To develop a simple,validated method for identifying and quantifying 1,3-butadiene(BD) in human blood by gas chromatography-mass spectrometry(GC-MS) and head-space gas chromatography(HS-GC).BD was identified by GC-MS ...To develop a simple,validated method for identifying and quantifying 1,3-butadiene(BD) in human blood by gas chromatography-mass spectrometry(GC-MS) and head-space gas chromatography(HS-GC).BD was identified by GC-MS and HS-GC,and quantified by HS-GC.The method showed that BD had a good linearity from 50 to 500μg/mL(r>0.99).The limits of detection and quantification were 10 μg/mL and 50 μg/mL,respectively.Both the intra-day precision and inter-day precision were <6.08%,and the accuracy was 96.98%-103.81%.The method was applied to an actual case,and the concentration of BD in the case was 242 μg/mL in human blood.This simple method is found to be useful for the routine forensic analysis of acute exposure to BD.展开更多
BACKGROUND Odontogenic infection is one of the common infectious diseases in oral and maxillofacial head and neck regions.Clinically,if early odontogenic infections such as acute periapical periodontitis,alveolar absc...BACKGROUND Odontogenic infection is one of the common infectious diseases in oral and maxillofacial head and neck regions.Clinically,if early odontogenic infections such as acute periapical periodontitis,alveolar abscess,and pericoronitis of wisdom teeth are not treated timely,effectively and correctly,the infected tissue may spread up to the skull and brain,down to the thoracic cavity,abdominal cavity and other areas through the natural potential fascial space in the oral and maxillofacial head and neck.Severe multi-space infections are formed and can eventually lead to life-threatening complications(LTCs),such as intracranial infection,pleural effusion,empyema,sepsis and even death.CASE SUMMARY We report a rare case of death in a 41-year-old man with severe odontogenic multi-space infections in the oral and maxillofacial head and neck regions.One week before admission,due to pain in the right lower posterior teeth,the patient placed a cigarette butt dipped in the pesticide"Miehailin"into the"dental cavity"to relieve the pain.Within a week,the infection gradually spread bilaterally to the floor of the mouth,submandibular space,neck,chest,waist,back,temporal and other areas.The patient had difficulty breathing,swallowing and eating,and was transferred to our hospital as an emergency admission.Following admission,oral and maxillofacial surgeons immediately organized consultations with doctors in otolaryngology,thoracic surgery,general surgery,hematology,anesthesia and the intensive care unit to assist with treatment.The patient was treated with the highest level of antibiotics(vancomycin)and extensive abscess incision and drainage in the oral,maxillofacial,head and neck,chest and back regions.Unfortunately,the patient died of septic shock and multiple organ failure on the third day after admission.CONCLUSION Odontogenic infection can cause serious multi-space infections in the oral and maxillofacial head and neck regions,which can result in multiple LTCs.The management and treatment of LTCs such as multi-space infections should be multidisciplinary led by oral and maxillofacial surgeons.展开更多
Head and neck lipomas are fairly common but their presentation in areas like submandibular, submental and sublingual regions are rarely seen. Lipomas are generally asymptomatic and gradually progressive in size, causi...Head and neck lipomas are fairly common but their presentation in areas like submandibular, submental and sublingual regions are rarely seen. Lipomas are generally asymptomatic and gradually progressive in size, causing aesthetic and functional deficits. Surgical excision remains the mainstay of treatment. Radiological investigations like CECT and MRI play a critical role in diagnosis and management of these lesions. We describe a case of a giant lipoma involving the sublingual, submandibular and submental region, and its management.展开更多
目的:探讨髋关节内侧间隙比值(the medial space ratio,MSR)和臀中肌状态对股骨头坏死(osteonecrosis of the femoral head,ONFH)塌陷的影响。方法:基于3名健康志愿者的髋部CT数据,建立7种不同MSR(14.35、16.35、18.35、20.35、22.35、2...目的:探讨髋关节内侧间隙比值(the medial space ratio,MSR)和臀中肌状态对股骨头坏死(osteonecrosis of the femoral head,ONFH)塌陷的影响。方法:基于3名健康志愿者的髋部CT数据,建立7种不同MSR(14.35、16.35、18.35、20.35、22.35、24.35、26.35)的左侧ONFH有限元模型。基于其中1名健康志愿者的正常MSR的ONFH有限元模型,构建7种不同臀中肌状态的ONFH有限元模型(75%、80%、85%、90%、95%、100%、105%),其中100%臀中肌状态对应臀中肌肌力为700 N。所有模型均基于日本骨坏死调查委员会分型C1型建模,并将股骨头前侧保留角和外侧保留角均设置为70°,同时将坏死区体积定义为股骨头体积的30%。模拟双下肢静立状态下模型的受力情况,测定不同MSR的ONFH有限元模型的股骨头最大应力、坏死区最大应力及坏死区最大位移,测定不同臀中肌状态的ONFH有限元模型的股骨头最大应力、坏死区最大应力及股骨头向外侧位移。结果:①模型验证结果。本研究建立的ONFH有限元模型的主要负重区为股骨头前、外侧区域,应力集中现象出现在坏死区上方与受力区重叠部位,股骨头最大应力为(5.050±0.377)MPa,与既往研究报道的坏死股骨头应力传导特征基本一致。②不同MSR的ONFH有限元模型应力和位移测定结果。当MSR≤20.35时(即MSR为14.35、16.35、18.35、20.35),模型的股骨头最大应力、坏死区最大应力、坏死区最大位移的组间差异均无统计学意义。当MSR>20.35时(即MSR为22.35、24.35、26.35),模型的股骨头最大应力、坏死区最大应力、坏死区最大位移均高于MSR≤20.35的模型。③不同臀中肌状态的ONFH有限元模型应力和股骨头向外侧位移测定结果。在正常MSR的ONFH有限元模型中,随着臀中肌状态好转,股骨头最大应力、坏死区最大应力、股骨头向外侧位移随之不断减小。结论:MSR>20.35时,股骨头和坏死区应力明显增大,塌陷风险增高;良好的臀中肌状态不仅能降低股骨头和坏死区应力,而且能对抗股骨头外移,降低股骨头塌陷风险。展开更多
文摘To develop a simple,validated method for identifying and quantifying 1,3-butadiene(BD) in human blood by gas chromatography-mass spectrometry(GC-MS) and head-space gas chromatography(HS-GC).BD was identified by GC-MS and HS-GC,and quantified by HS-GC.The method showed that BD had a good linearity from 50 to 500μg/mL(r>0.99).The limits of detection and quantification were 10 μg/mL and 50 μg/mL,respectively.Both the intra-day precision and inter-day precision were <6.08%,and the accuracy was 96.98%-103.81%.The method was applied to an actual case,and the concentration of BD in the case was 242 μg/mL in human blood.This simple method is found to be useful for the routine forensic analysis of acute exposure to BD.
