The post-resuscitation period is recognized as the main predictor of cardiopul-monary resuscitation(CPR)outcomes.The first description of post-resuscitation syndrome and stony heart was published over 50 years ago.Maj...The post-resuscitation period is recognized as the main predictor of cardiopul-monary resuscitation(CPR)outcomes.The first description of post-resuscitation syndrome and stony heart was published over 50 years ago.Major manifestations may include but are not limited to,persistent precipitating pathology,systemic ischemia/reperfusion response,post-cardiac arrest brain injury,and finally,post-cardiac arrest myocardial dysfunction(PAMD)after successful resuscitation.Why do some patients initially survive successful resuscitation,and others do not?Also,why does the myocardium response vary after resuscitation?These ques-tions have kept scientists busy for several decades since the first successful resuscitation was described.By modifying the conventional modalities of resu-scitation together with new promising agents,rescuers will be able to salvage the jeopardized post-resuscitation myocardium and prevent its progression to a dismal,stony heart.Community awareness and staff education are crucial for shortening the resuscitation time and improving short-and long-term outcomes.Awareness of these components before and early after the restoration of circulation will enhance the resuscitation outcomes.This review extensively addresses the underlying pathophysiology,management,and outcomes of post-resuscitation syndrome.The pattern,management,and outcome of PAMD and post-cardiac arrest shock are different based on many factors,including in-hospital cardiac arrest vs out-of-hospital cardiac arrest(OHCA),witnessed vs unwitnessed cardiac arrest,the underlying cause of arrest,the duration,and protocol used for CPR.Although restoring spontaneous circulation is a vital sign,it should not be the end of the game or lone primary outcome;it calls for better understanding and aggressive multi-disciplinary interventions and care.The development of stony heart post-CPR and OHCA remain the main challenges in emergency and critical care medicine.展开更多
Objective: To study the pathological basis of right atrial fibrillation in rheumatic heart disease (RHD) patients with atrial fibrillation (AF). Methods: Twenty-nine patients with mitral valve replacement of RHD were ...Objective: To study the pathological basis of right atrial fibrillation in rheumatic heart disease (RHD) patients with atrial fibrillation (AF). Methods: Twenty-nine patients with mitral valve replacement of RHD were divided into AF group (n=13) and sinus rhythm group (SN group) (n=16). There was no significant statistical difference in clinical factors between the 2 groups. During the operation of valve replace-ment, the samples of right atrial appendages were taken and the qualitative and quantitative study were made by light microscopy and electron microscopy. Results: (1) Light microscope: The interstitial fibrosis and the arrangement of myocardium was more disordered in AF group than that in SN group. However, no statistic difference was found in interstitial fibrosis and cellar hypertrophy degree between the 2 groups. (2) Electron microscope: Mitochondrial crosta broke and dissolved obviously in AF group. The mitochondrial volume in AF group was smaller than that in SN group. Volume density, average area and average perimeter in AF group were less than that in SN group ; specific surface in AF group was bigger than that in SN group. There was significant difference of above factors between the 2 groups; but there was no significant difference of surface density and numerical density on area in the 2 groups. Volume density of myofibril in AF group and SN group were less than that in SN group. (3)Split of Intercalated disc(ID) gap was found in AF group, and there was marrowing and floccular substance in ID gap. Conclusion : There were significant differences in the pathological changes of right atrial myocardium between AF and SN with RHD, these changes may be the im-portant pathological basis for RA fibrillation of AF patients with RHD.展开更多
目的研究危重患者院前转运过程中发生心脏骤停时影响心肺复苏成功的相关因素,为院前安全转运危重患者提供参考。方法回顾性分析2014年1月1日至2021年12月31日上海市闵行区医疗急救中心收治的危重患者转运途中发生心脏骤停者的病例资料,...目的研究危重患者院前转运过程中发生心脏骤停时影响心肺复苏成功的相关因素,为院前安全转运危重患者提供参考。方法回顾性分析2014年1月1日至2021年12月31日上海市闵行区医疗急救中心收治的危重患者转运途中发生心脏骤停者的病例资料,对疾病种类、既往史、生命体征、心肺复苏措施及结局等数据进行统计分析。结果8年间共接诊出现途中心脏骤停的危重患者363例,心肺复苏成功100例,成功率为27.55%(100/363),复苏成功组与复苏失败组在年龄、接诊地址、既往病史、格拉斯昏迷评分、是否恶性心律失常、抢救措施以及现场停留时间及心脏骤停时间与上车时间的时间差存在差异(P<0.05)。接诊疾病分类为神经系统疾病、格拉斯昏迷评分表(Glasgow Coma Scale,GCS)、除颤、心脏骤停发生前使用多巴胺以及心脏骤停与上车时间的时间差是急救转运途中危重患者复苏的独立影响因素(P<0.05)。结论接诊病史主要为神经系统疾病,GCS越高,抢救过程中有除颤,心脏骤停前使用过多巴胺均有利于患者复苏,而患者在转运到急救车辆后越久出现心脏骤停则复苏成功越低。加强院前急救医务人员现场处置能力,现场转运前的充分准备,以及保障转运过程中发生心脏骤停时的高质量复苏至关重要。展开更多
