NON-SYNDROMIC HEARING LOSS AND HIGH- THROUGHPUT STRATEGIES TO DECIPHER ITS GENETIC HETEROGENEITY

Hearing loss (HL) is the most common sensory disorder, affecting all age groups, ethnicities, and gen-ders. According to World Health Organization (WHO) estimates in 2005, 278 million people worldwide have moderate to profound HL in both ears. Results of the 2002 National Health Interview Survey indicate that nearly 31 million of all non-institutionalized adults (aged 18 and over) in the United States have trouble hearing. Epidemiological studies have estimated that approximately 50%of profound HL can be attributed to genetic causes. With over 60 genes implicated in nonsyndromic hearing loss, it is also an extremely het-erogeneous trait. Recent progress in identifying genes responsible for hearing loss enables otolaryngologists and other clinicians to apply molecular diagnosis by genetic testing. The advent of the $1000 genome has the potential to revolutionize the identification of genes and their mutations underlying genetic disorders. This is especially true for extremely heterogeneous Mendelian conditions such as deafness, where the muta-tion, and indeed the gene, may be private. The recent technological advances in target-enrichment methods and next generation sequencing offer a unique opportunity to break through the barriers of limitations im-posed by gene arrays. These approaches now allow for the complete analysis of all known deafness-causing genes and will result in a new wave of discoveries of the remaining genes for Mendelian disorders. This re-view focuses on describing genotype-phenotype correlations of the most frequent genes including GJB2, which is responsible for more than half of cases, followed by other common genes and on discussing the im-pact of genomic advances for comprehensive genetic testing and gene discovery in hereditary hearing loss.

Early detection of noise-induced hearing loss

BACKGROUND Noise-induced hearing loss(NIHL)is the second most common acquired hearing loss following presbycusis.Exposure to recreational noise and minimal use of hearing protection increase the prevalence of NIHL in young females.NIHL is irreversible.Identifying minor hearing pathologies before they progress to hearing problems that affect daily life is crucial.AIM To compare the advantages and disadvantages of extended high frequency(EHF)and otoacoustic emission and determine an indicator of hearing pathologies at the early sub-clinical stage.METHODS This cross-sectional study was implemented in West China Hospital of Sichuan University from May to September 2019.A total of 86 participants,aged 18-22 years,were recruited to establish normative thresholds for EHF.Another 159 adults,aged 18-25 years with normal hearing(0.25-8 kHz≤25 dBHL),were allocated to low noise and noise exposure groups.Distortion otoacoustic emission(DPOAE),transient evoked otoacoustic emissions(TEOAE),and EHF were assessed in the two groups to determine the superior technique for detecting early-stage noise-induced pathologies.The chi-square test was used to assess the noise and low noise exposure groups with respect to extended high-frequency audiometry(EHFA),DPOAE,and TEOAE.P≤0.05 was considered statistically significant.RESULTS A total of 86 participants(66 females and 20 males)aged between 18 and 22(average:20.58±1.13)years were recruited to establish normative thresholds for EHF.The normative thresholds for 9,10,11.2,12.5,14,16,18,and 20 kHz were 15,10,20,15,15,20,28,and 0 dBHL,respectively.A total of 201 participants were recruited and examined for eligibility.Among them,159 adults aged between 18 and 25 years were eligible in this study.No statistical difference was detected between the noise exposure and the low noise exposure groups using EHFA,DPOAE,and TEOAE(P>0.05)except in the right ear at 4 kHz using TEOAE(abnormal rate 20.4%vs 5.2%,respectively;P=0.05).CONCLUSION These results showed TEOAE as the earliest indicator of minor pathology compared to DPOAE and EHFA.However,a multicenter controlled study or prospective study is essential to verify these results.

