According to the definition of correlation dimension in fractal theory, this paper presented a method to determine and assess noise part in detected transient signal. Such work is essential to decrease the noise part ...According to the definition of correlation dimension in fractal theory, this paper presented a method to determine and assess noise part in detected transient signal. Such work is essential to decrease the noise part in the detected signal. It is proved that heart period signal (HPS) is one typical sort of transient chaotic signal. Through experiment and simulation, the analysis of chaotic HPS in the detected signal was done. In the end, we deepen the researches on attractor dimension of HPS for persons who are different in age.展开更多
目的:探索中国汉族人群(Klotho,KL)基因G-395A、F352V及C370S单核苷酸多态性(Single nucleotide polymorphisms,SNP)及其与心动周期信号谱特征的相关关系。方法:随机选择汉族自然人群个体177为研究对象[男96,女81例,平均年龄(65.11±...目的:探索中国汉族人群(Klotho,KL)基因G-395A、F352V及C370S单核苷酸多态性(Single nucleotide polymorphisms,SNP)及其与心动周期信号谱特征的相关关系。方法:随机选择汉族自然人群个体177为研究对象[男96,女81例,平均年龄(65.11±10.7)岁],获取其静脉血白细胞基因组DNA。采用等位基因特异性引物PCR技术检测Klotho基因3个位点的基因型,利用《HPS谱及其混沌特征分析系统软件》检测人群的卧位心动周期信号谱(Heart period signal,HPS)参数。结果:①KL基因G-395A SNP AA基因型携带者其绝对高频功率(Absolute high frequency power,AHP)及相对高频率(Relative high frequency power,RHP)参数较其GA携带者降低,均有显著性差异(P<0.05);同时携带AA基因型者的RHP参数也较GG携带者降低,亦有显著性差异(P<0.05)。②KL基因F352VSNP VV突变基因型携带者其相对超低频率(Relative ultra-lower frequencypower,RUP)、超低频/高频比值(RatioofAUP toAHP,RUH)参数值较FF野生型纯合子基因型携带者低,差异有显著性(P<0.05);携带VV基因型者绝对低频功率(Absolute lowfrequency power,ALP)、AHP、RHP以及总功率(Total power value,TPV)较其FF野生型携带者高,也有显著性差异(P<0.05);汉族人群KL基因F352V多态性的突变型VV基因型纯合子携带者其RUP、RUH参数值也较其FV杂合子携带者降低;突变型VV基因型纯合子携带者其RHP参数值则较FV杂合子携带者高,亦有显著性差异(P<0.05)。③KL基因C370S多态性的突变型SS基因型纯合子携带者其低频/高频比值(Ratio of absolute low frequency power to AHP,RLH)参数值较CC野生型纯合子携带者低有显著性差异,同时也较CS杂合子携带者低,其差异亦有显著性(P<0.05)。结论:KL基因G-395ASNP突变型AA与AHP、RHP减低有关;F352VSNP突变型VV与RUP、RUH减低有关,亦与其ALP、AHP、RHP以及总功率(Totalpower value,TPV)增高有关,这就提示klotho基因多态性与心动周期信号谱特征的有明确相关性。展开更多
Objective:Analyzing digital characteristics (chaotic and spectral features) of fetal and pregnant womans Heart Period Signal (HPS) can assess the autonomic function. Methods:Extracting and analyzing HPS of fetal and...Objective:Analyzing digital characteristics (chaotic and spectral features) of fetal and pregnant womans Heart Period Signal (HPS) can assess the autonomic function. Methods:Extracting and analyzing HPS of fetal and pregnant woman in perinatal period were realized by the method called visual programming. The hardware consists of electrode, amplifier, analog to digital converter (ADC) with 12bit, printer and microcomputer. Low level I/O operation for the ADC was finished by means of assembler in-line in Delphi (language) under Windows operating system. The software package was designed by Object Oriented Programming technique. So, all the system is a multi-media one and established under Windows. The subjects are in supine,electrocardiosignal (ECS) from the leads placed at symphysis pubica to inferior border of abdominal wall was acquired. ECS was preprocessed by wavelet filter. The sophisticated technique developed by our laboratory was used to accomplish analyzing digital characteristic of HPS. Results: The system could be used to assess fetal and pregnant womans autonomic function, furthermore, sympathetic and parasympathetic nervous function can be evaluated respectively and quantificationally.Discussions:(1) The system could be used to prognosis fetal distress. (2) Digital characteristic of fetal and other age segments HPS that vary with age could approve the viewpoint that there is a characteristic curve to suggest the physiological process of development, mature and senility, based on it, we could find the way of anti-senility. (3) Some digital parameters of fetal HPS locate between those of newborn and adult, which may imply that fetal autonomic nervous regulation is influenced by mothers nerve and endocrine.展开更多
文摘According to the definition of correlation dimension in fractal theory, this paper presented a method to determine and assess noise part in detected transient signal. Such work is essential to decrease the noise part in the detected signal. It is proved that heart period signal (HPS) is one typical sort of transient chaotic signal. Through experiment and simulation, the analysis of chaotic HPS in the detected signal was done. In the end, we deepen the researches on attractor dimension of HPS for persons who are different in age.