文摘BACKGROUND Odontogenic infection is one of the common infectious diseases in oral and maxillofacial head and neck regions.Clinically,if early odontogenic infections such as acute periapical periodontitis,alveolar abscess,and pericoronitis of wisdom teeth are not treated timely,effectively and correctly,the infected tissue may spread up to the skull and brain,down to the thoracic cavity,abdominal cavity and other areas through the natural potential fascial space in the oral and maxillofacial head and neck.Severe multi-space infections are formed and can eventually lead to life-threatening complications(LTCs),such as intracranial infection,pleural effusion,empyema,sepsis and even death.CASE SUMMARY We report a rare case of death in a 41-year-old man with severe odontogenic multi-space infections in the oral and maxillofacial head and neck regions.One week before admission,due to pain in the right lower posterior teeth,the patient placed a cigarette butt dipped in the pesticide"Miehailin"into the"dental cavity"to relieve the pain.Within a week,the infection gradually spread bilaterally to the floor of the mouth,submandibular space,neck,chest,waist,back,temporal and other areas.The patient had difficulty breathing,swallowing and eating,and was transferred to our hospital as an emergency admission.Following admission,oral and maxillofacial surgeons immediately organized consultations with doctors in otolaryngology,thoracic surgery,general surgery,hematology,anesthesia and the intensive care unit to assist with treatment.The patient was treated with the highest level of antibiotics(vancomycin)and extensive abscess incision and drainage in the oral,maxillofacial,head and neck,chest and back regions.Unfortunately,the patient died of septic shock and multiple organ failure on the third day after admission.CONCLUSION Odontogenic infection can cause serious multi-space infections in the oral and maxillofacial head and neck regions,which can result in multiple LTCs.The management and treatment of LTCs such as multi-space infections should be multidisciplinary led by oral and maxillofacial surgeons.
文摘Head and neck lipomas are fairly common but their presentation in areas like submandibular, submental and sublingual regions are rarely seen. Lipomas are generally asymptomatic and gradually progressive in size, causing aesthetic and functional deficits. Surgical excision remains the mainstay of treatment. Radiological investigations like CECT and MRI play a critical role in diagnosis and management of these lesions. We describe a case of a giant lipoma involving the sublingual, submandibular and submental region, and its management.
文摘目的:探讨髋关节内侧间隙比值(the medial space ratio,MSR)和臀中肌状态对股骨头坏死(osteonecrosis of the femoral head,ONFH)塌陷的影响。方法:基于3名健康志愿者的髋部CT数据,建立7种不同MSR(14.35、16.35、18.35、20.35、22.35、24.35、26.35)的左侧ONFH有限元模型。基于其中1名健康志愿者的正常MSR的ONFH有限元模型,构建7种不同臀中肌状态的ONFH有限元模型(75%、80%、85%、90%、95%、100%、105%),其中100%臀中肌状态对应臀中肌肌力为700 N。所有模型均基于日本骨坏死调查委员会分型C1型建模,并将股骨头前侧保留角和外侧保留角均设置为70°,同时将坏死区体积定义为股骨头体积的30%。模拟双下肢静立状态下模型的受力情况,测定不同MSR的ONFH有限元模型的股骨头最大应力、坏死区最大应力及坏死区最大位移,测定不同臀中肌状态的ONFH有限元模型的股骨头最大应力、坏死区最大应力及股骨头向外侧位移。结果:①模型验证结果。本研究建立的ONFH有限元模型的主要负重区为股骨头前、外侧区域,应力集中现象出现在坏死区上方与受力区重叠部位,股骨头最大应力为(5.050±0.377)MPa,与既往研究报道的坏死股骨头应力传导特征基本一致。②不同MSR的ONFH有限元模型应力和位移测定结果。当MSR≤20.35时(即MSR为14.35、16.35、18.35、20.35),模型的股骨头最大应力、坏死区最大应力、坏死区最大位移的组间差异均无统计学意义。当MSR>20.35时(即MSR为22.35、24.35、26.35),模型的股骨头最大应力、坏死区最大应力、坏死区最大位移均高于MSR≤20.35的模型。③不同臀中肌状态的ONFH有限元模型应力和股骨头向外侧位移测定结果。在正常MSR的ONFH有限元模型中,随着臀中肌状态好转,股骨头最大应力、坏死区最大应力、股骨头向外侧位移随之不断减小。结论:MSR>20.35时,股骨头和坏死区应力明显增大,塌陷风险增高;良好的臀中肌状态不仅能降低股骨头和坏死区应力,而且能对抗股骨头外移,降低股骨头塌陷风险。
