This paper explores the association between intestinal microecology and digestive health and disease recovery in children with pneumonia.Intestinal microecological imbalance is common in children with pneumonia,which ...This paper explores the association between intestinal microecology and digestive health and disease recovery in children with pneumonia.Intestinal microecological imbalance is common in children with pneumonia,which is closely associated with digestive health and disease recovery.Intestinal microecological imbalance may affect digestive enzyme activity,intestinal mucosal barrier function,and nutrient absorption,which in turn affects digestive health.In addition,intestinal microecological imbalances may be associated with immune regulation,inflammatory responses,and pathogen suppression,affecting disease recovery.Strategies to regulate intestinal microecology include probiotic supplementation,dietary modification,and pharmacological treatment.Currently,the study of intestinal microecology in children with pneumonia faces challenges,and there is a need for improved research methods,individualized treatment strategies,and the development of novel probiotics.In conclusion,the intestinal microecology of children with pneumonia is closely related to digestive health and disease recovery,and the regulation of intestinal microecology is of great significance to the treatment of children with pneumonia.Furthermore,future research should further explore the application of the microecology of the intestinal microecology in the treatment of children with pneumonia.展开更多
Hepatitis C virus(HCV)is a blood-borne pathogen that has a worldwide distribution and infects millions of people.Care-associated HCV infections represented a huge part of hepatitis C burden in the past via contaminate...Hepatitis C virus(HCV)is a blood-borne pathogen that has a worldwide distribution and infects millions of people.Care-associated HCV infections represented a huge part of hepatitis C burden in the past via contaminated blood and unsafe injections and continue to be a serious problem of public health.The present review proposes a panorama of health care-associated HCV infections via the three mode of contamination that have been identified:(1)infected patient to non-infected patient;(2)infected patient to non-infected health careworker(HCW);and(3)infected HCW to non infected patient.For each condition,the circumstances of contamination are described together with the means to prevent them.As a whole,the more important risk is represented by unsafe practices regarding injections,notably with the improper use of multidose vials used for multiple patients.The questions of occupational exposures and infected HCWs are also discussed.In terms of prevention and surveillance,the main arm for combating care-associated HCV infections is the implementation of standard precautions in all the fields of cares,with training programs and audits to verify their good application.HCWs must be sensitized to the risk of blood-borne pathogens,notably by the use of safety devices for injections and good hygiene practices in the operating theatre and in all the invasive procedures.The providers performing exposed-prone procedures must monitor their HCV serology regularly in order to detect early any primary infection and to treat it without delay.With the need to stay vigilant because HCV infection is often a hidden risk,it can be hoped that the number of people infected by HCV via health care will decrease very significantly in the next years.展开更多
Health care-associated infections(HCAIs)pose a substantial threat to immunocompromised individuals and represent a frequent adverse event in health care delivery.The aim of this study was to evaluate the global resear...Health care-associated infections(HCAIs)pose a substantial threat to immunocompromised individuals and represent a frequent adverse event in health care delivery.The aim of this study was to evaluate the global research landscape of HCAIs among immunocompromised populations before and during the COVID-19 pandemic.A systematic search of articles published between 2013 and 2022 in the Web of Science Core Collection database was conducted,and content analytics and integrated science mapping were used for data analysis and interpretation.The review identified 1,473 articles.Only 633 articles authored by 4,151 individuals and published in 366 journals were included.The average citation rate was 14.27 per document,and research production grew annually by 9.07%peaking in 2021 during the COVID-19 pandemic but declining in 2022.The United States emerged as the most productive country,with 743 publication appearances and 2,485 citations.Keywords such as“epidemiology,”“infection,”“mortality,”and“risk factors”were frequently encountered in the analyzed literature.The main research themes,including“mortality,”“sepsis,”“immunosuppression,”“expression,”and“pneumonia,”underscored the focal points of importance within this domain.This study highlighted the growing interest regarding HCAIs in immunocompromised populations,especially during the COVID-19 pandemic.The study findings underscore the need to advance research efforts to understand different immunocompromised states,develop tailored infection prevention measures,and address health care disparities to mitigate the burden of HCAIs among immunocompromised individuals.展开更多
Objective Airborne microbial communities include a significant number of uncultured and poorly characterized bacteria.No effective method currently exists to evaluate the health risks of such complex bacterial populat...Objective Airborne microbial communities include a significant number of uncultured and poorly characterized bacteria.No effective method currently exists to evaluate the health risks of such complex bacterial populations,particularly for pneumonia.Methods We developed a method to evaluate risks from airborne microorganisms,guided by the principle that closer evolutionary relationships reflect similar biological characteristics,and thus used16 S rDNA sequences of 10 common pneumonia-related bacterial pathogens.We calculated a risk of breath-related(Rbr)index of airborne bacterial communities and verified effectiveness with artificial flora and a clinical project.Results We suggested applying Rbr80 to evaluate the health risks of airborne bacterial communities that comprise 80% of dominant operational taxonomic units(OTUs).The feasibility of Rbr80 was confirmed by artificial flora and by pneumonia data from a hospital.A high Rbr80 value indicated a high risk of pneumonia from airborne bacterial communities.Conclusion Rbr80 is an effective index to evaluate the pneumonia-associated risk from airborne bacteria.Values of Rbr80 greater than 15.40 are considered high risk.展开更多
基金Shandong Province Traditional Chinese Medicine Science and Technology Project"Efficacy Evaluation of Acupoint Application Synergy Model Intervention in Bronchoscopic Treatment of Severe Mycoplasma Pneumonia in Children"(Project No.2020M177)。
文摘This paper explores the association between intestinal microecology and digestive health and disease recovery in children with pneumonia.Intestinal microecological imbalance is common in children with pneumonia,which is closely associated with digestive health and disease recovery.Intestinal microecological imbalance may affect digestive enzyme activity,intestinal mucosal barrier function,and nutrient absorption,which in turn affects digestive health.In addition,intestinal microecological imbalances may be associated with immune regulation,inflammatory responses,and pathogen suppression,affecting disease recovery.Strategies to regulate intestinal microecology include probiotic supplementation,dietary modification,and pharmacological treatment.Currently,the study of intestinal microecology in children with pneumonia faces challenges,and there is a need for improved research methods,individualized treatment strategies,and the development of novel probiotics.In conclusion,the intestinal microecology of children with pneumonia is closely related to digestive health and disease recovery,and the regulation of intestinal microecology is of great significance to the treatment of children with pneumonia.Furthermore,future research should further explore the application of the microecology of the intestinal microecology in the treatment of children with pneumonia.
