Promoting People-to-People Bond among Countries along the Routes of the Belt and Road——Sidelights of CAFIU Delegation's Visit to Sri Lanka,Brunei and ROK Headed by Vice-President Zhang Baowen

At the invitation of Sri Lanka-China Friendship Association(SLCFA),Brunei-China Friendship Association(BCFA)and National Strategy Institute of the ROK(NSI),Mr.Zhang Baowen,Vice-Chairman of NPC Standing Committee,Chairman of the Central Committee of China Democratic League and

Secretary-General Ni Jian Headed a Delegation to Visit ROK, Japan and Sri Lanka

At the invitation of National Strategy Institute of ROK (NSI), Japan&China Technological Youth Interchange Society and Sri Lanka-China Friendship Association (SLCFA), CAFIU’s Secretary-General Ni Jian headed a five-member delegation to visit the three countries from March 24 to April 2.

President Zhou Tienong Headed a Delegation to Visit Hungary and Denmark

At the invitation of the"World Bridge"Foundation of Hungary and the Danish-Chinese Business Forum,Mr.Zhou Tienong,ViceChairman of the Standing Committee of the 11th National People’s Congress and CAFIU’s President headed a CAFIU delegation to visit Hungary and Denmark from June 4 to 13,2013.

Strengthen Understanding and Promote Cooperation——Highlights of Visit to Yugoslavia by Delegation Headed by Vice-President Yu Wen by Cao Rongfei

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Tan Zhiqiang Headed an Investigation Delegation to Fujian Province

On the invitation of the Straits Textile & Clothing Fair (STCF) committee of Shishi City,Fujian

Actively Promoting Regional Space Cooperation——Vice Administrator, Loan Enjie headed a delegation to attend the Second Asia-Pacific Conference on Multilateral Cooperation in Space Technology and Applications

A Chinese delegation of 24 persons headed by Mr. Luan Enjie, Vice Administrator of China National Space Administration (CNSA) attended the Second Asia-Pacific Conference on Multilateral Cooperation in Space Technology and Applications held at Islamabad, the Capital of Pakistan from April 22 to 26, 1995. Following the First AsiaPacific Workshop held in Beijing in December, 1992, and the First Asia-Pacific Conference on Multilateral Cooperation in

Influence of surface cracking,anchor head profile,and anchor head size on cast-in headed anchors in geopolymer concrete

In this study,the concrete cone capacity,concrete cone angle,and load–displacement response of cast-in headed anchors in geopolymer concrete are explored using numerical analyses.The concrete damaged plasticity(CDP)model in ABAQUS is used to simulate the behavior of concrete substrates.The tensile behavior of anchors in geopolymer concrete is compared with that in normal concrete as well as that predicted by the linear fracture mechanics(LFM)and concrete capacity design(CCD)models.The results show that the capacity of the anchors in geopolymer concrete is 30%–40%lower than that in normal concrete.The results also indicate that the CCD model overestimates the capacity of the anchors in geopolymer concrete,whereas the LFM model provides a much more conservative prediction.The extent of the difference between the predictions by the numerical analysis and those of the above prediction models depends on the effective embedment depth of the anchor and the anchor head size.The influence of concrete surface cracking on the capacity of the anchor is shown to depend on the location of the crack and the effective embedment depth.The influence of the anchor head profile on the tensile capacity of the anchors is found to be insignificant.

面向热轧带钢表面缺陷检测的YOLOv5算法优化分析

单阶段目标检测网络YOLOv5在处理热轧带钢表面缺陷的特征提取与感受特征融合时存在一定不足。文章提出一种适用于热轧带钢表面缺陷检测的优化YOLOv5算法,该算法通过IOUK-means++算法调整Anchor聚类锚框设定,并增加Dynamic Head目标检测头,引入通道注意力机制(C3_CA),同时结合Hard Swish激活函数与WIoU_Loss边界框回归函数,有效提高热轧带钢表面缺陷检测的综合精度。由NEU-DET数据集测试结果表明,相较于单阶段YOLOv5算法融合结果,优化后的YOLOv5网络模型的均值平均精度(mAP)可提高至75.7%,且网络约束率可有效提升6.1%。上述优化YOLOv5算法对热轧带钢表面缺陷位置勘定、分类指向与影响评估具有有益参考,同时也为金属表面的高精度筛检提供重要支持。

