机构是渥太华大学,发文量最多的国家是美国。(2)通过关键词分析发现研究的热点聚焦于脑损伤模型的建立用来模拟和预测脑震荡的损伤;脑震荡损伤机制的解析;防护设备和装置的优化设计。(3)通过文献共被引分析发现脑损伤的预测与评估是该领域的知识基础亦是研究热点。(4)有限元方法运用在脑震荡领域的研究热点主要围绕头部损伤预测为主题展开,结合探索大脑损伤机制以及防护装备的设计与改进。(5)随着人工智能与材料学的进步,未来有限元方法在脑震荡损伤领域的研究热点将集中于脑损伤模型、测试方法与防护装备的改进。展开更多
文摘Equivalent source layer (ESL) imaging is an important kind of high-resolution electro- encephalogram (EEG) imaging. It consists of two categories: equivalent dipole layer (EDL) and equivalent charge layer (ECL). Both of them are assumed to be located on or near the cortical surface and have been proposed as high-resolution imaging modalities or as intermediate steps to estimate the epicortical potential. Here, EDL and ECL based on a realistic head model are presented, both simulations and real data experiment are done to compare these two models. The results show that ECL can provide higher spatial resolution about source location than EDL does.
基金The authors thank Qingming Luo's group for providing VCH dataset.This research was supported by the Fundamental Research Funds for the Central Universities (grant No.ZYGX2012J114)the National Natural Science Foundation of China (grant No.61308114)the Specialized Research Fund for the Doctoral Program of Higher Education (grant No.20130185120024).
文摘Modeling Light propagation within human head to deduce spatial sensitivity distribution(SSD)is important for Near-infrared spectroscopy(NIRS)/imaging(NIRI)and diffuse correlation tomography.Lots of head models have been used on this issue,including layered head model,artificial simplified head model,MRI slices described head model,and visible human head model.Hereinto,visible Chinese human(VCH)head model is considered to be a most faithful presentation of anatomical structure,and has been highlighted to be employed in modeling light propagation.However,it is not practical for all researchers to use VCH head models and actually increasing number of people are using magnet resonance imaging(MRI)head models.Here,all the above head models were simulated and compared,and we focused on the effect of using di®erent head models on predictions of SSD.Our results were in line with the previous reports on the effect of cerebral cortex folding geometry.Moreover,the in fluence on SSD increases with thefidelity of head models.And surprisingly,the SSD percentages in scalp and gray matter(region of interest)in MRI head model were found to be 80%and 125%higher than in VCH head model.MRI head models induced nonignorable discrepancy in SSD estimation when compared with VCH head model.This study,as we believe,is the first to focus on comparison among full serials of head model on estimating SSD,and provided quantitative evidence for MRI head model users to calibrate their SSD estimation.
基金Supported by the National Key R&D Program of China(2022YFC2402203)the Key R&D Program of Hebei(21372002D)。
文摘Invasive techniques are becoming increasingly important in the presurgical evaluation of epilepsy.Adopting the electrophysiological source imaging(ESI)of interictal scalp electroencephalography(EEG)to localize the epileptogenic zone remains a challenge.The accuracy of the preoperative localization of the epileptogenic zone is key to curing epilepsy.The T1 MRI and the boundary element method were used to build the realistic head model.To solve the inverse problem,the distributed inverse solution and equivalent current dipole(ECD)methods were employed to locate the epileptogenic zone.Furthermore,a combination of inverse solution algorithms and Granger causality connectivity measures was evaluated.The ECD method exhibited excellent focalization in lateralization and localization,achieving a coincidence rate of 99.02%(p<0.05)with the stereo electroencephalogram.The combination of ECD and the directed transfer function led to excellent matching between the information flow obtained from intracranial and scalp EEG recordings.The ECD inverse solution method showed the highest performance and could extract the discharge information at the cortex level from noninvasive low-density EEG data.Thus,the accurate preoperative localization of the epileptogenic zone could reduce the number of intracranial electrode implantations required.