文摘Hepatitis C virus(HCV)is a blood-borne pathogen that has a worldwide distribution and infects millions of people.Care-associated HCV infections represented a huge part of hepatitis C burden in the past via contaminated blood and unsafe injections and continue to be a serious problem of public health.The present review proposes a panorama of health care-associated HCV infections via the three mode of contamination that have been identified:(1)infected patient to non-infected patient;(2)infected patient to non-infected health careworker(HCW);and(3)infected HCW to non infected patient.For each condition,the circumstances of contamination are described together with the means to prevent them.As a whole,the more important risk is represented by unsafe practices regarding injections,notably with the improper use of multidose vials used for multiple patients.The questions of occupational exposures and infected HCWs are also discussed.In terms of prevention and surveillance,the main arm for combating care-associated HCV infections is the implementation of standard precautions in all the fields of cares,with training programs and audits to verify their good application.HCWs must be sensitized to the risk of blood-borne pathogens,notably by the use of safety devices for injections and good hygiene practices in the operating theatre and in all the invasive procedures.The providers performing exposed-prone procedures must monitor their HCV serology regularly in order to detect early any primary infection and to treat it without delay.With the need to stay vigilant because HCV infection is often a hidden risk,it can be hoped that the number of people infected by HCV via health care will decrease very significantly in the next years.
文摘Health care-associated infections(HCAIs)pose a substantial threat to immunocompromised individuals and represent a frequent adverse event in health care delivery.The aim of this study was to evaluate the global research landscape of HCAIs among immunocompromised populations before and during the COVID-19 pandemic.A systematic search of articles published between 2013 and 2022 in the Web of Science Core Collection database was conducted,and content analytics and integrated science mapping were used for data analysis and interpretation.The review identified 1,473 articles.Only 633 articles authored by 4,151 individuals and published in 366 journals were included.The average citation rate was 14.27 per document,and research production grew annually by 9.07%peaking in 2021 during the COVID-19 pandemic but declining in 2022.The United States emerged as the most productive country,with 743 publication appearances and 2,485 citations.Keywords such as“epidemiology,”“infection,”“mortality,”and“risk factors”were frequently encountered in the analyzed literature.The main research themes,including“mortality,”“sepsis,”“immunosuppression,”“expression,”and“pneumonia,”underscored the focal points of importance within this domain.This study highlighted the growing interest regarding HCAIs in immunocompromised populations,especially during the COVID-19 pandemic.The study findings underscore the need to advance research efforts to understand different immunocompromised states,develop tailored infection prevention measures,and address health care disparities to mitigate the burden of HCAIs among immunocompromised individuals.
基金supported by the CAMS Innovation Fund for Medical Science[CIFMS,2018-I2M-1-001]the National Key R&D Program of China[2017YFC0702800]+1 种基金the National Natural Science Foundation of China[82070103]the Central Public-interest Scientific Institution Basal Research Fund[2016ZX310037]。
文摘Objective Airborne microbial communities include a significant number of uncultured and poorly characterized bacteria.No effective method currently exists to evaluate the health risks of such complex bacterial populations,particularly for pneumonia.Methods We developed a method to evaluate risks from airborne microorganisms,guided by the principle that closer evolutionary relationships reflect similar biological characteristics,and thus used16 S rDNA sequences of 10 common pneumonia-related bacterial pathogens.We calculated a risk of breath-related(Rbr)index of airborne bacterial communities and verified effectiveness with artificial flora and a clinical project.Results We suggested applying Rbr80 to evaluate the health risks of airborne bacterial communities that comprise 80% of dominant operational taxonomic units(OTUs).The feasibility of Rbr80 was confirmed by artificial flora and by pneumonia data from a hospital.A high Rbr80 value indicated a high risk of pneumonia from airborne bacterial communities.Conclusion Rbr80 is an effective index to evaluate the pneumonia-associated risk from airborne bacteria.Values of Rbr80 greater than 15.40 are considered high risk.