Artificial intelligence-driven radiomics study in cancer:the role of feature engineering and modeling

Modern medicine is reliant on various medical imaging technologies for non-invasively observing patients’anatomy.However,the interpretation of medical images can be highly subjective and dependent on the expertise of clinicians.Moreover,some potentially useful quantitative information in medical images,especially that which is not visible to the naked eye,is often ignored during clinical practice.In contrast,radiomics performs high-throughput feature extraction from medical images,which enables quantitative analysis of medical images and prediction of various clinical endpoints.Studies have reported that radiomics exhibits promising performance in diagnosis and predicting treatment responses and prognosis,demonstrating its potential to be a non-invasive auxiliary tool for personalized medicine.However,radiomics remains in a developmental phase as numerous technical challenges have yet to be solved,especially in feature engineering and statistical modeling.In this review,we introduce the current utility of radiomics by summarizing research on its application in the diagnosis,prognosis,and prediction of treatment responses in patients with cancer.We focus on machine learning approaches,for feature extraction and selection during feature engineering and for imbalanced datasets and multi-modality fusion during statistical modeling.Furthermore,we introduce the stability,reproducibility,and interpretability of features,and the generalizability and interpretability of models.Finally,we offer possible solutions to current challenges in radiomics research.

Regulation of 2-acetyl-1-pyrroline and grain quality in early-season indica fragrant rice by nitrogen and silicon fertilization under different plantation methods

Fragrant rice has a high market value,and it is a popular rice type among consumers owing to its pleasant flavor.Plantation methods,nitrogen(N)fertilizers,and silicon(Si)fertilizers can affect the grain yield and fragrance of fragrant rice.However,the core commercial rice production attributes,namely the head rice yield(HRY)and 2-acetyl-1-pyrroline(2-AP)content of fragrant rice,under various nitrogen and silicon(N-Si)fertilization levels and different plantation methods remain unknown.The field experiment in this study was performed in the early seasons of 2018 and 2019 with two popular indica fragrant rice cultivars(Yuxiangyouzhan and Xiangyaxiangzhan).They were grown under six N-Si fertilization treatments(combinations of two levels of Si fertilizer,0 kg Si ha^(−1)(Si0)and 150 kg Si ha^(−1)(Si1),and three levels of N fertilizer,0 kg N ha^(−1)(N0),150 kg N ha^(−1)(N1),and 220 kg N ha^(−1)(N2))and three plantation methods(artificial transplanting(AT),mechanical transplanting(MT),and mechanical direct-seeding(MD)).The results showed that the N-Si fertilization treatments and all the plantation methods significantly affected the HRY and 2-AP content and related parameters of the two different fragrant rice cultivars.Compared with the Si0N0 treatment,the N-Si fertilization treatments resulted in higher HRY and 2-AP contents.The rates of brown rice,milled rice,head rice,and chalky rice of the fragrant rice also improved with the N-Si fertilization treatments.The N-Si fertilization treatments increased the activities of N metabolism enzymes and the accumulation of N and Si in various parts of the fragrant rice,and affected their antioxidant response parameters.The key parameters for the HRY and 2-AP content were assessed by redundancy analysis.Furthermore,the structural equation model revealed that the Si and N accumulation levels indirectly affected the HRY by affecting the N metabolism enzyme activity,N use efficiency,and grain quality of fragrant rice.Moreover,high N and Si accumulation directly promoted the 2-AP content or affected the antioxidant response parameters and indirectly regulated 2-AP synthesis.The interactions of the MT method with the N-Si fertilization treatments varied in the fragrant rice cultivars in terms of the HRY and 2-AP content,whereas the MD method was beneficial to the 2-AP content in both fragrant rice cultivars under the N-Si fertilization treatments.

