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Association between availability of glucose-lowering drugs in primary health institutions and diabetes patients’medication adherence:a cross-sectional study in Shandong Province,China
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作者 Jiansen Yao Haipeng Wang +4 位作者 Di Shao Jia Yin Xiaolei Guo Xiao Yin Qiang Sun 《Global Health Journal》 2021年第2期83-89,共7页
Background:Primary health care system is a critical component of diabetes care and management.This article aimed to analyze the availability of glucose-lowering drugs in primary health institutions(PHIs)in China,and t... Background:Primary health care system is a critical component of diabetes care and management.This article aimed to analyze the availability of glucose-lowering drugs in primary health institutions(PHIs)in China,and to explore the relationship between availability of glucose-lowering drugs and medication adherence among type 2 diabetes mellitus(T2DM)patients.Methods:This cross-sectional study conducted in Shandong Province,eastern China(hereafter referred to as Shandong),between August and December 2017.In total,2520 community-managed T2DM patients were selected from 68 PHIs in Shandong,including 62 village-level and 6 township-level PHIs.The self-developed questionnaire was used to survey the availability of glucose-lowering drugs in PHIs.Patients’medication adherence was assessed by four self-reported questions,and was classified as either adherent or non-adherent.Descriptive statistics was used to analyze the availability of glucose-lowering drugs in PHIs and the medication adherence among the T2DM patients.Multilevel logistic regression models were used to explore the relationship between the availability of glucose-lowering drugs in PHIs and patients’medication adherence.Results:A total of 1866 T2DM patients prescribed with at least one glucose-lowering drug were included in analysis.Among them,58.5%patients followed their antidiabetic treatment well.In village-level PHIs,the patient’s adherence rate was lower than in township-level PHIs(55.9%vs.61.1%,P<0.05).Among the 68 PHIs,average(2.53±0.97)glucose-lowering products(generic names)were available,which in village-level PHIs were less than in township-level PHIs(2.47 vs.3.17,P<0.05).And the number of available glucose-lowering products in PHIs was associated with the adherence of T2DM patients.Conclusion:Poor availability of glucose-lowering products was found in PHIs in Shandong.The availability of glucose-lowering products in PHIs was positively associated with patients’medication adherence,and could be enhanced to improve the control of diabetes in primary care settings. 展开更多
关键词 Diabetes mellitus Primary health institutions Medication adherence SHANDONG China
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Research on the Construction of Pharmacy Organization and the Development of Pharmaceutical Services in China’s Primary Medical and Health Institutions—Based on the Survey of 5 Provinces
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作者 Cai Hongning Sun Lihua 《Asian Journal of Social Pharmacy》 2021年第1期93-101,共9页
Objective To explore the current situation and problems of the pharmacy organization and pharmaceutical services in primary medical and health institutions so as to provide a reference for improving relevant policies.... Objective To explore the current situation and problems of the pharmacy organization and pharmaceutical services in primary medical and health institutions so as to provide a reference for improving relevant policies.Methods Multi-stage stratified random sampling was used to collect questionnaires from primary medical and health institutions in 5 provinces,and 102 questionnaires were distributed.Then Excel 2016 and IBM SPSS 21.0 software were applied for descriptive statistical analysis,chi-square test and multiple response analysis.Results and Conclusion A total of 92 primary medical and health institutions participated in the survey,and 92 valid questionnaires were recovered.The survey shows that 54.1%of the institutions have established more than 8 pharmaceutical administration regulations.63.5%and 31.8%of the institutions have formulated pharmaceutical administration and pharmacotherapy team charters(or management systems).29.7%of institutions have pharmacy personnel in accordance with relevant regulations.The higher proportion of pharmacy services are prescription review and adjustment,medication guidance,collecting and reporting adverse reactions,medication errors and medication hazard information.Primary medical and health institutions still need to further improve their pharmaceutical administration system,organizational structure,pharmacy professional training and clinical pharmacy service. 展开更多