文摘The difficulty in establishing the finite element model of head and cervical spine is interpreted in the study. A head-neck 3D model is constructed accurately and quickly by the technology of CT scan,the automatically modeling of Mimics software and the RE technology of Geomagic software. Then the finite element model of the head-neck which is close to the real one is set up by the preprocessor of the FEM soft ware ANSYS. After the transient finite element analysis is performed on the model,the historical response of the displacement of the head is obtained. The result is validated by the result of the existed experiment. The stress,as well as the deformation,of nodes in the head and the cervical spine at any time benefits a lot to the clinic study on the injure to the head and neck caused by the impacts. And all the analysis is done by limited computer available.
基金Project(DY105 03 02 1) supported by the Deep Ocean Technology Development Itemproject(50474052) supportedby the National Natural Science Foundation of China
文摘According to the characteristics of spiral mining head for deep seabed cobalt-rich crust, the kinematic model, cutting loads model, quantity of cutting picks model of mining head, granularity distribution model and energy consumption model were constructed. Based on these models, computer simulation program of cutting loads was developed with VB software. The mechanical parameters of mining head were obtained in the cutting depth range of 5160 mm. Making use of the simulation results, the effect of cutting depth of spiral mining head on the mining process was studied. The results show that the maximum force of single pick is 4.7051kN, the maximum force and torque of spiral drum of mining head are respectively 34.1668kN and 3.8795kN·m at the cutting depth of 160mm.
基金The National 863 Program (2007AA02Z458)Science and Technology Program of Guangdong Province (2005B34001004)+1 种基金Science and Technology Program of Guangzhou (2005Z3-E0151)Medical Science Research Fund of Guangdong Province (B2005083, B2007107)
文摘Objective To establish an experimental model of early stage avascular necrosis of the femoral head (ANFH) caused by corticosteroid in adult rabbits and to observe the pathological changes with various imaging techniques. Methods ANFH was induced by a combination of hypersensitivity vasculitis caused by injection of horse serum and subsequent administration of a high dose of corticosteroid. The pathological changes were detected with digital radiography (DR), computed tomography (CT), magnetic resonance imaging (MRI), ink artery infusion angiography, hematoxylin-eosin staining, and immunohistochemistry. Results The imageological and pathological changes corresponded to the clinical characteristics of early stage ANFH. DR showed bilaterally increased bone density, an unclear epiphyseal line, and blurred texture of cancellous bone. CT showed spot-like low-density imaging of cancellous bone, thinner cortical bone, osteoporosis, and an unclear epiphyseal line. MR! showed bone marrow edema and spot-like high signals in T2-weighted imaging in cancellous bone. Ink artery infusion angiography showed fewer obstructed blood vessels in the femoral head. HE staining of pathological sections showed fewer trabeculae and thin bone, an increased proportion of empty osteocyte lacunae, decreased hematopoiesis, thrombosis, and fat cell hypertrophy. Immunohistochemistry showed attenuated expression of vascular endothelial growth factor in osteoblasts and chondrocytes, and on the inner membrane of blood vessels. Conclusion Experimental rabbit model of early stage ANFH caused by corticosteroid can be successfully established and provide the foundation for developing effective methods to treat early stage ANFH.
基金Supported by National Natural Science Foundation of China(Grant No.51275339)National Basic Research Program of China(973 Program,Grant No.2013CB035402)
文摘Full face rock tunnel boring machine(TBM) has been widely used in hard rock tunnels, however, there are few published theory about cutter-head design, and the design criteria of cutter-head under complex geological is not clear yet. To deal with the complex relationship among geological parameters, cutter parameters, and operating parameters during tunneling processes, a cutter-head load model is established by using CSM(Colorado school of mines) prediction model. Force distribution on cutter-head under a certain geology is calculated with the new established load model, and result shows that inner cutters bear more force than outer cutters, combining with disc cutters abrasion; a general principle of disc cutters' layout design is proposed. Within the model, the relationship among rock uniaxial compressive strength(UCS), penetration and thrust on cutter-head are analyzed, and the results shows that with increasing penetration, cutter thrust increases, but the growth rate slows and higher penetration makes lower special energy(SE). Finally, a fitting mathematical model of ZT(ratio of cutter-head torque and thrust) and penetration is established, and verified by TB880 E, which can be used to direct how to set thrust and torque on cutter-head. When penetration is small, the cutter-head thrust is the main limiting factor in tunneling; when the penetration is large, cutter-head torque is the major limiting factor in tunneling. Based on the new cutter-head load model, thrust and torque characteristics of TBM further are researched and a new way for cutter-head layout design and TBM tunneling operations is proposed.