Long non-coding RNA H19 regulates neurogenesis of induced neural stem cells in a mouse model of closed head injury

Stem cell-based therapies have been proposed as a potential treatment for neural regeneration following closed head injury.We previously reported that induced neural stem cells exert beneficial effects on neural regeneration via cell replacement.However,the neural regeneration efficiency of induced neural stem cells remains limited.In this study,we explored differentially expressed genes and long non-coding RNAs to clarify the mechanism underlying the neurogenesis of induced neural stem cells.We found that H19 was the most downregulated neurogenesis-associated lnc RNA in induced neural stem cells compared with induced pluripotent stem cells.Additionally,we demonstrated that H19 levels in induced neural stem cells were markedly lower than those in induced pluripotent stem cells and were substantially higher than those in induced neural stem cell-derived neurons.We predicted the target genes of H19 and discovered that H19 directly interacts with mi R-325-3p,which directly interacts with Ctbp2 in induced pluripotent stem cells and induced neural stem cells.Silencing H19 or Ctbp2 impaired induced neural stem cell proliferation,and mi R-325-3p suppression restored the effect of H19 inhibition but not the effect of Ctbp2 inhibition.Furthermore,H19 silencing substantially promoted the neural differentiation of induced neural stem cells and did not induce apoptosis of induced neural stem cells.Notably,silencing H19 in induced neural stem cell grafts markedly accelerated the neurological recovery of closed head injury mice.Our results reveal that H19 regulates the neurogenesis of induced neural stem cells.H19 inhibition may promote the neural differentiation of induced neural stem cells,which is closely associated with neurological recovery following closed head injury.

融合MacBERT和Talking⁃Heads Attention实体关系联合抽取模型

针对现有的医学文本关系抽取任务模型在训练过程中存在语义理解能力不足,可能导致关系抽取的效果不尽人意的问题,文中提出一种融合MacBERT和Talking⁃Heads Attention的实体关系联合抽取模型。该模型首先利用MacBERT语言模型来获取动态字向量表达,MacBERT作为改进的BERT模型,能够减少预训练和微调阶段之间的差异,从而提高模型的泛化能力;然后,将这些动态字向量表达输入到双向门控循环单元(BiGRU)中,以便提取文本的上下文特征。BiGRU是一种改进的循环神经网络(RNN),具有更好的长期依赖捕获能力。在获取文本上下文特征之后,使用Talking⁃Heads Attention来获取全局特征。Talking⁃Heads Attention是一种自注意力机制,可以捕获文本中不同位置之间的关系,从而提高关系抽取的准确性。实验结果表明,与实体关系联合抽取模型GRTE相比,该模型F1值提升1%,precision值提升0.4%,recall值提升1.5%。

Tilapia Head Glycolipid Alleviates Indomethacin-Induced Gastric Ulcer via Regulating Oxidative Stress and Inflammation Through COX/PGE2 Signaling Pathway in Adult Rats

The aim of this experiment was to investigate the ameliorative effect and molecular mechanism of tilapia head glycolipid(TH-GL)on indomethacin(IDM)-induced gastric ulcer in male Sprague Dawley(SD)rats.The gastric ulcer model was established by oral administration of 30mgkg^(-1) IDM after 7 days of TH-GL or omeprazole(OME)administration in rats.Then the macroscopic gastric injury symptoms,gastric mucosa protective factor cyclooxygenase 1(COX-1),cyclooxygenase 2(COX-2),prostaglandin E_(2)(PGE_(2)),the levels of oxidative stress,and inflammatory cytokine expression levels in the rats were analyzed.The experimental results showed that multiple ulcers appeared on the gastric surface of the rats in the model group.Compared to the model group,TH-GL significantly alleviated gastric ulcers and reduced the gastric damage index in rats.In addition,TH-GL significantly promoted the expression of constitutive enzyme COX-1 while inhibited the expression of inducible enzyme COX-2,and make PGE2 maintain at normal levels.TH-GL also inhibited oxidative stress and inflammatory responses,increased superoxide dismutase(SOD)activity and glutathione(GSH)content,decreased the level of malondialdehyde(MDA)and the content of pro-inflammatory factor.In conclusion,these results suggested that TH-GL could maintain the expression levels of COX-1 and PGE2 while inhibit the expression of COX-2 in the gastric of rat and then prevent IDM-induced gastric ulcer,which may be related to the regulation of oxidative stress and inflammatory response.Therefore,TH-GL might be a new option for the prevention of gastric diseases induced by IDM.

