期刊文献+
共找到945篇文章
< 1 2 48 >
每页显示 20 50 100
Cardiopulmonary Response to Exercise at High Altitude in Adolescents with Congenital Heart Disease
1
作者 Lukas Minder Markus Schwerzmann +4 位作者 Thomas Radtke Hugo Saner Prisca Eser Matthias Wilhelm Jean-Paul Schmid 《Congenital Heart Disease》 SCIE 2021年第6期597-608,共12页
Objective:To extend our knowledge on tolerance of acute high-altitude exposure and hemodynamic response to exercise in adolescents with congenital heart disease(AscCHD)without meaningful clinical or functional restric... Objective:To extend our knowledge on tolerance of acute high-altitude exposure and hemodynamic response to exercise in adolescents with congenital heart disease(AscCHD)without meaningful clinical or functional restriction.Methods:A symptom limited cardiopulmonary exercise stress test and a non-invasive cardiac output measurement during steady state exercise were performed at 540 m and at 3454 m a.s.l.Symptoms of acute mountain sickness were noted.Results:We recruited 21 healthy controls and 16 AscCHD(59%male,mean age 14.7±1.1 years).Three subjects(2 controls,1 AscCHD)presented light symptoms of acute mountain sickness(dizziness and headache).During the symptom limited exercise test at lowland,control subjects showed a significantly higher power to weight index(3.5±0.6 W/kg vs.3.0±0.7 W/kg,p<0.001),heart rate(188.8±10.41/min vs.179.4±13.11/min,p<0.050)and ventilation(92.8±22.9 l/min vs.75.4±18.6 l/min,<0.050).At altitude,power to weight index only remained significantly higher in the control group(2.8±0.6 W/kg vs.2.6±0.6 W/kg,p<0.001).Pulmonary blood flow(PBF)at lowland showed no difference between the control and the AscCHD group,neither at rest(5.4±0.8 l/min vs.5.1±0.9 l/min,p=0.308),nor during the steady state test(10.6±2.4 l/min vs.10.5±2.0 l/min,p=0.825).At high altitude,PBF increased by 110%and 112%,respectively(12.8±2.32 l/min vs.12.5±3.0 l/min;intergroup difference:p=0.986).Conclusions:High altitude exposure was well tolerated in an unselected group of AscCHD.No significant difference in the cardio-pulmonary adaptation to a control group was noted during a steady state exercise.Symptoms of minor acute mountain sickness did occur,which should however not be misinterpreted as signs of hemodynamic maladaptation. 展开更多
关键词 Adolescents with congenital heart disease high altitude non-invasive cardiac output measurement exercise
下载PDF
Genetic testing in congenital heart disease:A clinical approach 被引量:10
2
作者 Marie A Chaix Gregor Andelfinger Paul Khairy 《World Journal of Cardiology》 CAS 2016年第2期180-191,共12页
Congenital heart disease(CHD) is the most common type of birth defect. Traditionally, a polygenic model defined by the interaction of multiple genes and environmental factors was hypothesized to account for different ... Congenital heart disease(CHD) is the most common type of birth defect. Traditionally, a polygenic model defined by the interaction of multiple genes and environmental factors was hypothesized to account for different forms of CHD. It is now understood that the contribution of genetics to CHD extends beyond a single unified paradigm. For example, monogenic models and chromosomal abnormalities have been associated with various syndromic and non-syndromic forms of CHD. In such instances, genetic investigation and testing may potentially play an important role in clinical care. A family tree with a detailed phenotypic description serves as the initial screening tool to identify potentially inherited defects and to guide further genetic investigation. The selection of a genetic test is contingent upon the particular diagnostic hypothesis generated by clinical examination. Genetic investigation in CHD may carry the potential to improve prognosis by yielding valuable information with regards to personalized medical care, confidence in the clinical diagnosis, and/or targeted patient followup. Moreover, genetic assessment may serve as a tool to predict recurrence risk, define the pattern of inheritance within a family, and evaluate the need for further family screening. In some circumstances, prenatal or preimplantation genetic screening could identify fetuses or embryos at high risk for CHD. Although genetics may appear to constitute a highly specialized sector of cardiology, basic knowledge regarding inheritance patterns, recurrence risks, and available screening and diagnostic tools, including their strengths and limitations, could assist the treating physician in providing sound counsel. 展开更多
关键词 congenital heart disease GENETICS GENETIC SCREENING GENETIC testing
下载PDF
Cardiorespiratory fitness measured with cardiopulmonary exercise testing and mortality in patients with cardiovascular disease:A systematic review and meta-analysis 被引量:10
3
作者 Yasmin Ezzatvar MikelIzquierdo +3 位作者 Julio Núñez Joaquín Calatayud Robinson Ramírez-Vélez Antonio García-Hermoso 《Journal of Sport and Health Science》 SCIE 2021年第6期609-619,F0003,共12页