关键词 primary health care institutions pharmaceutical administration system construction organizational structure pharmaceutical service
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Study on the demand for public health professional after the COVID-19 epidemic in Zhejiang Province, China: A survey based on human-machine collaboration
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作者 Chunyan Yang Weiwei Sun +2 位作者 Shize Wang Jianlie Jin Feng Chen 《教育技术与创新》 2023年第2期1-11,共11页
To understand the needs of public health institutions in Zhejiang Province,China for public health personnel,and provide basis for training public health personnel.Methods:512 public health institutions in Zhejiang Pr... To understand the needs of public health institutions in Zhejiang Province,China for public health personnel,and provide basis for training public health personnel.Methods:512 public health institutions in Zhejiang Province were randomly selected from different levels and regions,and the number of ublic health professional and the demand for professional ability were investigated by questionnaire.Results:The preventive medicine personnel in public health institutions in Zhejiang Province are insufficient;There is a certain disjunction or dislocation between the abilities and needs of public health professional;The way of continuing education for public health professional is single and the opportunities are few.Conclusion:Zhejiang Province should appropriately expand the enrollment of preventive medicine majors,especially high-level preventive medicine talents,deepen the education and teaching reform of preventive medicine majors,and strengthen the continuing education and training of public health professional to meet the needs of public health services after the COVID-19 epidemic. 展开更多
关键词 health institutions Public health professional COVID-19 Investigation and research
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Exploration on the Implementation of the Integration of Medical and Preventive Model in China’s Primary Health Care Institutions
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作者 Chen Hui Wang Shuling 《Asian Journal of Social Pharmacy》 2022年第2期167-177,共11页
Objective To explore the different modes and approaches of medical and preventive integration in current primary health care institutions in China.Methods Through literature analysis,field research,telephone interview... Objective To explore the different modes and approaches of medical and preventive integration in current primary health care institutions in China.Methods Through literature analysis,field research,telephone interviews,and other methods the implementation status was evaluated to systematically study the main experience and effect of implementing medical and preventive integration services in pilot areas.Results and Conclusion At present,there are three implementation modes of medical-prevention integration,namely,vertical mode based on the medical community,internal mode with optimized service process,and internal mode with great service capabilities.The three medical-prevention integration modes have their respective focuses,but they need to be further improved in terms of policy support,technical staffing,information system construction,and drug use. 展开更多
关键词 primary health care institution medical and preventive integration model
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Remuneration Reforms in Public Sector: A Case of Russian Healthcare
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作者 Marina Kolosnitsyna 《Chinese Business Review》 2012年第1期109-118,共10页