Identification of two novel missense WFS1 mutations,H696Y and R703H,in patients with non-syndromic low-frequency sensorineural hearing loss

Non-syndromic low-frequency sensorineural hearing loss （LFSNHL） is an unusual type of hearing loss in which frequencies ≤2000 Hz predominantly are affected. To date, different mutations in two genes, DIAPHI and WFSI, have been found to be associated with LFSNHL. Here, we report a five-generation Chinese family with postlingual and progressive LFSNHL. We mapped the disease locus to a 2.5 Mb region on chromosome 4p16 between markers SNP_A-2167174 and D4S431, overlapping with the DFNA6/14/38 locus. Sequencing of candidate gene revealed a heterozygous c.2086C〉T substitution in exon 8 of WFS1, leading to p.H696Y substitution at the C-terminus of Wolframin （WFS 1）. In addition, we performed mutational screening of WFS1 in 37 sporadic patients, 7--50 years of age, with LFSNHL. We detected a heterozygous c.2108G〉A substitution in exon 8 of WFSI, leading to p.R703H substitution in a patient. The H696 and R703 in WFS1 are highly conserved across species, including human, orangutan, rat, mouse, and frog （Xenopus）, Sequence analysis demonstrated the absence of c.2086C〉T or c.210gG〉A substitutions in the WFS1 genes among 200 unrelated control subjects of Chinese background, supporting the hypothesis that they represent causative mutations, and not rare polymorphisms. Our data provide additional molecular and clinical information for establishing a better genotype-phenotype correlation for LFSNHL.

The Effect of a High-Frequency-Hearing-Threshold Weighted Value on the Diagnosis of Occupational-Noise-Induced Deafness

Objective: In order to provide a theoretical basis for the revision of the current diagnostic criteria for occupational noise-induced deafness (ONID), we evaluated the degree of ONID by analyzing different high-frequency-hearing- threshold-weighted values (HFTWVs). Methods: A retrospective study was conducted to evaluate the diagnosis of patients with ONID from January 2016 to January 2017 in Guangdong province, China. Based on 3 hearing tests (each interval between the tests was greater than 3 days), the minimum threshold value of each frequency was obtained using the 2007 edition’s diagnostic criteria for ONID. The speech frequency and the HFTWVs were analyzed based on age, noise exposure, and diagnostic classi-fication using SPSS21.0. Results: 168 patients in total were involved in this study, 154 males and 14 females, and the average age was 41.18 ± 6.07. The diagnosis rate was increased by the weighted value of the high frequencies and was more than the mean value of the pure speech frequency (MVPSF). The diagnosis rate for the weighted 4 kHz frequency level increased by 13.69% (χ2 = 9.880, P = 0.002), the weighted 6 kHz level increased by 15.47% (χ2 = 9.985, P = 0.002), and the weighted 4 kHz + 6 kHz level increased by 15.47% (χ2 = 9.985, P = 0.002). The differences were all statistically significant. The diagnostic rate of the different thresholds showed no obvious difference between the genders. The age groups were divided into less than or equal to 40 years old (group A) and 40 - 50 years old (group B). There were several groups with a high frequency: high frequency weighted 4 kHz ( group A χ2 = 3.380, P = 0.050;group B χ2 = 4.054, P = 0.032), high frequency weighted 6 kHz (group A χ2 = 6.362, P = 0.012;group B χ2 = 4.054, P = 0.032), weighted 4 kHz + 6 kHz (group A χ2 = 6.362 P = 0.012;B χ2 = 4.054, P = 0.032) than those of MVPSF in the same group on ONID diagnosis rate. The differences between the groups were statistically significant. There was no significant difference between the age groups (χ2 = 2.265, P = 0.944). The better ear’s (the smaller hearing threshold weighted value) MVPSF and the weighted values for the different high frequencies were examined in light of the number of working years;the group that was exposed to noise for more than 10 years had significantly higher values than those of the average thresholds of each frequency band in the groups with 3 - 5 years of exposure (F = 2.271, P = 0.001) and 6 - 10 years of exposure (F = 1.563, P = 0.046). The differences were statistically significant. The different HFTWVs were higher than those of the MVPSF values, and the high frequency weighted 4 kHz + 6 kHz level showed the greatest difference, with an average increase of 2.83 dB. The diagnostic rate that included the weighted high frequency values was higher for the mild, moderate, and severe cases than those patients who were only screened with the pure frequency tests. The results of the comparisons of the diagnosis rates for mild ONID were as follows: the weighted 3 kHz high frequency level (χ2 = 3.117, P = 0.077) had no significant difference, but the weighted 4 kHz level (χ2 = 10.835, P = 0.001), 6 kHz level (χ2 = 9.985, P = 0.002), 3 kHz + 4 kHz level (χ2 = 6.315, P = 0.012), 3 kHz + 6 kHz level (χ2 = 6.315, P = 0.012), 4 kHz + 6 kHz level (χ2 = 9.985, P = 0.002), and 3 kHz + 4 kHz + 6 kHz level (χ2 = 7.667, P = 0.002) were significantly higher than the diagnosis rate of the mean value of the PSF. There was no significant difference between the 2 groups for the moderate and severe grades (P > 0.05). Conclusion: Different HFTWVs increase the diagnostic rate of ONID. The weighted 4 kHz, 6 kHz, and 4 kHz + 6 kHz high frequency values greatly affected the diagnostic results, and the weighted 4 kHz + 6 kHz high frequency hearing threshold value has the maximum the effect on the ONID diagnosis results.