Background Cardiorespiratory fitness(CRF)is inversely associated with mortality in apparently healthy subjects and in some clinical populations,but evidence for the association between CRF and all-cause and/or cardiov... Background Cardiorespiratory fitness(CRF)is inversely associated with mortality in apparently healthy subjects and in some clinical populations,but evidence for the association between CRF and all-cause and/or cardiovascular disease(CVD)mortality in patients with established CVD is lacking.This study aimed to quantify this association.Methods We searched for prospective cohort studies that measured CRF with cardiopulmonary exercise testing in patients with CVD and that examined all-cause and CVD mortality with at least 6 months of follow-up.Pooled hazard ratios(HRs)were calculated using random-effect inverse-variance analyses.Results Data were obtained from 21 studies and included 159,352 patients diagnosed with CVD(38.1%female).Pooled HRs for all-cause and CVD mortality comparing the highest vs.lowest category of CRF were 0.42(95%confidence interval(95%CI):0.28–0.61)and 0.27(95%CI:0.16–0.48),respectively.Pooled HRs per 1 metabolic equivalent(1-MET)increment were significant for all-cause mortality(HR=0.81;95%CI:0.74–0.88)but not for CVD mortality(HR=0.75;95%CI:0.48–1.18).Coronary artery disease patients with high CRF had a lower risk of all-cause mortality(HR=0.32;95%CI:0.26–0.41)than did their unfit counterparts.Each 1-MET increase was associated with lower all-cause mortality risk among coronary artery disease patients(HR=0.83;95%CI:0.76–0.91)but not lower among those with heart failure(HR=0.69;95%CI:0.36–1.32).Conclusion A better CRF was associated with lower risk of all-cause mortality and CVD.This study supports the use of CRF as a powerful predictor of mortality in this population. 展开更多
关键词 cardiopulmonary fitness Coronary artery disease exercise capacity heart failure SURVIVAL
下载PDF
Effect of Hemodilution on Fluctuation of Cerebral Oxygen Saturation during Cardiopulmonary Bypass in Children with Cyanotic Congenital Heart Disease
4
作者 Misook Seo In-Kyung Song +2 位作者 Hye-Mee Kwon Byungdoo Andrew Lee Won-Jung Shin 《Congenital Heart Disease》 SCIE 2021年第2期123-136,共14页
Background:In patients with cyanotic congenital heart disease(CHD),cerebral oxygenation may be maintained by elevations in hematocrit(Hct).Hemodilution accompanying cardiopulmonary bypass(CPB),however,can disrupt cere... Background:In patients with cyanotic congenital heart disease(CHD),cerebral oxygenation may be maintained by elevations in hematocrit(Hct).Hemodilution accompanying cardiopulmonary bypass(CPB),however,can disrupt cerebral oxygen balance,leading to fluctuations in cerebral oxygen saturation(ScO_(2)).The present study investigated the effects of Hct changes on the fluctuation of ScO_(2)during CPB in cyanotic CHD using performance measurement(PM).Methods:Children with CHD(51 acyanotic and 46 cyanotic)who had undergone cardiac surgery using CPB were enrolled.Median performance error(MDPE),median absolute performance error(MDAPE),and wobble parameters of ScO_(2)were calculated before(reference value),during,and after CPB.Correlations of PM parameters with Hct and reductions in Hct(ΔHct)were also evaluated.Results:Before CPB,patients with cyanotic CHD had lower MDPE and larger wobble than those with acyanotic CHD,although mean ScO_(2)did not differ significantly between the two groups.During CPB,ScO_(2)of acyanotic CHD increased asΔHct increased,but PM variables were not associated withΔHct.In cyanotic CHD,MDPE(r=−0.324,p=0.032)and MDAPE(r=0.339,p=0.024)correlated significantly withΔHct during CPB.After CPB,MDPE(r=0.574,p=0.025)and MDAPE(r=−0.543,p=0.036)were significantly correlated with Hct in children with cyanotic CHD who underwent palliative surgery.Conclusion:Therefore,ScO_(2)fluctuation during CPB in children with cyanotic CHD may be affected by the decrease in Hct,suggesting that excessive hemodilution can negatively influence the maintenance of cerebral oxygenation in these patients. 展开更多
关键词 cardiopulmonary bypass cerebral oxygen saturation CHILDREN congenital heart disease HEMODILUTION
下载PDF
Effect of Exercise-Based Cardiac Rehabilitation on Cardiorespiratory Fitness in Adults with Congenital Heart Disease
5
作者 Prisca Eser Thomas Gruber +7 位作者 Thimo Marcin Claudia Boeni Kerstin Wustmann Christina DeLuigi Matthias Greutmann Daniel Tobler Markus Schwerzmann Matthias Wilhelm 《Congenital Heart Disease》 SCIE 2021年第1期73-84,共12页
Background:The purpose of this study was to investigate whether patients with adult congenital heart disease(ACHD)benefit from exercise-based cardiac rehabilitation(CR)short-and long-term with regard to improvement of... Background:The purpose of this study was to investigate whether patients with adult congenital heart disease(ACHD)benefit from exercise-based cardiac rehabilitation(CR)short-and long-term with regard to improvement of cardiorespiratory fitness.Methods:Cardiopulmonary exercise tests(CPET)completed by ACHD patients between January 2000 and October 2019 were analysed retrospectively.Linear mixed models were performed for peak oxygen consumption(VO_(2))with patients as random effect and age,sex,disease classification,preceding surgery(≤3 months)and preceding CR(≤4 weeks for short term and>4 weeks for long term)as fixed effects.Results:1056 CPETs