In 2008 remuneration reform for public sector was introduced in Russia. Its main idea was to implement P4P principle well-known in business, including more flexible approach to wage setting. This paper presents an att... In 2008 remuneration reform for public sector was introduced in Russia. Its main idea was to implement P4P principle well-known in business, including more flexible approach to wage setting. This paper presents an attempt to estimate an influence of the new remuneration system (NRS) on earnings level, inequalities and job motivation. The estimates are based on microdata of monitoring survey of healthcare economic problems conducted in Russia in 2009 and 2010. The extended specification of Mincer earning equation and probit-models were used. One could observe increasing wage rates and earning inequalities within healthcare institutions adopted NRS though worker's experience and regional economic differences remain significant wage determining factors. As it occurs, NRS is widely adopted by large regional and central hospitals while smaller health care institutions show less enthusiasm in implementing reform. Obviously, the larger institutions have more money and better educated administrative staff to introduce the new system. Those chief physicians who adopted NRS point out a positive correlation between earnings and individual input. At the same time, those committed to old principles of wage setting more often note declining job turnover. This latter result could possibly indicate negative personnel sorting, less productive workers tending to stay with employer who doesn't assess their performance. As concerns anticipated NRS results such as increasing motivation and quality of health services, the evidence is still ambiguous. 展开更多
关键词 remuneration system pay for performance health care institutions job motivation
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National Institutes of Health Funding for disease categories related to Neural Regeneration Research
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《Neural Regeneration Research》 SCIE CAS CSCD 2011年第26期2053-2080,共28页
The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation's medical research agency-making important discoveries that improve health and save lives.Thanks in... The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services, is the nation's medical research agency-making important discoveries that improve health and save lives.Thanks in large part to NIH-funded medical research, Americans today are living longer and healthier. Life expectancy in the United States has jumped from 47 years in 1900 to 78 years as reported in 2009, and disability in people over age 65 has dropped dramatically in the past 3 decades. In recent years, nationwide rates of new diagnoses and deaths from all cancers combined have fallen significantly. 展开更多
关键词 NS NEI National Institutes of health Funding for disease categories related to Neural Regeneration Research CTR HD NCI DC NIH ATP DE
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Description of the National Institutes of Health
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《Neural Regeneration Research》 SCIE CAS CSCD 2011年第15期1189-1200,共12页
Introduction The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services is the nation's medical research agency-making important discoveries that improve health and save liv... Introduction The National Institutes of Health (NIH), a part of the U.S. Department of Health and Human Services is the nation's medical research agency-making important discoveries that improve health and save lives.Thanks in large part to NIH-funded medical research, Americans today are living longer and healthier. Life expectancy in the United States has jumped from 47 years in 1900 to 78 years as reported in 2009, and disability in people over age 65 has dropped dramatically in the past 3 decades. In recent years, nationwide rates of new diagnoses and deaths from all cancers combined have fallen significantly. 展开更多
关键词 NIH Description of the National Institutes of health
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强基层:深圳南山区域医疗联合体的策略和效果 被引量:4
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作者 罗力 陈渊青 +7 位作者 张飞 许全成 范轶 李萍 吴萍 陈萌萱 任柏冰 张天天 《中国卫生资源》 CSCD 北大核心 2023年第1期57-60,共4页
目的分析区域医疗联合体(以下简称“医联体”)政策指引下深圳南山区域医联体发展的探索,为其他地区医药卫生体制改革提供参考。方法通过知情人访谈、现场调研、二次资料分析、头脑风暴等方法剖析深圳南山区域医联体强基层的策略背景、... 目的分析区域医疗联合体(以下简称“医联体”)政策指引下深圳南山区域医联体发展的探索,为其他地区医药卫生体制改革提供参考。方法通过知情人访谈、现场调研、二次资料分析、头脑风暴等方法剖析深圳南山区域医联体强基层的策略背景、实施内容和实施效果。结果统一管理所有基层医疗卫生机构,实行标准化建设,有助于更好地发展基层医疗卫生机构;实施区域学科联盟,以契约方式加强医院和基层医疗卫生机构的人员联系,具有可行性。结论强基层是医药卫生体制改革的重点,深圳南山区域医联体强基层的策略具有参考借鉴价值。 展开更多