Basal defense is enhanced in a wheat cultivar resistant to Fusarium head blight

Fusarium head blight(FHB),mainly caused by the fungal pathogen Fusarium graminearum,is one of the most destructive wheat diseases.Besides directly affecting the yield,the mycotoxin residing in the kernel greatly threatens the health of humans and livestock.Xinong 979(XN979)is a widely cultivated wheat elite with high yield and FHB resistance.However,its resistance mechanism remains unclear.In this study,we studied the expression of genes involved in plant defense in XN979 by comparative transcriptomics.We found that the FHB resistance in XN979 consists of two lines of defense.The first line of defense,which is constitutive,is knitted via the enhanced basal expression of lignin and jasmonic acid(JA)biosynthesis genes.The second line of defense,which is induced upon F.graminearum infection,is contributed by the limited suppression of photosynthesis and the struggle of biotic stress-responding genes.Meanwhile,the effective defense in XN979 leads to an inhibition of fungal gene expression,especially in the early infection stage.The formation of the FHB resistance in XN979 may coincide with the breeding strategies,such as selecting high grain yield and lodging resistance traits.This study will facilitate our understanding of wheat-F.graminearum interaction and is insightful for breeding FHB-resistant wheat.

Author biographies of EIC's choice

Dr.Atefe R.Tari is a researcher at the Cardiac Exercise Research Group(CERG),at the Norwegian University of Science and Technology,and at the Department of Neurology and Clinical Neurophysiology,St.Olavs Hospital,Norway.Before defending her PhD in medicine in 2022,she had published 12 papers,several in high-ranking journals.Dr.Tari is heading her dedicated research group within CERG,focusing on the effects of exercise training on Alzheimer's disease.She is also co-principle investigator of the ExPlas trial examining the effect of plasma transfusions from young fit individuals on cognitive function in patients with Alzheimer’s disease.Mainly her research focuses on exploring the molecular secrets underlying the beneficial effects of exercise training on cognitive function—aiming to unravel in detail the molecular choreography of exercise training to discover molecular markers linked to various disease models.

Hepatobiliary & Pancreatic Diseases International

Hepatobiliary&Pancreatic Diseases International publishes peer-reviewed original papers,reviews(meta-analysis,systematic review)and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases.Papers cover the medical,surgical,radiological,pathological,biochemical,physiological and histological aspects of the subject areas under the headings Liver,Biliary,Pancreas,Transplantation,Research,Editorials,Review Articles,New Techniques,Clinical Images,Viewpoints and Letters to the Editor.The journal also deals with the basic sciences and experimental work.All submitted papers are reviewed by at least two referees in the field of the submitted paper.For detailed instructions concerning the submission of manuscripts,please refer to the Instructions for Authors in each issue of the journal.Full articles are available at ScienceDirect.

Hepatobiliary&Pancreatic Diseases International

Aims and Scope Hepatobiliary&Pancreatic Diseases International publishes peerreviewed original papers,reviews(meta-analysis,systematic review)and editorials concerned with clinical practice and research in the fields of hepatobiliary and pancreatic diseases.Papers cover the medical,surgical,radiological,pathological,biochemical,physiological and histological aspects of the subject areas under the headings Liver,Biliary,Pancreas,Transplantation,Research,Editorials,Review Articles,New Techniques,Clinical Images,Viewpoints and Letters to the Editor.The journal also deals with the basic sciences and experimental work.All submitted papers are reviewed by at least two referees in the field of the submitted paper.For detailed instructions concerning the submission of manuscripts,please refer to the Instructions for Authors in each issue of the journal.Full articles are available at Science Direct.

Experimental and numerical simulation study on forced ventilation and dust removal of coal mine heading surface

In order to study the problems of unreasonable airflow distribution and serious dust pollution in a heading surface,an experimental platform for forced ventilation and dust removal was built based on the similar principles.Through the similar experiment and numerical simulation,the distribution of airflow field in the roadway and the spatial and temporal evolution of dust pollution under the conditions of forced ventilation were determined.The airflow field in the roadway can be divided into three zones:jet zone,vortex zone and reflux zone.The dust concentration gradually decreases from the head to the rear of the roadway.Under the forced ventilation conditions,there is a unilateral accumulation of dust,with higher dust concentrations away from the ducts.The position of the equipment has an interception effect on the dust.The maximum error between the test value and the simulation result is 12.9%,which verifies the accuracy of the experimental results.The research results can provide theoretical guidance for the application of dust removal technology in coal mine.