of 311 ACHD patients with simple(7),moderate(188)or great(116)complexity heart defects were analysed.The 59 patients who completed a CR(median age 27 yrs,38%females)increased peak VO_(2)from before to after CR by a median of 2.7(IQR–0.6 to 5.5)ml/kg/min.However,in the multivariate mixed model,peak VO_(2)was non-significantly increased short-term after CR(β0.8,95%CI–0.7 to 2.4),not maintained long-term after CR(β0.0,95%CI–1.7 to 1.6)but significantly reduced after surgery(β–5.1,95%CI–7.1 to–3.1).The 20 CR patients after surgery increased their peak VO_(2)by 6.2(IQR 3.6–9.5)ml/kg/min,while the 39 CR patients without preceding surgery increased it by 0.9(IQR–1.5 to 3.1)ml/kg/min.Conclusions:The increase in peak VO_(2)with CR was mainly due to recovery from surgical intervention.The small independent benefit from CR was not maintained long-term,highlighting the potential to improve current CR concepts in ACHD populations. 展开更多
关键词 Grown-ups with congenital heart disease exercise training cardiac rehabilitation surgical intervention peak oxygen consumption cardiorespiratory fitness
下载PDF
New Parameters of Cardiopulmonary Exercise Testing in Patients with Chronic Heart Failure: Practical Applications
6
作者 P. Gibelin A. Aldossari +2 位作者 D. Bertora P. Moceri T. Hugues 《International Journal of Clinical Medicine》 2012年第6期532-537,共6页
Cardiopulmonary exercise testing (CPX) has become the cornerstone of risk stratification for heart failure patients. Peak oxygen consumption (VO2) was the first CPX variable to demonstrate prognostic value and is stil... Cardiopulmonary exercise testing (CPX) has become the cornerstone of risk stratification for heart failure patients. Peak oxygen consumption (VO2) was the first CPX variable to demonstrate prognostic value and is still the most frequently analyzed variable in clinical practice. More recently, several investigations have shown that ventilatory efficiency, typically expressed as the minute ventilation/carbon dioxide production (VE/VCO2) slope, is a strong prognostic marker in patient with HF. The majority of studies report the VE/VCO2 slope to be prognostically superior to peak VO2 which underscore the clinical importance of assessing ventilatory efficiency in HF patients. Other expressions of ventilatory inefficiency like exercise oscillatory breathing (EOB), oxygen uptake efficiency slope (OUES), end-tidal carbon dioxide pressure (PET CO2) at rest, and haemodynamic responses such as heart rate recovery (HRR) are strong predictors of outcomes in patients with heart failure (HF). So there is a need for simplified approaches that integrate the additive prognostic information from cardiopulmonary exercise testing. 展开更多
关键词 NEW Parameters cardiopulmonary exercise testing CHRONIC heart FAILURE
下载PDF
Depression in adults with congenital heart disease-public health challenge in a rapidly expanding new patient population 被引量:3
7
作者 Linda B Pauliks 《World Journal of Cardiology》 CAS 2013年第6期186-195,共10页
There is a growing population of adults with congenital heart disease(CHD) due to improved survival beyond childhood.It has been suggested that adults with CHD may be at increased risk for mental health problems,parti... There is a growing population of adults with congenital heart disease(CHD) due to improved survival beyond childhood.It has been suggested that adults with CHD may be at increased risk for mental health problems,particularly depression.The reported incidence of depression in CHD varies from 9% to 30%.This review examines the evidence for a higher depression rate in CHD vs general population.Possible explanations are offered from a variety of disease models,ranging from brain injury to the psychoanalytical approach.Risk factors for an abnormal emotional adjustment and depression include early exposure to stress from illness and medical interventions in infancy,separation from the parents during hospitalizations and brain organic syndromes.Later in life,patients often have to cope with physical limitations.Recent improvements in care may be protective.Current patients may benefit from an earlier age at first surgical intervention,fewer reoperations and inclusion to the mainstream schooling,among other factors.At this point,there is little systematic knowledge about evidence-based therapeutic interventions for depression in adults with CHD.Health care providers of patients with CHD should be aware of mental health challenges and may take a more proactive approach to identifying patients at risk for depression. 展开更多
关键词 congenital heart disease cardiopulmonary BYPASS DEPRESSION OUTCOMES research
下载PDF
Serum oxidizability potential of ischemic heart disease patients is associated with exercise test results and disease severity 被引量:1
8
作者 Allah Shanati Yelena Rivlin +2 位作者 Sergei Shnizer Uri Rosenschein Ehud Goldhammer 《World Journal of Cardiology》 CAS 2009年第1期46-50,共5页