关键词 区域学科联盟regional discipline alliance 基层医疗卫生机构grassroots medical and health institution 区域医疗集团regional medical group 家庭医生family doctor 深圳南山Shenzhen Nanshan
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INSTITUTE OF ENVIRONMENTAL HEALTH AND ENGINEERING CHINESE ACADEMY OF PREVENTIVE MEDICINE
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《Biomedical and Environmental Sciences》 SCIE CAS CSCD 1993年第4期W003-W003,共1页
The Institute of Environmental Health and Engineering,consisting of the previousDepartment of Environmental Health and the Department of Sanitary andEnvironmental Engineering of the Institute of Health founded in 1954... The Institute of Environmental Health and Engineering,consisting of the previousDepartment of Environmental Health and the Department of Sanitary andEnvironmental Engineering of the Institute of Health founded in 1954,was establishedin1986.This Institute has around 220 staff in total and 11 departments,namely,theDepartment of Environmental Epidemiology;Department of EnvironmentalChemistry;Department of Environmental Toxicology;Department of EnvironmentalMicrobiology;Department of Soil Hygiene;Department of Water Treatment; 展开更多
关键词 INSTITUTE OF ENVIRONMENTAL health AND ENGINEERING CHINESE ACADEMY OF PREVENTIVE MEDICINE
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上海妇幼保健系统党员和业务骨干“双培养”工作现状与对策建议 被引量:1
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作者 金晔 张辉 +4 位作者 黄思颖 郝思佳 曹海亮 李文先 沙卫涛 《中国卫生资源》 CSCD 北大核心 2023年第6期768-772,共5页
目的调查当前上海市妇幼保健机构党员和业务骨干“双培养”工作现状,对本系统人才队伍建设提出对策建议,为打造一支政治过硬、业务精湛、作风优良的妇幼健康人才队伍打好基础。方法通过召开1场人才工作专题会,发放17张机构调查表和321... 目的调查当前上海市妇幼保健机构党员和业务骨干“双培养”工作现状,对本系统人才队伍建设提出对策建议,为打造一支政治过硬、业务精湛、作风优良的妇幼健康人才队伍打好基础。方法通过召开1场人才工作专题会,发放17张机构调查表和321份调查问卷,到3个区妇幼保健院(所)实地调研,收集17家机构工作总结等方式,了解2020—2022年上海市、区两级17家妇幼保健机构党员和业务骨干“双培养”工作情况。结果上海妇幼保健系统党员和业务骨干“双培养”工作在机制建设、思想引领和培养方式上已经取得一定成效,但在受访者中,仍有39.75%对该项工作不了解;57%的非党员业务骨干不愿意或不确定是否入党;82名非业务骨干党员认为自身与业务骨干在工作格局(27.27%)、管理能力(24.43%)、业务能力(14.2%)和人际沟通能力(11.93%)等方面存在差距。结论本市妇幼保健系统要进一步加强党员和业务骨干“双培养”工作的推进力度:一要立足“党管”、立足“精准”、立足“长远”;二要加强对业务骨干思想引领和文化引领;三要实现党员工作格局、职业素养和综合实力三方面超越,从而不断提升人才素质,夯实妇幼事业的人才基础。 展开更多
关键词 党员member of the Chinese Communist Party 业务骨干key personnel 双培养dual development 妇幼保健机构women and children’s health care institution
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Shadow Extraction and Elimination of Moving Vehicles for Tracking Vehicles
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作者 Kalpesh Jadav Vishal Sorathiya +5 位作者 Walid El-Shafai Torki Altameem Moustafa HAly Vipul Vekariya Kawsar Ahmed Francis MBui 《Computers, Materials & Continua》 SCIE EI 2023年第11期2009-2030,共22页
Shadow extraction and elimination is essential for intelligent transportation systems(ITS)in vehicle tracking application.The shadow is the source of error for vehicle detection,which causes misclassification of vehic... Shadow extraction and elimination is essential for intelligent transportation systems(ITS)in vehicle tracking application.The shadow is the source of error for vehicle detection,which causes misclassification of vehicles and a high false alarm rate in the research of vehicle counting,vehicle detection,vehicle tracking,and classification.Most of the existing research is on shadow extraction of moving vehicles in high intensity and on standard datasets,but the process of extracting shadows from moving vehicles in low light of real scenes is difficult.The real scenes of vehicles dataset are generated by self on the Vadodara–Mumbai highway during periods of poor illumination for shadow extraction of moving vehicles to address the above problem.This paper offers a robust shadow extraction of moving vehicles and its elimination for vehicle tracking.The method is distributed into two phases:In the first phase,we extract foreground regions using a mixture of Gaussian model,and then in the second phase,with the help of the Gamma correction,intensity ratio,negative transformation,and a combination of Gaussian filters,we locate and remove the shadow region from the foreground areas.Compared to the outcomes proposed method with outcomes of an existing method,the suggested method achieves an average true negative rate of above 90%,a shadow detection rate SDR(η%),and a shadow discrimination rate SDR(ξ%)of 80%.Hence,the suggested method is more appropriate for moving shadow detection in real scenes. 展开更多