基金Under the auspices of National Youth Science Foundation of China(No.41001294)Key Project of National Natural Science Foundation of China(No.40930531)Research Fund of State Key Laboratory Resources and Environment Information System(No.2010KF0002SA)
文摘In China′s Loess Plateau area, gully head is the most active zone of a drainage system in gully areas. The differentiation of loess gully head follows geospatial patterns and reflects the process of the loess landform development and evolution of its drainage system to some extent. In this study, the geomorphic meaning, basic characteristics, morphological structure and the basic types of loess gully heads were systematically analysed. Then, the loess gully head′s conceptual model was established, and an extraction method based on Digital Elevation Model(DEM) for loess gully head features and elements was proposed. Through analysing the achieved statistics of loess gully head features, loess gully heads have apparently similar and different characteristics depending on the different loess landforms where they are found. The loess head characteristics reflect their growth period and evolution tendency to a certain degree, and they indirectly represent evolutionary mechanisms. In addition, the loess gully developmental stages and the evolutionary processes can be deduced by using loess gully head characteristics. This study is of great significance for development and improvement of the theoretical system for describing loess gully landforms.
基金supported by the Project IPL/2016/Soft Imob/ISEL and Project LAETA—UID/EMS/50022/2019
文摘Immobilization devices may be a valuable aid to ensure the improved effectiveness of radiotherapy treatments where constraining the movements of specific anatomical segments is crucial. This need is also present in other situations, specifically when the superposition of various medical images is required for fine identification and characterization of some pathologies. Because of their structural characteristics, existing head immobilization systems may be claustrophobic and very uncomfortable for patients, during both the modeling and usage stages. Because of this, it is important to minimize all the discomforts related to the mask to alleviate patients’ distress and to simultaneously guarantee and maximize the restraint effectiveness of the mask. In the present work, various head immobilization mask models are proposed based on geometrical information extracted from computerized tomography images and from 3D laser scanning point clouds. These models also consider the corresponding connection to a radiotherapy table, as this connection is easily altered to accommodate various manufacturers’ solutions. A set of materials used in the radiotherapy field is considered to allow the assessment of the stiffness and strength of the masks when submitted to typical loadings.
文摘背景:由身体接触性运动或交通事故造成的脑震荡远比人们想象的更为严重与常见,近年来引起了媒体、医学界及体育界的广泛关注与高度重视。目的:采用文献计量学方法对有限元方法在脑震荡领域的研究热点与趋势进行可视化分析,从而为中国在该领域的研究提供一定的参考。方法:基于Web of Science核心集数据库进行文献检索,检索主题词策略为(TS=(Concussion)) AND TS=(Finite element),利用CiteSpace 6.2.R4可视化工具对纳入文献的作者、国家、机构、关键词及被引文献等进行可视化分析。结果与结论:(1)共计纳入215篇文献,发文量与被引量总体上呈上升趋势;学科分布涉及生物医学工程、生物物理学、运动科学、临床神经学及神经科学等学科,呈现多学科交叉融合的趋势;发文量最多的作者是来自爱尔兰都柏林大学的Gilchrist M,发文量最多的机构是渥太华大学,发文量最多的国家是美国。(2)通过关键词分析发现研究的热点聚焦于脑损伤模型的建立用来模拟和预测脑震荡的损伤;脑震荡损伤机制的解析;防护设备和装置的优化设计。(3)通过文献共被引分析发现脑损伤的预测与评估是该领域的知识基础亦是研究热点。(4)有限元方法运用在脑震荡领域的研究热点主要围绕头部损伤预测为主题展开,结合探索大脑损伤机制以及防护装备的设计与改进。(5)随着人工智能与材料学的进步,未来有限元方法在脑震荡损伤领域的研究热点将集中于脑损伤模型、测试方法与防护装备的改进。
基金supported by the National Natural Science Foundation of China (No. 52174099)the Science and Technology Innovation Program of Hunan Province, China (No. 2023RC3050)。