AIM:To find out whether serum oxidizability potential correlates with exercise test(EXT) parameters and predicts their results in chronic ischemic heart disease(IHD) patients.METHODS:Oxidizability potential was determ... AIM:To find out whether serum oxidizability potential correlates with exercise test(EXT) parameters and predicts their results in chronic ischemic heart disease(IHD) patients.METHODS:Oxidizability potential was determined in a group of chronic IHD patients who underwent a symptom limited EXT upon initiation of a cardiac rehabilitation program.The thermo-chemiluminescence(TCL) assay was used to assess serum oxidizability potential.This assay is based on heat-induced oxidation of serum,leading to the formation of electronically excited species in the form of unstable carbonyls,which further decompose into stable carbonyls and light energy(low chemiluminescence).Measured photons emission is represented by a kinetic curve which is described by its amplitude and slope(= ratio).We assessed the correlations of TCL ratio with exercise duration,metabolic equivalents(METS),maximal heart rate(mHR),maximal systolic BP,> 1 mm S-T depression,diabetes,hypertension,smoking,left ventricular ejection fraction(LVEF) > or < 40%,previous myocardial infarction,and aorto-coronary bypass surgery and compared to the TCL ratio measured in a group of healthy controls.RESULTS:A high TCL ratio(%) correlated well with METS(r = 0.84),with mHR(r = 0.79) and with exercise induced S-T segment shift(r = 0.87,P < 0.05).A lower serum oxidizability potential,expressed as a low TCL ratio,thus suggestive of a previous high oxidative stress,was found in IHD patients compared to healthy controls,and,in particular,in patients with low LVEF%.The TCL ratio(%) in IHD patients was 193 ± 21,compared to 215 ± 13 in controls(P < 0.05),and was 188 ± 14.7 in patients with LVEF < 40% as compared to 200 ± 11.9 in those with LVEF > 40%(P < 0.01).A trend for lower TCL ratio(%) was found in diabetic,hypertensive,and post-coronary bypass surgery patients.A paradoxically low TCL ratio(low oxidizability potential) was observed in patients without S-T depression compared to patients with S-T depression(189 ± 22 vs 201 ± 15,P = NS),due to the fact these patients had a much lower LVEF% and a lower exercise capacity.CONCLUSION:Serum oxidizability potential is associated with EXT parameters,results,and IHD severity.TCL ratio is an "easy-to-measure marker" that might be incorporated into risk assessment and prediction in chronic IHD patients. 展开更多
关键词 OXIDATIVE stress exercise test ISCHEMIC heart disease
下载PDF
Prognostic Value of Cardiopulmonary Exercise Test in Elderly Women with Heart Failure and Reduced or Preserved Ejection Fraction
9
作者 Angela Beatrice Scardovi Renata De Maria +5 位作者 Alessandro Ferraironi Marco Renzi Franco Turi Marina Parolini Tiziana Di Giacomo Roberto Ricci 《World Journal of Cardiovascular Diseases》 2014年第7期341-349,共9页
The prognostic role of cardiopulmonary exercise test (CPET) in elderly women with chronic heart failure (HF) has not yet been clarified. We assessed the incremental value of CPET variables for risk stratification in f... The prognostic role of cardiopulmonary exercise test (CPET) in elderly women with chronic heart failure (HF) has not yet been clarified. We assessed the incremental value of CPET variables for risk stratification in female HF patients with preserved or reduced left ventricular ejection fraction (LVEF). We prospectively followed up 131 female HF outpatients aged 72 [interquartile range 62 - 77] years after a symptom limited CPET. 34% had ischemic heart disease and 14% permanent atrial fibrillation, 24% were in NYHA class III. LVEF was 50% [interquartile range 36 - 62], peak oxygen consumption was 11.3 [interquartile range 9.2 - 13.5] ml/kg/min;the slope of the regression line relating ventilation to CO2 output was 33.9 [interquartile range 30.3 - 44.9];40% of patients showed exercise oscillatory breathing during CPET. During a median follow-up of 18 months [interquartile range 8 - 54], overall 39 patients (29.7%) met the combined end-point of cardiovascular mortality or HF admission using a time-to-first event approach. Moderate to severe mitral regurgitation, slope, exercise oscillatory breathing were independently associated to cardiovascular mortality or HF admission. When CPET ventilatory variables were added to clinical and echocardiographic parameters, prediction of the combined point improved significantly (AUC 0.755 (95% CI 0.662 to 0.832) vs 0.634 (95% CI 0.536 to 0.725), p = 0.016). In conclusion, among elderly female HF patients the CPET derived parameters EOB and VE/VCO2 slope emerged as strong prognostic markers, with additive predictive value to clinical and echocardiographic parameters in patients with both reduced and preserved LVEF. 展开更多
关键词 WOMEN heart Failure cardiopulmonary exercise Test Ventilatory INEFFICIENCY
下载PDF
Effects of a Cardiac Rehabilitation Program in Patients with Congenital Heart Disease
10
作者 Nathalie Dedieu Luis Fernández +2 位作者 Elvira Garrido-Lestache Inmaculada Sánchez Maria Jesus Lamas 《Open Journal of Internal Medicine》 2014年第1期22-27,共6页