关键词 Change illuminations ImageJ software intelligent traffic systems mixture of Gaussian model National Institute of health vehicle tracking
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上海市公共卫生技术服务机构传染病防治检测技术服务能力现况调查
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作者 徐毅 《中国卫生资源》 北大核心 2022年第2期154-159,共6页
目的 了解上海市公共卫生技术服务机构传染病防治检测技术服务能力现状,为进一步提升传染病防治检测技术服务行业总体能级水平提出建议,为相关政策和措施制定提供科学依据。方法 2020年4—6月,对上海市开展公共卫生技术服务的社会机构... 目的 了解上海市公共卫生技术服务机构传染病防治检测技术服务能力现状,为进一步提升传染病防治检测技术服务行业总体能级水平提出建议,为相关政策和措施制定提供科学依据。方法 2020年4—6月,对上海市开展公共卫生技术服务的社会机构和市区两级疾病预防控制机构开展问卷调查,收集2019年度开展传染病防治检测技术服务的业务量和市场供需,以及截至2020年6月在6大类40项传染病防治检测技术服务细分领域能力参数的储备情况。结果 被调查机构2019年全年共提供31 763次传染病防治领域检测技术服务。社会委托性质技术服务为主要需求方,出具社会委托性质报告占报告总数的78.3% (24 859份),社会机构为该领域检测技术服务的主要提供方,出具报告占报告总数的73.1%(23 207份)。截至2020年6月,能力储备率最高的是医疗机构环境卫生学监测项目(82.7%),最低的是消毒灭菌设备项目(11.5%)。疾病预防控制机构的传染病防治领域检测技术服务总体能力储备率(50.0%)高于社会机构(25.9%),在医疗器械及物品细菌学监测、消毒剂项目的能力储备率上疾病预防控制机构和社会机构存在差异(P<0.05)。环氧乙烷低温灭菌综合性能监测/化学监测能力参数尚为“零能力储备”。结论 上海市传染病防治领域检测技术服务市场已形成一定规模,检测技术服务能力储备已有一定基础,疾病预防控制机构总体能力储备高于社会机构。细分领域能力储备不均衡,部分能力欠缺有待提升。疾病预防控制机构和社会机构共同作为传染病防治领域检测技术服务提供方,发挥各自优势特点,依托质量控制中心平台,共同提升传染病防治领域检测技术服务能力水平,促进传染病防治领域检测技术服务行业发展。 展开更多
关键词 技术服务能力technical service capability 公共卫生技术服务机构public health technical service institution 传染病防治prevention and treatment of infectious diseases 检测detection
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不同类型公立医疗卫生机构门诊患者满意度比较 被引量:2
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作者 张懿中 邹冬冬 +3 位作者 刘国华 陆婧 曹思雨 薛迪 《中国卫生资源》 北大核心 2022年第2期163-166,171,共5页
目的 在控制门诊患者的人口学和临床特征后,比较不同类型公立医疗卫生机构的门诊患者满意度,为公立医疗卫生机构和卫生行政部门开展绩效考核提供参考信息。方法 对上海市107所公立医疗卫生机构开展门诊患者满意度问卷调查,通过多层混合... 目的 在控制门诊患者的人口学和临床特征后,比较不同类型公立医疗卫生机构的门诊患者满意度,为公立医疗卫生机构和卫生行政部门开展绩效考核提供参考信息。方法 对上海市107所公立医疗卫生机构开展门诊患者满意度问卷调查,通过多层混合线性模型分析和Snijders & Bosker法比较不同类型公立医疗卫生机构的门诊患者满意度。结果 在控制医疗卫生机构的随机效应以及其他固定效应后,公立三级综合医院和三级专科医院的门诊患者满意度相对较低,且高住院病例组合指数组医院的门诊患者总体满意度和对医生服务满意度有走低趋势。此外,公立医疗卫生机构类型可解释69.13%的机构间门诊患者总体满意度差异。结论 诸多因素可能导致公立三级医院门诊患者总体满意度相对较低,医疗卫生机构应聚焦于可控因素以提升门诊患者满意度。 展开更多
关键词 满意度satisfaction 公立医疗卫生机构public medical and health institution 影响influence 门诊患者outpatient
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2020年上海市公立医疗卫生机构门诊患者满意度调查 被引量:2
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作者 邹冬冬 张懿中 +3 位作者 俞卓伟 曹思雨 陈淑雯 薛迪 《中国卫生资源》 北大核心 2022年第2期160-162,171,共4页
目的 分析2020年上海市公立医疗卫生机构的门诊患者满意度,为上海市公立医疗卫生机构改善服务质量和卫生行政部门加强服务质量的监管提供决策依据。方法 对上海市107所公立医疗卫生机构进行门诊患者满意度调查。结果 门诊患者对医疗服... 目的 分析2020年上海市公立医疗卫生机构的门诊患者满意度,为上海市公立医疗卫生机构改善服务质量和卫生行政部门加强服务质量的监管提供决策依据。方法 对上海市107所公立医疗卫生机构进行门诊患者满意度调查。结果 门诊患者对医疗服务满意度的总体评分平均为4.78分,但门诊患者对等候时间不满意或较不满意率相对较高。此外,机构间总体满意率差异较大。结论 2020年上海市公立医疗卫生机构门诊患者的满意度处于高水平,但部分公立医疗卫生机构应采取有效措施提高患者满意度,门诊等候时间应进一步缩短。 展开更多
关键词 门诊满意度outpatient satisfaction 医疗服务medical service 公立医疗卫生机构public medical and health institution 疫情防控epidemic prevention and control 上海市Shanghai
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Efficacy of cattle encephalon glycoside and ignotin in patients with acute cerebral infarction: a randomized, double-blind, parallel-group, placebo-controlled study 被引量:60
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作者 Hui Zhang Chuan-Ling Li +11 位作者 Feng Wan Su-Juan Wang Xiu-E Wei Yan-Lei Hao Hui-Lin Leng Jia-Min Li Zhong-Rui Yan Bao-Jun Wang Ren-Shi Xu Ting-Min Yu Li-Chun Zhou Dong-Sheng Fan 《Neural Regeneration Research》 SCIE CAS CSCD 2020年第7期1266-1273,共8页
Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuropr... Cattle encephalon glycoside and ignotin(CEGI)injection is a compound preparation formed by a combination of muscle extract from hea lthy rabbits and brain gangliosides from cattle,and it is generally used as a neuroprotectant in the treatment of central and peripheral nerve injuries.However,there is still a need for high-level clinical evidence from large samples to support the use of CEGI.We therefore carried out a prospective,multicenter,randomized,double-blind,parallel-group,placebo-controlled study in which we recruited 319 patients with acute cerebral infarction from 16 centers in China from October 2013 to May 2016.The patients were randomized at a 3:1 ratio into CEGI(n=239;155 male,84 female;61.2±9.2 years old)and placebo(n=80;46 male,34 female;63.2±8.28 years old)groups.All patients were given standard care once daily for 14 days,including a 200 mg aspirin enteric-coated tablet and 20 mg atorvastatin calcium,both taken orally,and intravenous infusion of 250–500 mL 0.9%sodium chloride containing 40 mg sodium tanshinone IIA