Objective:To observe the possibility of neoplasm needle track implantation after radioactive seeds implantation and seek preventive measures to avoid it.Methods:Superficial tissue of 250 seeding needle cores and 250 s...Objective:To observe the possibility of neoplasm needle track implantation after radioactive seeds implantation and seek preventive measures to avoid it.Methods:Superficial tissue of 250 seeding needle cores and 250 stylophores employed in neoplasm radioactive seeds implantation was smeared on slides to search for tumor cells.All patients received chemotherapy or endocrine therapy after operations.Ultrasound B-mode or computer tomography(CT)was performed at 10th day,30th day,60th day,and 180th day post operation to detect neoplasm implantation metastasis through needle tracks. Results:Positive cells were found on 13 of 250(5.20%)cores,and 7 of 250(2.80%)stylophores.The difference was not sta- tistically significant(P>0.05).The positive cells frequency of needles those traversed distance less than 3 cm in normal tissue was 6.19%(13/210),while the frequency of the others those traversed longer distance in normal tissue was 2.41%(7/290). The positive cells frequency of needles traversing different distances in normal tissues is significantly different(P<0.05).No neoplasm was detected through needle tracks by ultrasound B-mode or CT in 180 days after operation.Conclusion:Tumor cells could ablate into the needle track during radioactive seed implantation.Some preventive measures,such as optimization of pre-operation and intra-operation treatment plan,chemotherapy or endocrine therapy after operation,may be beneficial to avoid the implantation metastasis of neoplasm in seeding needle tracks.展开更多
Rhabdomyosarcomas(RMSs)are highly malignant soft-tissue sarcomas.Head and neck RMSs often pose unique challenges to treatment because of their closeness to important structures.We here report a rare case of a 1-year-o...Rhabdomyosarcomas(RMSs)are highly malignant soft-tissue sarcomas.Head and neck RMSs often pose unique challenges to treatment because of their closeness to important structures.We here report a rare case of a 1-year-old boy with a 1-month history of right eye swelling and an eye mass.Biopsy of deep tumors in the maxillofacial region supports embryonal RMS.Postoperative positron emission computed tomography showed a 5.0 cm×4.8 cm×4.2 cm malignant tumor in the right maxillary region.In accordance with the international RMS study group guideline,the child was diagnosed with IIIa and TNM stage T2bN1M1 embryonal RMS.The child was treated with a combination of chemotherapy and ^(125)I seed implantation radiotherapy and eventually achieved partial remission.This case report shows that ^(125)I seed implantation is a safe and effective means of delivering radiotherapy to young children with head and neck RMSs.It may be an option for children with RMSs for whom surgery or external radiotherapy is unsuitable.展开更多
文摘Objective:To observe the possibility of neoplasm needle track implantation after radioactive seeds implantation and seek preventive measures to avoid it.Methods:Superficial tissue of 250 seeding needle cores and 250 stylophores employed in neoplasm radioactive seeds implantation was smeared on slides to search for tumor cells.All patients received chemotherapy or endocrine therapy after operations.Ultrasound B-mode or computer tomography(CT)was performed at 10th day,30th day,60th day,and 180th day post operation to detect neoplasm implantation metastasis through needle tracks. Results:Positive cells were found on 13 of 250(5.20%)cores,and 7 of 250(2.80%)stylophores.The difference was not sta- tistically significant(P>0.05).The positive cells frequency of needles those traversed distance less than 3 cm in normal tissue was 6.19%(13/210),while the frequency of the others those traversed longer distance in normal tissue was 2.41%(7/290). The positive cells frequency of needles traversing different distances in normal tissues is significantly different(P<0.05).No neoplasm was detected through needle tracks by ultrasound B-mode or CT in 180 days after operation.Conclusion:Tumor cells could ablate into the needle track during radioactive seed implantation.Some preventive measures,such as optimization of pre-operation and intra-operation treatment plan,chemotherapy or endocrine therapy after operation,may be beneficial to avoid the implantation metastasis of neoplasm in seeding needle tracks.
基金Beijing Municipal Natural Science Foundation,Grant/Award Number:7222054Beijing Research Ward Project,Grant/Award Number:BCRW202101。
文摘Rhabdomyosarcomas(RMSs)are highly malignant soft-tissue sarcomas.Head and neck RMSs often pose unique challenges to treatment because of their closeness to important structures.We here report a rare case of a 1-year-old boy with a 1-month history of right eye swelling and an eye mass.Biopsy of deep tumors in the maxillofacial region supports embryonal RMS.Postoperative positron emission computed tomography showed a 5.0 cm×4.8 cm×4.2 cm malignant tumor in the right maxillary region.In accordance with the international RMS study group guideline,the child was diagnosed with IIIa and TNM stage T2bN1M1 embryonal RMS.The child was treated with a combination of chemotherapy and ^(125)I seed implantation radiotherapy and eventually achieved partial remission.This case report shows that ^(125)I seed implantation is a safe and effective means of delivering radiotherapy to young children with head and neck RMSs.It may be an option for children with RMSs for whom surgery or external radiotherapy is unsuitable.