The beneficial effects of the programs of cardiac rehabilitation in adults are widely known. Nevertheless, the accomplishment of these programs in patients with congenital heart is scarcely developed. In this study, w... The beneficial effects of the programs of cardiac rehabilitation in adults are widely known. Nevertheless, the accomplishment of these programs in patients with congenital heart is scarcely developed. In this study, we want to evaluate the preliminary results of a program of cardiac rehabilitation. Patients and methods: Thirty-three patients aged 8 to 40 completed the rehabilitation program. Thirty-one of them had an operated congenital heart disease, one had an implantable cardioverter defibrillator, and another was a patient with arterial hypertension and obesity. Data before and after the program were compared. Results: Improvements were found in all of the measured parameters. We found a statistically significant difference in maximum heart rate, exercise duration, foreseen heart rate’s percentage and increase of metabolic equivalents. Twenty-seven of 33 patients noticed a significant improvement in their quality of life at the end of the program. Conclusion: Initial results seem to be encouraging and we consider the experience very positive since the program achieved an improvement in the functional capacity of our patients. In our opinion, these observations and the results of our study provide strong arguments for the incorporation of cardiac rehabilitation into the care of many patients with congenital heart disease. 展开更多
关键词 congenital heart disease exercise Test Quality of LIFE
下载PDF
Ophthalmic Evaluation of Children from the Tibet Plateau with Congenital Heart Disease
11
作者 Guiqin Wang Qian Shi +4 位作者 Lin Sun Jing Wang Lei Li Tianchang Li Wei Wang 《Eye Science》 CAS 2014年第3期134-137,共4页
Purpose:To perform ophthalmic examinations to evaluate the ocular characteristics of children living in the Tibet plateau and diagnosed with congenital heart disease.Methods:.Children with congenital heart disease und... Purpose:To perform ophthalmic examinations to evaluate the ocular characteristics of children living in the Tibet plateau and diagnosed with congenital heart disease.Methods:.Children with congenital heart disease underwent a conventional ocular examination including distant acuity test,slit-lamp examination,.fundus examination,.non-contact intraocular pressure measurement,.measurement of corneal thickness, and fundus photography.Results: Forty-two Tibetan children, aged between 4 and 18 years and diagnosed with congenital heart disease,.were enrolled in this study..The percentage of low visual acuity was4.76%, mean intraocular pressure was(13.67±2.15) mm Hg,average corneal thickness was(492.55±33.79) μm,.96.43%had an anterior chamber depth of 1 / 2 corneal thickness(CT),and 35.7% had an obvious fundus vascular tortuosity.Conclusion:.This study adds to the understanding of the ocular status of the population living in the Tibet plateau, thereby offering clinical evidence for the prevention and treatment of eye diseases in this area. 展开更多
关键词 先天性心脏病 眼科检查 西藏高原 评估 儿童 心脏疾病 非接触式 压力测量
下载PDF
Endothelial progenitor cells mobilization after maximal exercise according to heart failure severity 被引量:2
12
作者 Christos Kourek Eleftherios Karatzanos +7 位作者 Katherina Psarra Georgios Georgiopoulos Dimitrios Delis Vasiliki Linardatou Gerasimos Gavrielatos Costas Papadopoulos Serafim Nanas Stavros Dimopoulos 《World Journal of Cardiology》 2020年第11期526-539,共14页
BACKGROUND Vascular endothelial dysfunction is an underlying pathophysiological feature of chronic heart failure(CHF).Patients with CHF are characterized by impaired vasodilation and inflammation of the vascular endot... BACKGROUND Vascular endothelial dysfunction is an underlying pathophysiological feature of chronic heart failure(CHF).Patients with CHF are characterized by impaired vasodilation and inflammation of the vascular endothelium.They also have low levels of endothelial progenitor cells(EPCs).EPCs are bone marrow derived cells involved in endothelium regeneration,homeostasis,and neovascularization.Exercise has been shown to improve vasodilation and stimulate the mobilization of EPCs in healthy people and patients with cardiovascular comorbidities.However,the effects of exercise on EPCs in different stages of CHF remain under investigation.AIM To evaluate the effect of a symptom-limited maximal cardiopulmonary exercise testing(CPET)on EPCs in CHF patients of different severity.METHODS Forty-nine consecutive patients(41 males)with stable CHF[mean age(years):56±10,ejection fraction(EF,%):32±8,peak oxygen uptake(VO2,mL/kg/min):18.1±4.4]underwent a CPET on a cycle ergometer.Venous blood was sampled before and after CPET.Five circulating endothelial populations were quantified by flow cytometry:Three subgroups of EPCs[CD34+/CD45-/CD133+,CD34+/CD45-/CD133+/VEGFR2 and CD34+/CD133+/vascular endothelial growth factor receptor 2(VEGFR2)]and two subgroups of circulating endothelial cells(CD34+/CD45-/CD133-and CD34+/CD45-/CD133-/VEGFR2).Patients were divided in two groups of severity according to the median value of peak VO2(18.0 mL/kg/min),predicted peak VO2(65.5%),ventilation/carbon dioxide output slope(32.5)and EF(reduced and mid-ranged EF).EPCs values are expressed as median(25th-75th percentiles)in cells/106 enucleated cells.RESULTS Patients with lower