sulfonate.Based on conventional treatment,patients in the CEGI and placebo groups were given 12 mL CEGI or 12 mL sterile water,respectively,in an intravenous drip of 250 mL 0.9%sodium chloride(2 mL/min)once daily for 14 days.According to baseline National Institutes of Health Stroke Scale scores,patients in the two groups were divided into mild and moderate subgroups.Based on the modified Rankin Scale results,the rate of patients with good outcomes in the CEGI group was higher than that in the placebo group,and the rate of disability in the CEGI group was lower than that in the placebo group on day 90 after treatment.In the CEGI group,neurological deficits were decreased on days 14 and 90 after treatment,as measured by the National Institutes of Health Stroke Scale and the Barthel Index.Subgroup analysis revealed that CEGI led to more significant improvements in moderate stroke patients.No drug-related adverse events occurred in the CEGI or placebo groups.In conclusion,CEGI may be a safe and effective treatment for acute cerebral infarction patients,especially for moderate stroke patients.This study was approved by the Ethical Committee of Peking University Third Hospital,China(approval No.2013-068-2)on May 20,2013,and registered in the Chinese Clinical Trial Registry(registration No.ChiCTR1800017937). 展开更多
关键词 acute cerebral infarction Barthel Index cattle encephalon glycoside and ignotin modified Rankin Scale National Institutes of health Stroke Scale NEUROPROTECTANTS recovery rate stroke
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Development of an Arabic version of the National Eye Institute Visual Function Questionnaire as a tool to study eye diseases patients in Egypt 被引量:8
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作者 Nizar Saleh Abdelfattah Mohamed Amgad +14 位作者 Ahmed A Salama Marina E Israel Ghada A Elhawary Ahmed E Radwan Mohamed M Elgayar Tamer M EL Nakhal Islam T Elkhateb Heba A Hashem Doha K Embaby Amira A Elabd Reem K Elwy Magdi S Yacoub Hamdy Salem Mohamed Abdel-Baqy Ahmad Kassem 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2014年第5期891-897,共7页
AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled a... AIM:To develop and test an Arabic version of the National Eye Institute Visual Function Questionnaire-25(NEI-VFQ-25).METHODS:NEI-VFQ-25 was translated into Arabic according to WHO translation guidelines. We enrolled adult consenting patients with bilateral chronic eye diseases who presented to 14 hospitals across Egypt from October to December 2012, and documented their clinical findings. Psychometric properties were then tested using STATA.RESULTS:We recruited 379 patients, whose mean age was(54.5±15)y. Of 46.2% were males, 227 had cataract,31 had glaucoma, 23 had retinal detachment, 37 had diabetic retinopathy, and 61 had miscellaneous visual defects. Non-response rate and the floor and ceiling numbers of the Arabic version(ARB-VFQ-25) were calculated. Internal consistency was high in all subscales(except general health), with Cronbach-α ranging from0.702-0.911. Test-retest reliability was high(intraclass correlation coefficient 0.79).CONCLUSION:RB-VFQ-25 isareliableandvalidtool for assessing visual functions of Arabic speaking patients. However, some questions had high non-response rates and should be substituted by available alternatives. Our results support the importance of including self-reported visual functions as part of routine ophthalmologic examination. 展开更多
关键词 ARABIC PSYCHOMETRICS questionnaires National Institutes of health visual function questionnaire
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Management of chronic hepatitis B infection: Current treatment guidelines, challenges, and new developments 被引量:42
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作者 Ceen-Ming Tang Tung On Yau Jun Yu 《World Journal of Gastroenterology》 SCIE CAS 2014年第20期6262-6278,共17页