文摘目的:探索中国汉族人群(Klotho,KL)基因G-395A、F352V及C370S单核苷酸多态性(Single nucleotide polymorphisms,SNP)及其与心动周期信号谱特征的相关关系。方法:随机选择汉族自然人群个体177为研究对象[男96,女81例,平均年龄(65.11±10.7)岁],获取其静脉血白细胞基因组DNA。采用等位基因特异性引物PCR技术检测Klotho基因3个位点的基因型,利用《HPS谱及其混沌特征分析系统软件》检测人群的卧位心动周期信号谱(Heart period signal,HPS)参数。结果:①KL基因G-395A SNP AA基因型携带者其绝对高频功率(Absolute high frequency power,AHP)及相对高频率(Relative high frequency power,RHP)参数较其GA携带者降低,均有显著性差异(P<0.05);同时携带AA基因型者的RHP参数也较GG携带者降低,亦有显著性差异(P<0.05)。②KL基因F352VSNP VV突变基因型携带者其相对超低频率(Relative ultra-lower frequencypower,RUP)、超低频/高频比值(RatioofAUP toAHP,RUH)参数值较FF野生型纯合子基因型携带者低,差异有显著性(P<0.05);携带VV基因型者绝对低频功率(Absolute lowfrequency power,ALP)、AHP、RHP以及总功率(Total power value,TPV)较其FF野生型携带者高,也有显著性差异(P<0.05);汉族人群KL基因F352V多态性的突变型VV基因型纯合子携带者其RUP、RUH参数值也较其FV杂合子携带者降低;突变型VV基因型纯合子携带者其RHP参数值则较FV杂合子携带者高,亦有显著性差异(P<0.05)。③KL基因C370S多态性的突变型SS基因型纯合子携带者其低频/高频比值(Ratio of absolute low frequency power to AHP,RLH)参数值较CC野生型纯合子携带者低有显著性差异,同时也较CS杂合子携带者低,其差异亦有显著性(P<0.05)。结论:KL基因G-395ASNP突变型AA与AHP、RHP减低有关;F352VSNP突变型VV与RUP、RUH减低有关,亦与其ALP、AHP、RHP以及总功率(Totalpower value,TPV)增高有关,这就提示klotho基因多态性与心动周期信号谱特征的有明确相关性。
文摘Objective:Analyzing digital characteristics (chaotic and spectral features) of fetal and pregnant womans Heart Period Signal (HPS) can assess the autonomic function. Methods:Extracting and analyzing HPS of fetal and pregnant woman in perinatal period were realized by the method called visual programming. The hardware consists of electrode, amplifier, analog to digital converter (ADC) with 12bit, printer and microcomputer. Low level I/O operation for the ADC was finished by means of assembler in-line in Delphi (language) under Windows operating system. The software package was designed by Object Oriented Programming technique. So, all the system is a multi-media one and established under Windows. The subjects are in supine,electrocardiosignal (ECS) from the leads placed at symphysis pubica to inferior border of abdominal wall was acquired. ECS was preprocessed by wavelet filter. The sophisticated technique developed by our laboratory was used to accomplish analyzing digital characteristic of HPS. Results: The system could be used to assess fetal and pregnant womans autonomic function, furthermore, sympathetic and parasympathetic nervous function can be evaluated respectively and quantificationally.Discussions:(1) The system could be used to prognosis fetal distress. (2) Digital characteristic of fetal and other age segments HPS that vary with age could approve the viewpoint that there is a characteristic curve to suggest the physiological process of development, mature and senility, based on it, we could find the way of anti-senility. (3) Some digital parameters of fetal HPS locate between those of newborn and adult, which may imply that fetal autonomic nervous regulation is influenced by mothers nerve and endocrine.