peak VO2 increased the mobilization of CD34+/CD45-/CD133+[pre CPET:60(25-76)vs post CPET:90(70-103)cells/106 enucleated cells,P<0.001],CD34+/CD45-/CD133+/VEGFR2[pre CPET:1(1-4)vs post CPET:5(3-8)cells/106 enucleated cells,P<0.001],CD34+/CD45-/CD133-[pre CPET:186(141-361)vs post CPET:488(247-658)cells/106 enucleated cells,P<0.001]and CD34+/CD45-/CD133-/VEGFR2[pre CPET:2(1-2)vs post CPET:3(2-5)cells/106 enucleated cells,P<0.001],while patients with higher VO2 increased the mobilization of CD34+/CD45-/CD133+[pre CPET:42(19-73)vs post CPET:90(39-118)cells/106 enucleated cells,P<0.001],CD34+/CD45-/CD133+/VEGFR2[pre CPET:2(1-3)vs post CPET:6(3-9)cells/106 enucleated cells,P<0.001],CD34+/CD133+/VEGFR2[pre CPET:10(7-18)vs post CPET:14(10-19)cells/106 enucleated cells,P<0.01],CD34+/CD45-/CD133-[pre CPET:218(158-247)vs post CPET:311(254-569)cells/106 enucleated cells,P<0.001]and CD34+/CD45-/CD133-/VEGFR2[pre CPET:1(1-2)vs post CPET:4(2-6)cells/106 enucleated cells,P<0.001].A similar increase in the mobilization of at least four out of five cellular populations was observed after maximal exercise within each severity group regarding predicted peak,ventilation/carbon dioxide output slope and EF as well(P<0.05).However,there were no statistically significant differences in the mobilization of endothelial cellular populations between severity groups in each comparison(P>0.05).CONCLUSION Our study has shown an increased EPCs and circulating endothelial cells mobilization after maximal exercise in CHF patients,but this increase was not associated with syndrome severity.Further investigation,however,is needed. 展开更多
关键词 Chronic heart failure Endothelial progenitor cells Circulating endothelial cells Maximal exercise cardiopulmonary exercise testing SEVERITY
下载PDF
TWO METHODS TO IMPROVE THE ACCURACY OF TREADMILL EXERCISE TESTING──ANALYSIS OF 147 CASESIN CONTRAST WITH CORONARY ANGIOGRAPHY 被引量:1
13
作者 朱顺和 王彬尧 +3 位作者 励锦华 冯笔华 杜勇平 郑道声 《Medical Bulletin of Shanghai Jiaotong University》 CAS 1999年第1期60-62,共3页
objective To study how to improve the accuracy of treadmill exercise testing(TET).Methods TET was performed before coronary angiography (CAG) for 147 subjects admitted into our departmentbecause of suspicion of angina... objective To study how to improve the accuracy of treadmill exercise testing(TET).Methods TET was performed before coronary angiography (CAG) for 147 subjects admitted into our departmentbecause of suspicion of angina or coronary artery disease (CAD), then: (1) Every subject was inquired about hissymptoms and physically examined in detail before the testing. Chest pain was divided into ischemic (ICP) ornon - ischemic (NICP) pattern. (2) Informations got from TET, like angina, ST segment depression, and SPB ratio,were analyzed in detail. Results (1) When the patients showed chest pain of ICP pattern and positive TETresults, the sensitivity of TET would be 95%, for patients with NICP chest pain, the negative result of TET meansthat their coronary arteries is normal with the accurate possibility of 98%. (2) By our new criteria of TET, thesensitivity and specificity of TET were 89% and 95% respectively, both higher than those in theliterature. Conclusion in this report, we found TET was more sensitive and accurate if we knew the symptomsprior, especially in detail the characteristics of chest pain, and consider different parameters in combination. 展开更多
关键词 TREADMILL exercise testing CORONARY ANGIOGRAPHY ISCHEMIC heart disease ANGINA
下载PDF
A 49-year-old male with sleep-disordered breathing and nocturnal paroxysmal dyspnea after congenital heart defect correction
14
作者 Qi Jin Qin Luo +5 位作者 Zhihui Zhao Qing Zhao Xue Yu Lu Yan Liu Gao Zhihong Liu 《中国循环杂志》 CSCD 北大核心 2018年第S01期169-169,共1页
Rationale PH is a pathophysiological disorder involving multiple clinical conditions and is often concomitant with other cardiopulmonary diseases,and related differential diagnosis is quite tricky for its various etio... Rationale PH is a pathophysiological disorder involving multiple clinical conditions and is often concomitant with other cardiopulmonary diseases,and related differential diagnosis is quite tricky for its various etiologies.Patient characteristics A 49-year-old man presented with 1-year history of nocturnal paroxysmal dyspnea and was transferred to our hospital. 展开更多
关键词 congenital heart defect correction cardiopulmonary diseases various ETIOLOGIES
下载PDF
Progresses in genetic testing in congenital heart disease
15
作者 Han Gao Ying Liu +2 位作者 Wei Sheng Weinian Shou Guoying Huang 《医学+(英文)》 2024年第2期64-77,共14页