Chronic hepatitis B(CHB)virus infection is a global public health problem,affecting more than 400 million people worldwide.The clinical spectrum is wide,ranging from a subclinical inactive carrier state,to progressive... Chronic hepatitis B(CHB)virus infection is a global public health problem,affecting more than 400 million people worldwide.The clinical spectrum is wide,ranging from a subclinical inactive carrier state,to progressive chronic hepatitis,cirrhosis,decompensation,and hepatocellular carcinoma.However,complications of hepatitis B virus(HBV)-related chronic liver disease may be reduced by viral suppression.Current international guidelines recommend first-line treatment of CHB infection with pegylated interferon,entecavir,or tenofovir,but the optimal treatment for an individualpatient is controversial.The indications for treatment are contentious,and increasing evidence suggests that HBV genotyping,as well as serial on-treatment measurements of hepatitis B surface antigen and HBV DNA kinetics should be used to predict antiviral treatment response.The likelihood of achieving a sustained virological response is also increased by extending treatment duration,and using combination therapy.Hence the paradigm for treatment of CHB is constantly evolving.This article summarizes the different indications for treatment,and systematically reviews the evidence for the efficacy of various antiviral agents.It further discusses the shortcomings of current guidelines,use of rescue therapy in drug-resistant strains of HBV,and highlights the promising clinical trials for emerging therapies in the pipeline.This concise overview presents an updated practical approach to guide the clinical management of CHB. 展开更多
关键词 Chronic hepatitis B virus infection National institute for health and care excellence Treatment guidelines INTERFERON Pegylated interferon Nucleos(t)ide analogues Antiviral resistance Rescue therapy Clinical trials
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Leukoaraiosis is associated with clinical symptom severity,poor neurological function prognosis and stroke recurrence in mild intracerebral hemorrhage:a prospective multi-center cohort study 被引量:5
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作者 Tian-Qi Xu Wei-Zhi Lin +6 位作者 Yu-Lan Feng Fan-Xia Shen Jie Chen Wei-Wen Wu Xiao-Dong Zhu Lin Gu Yi Fu 《Neural Regeneration Research》 SCIE CAS CSCD 2022年第4期819-823,共5页
Leukoaraiosis(LA)results from ischemic injury in small cerebral vessels,which may be attributable to decreased vascular density,reduced cerebrovascular angiogenesis,decreased cerebral blood flow,or microcirculatory dy... Leukoaraiosis(LA)results from ischemic injury in small cerebral vessels,which may be attributable to decreased vascular density,reduced cerebrovascular angiogenesis,decreased cerebral blood flow,or microcirculatory dysfunction in the brain.In this study,we enrolled 357 patients with mild intracerebral hemorrhage(ICH)from five hospitals in China and analyzed the relationships between LA and clinical symptom severity at admission,neurological function prognosis at 3 months,and 1-year stroke recurrence.Patients were divided into groups based on Fazekas scale scores:no LA(n=83),mild LA(n=64),moderate LA(n=98)and severe LA(n=112).More severe LA,larger hematoma volume,and higher blood glucose level at admission were associated with more severe neurological deficit.More severe LA,older age and larger hematoma volume were associated with worse neurological function prognosis at 3 months.In addition,moderate-to-severe LA,admission glucose and symptom-free cerebral infarction were associated with 1-year stroke recurrence.These findings suggest that LA severity may be a potential marker of individual ICH vulnerability,which can be characterized by poor tolerance to intracerebral attack or poor recovery ability after ICH.Evaluating LA severity in patients with mild ICH may help neurologists to optimize treatment protocols.This study was approved by the Ethics Committee of Ruijin Hospital Affiliated to Shanghai Jiao Tong University(approval No.12)on March 10,2011. 展开更多
关键词 clinical symptom severity functional dependence intracerebral hemorrhage LEUKOARAIOSIS modified Rankin scale National Institute health of Stroke Scale PROGNOSIS stroke recurrence white matter hyperintensities
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Major ozonated autohemotherapy promotes the recovery of upper limb motor function in patients with acute cerebral infarction 被引量:23
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作者 Xiaona Wu Zhensheng Li +4 位作者 Xiaoyan Liu Haiyan Peng Yongjun Huang Gaoquan Luo Kairun Peng 《Neural Regeneration Research》 SCIE CAS CSCD 2013年第5期461-468,共8页