High-frequency magnetic properties and core loss of carbonyl iron composites with easy plane-like structures

To fully release the potential of wide bandgap(WBG)semiconductors and achieve high energy density and efficiency,a carbonyl iron soft magnetic composite(SMC)with an easy plane-like structure is prepared.Due to this structure,the permeability of the composite increases by 3 times(from 7.5 to 21.5)at 100 MHz compared with to the spherical carbonyl iron SMC,and the permeability changes little at frequencies below 100 MHz.In addition,the natural resonance frequency of the composite shifts to higher frequencies at 1.7 GHz.The total core losses of the composites at 10,20,and 30 m T are80.0,355.3,and 810.7 m W/cm^(3),respectively,at 500 k Hz.Compared with the spherical carbonyl iron SMC,the core loss at500 k Hz is reduced by more than 60%.Therefore,this kind of soft magnetic composite with an easy plane-like structure is a good candidate for unlocking the potential of WBG semiconductors and developing the next-generation power electronics.

Low-loss Cd-substituted Mg ferrites with matching impedance for high-frequency-range antennas

The effects of Cd^(2+) ions on the microstructure,magnetic properties,and dielectric properties of Bi_(2)O_(3)-added MgFe_(2)O_(4) ferrites(Cd_(x)Mg_(1-x)Fe_(2)O_(4),x=0.00,0.15,0.30 and 0.45)are obtained by adopting the solid-state reaction method at a low temperature(910℃).The objective is to achieve matching impedances,low magnetic and dielectric losses(tanδμand tanδε,respectively),and a relatively large miniaturization factor to reduce antenna size.Experimental results indicate that the cations occupying the tetrahedral(A)and octahedral(B)ion sites are redistributed,resulting in an enhanced super-exchange interaction between the two sublattices.As a result,improved magnetization,including the increase in saturation magnetization(41.74 emu/g)and decrease in coercivity(63.75 Oe),is realized.The real part of permeability(μ')also increases with increasing concentration of Cd^(2+) ions.When x is 0.15,matching impedances with equivalent μ'and ε'values are obtained over a long frequency range(1–150MHz).Moreover,the formation of a dense microstructure guarantees that losses occur at low orders of magnitude(tanδμ≈10−2 and tanδε≈10−3).Accordingly,these properties afford wide application perspectives for the proposed compounds in the high-frequency region,i.e.,from high-frequency to very-high-frequency bands.

Low-Microwave Loss Coplanar Waveguides Fabricated on High-Resistivity Silicon Substrate

Three kinds of coplanar waveguides （CPWs） are designed and fabricated on different silicon substrates---common low-resistivity silicon substrate （LRS）, LRS with a 3μm-thick silicon oxide interlayer, and high-resistivity silicon （HRS） substrate. The results show that the microwave loss of a CPW on LRS is too high to be used, but it can be greatly reduced by adding a thick interlayer of silicon oxide between the CPW transmission lines and the LRS.A CPW directly on HRS shows a loss lower than 2dB/cm in the range of 0-26GHz and the process is simple,so HRS is a more suitable CPW substrate.

Auditory perceptual efficacy of nonlinear frequency compression used in hearing aids:A review