Congenital heart disease(CHD)encompasses a range of structural malformations affecting the heart and major blood vessels present at birth.The genetic under-pinnings of CHD have long been recognized as pivotal,facilita... Congenital heart disease(CHD)encompasses a range of structural malformations affecting the heart and major blood vessels present at birth.The genetic under-pinnings of CHD have long been recognized as pivotal,facilitated by a deeper mo-lecular understanding of cardiogenesis.Various genetic variants,including single nucleotide variations,structural variations,and chromosomal abnormalities,have been identified in association with both syndromic and non-syndromic CHD.As ge-netic technologies evolve and improve,the application of genetic testing in CHD patients promises to yield valuable insights for both clinical practice and basic sci-ence.With the advancement of cohort studies,genomic data on these variations can be robustly collected and classified according to their pathogenicity,thereby en-hancing our understanding of CHD genetics.Numerous tools have been developed to interpret variants identified in both coding and non-coding regions through genetic testing,providing substantial reference points for clinical decision-making in CHD management.The integration of genetic testing stands to benefit CHD management across various fronts,including diagnosis,prognosis prediction,and recurrence risk estimation.A thorough understanding of the genetic investigations and clinical practices related to CHD genetics is essential for the advanced application of genetic testing in CHD cases.By leveraging this knowledge,healthcare professionals can effectively incorporate genetic testing into the broader framework of CHD care,ul-timately improving patient outcomes and advancing our understanding of these complex conditions. 展开更多
关键词 congenital heart disease Genetic testing GENETICS Clinical practice
原文传递
同步12导联动态心电图检查联合平板运动试验诊断冠心病的效能
16
作者 张亚梦 杜新超 赵一灿 《中国民康医学》 2025年第2期106-108,共3页
目的:观察同步12导联动态心电图(AECG)检查联合平板运动试验(TET)诊断冠状动脉粥样硬化性心脏病(CHD)的效能。方法:选取2022—2023年该院收治的98例疑似CHD患者进行前瞻性研究,所有患者均给予冠状动脉造影(CAG)、AECG、TET检查。以CAG... 目的:观察同步12导联动态心电图(AECG)检查联合平板运动试验(TET)诊断冠状动脉粥样硬化性心脏病(CHD)的效能。方法:选取2022—2023年该院收治的98例疑似CHD患者进行前瞻性研究,所有患者均给予冠状动脉造影(CAG)、AECG、TET检查。以CAG检查为“金标准”,统计AECG、TET单项及联合检查诊断CHD的结果,比较AECG、TET单项及联合检查诊断CHD的效能及不同病变血管支数的符合率。结果:98例疑似CHD患者中,经CAG检查诊断阳性54例,阴性44例;AECG检查诊断阳性39例,阴性59例;TET检查诊断阳性46例,阴性52例;联合检查诊断阳性54例,阴性44例。AECG联合TET检查诊断CHD的灵敏度、准确度、阳性预测值均高于二者单项检查,差异有统计学意义(P<0.05)。AECG联合TET检查诊断CHD单支、双支病变血管的符合率均高于二者单项检查,差异有统计学意义(P<0.05)。结论:AECG联合TET检查诊断CHD的效能高于二者单项检查。 展开更多
关键词 冠状动脉粥样硬化性心脏病 同步12导联动态心电图 平板运动试验 检查 诊断
下载PDF
活动平板运动试验在隐匿性冠心病中的应用研究
17
作者 郑云平 简艳红 李根林 《中国医学创新》 2025年第2期144-147,共4页
目的:探讨活动平板运动试验对隐匿性冠心病的诊断价值。方法:选取2022年1月—2023年10月新余市人民医院收治的81例疑似隐匿性冠心病患者,行活动平板运动试验,以冠状动脉造影(coronary angiography,CAG)结果为金标准进行对比,分析活动平... 目的:探讨活动平板运动试验对隐匿性冠心病的诊断价值。方法:选取2022年1月—2023年10月新余市人民医院收治的81例疑似隐匿性冠心病患者,行活动平板运动试验,以冠状动脉造影(coronary angiography,CAG)结果为金标准进行对比,分析活动平板运动试验对隐匿性冠心病的诊断价值。结果:81例高度疑似隐匿性冠心病患者中,CAG诊断阳性患者71例,其中轻度狭窄占比26.76%,中度狭窄占比49.30%,重度狭窄占比23.94%。CAG阳性组最大运动耐量、运动峰值心率、运动峰值收缩压(SBP)、活动平板运动试验运动中峰值心率与运动试验结束后1 min、2 min恢复期心率的差值(ΔHR1、ΔHR2)均低于CAG阴性组(P<0.05)。活动平板运动试验诊断阳性65例,与CAG诊断结果的一致性较高(Kappa=0.611)。以CAG诊断结果为金标准,活动平板运动试验诊断隐匿性冠心病的敏感度为91.55%,特异度为80.00%,诊断准确率为90.12%,阳性预测值为97.01%,阴性预测值为57.14%。结论:活动平板运动试验可有效诊断隐匿性冠心病,且与CAG诊断结果的一致性较高,或许可替代CAG检查作为疑似隐匿性冠心病的首选筛查方法。 展开更多
关键词 隐匿性冠心病 活动平板运动试验 诊断价值 敏感度 特异度 诊断准确率
下载PDF
Rehabilitation training improves exercise tolerance after percutaneous coronary intervention 被引量:6
18
作者 Fang Cui Yusheng Ren +1 位作者 Heng Jin Bo Cui 《The Journal of Biomedical Research》 CAS 2012年第4期248-252,共5页
The aim of this present study was to investigate the effects of training on exercise tolerance of patients with coronary heart disease after percutaneous coronary intervention.Fifty-seven cases of coronary heart disea... The aim of this present study was to investigate the effects of training on exercise tolerance of patients with coronary heart disease after percutaneous coronary intervention.Fifty-seven cases of coronary heart disease after percutaneous coronary intervention were divided randomly into the rehabilitation training group(26 cases) and control group(31 cases).Patients in the rehabilitation training group received rehabilitation training at different stages and exercise intensities 3 d after percutaneous coronary intervention for 3 months.The heart rate,blood pressure,ECG changes in treadmill exercise test,and the frequency of anginal episodes were observed.The results showed that NST and ΣST of ECG and the frequency of anginal episodes were significantly reduced in the rehabilitation training group.In addition,exercise tolerance was improved and the total exercise time was lengthened in these patients.Moreover,ST segment depression time and emergence time of angina with exercise were also lengthened compared with controls(P 〈 0.05,or 0.01).However,the heart rate and blood pressure before and after exercise of the two groups were similar.The study indicated that rehabilitation training could significantly relieve angina,amend ischemic features of ECG,and improve exercise tolerance of coronary heart disease patients after percutaneous coronary intervention. 展开更多
关键词 coronary heart disease percutaneous coronary intervention rehabilitation training exercise tolerance treadmill exercise test
下载PDF
Comparison of clinical outcomes and postoperative recovery between two open heart surgeries:minimally invasive right subaxillary vertical thoracomy and traditional median sternotomy 被引量:10
19
作者 Chuan-Xian Hu Juan Tan +2 位作者 Sheng Chen Hui Ding Zhi-Wei Xu 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2014年第8期625-629,共5页