Major ozonated autohemotherapy is classically used in treating ischemic disorder of the lower limbs In the present study, we performed major ozonated autohemotherapy treatment in patients with acute cerebral infarctio... Major ozonated autohemotherapy is classically used in treating ischemic disorder of the lower limbs In the present study, we performed major ozonated autohemotherapy treatment in patients with acute cerebral infarction, and assessed outcomes according to the U.S. National Institutes of Health Stroke Score, Modified Rankin Scale, and transcranial magnetic stimulation motor-evoked potential. Compared with the control group, the clinical total effective rate and the cortical potential rise rate of the upper limbs were significantly higher, the central motor conduction time of upper limb was significantly shorter, and the upper limb motor-evoked potential amplitude was significantly increased, in the ozone group. In the ozone group, the National Institutes of Health Stroke Score was positively correlated with the central motor conduction time and the motor-evoked potential amplitude of the upper limb. Central motor conduction time and motor-evoked potential amplitude of the upper limb may be effective indicators of motor-evoked potentials to assess upper limb motor function in cerebral infarct patients. Furthermore, major ozonated autohemotherapy may promote motor function recovery of the upper limb in patients with acute cerebral infarction. 展开更多
关键词 neural regeneration clinical practice ozone cerebral infarction evoked potential motor upper limbs upper limb paralysis motor function central motor conduction time amplitude National Institutes of health Stroke Score grants-supported paper photographs-containing paper neuroregenertion
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Fluoroquinolone-macrolide combination therapy for chronic bacterial prostatitis: retrospective analysis of pathogen eradication rates, inflammatory findings and sexual dysfunction 被引量:13
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作者 Vittorio Magri Emanuele Montanari +5 位作者 Visnja Skerk Alemka Markotic Emanuela Marras Antonella Restelli Kurt G Naber Gianpaolo Perletti 《Asian Journal of Andrology》 SCIE CAS CSCD 2011年第6期819-827,共9页
We previously demonstrated the safety and efficacy of fluoroquinolone-macrolide combination therapy in category Ⅱ chronic bacterial prostatitis (CBP). The aim of this study is to retrospectively compare the microbi... We previously demonstrated the safety and efficacy of fluoroquinolone-macrolide combination therapy in category Ⅱ chronic bacterial prostatitis (CBP). The aim of this study is to retrospectively compare the microbiological and clinical findings of two treatment schemes for CBP based on the combination of azithromycin (500 rag, thrice-weekly) with a once-daily 500- or 750-mg dose of ciprofloxacin (Cipro-500 or Cipro-750 cohort, respectively). Combined administration of azithromycin (1500 mg week^-1) with ciprofloxacin at the rate of 750 mg day^- 1 for 4 weeks rather than at 500 mg day^- 1 for 6 weeks increased the eradication rates from 62.35% to 77.32% and the total bacteriological success from 71.76% to 85.57%. A significant decrease in pain and voiding signs/symptoms and a significant reduction in inflammatory leukocyte counts and serum prostate-specific antigen (PSA) were sustained throughout an 18-month follow-up period in both groups. Ejaculatory pain, haemospermia and premature ejaculation were significantly attenuated on microbiological eradication in both groups, but the latter subsided more promptly in the Cipro-750 cohort. In total, 59 Cipro-750 patients showed mild-to-severe erectile dysfunction (ED) at baseline, while 22 patients had no ED on microbiological eradication and throughout the follow-up period. In conclusion fluoroquinolone-macrolide therapy resulted in pathogen eradication and CBP symptom attenuation, including pain, voiding disturbances and sexual dysfunction. A once-daily 750-mg dose of ciprofloxacin for 4 weeks showed enhanced eradication rates and lower inflammatory white blood cell counts compared to the 500-mg dose for 6 weeks. Our results are open to further prospective validation. 展开更多
关键词 AZITHROMYCIN chronic bacterial prostatitis chronic pelvic pain syndrome CIPROFLOXACIN erectile dysfunction InternationalIndex of Erectile Function (IIEF) National Institutes of health Chronic Prostatitis Symptom Index (NiH-CPSI)
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