文摘The post-resuscitation period is recognized as the main predictor of cardiopul-monary resuscitation(CPR)outcomes.The first description of post-resuscitation syndrome and stony heart was published over 50 years ago.Major manifestations may include but are not limited to,persistent precipitating pathology,systemic ischemia/reperfusion response,post-cardiac arrest brain injury,and finally,post-cardiac arrest myocardial dysfunction(PAMD)after successful resuscitation.Why do some patients initially survive successful resuscitation,and others do not?Also,why does the myocardium response vary after resuscitation?These ques-tions have kept scientists busy for several decades since the first successful resuscitation was described.By modifying the conventional modalities of resu-scitation together with new promising agents,rescuers will be able to salvage the jeopardized post-resuscitation myocardium and prevent its progression to a dismal,stony heart.Community awareness and staff education are crucial for shortening the resuscitation time and improving short-and long-term outcomes.Awareness of these components before and early after the restoration of circulation will enhance the resuscitation outcomes.This review extensively addresses the underlying pathophysiology,management,and outcomes of post-resuscitation syndrome.The pattern,management,and outcome of PAMD and post-cardiac arrest shock are different based on many factors,including in-hospital cardiac arrest vs out-of-hospital cardiac arrest(OHCA),witnessed vs unwitnessed cardiac arrest,the underlying cause of arrest,the duration,and protocol used for CPR.Although restoring spontaneous circulation is a vital sign,it should not be the end of the game or lone primary outcome;it calls for better understanding and aggressive multi-disciplinary interventions and care.The development of stony heart post-CPR and OHCA remain the main challenges in emergency and critical care medicine.
文摘Objective: To study the pathological basis of right atrial fibrillation in rheumatic heart disease (RHD) patients with atrial fibrillation (AF). Methods: Twenty-nine patients with mitral valve replacement of RHD were divided into AF group (n=13) and sinus rhythm group (SN group) (n=16). There was no significant statistical difference in clinical factors between the 2 groups. During the operation of valve replace-ment, the samples of right atrial appendages were taken and the qualitative and quantitative study were made by light microscopy and electron microscopy. Results: (1) Light microscope: The interstitial fibrosis and the arrangement of myocardium was more disordered in AF group than that in SN group. However, no statistic difference was found in interstitial fibrosis and cellar hypertrophy degree between the 2 groups. (2) Electron microscope: Mitochondrial crosta broke and dissolved obviously in AF group. The mitochondrial volume in AF group was smaller than that in SN group. Volume density, average area and average perimeter in AF group were less than that in SN group ; specific surface in AF group was bigger than that in SN group. There was significant difference of above factors between the 2 groups; but there was no significant difference of surface density and numerical density on area in the 2 groups. Volume density of myofibril in AF group and SN group were less than that in SN group. (3)Split of Intercalated disc(ID) gap was found in AF group, and there was marrowing and floccular substance in ID gap. Conclusion : There were significant differences in the pathological changes of right atrial myocardium between AF and SN with RHD, these changes may be the im-portant pathological basis for RA fibrillation of AF patients with RHD.
文摘目的研究危重患者院前转运过程中发生心脏骤停时影响心肺复苏成功的相关因素,为院前安全转运危重患者提供参考。方法回顾性分析2014年1月1日至2021年12月31日上海市闵行区医疗急救中心收治的危重患者转运途中发生心脏骤停者的病例资料,对疾病种类、既往史、生命体征、心肺复苏措施及结局等数据进行统计分析。结果8年间共接诊出现途中心脏骤停的危重患者363例,心肺复苏成功100例,成功率为27.55%(100/363),复苏成功组与复苏失败组在年龄、接诊地址、既往病史、格拉斯昏迷评分、是否恶性心律失常、抢救措施以及现场停留时间及心脏骤停时间与上车时间的时间差存在差异(P<0.05)。接诊疾病分类为神经系统疾病、格拉斯昏迷评分表(Glasgow Coma Scale,GCS)、除颤、心脏骤停发生前使用多巴胺以及心脏骤停与上车时间的时间差是急救转运途中危重患者复苏的独立影响因素(P<0.05)。结论接诊病史主要为神经系统疾病,GCS越高,抢救过程中有除颤,心脏骤停前使用过多巴胺均有利于患者复苏,而患者在转运到急救车辆后越久出现心脏骤停则复苏成功越低。加强院前急救医务人员现场处置能力,现场转运前的充分准备,以及保障转运过程中发生心脏骤停时的高质量复苏至关重要。