Many patients with sensorineural hearing loss have a precipitous high-frequency loss with relatively good thresholds in the low frequencies.This present paper briefly introduces and compares the basic principles of four types of frequency lowering algorithms with emphasis on nonlinear frequency compression(NLFC). A review of the effects of the NLFC algorithm on speech and music perception and sound quality appraisal is then provided. For vowel perception, it seems that the benefits provided by NLFC are limited, which are probably related to the parameter settings of the compression. For consonant perception, several studies have shown that NLFC provides improved perception of highfrequency consonants such as/s/and/z/. However, a few other studies have demonstrated negative results in consonant perception. In terms of sentence recognition, persistent use of NLFC might provide improved performance. Compared to the conventional processing, NLFC does not alter the speech sound quality appraisal and music perception as long as the compression setting is not too aggressive. In the subsequent section,the relevant factors with regard to NLFC settings, time-course of acclimatization, listener characteristics, and perceptual tasks are discussed.Although the literature shows mixed results on the perceptual efficacy of NLFC, this technique improved certain aspects of speech understanding in certain hearing-impaired listeners. Little research is available on speech perception outcomes in languages other than English. More clinical data are needed to verify the perceptual efficacy of NLFC in patients with precipitous high-frequency hearing loss. Such knowledge will help guide clinical rehabilitation of those patients.

Research on Nonlinear Frequency Compression Method of Hearing Aid with Adaptive Compression Ratio

To make full use of the residual audible frequency band of hearing-loss patients and improve the intelligibility of speech,an adaptive nonlinear frequency compression(NFC)algorithm is proposed,which amplifies signals below the cutoff frequency while compresses signals above the cutoff frequency.Firstly,high-frequency signals are decomposed to critical band signals according to the BARK scale.Secondly,the global compression ratio is determined according to the patient's cutoff frequency and maximum audible frequency.Thirdly,the sub-band compression ratio is adaptively determined based on the global compression ratio and normalized average energy of subband signals.Finally,the high frequency signals are transposed to low frequency bands by compression mapping,and the phases are adjusted to the same as the original low frequency signals.Experimental results of speech intelligibility with nine subjects demonstrate that compared to conventional amplitude amplification and nonlinear frequency compression algorithms the proposed algorithm significantly improves the intelligibility of initials and sentences,while not affects the intelligibility of finals and tones significantly.

A Novel Flexible Antenna at Very High Frequency Band for On-Body Applications

This paper proposes a novel flexible antenna design operating at very high frequency(VHF)band for on-body applications such as human body communication(HBC).The antenna consists of back-to-back E-shaped fractal and complimentary structures designed over a thin flex-ible substrate.The overall design working on the principle of fractal geometries and capacitive coupling is highly beneficial to achieve better antenna characteristics even at low frequencies around 35 MHz-45 MHz that are being used for HBC application.The proposed antenna obtained a large bandwidth of around 10.0 MHz in air and a bandwidth of around 8.0 MHz during on-body opera-tion.The antenna has been tested in three different scenarios viz.air,on-body single antenna and on-body communication using two antennas.The insertion loss is reduced to a minimum in all three scenarios,which is quite beneficial for better signal transmission.The size miniaturization with high flexibility in such low frequencies has also been achieved in the paper that makes the proposed design suitable for human body communication applications.

Impairment of extra-high frequency auditory thresholds in subjects with elevated levels of fasting blood glucose

This study was performed to assess whether there is an association between elevated Fasting Blood Glucose(FBG) and hearing impairment in Bangladeshi population. A total of 142 subjects(72 with elevated FBG; 70 control) were included in the study. The mean auditory thresholds of the control subjects at 1,4,8 and 12 kHz frequencies were 6.35 ± 0.35,10.07 ± 0.91,27.57 ± 1.82, 51.28 ± 3.01 dB SPL(decibel sound pressure level), respectively and that of the subjects with elevated FBG were 8.33 ± 0.66,14.37 ± 1.14, 38.96 土 2.23, and 71.11 ± 2.96 dB.respectively. The auditory thresholds of the subjects with elevated FBG were significantly(p < 0.05) higher than the control subjects at all the above frequencies, although hearing impairment was most evidently observed at an extra-high(12 kHz) frequency. Subjects with a long duration of diabetes(>10 years) showed significantly(p < 0.05) higher level of auditory thresholds at 8 and 12 kHz, but not at 1 and 4 kHz frequencies,compared to subjects with shorter duration of diabetes(≤10 years). In addition, based on the data of odds ratio, more acute impairment of hearing at the extra-high frequency was observed in diabetic subjects of both older(>40 years) and younger(<40 years) age groups compared to the respective controls. The binary logistic regression analysis showed a 5.79-fold increase in the odds of extra-high frequency hearing impairment in diabetic subjects after adjustment for age, gender and BMI. This study provides conclusive evidence that auditory threshold at an extra-high frequency could be a sensitive marker for hearing impairment in diabetic subjects.