Objective: To compare the clinical outcomes of minimally invasive right subaxillary vertical thoracotomy and traditional median stemotomy through right atrium in treatment of common congenital heart diseases. Methods:... Objective: To compare the clinical outcomes of minimally invasive right subaxillary vertical thoracotomy and traditional median stemotomy through right atrium in treatment of common congenital heart diseases. Methods: Clinical data of 59 cases of common congenital heart diseases treated with minimally invasive right axillary vertical thoracotomy from May, 2011 to February, 2013 and 77 cases of same diseases with traditional median stemotomy in the past three years were retrospectively analyzed, including atrial septal defect, membranous ventricular septal defect and partial endocardial cushion defect. The results were compared from the two groups, including the time for operation and cardiopulmonary bypass, amount of blood transfusion, postoperative drainage, ventilation time, hospital stay, and prognosis. Results: No severe complications happened in both groups, like deaths or secondary surgery caused by bleeding. No significant differences were in CPB time and postoperative ventilator time between groups (P>0.05), while for all of the operative time, the length of incision, postoperative drainage and hospital stay, minimally invasive right axillary vertical thoracotomy was superior to median stemotomy, with statistically significant differences (P<0.05). In six month followup after operation, no complications of residual deformity and pericardial effusion were found in both groups by doing echocardiography, but mild pectus carinatum was found in 8 patients in the traditional median sternotomy group (traditional group), whereas patients in another group were well recovered. Conclusions: Minimally invasive right subaxillary vertical thoracotomy for common congenital heart diseases is as safe as traditional median stemotomy, without the increasing incidence of postoperative complications. Additionally, compared with traditional median stemotomy, minimally - invasive right subaxillary vertical thoracotomy is better in the aspects of hidden incision, appearance, and postoperative recovery. 展开更多
关键词 Minimally invasive surgery congenital heart diseases Right subaxillary vertical thoracotomy Traditional median stemotomy cardiopulmonary bypass
下载PDF
Clinical features and determinants of VO_(2peak) in de novo heart transplant recipients 被引量:1
20
作者 Katrine Rolid Arne K Andreassen +7 位作者 Marianne Yardley Elisabeth Bj?rkelund Kristjan Karason Julia P Wigh Christian H Dall Finn Gustafsson Lars Gullestad Kari Nytr?en 《World Journal of Transplantation》 2018年第5期188-197,共10页
AIM To study exercise capacity and determinants of early peak oxygen consumption(VO_(2peak)) in a cohort of de novo heart transplant(HTx) recipients. METHODS To determine possible central(chronotropic responses, cardi... AIM To study exercise capacity and determinants of early peak oxygen consumption(VO_(2peak)) in a cohort of de novo heart transplant(HTx) recipients. METHODS To determine possible central(chronotropic responses, cardiopulmonary and hemodynamic function) and peripheral factors(muscular exercise capacity and body composition) predictive of VO_(2peak), a number of different measurements and tests were performed, as follows: Cardiopulmonary exercise testing(CPET) was performed mean 11 wk after surgery in 81 HTx recipients > 18 years and was measured with breath by breath gas exchange on a treadmill or bicycle ergometer. Metabolic/respiratory measures include VO_(2peak) and VE/VCO2 slope. Additional measures included muscle strength testing, bioelectrical impedance analysis, echocardiography, blood sampling and health-related quality of life. Based on the VO_(2peak)(mL/kg per minute) median value, the study population was divided into two groups defined as a low-capacity group and a high-capacity group. Potential predictors were analyzed using multiple regression analysis with VO_(2peak)(L/min) as the dependent variable.RESULTS The mean ± standard deviation(SD) age of the total study population was 49 ± 13 years, and 73% were men. This de novo HTx cohort demonstrated a median VO_(2peak) level of 19.4 mL/kg per min at 11 ± 1.8 wk postHTx. As compared with the high-capacity group, the low-capacity group exercised for a shorter time, had lower maximal ventilation, O_2 pulse, peak heart rate and heart rate reserve, while the VE/VCO_2 slope was higher. The low-capacity group had less muscle strength and muscular exercise capacity in comparison with the highcapacity group. In order of importance, O_2 pulse, heart rate reserve, muscular exercise capacity, body mass index, gender and age accounted for 84% of the variance in VO_(2peak)(L/min). There were no minor or major serious adverse events during the CPET. CONCLUSION Although there is great individual variance among de novo HTx recipients, early VO_(2peak) measures appear to be influenced by both central and peripheral factors. 展开更多
关键词 cardiopulmonary exercise testing Early VO2peak De novo heart TRANSPLANT Health related quality of life MUSCLE strength
下载PDF
上一页 1 2 48 下一页 到第
使用帮助 返回顶部