利用非线性损耗提升全固态单频激光器输出功率研究进展(特邀)

全固态单频连续波激光器因其噪声低、线宽窄、光束质量好、功率稳定性高等优点已经被广泛应用于产生非经典光场、冷原子物理研究、引力波探测等诸多领域。随着科学技术的不断发展,传统的全固态激光器的输出功率已经不能满足前沿领域的需求,因此亟需在保持全固态激光器整体性能的同时进一步提升激光器的输出功率。为此首先需要更高的泵浦功率,而这将使激光器内部增益提高,在腔内损耗不变的情况下,原非振荡模式也将满足起振条件,从而使激光器在跳模或多模状态下运转。此外,激光晶体的热效应和损伤阈值也限制了输出功率的提高。本文介绍了一种利用非线性损耗大幅度提升全固态单频连续波激光器的输出功率的技术和方法。通过在谐振腔中引入非线性损耗,使主模经受的非线性损耗是次模的一半。在模式竞争的作用下,谐振腔内的模式被更进一步的选择,从而允许全固态单频激光器在更高的增益下保持单纵模运转。通过在谐振腔内插入多块增益晶体可以有效缓解由于激光增益晶体热效应的限制,从而实现更高功率的单频激光输出。目前高功率全固态连续波激光器的输出功率已经达到了一百瓦的量级,且还在进一步提高。通过在谐振腔内引入非线性损耗,全固态单频连续波激光器的整体性能在得以保障和提高的同时,其应用范围也得到了进一步的推广。

高低频复合励磁磁心损耗量化的研究

针对高低频复合励磁磁元件磁心损耗难以精确测量和建模的问题,在详细分析现有磁心损耗测量方法和磁心损耗模型局限性的基础上,根据直流功率法测量原理搭建高低频复合励磁磁心损耗测量系统,利用损耗能精确测量的空心电感验证其测量精度。最后,基于直流偏置下脉宽调制(pulse width modulation,PWM)波励磁的磁心损耗模型,提出高低频复合励磁磁性元件的磁心损耗预测模型,并实验验证预测模型最大相对误差为-8.83%,具有较高的精度。

High-frequency magnetic properties of biphase Ce_(2)Fe_(17)N_(3)/α-Fe microflakes with easy-plane anisotropy

Soft magnetic composites(SMCs)are effective as magnetic powder cores in an inductor.Due to high saturation magnetization,large magnetocrystalline anisotropy and high operating frequency of M(metal)-RE(rear earth)soft magnetic composites,it is possible to miniaturize inductor cores by reducing total loss,especially eddy current loss and excess loss at high frequencies.In this article,the characteristics of Ce_(2)Fe_(17)N_(3)/α-Fe(CFN/F)loss per volume and effective permeability reaching a high frequency of 3 MHz are investigated.The biphase CFN/F composite exhibits a high permeability of 16 at 70 MHz,which is two times greater than that of pure Ce_(2)Fe_(17)N_(3)(CFN)powders.The total loss is as low as 545 mW/cm^(3)at 3 MHz and 6 mT.The direct current(DC)-bias properties have a percent of permeability exceeding 65% at H=7960 A/m.This phenomenon indicates that our material has a higher working frequency and lower core loss than other materials;the biphase CFN/F structure is a promising and efficient approach for developing the miniaturized radio frequency(RF)inductor core.

3D封装玻璃通孔高频特性分析与优化

建立了3D封装玻璃通孔(TGV)电磁仿真分析模型,对TGV高频信号特性进行了分析,得到了回波损耗S11仿真结果,并研究了信号频率、通孔类型、通孔最大直径、通孔高度、通孔最小直径对S11的影响。选取TGV关键结构通孔最大直径、通孔高度、通孔最小直径尺寸为设计参数,以TGV在信号频率10 GHz下的S11作为目标值,采用响应曲面法,设计17组试验进行仿真,并拟合了TGV S11与其关键结构参数的关系模型。结合遗传算法对拟合模型进行优化,得到TGV S11最优的组合参数:通孔最大直径65μm、通孔高度360μm、通孔最小直径尺寸44μm。对最优组合参数进行验证,发现最优参数组合仿真结果较基本模型S11减小了1.593 5 dB,实现了TGV的结构优化。

大剂量糖皮质激素冲击疗法对单侧全聋型突发性聋患者的临床疗效观察

目的 探讨大剂量糖皮质激素冲击疗法对单侧全聋型突发性聋(sudden sensorineural hearing loss, SSNHL)患者的临床疗效及安全性。方法 选取2020年8月至2022年8月内蒙古医科大学附属医院单侧全聋型SSNHL患者52例。随机分为治疗组和对照组,每组各26例。对照组采用糖皮质激素常规治疗,治疗组采用大剂量糖皮质激素冲击疗法,比较两组患者听力改善效果及不良反应情况。结果 52例患者中,男20例,女32例,年龄22~65岁,平均(45.4±11.3)岁。两组治疗后平均听阈值低于治疗前,且治疗组低于对照组;治疗组总有效率高于对照组(80.77%比53.85%),治疗期间治疗组不良反应发生率高于对照组(61.54%比19.23%),差异均有统计学意义(P<0.05)。结论 大剂量糖皮质激素冲击疗法能够有效改善单侧全聋型SSNHL患者听力,但治疗期间不良反应发生率较高。

带散射体的电力系统多级传输线高频耦合模型

高频电磁场会与架空输电线路产生耦合,一旦高频电磁场的波长小于传输线的高度,经典传输线理论就不再适用。传统的全波数值算法虽然可以解决这一问题,但求解效率不高,需要消耗大量的时间与计算资源。此外,电力系统输电线路往往有多个垂直端,线路布局复杂,而以往针对电力系统传输线的高效求解研究都是只有左右两个垂直端的较为简单的模型,与实际电力系统传输线的结构不符,没有考虑中间带有垂直端的情况。为了解决这些问题,文中提出一种理论有效的方法来解决有损耗地面上方带有散射体的电力系统多级传输线的高频电磁场耦合问题。采用计算效率高的渐近法,并在渐近法中引入散射体的概念,以考虑更复杂的电路结构。最后通过数值算例验证了该方法的准确性和有效性。

GIS内置特高频传感器性能参数仿真研究

为了提高气体绝缘组合电器局部放电的检测效果,对内置圆盘型特高频传感器进行了性能参数的仿真研究。通过建立回波损耗参数S11和有效高度的测试仿真模型,分析了传感器圆盘直径、介电常数和短路针距离对性能的影响。结果表明:对于内置式特高频传感器,圆盘半径为75 mm,介电常数维持在3~4之间,短路针距离圆心距离为60 mm左右时,回波损耗和灵敏度达到最优。研究发现,随着圆盘直径增大,传感器的谐振频率和有效高度逐渐降低。同时,介电常数和短路针距离的增加导致谐振频率降低,有效高度增加。

高频柔性覆铜板用低介电聚酰亚胺研究进展

随着5G通信技术的快速发展,迫切需要在高频下具有低介电常数(D_(k))和低介电损耗(D_(f))的高性能聚合物作为介电材料。聚酰亚胺(PI)以其优异的综合性能,在柔性基板领域应用广泛。然而普通PI在高频下具有较高的D_(k)和D_(f),难以满足5G或更高通信频率的实际应用需求。本文从改变PI的本体结构和引入聚酯结构2个方面,重点综述了近年来低介电PI薄膜的研究进展,并对高频下低介电高分子材料的发展前景进行了展望。

11 GHz不同室内场景的WBAN信道特性研究

为了探索高频段室内无线体域网通信的可行性,对11 GHz室内无线体域网的传播特性进行了测量与研究。基于大量的测量数据,给出了11 GHz频段室内无线体域网的路径损耗、阴影效应与均方根时延扩展的统计特性。针对体对体通信时人体相对角度变化的场景,提出了一种具有相对角度影响的路径损耗模型,该模型利用了与身体角度相关的路径损耗指数、浮动截距以及身体角度因子修正相对角度变化引入的路径损耗。为了验证模型的适用性,对比分析了在小型空教室和大型会议室两种不同场景下相对角度变化对信道传播特性的影响。研究结果表明:在收发端距离固定的情况下,路径损耗指数、浮动截距和由相对角度引起的路径损耗(Path Loss caused by Relative Angle,PLRA)均与相对角度具有三角函数关系;在收发端相对角度固定时,PLRA与收发端距离无关,仅与相对角度有关。上述研究结果可以为11 GHz频段在未来室内无线体域网的使用提供理论基础与实践依据。