Ischemic heart disease (IHD) is the most common cause of death around the world. Nowadays Platelet counts (PC) and volumetric platelet indices are available routinely in most laboratories and reflect the level of mobi...Ischemic heart disease (IHD) is the most common cause of death around the world. Nowadays Platelet counts (PC) and volumetric platelet indices are available routinely in most laboratories and reflect the level of mobility and production of platelets. It seems that the excessive flexibility and size of the platelets and their local activation have correlation with extent of ischemic heart disease. So our objective is the study of platelet indices in ischemic heart disease. This non-randomized prospective study was performed on 245 patients with ischemic heart disease, who underwent the coronary angiography. The patients were divided into four groups: stable angina, unstable angina, acute myocardial infarction and control group;and then platelet indices, including the platelet counts (PC), the average platelet volume (MPV), the Platelet Distribution Width (PDW) and plateletcrit (PCT) in each group with the extent of coronary disease were compared based on an Syntax Score system and observational methods. The average ages of the patients were 57 years and 65% of them were male and the rest were female. A significant difference is exists between indices in all three groups compared to the control that this difference was related to gender and the type of the coronary artery involvement. However, only in infarction group, PDW in different disease intensities was significantly different. In this study, unlike many of the previous studies no relationship was found between the MPV with the extent of coronary disease.展开更多
目的探讨Kringle结构IV型-2亚型结构(KIV-2)拷贝数及载脂蛋白a[Apo(a)]颗粒大小与2型糖尿病和冠心病的相关性。方法回顾性选取2019年6月至2020年6月于复旦大学附属中山医院青浦分院就诊的180例体检者为研究对象,对临床资料进行收集和分...目的探讨Kringle结构IV型-2亚型结构(KIV-2)拷贝数及载脂蛋白a[Apo(a)]颗粒大小与2型糖尿病和冠心病的相关性。方法回顾性选取2019年6月至2020年6月于复旦大学附属中山医院青浦分院就诊的180例体检者为研究对象,对临床资料进行收集和分析后将其分为3组:正常对照组、冠心病组和糖尿病组,每组各60例。检测3组人群的空腹血糖、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和脂蛋白(a)[Lp(a)]含量;通过RT-PCR法测定KIV-2拷贝数,并通过检测KIV-2结构重复数确定Apo(a)颗粒大小;分析Lp(a)拷贝数、Apo(a)颗粒大小分别与2型糖尿病和冠心病的关系。结果冠心病组和糖尿病组空腹血糖、2 h PG、HbA1c、总胆固醇、甘油三酯、LDL-C、Lp(a)水平均高于正常对照组,HDL-C、KIV-2拷贝数低于正常对照组,差异均有统计学意义(P<0.05),而冠心病组与糖尿病组HDL-C水平比较,差异无统计学意义(P>0.05)。2型糖尿病和冠心病分别与KIV-2拷贝数相关性显著,与Apo(a)颗粒大小相关性不显著,且LP(a)浓度与KIV-2拷贝呈负相关。结论Apo(a)颗粒大小与2型糖尿病和冠心病无明显相关性,而KIV-2拷贝数与2型糖尿病和冠心病有明显相关性。检测KIV-2拷贝数可为2型糖尿病和冠心病的诊断与治疗提供依据。展开更多
目的研究心肌炎患儿的长程心率变异(HRV)改变及其与心脏大小和功能的相关性。方法对100例心肌炎患儿(心肌炎组)和50例健康儿童(对照组)分别行24 h心率变异分析,得出连续平均正常R-R间期标准差(SDNN),每5 min R-R间期平均值的标准差(SDAN...目的研究心肌炎患儿的长程心率变异(HRV)改变及其与心脏大小和功能的相关性。方法对100例心肌炎患儿(心肌炎组)和50例健康儿童(对照组)分别行24 h心率变异分析,得出连续平均正常R-R间期标准差(SDNN),每5 min R-R间期平均值的标准差(SDANN),每5 min正常R-R间期标准差的平均值(SDNN index),相邻正常R-R间期差值的均方根值(rMSSD),相邻R-R间期之差大于50ms的心搏次数占总心搏次数的百分比(PNN50),总功率TP(0-0.4Hz),低频成分LF(0.04-0.15Hz),高频成分HF(0.15-0.4Hz)及LF/HF等指标。并空腹测定肌酸激酶同工酶(CKMB)和肌钙蛋白I(cTnI),同时接受经胸超声心动图检查,取得左房舒张末期前后径(LAED)、左室舒张末期前后径(LVED)、左室射血分数(LVEF)和短轴缩短率(LVFS)等指标。对两组的上述指标进行比较,并分析心肌炎患儿的心率变异性与心脏大小和功能的相关性。结果与对照组相比,心肌炎组的SDNNr、MSSD、PNN50、HF显著降低(P均<0.05),SDANN、SDNN index、TP、LF略降低(P均>0.05);心肌炎患儿CKMB显著增高(P<0.01),cTnI和LAED明显增高(P均<0.05);心肌炎组的SDNN与LAED、LVEF呈中等相关(r=-0.52,r=0.49,P均<0.05),其余HRV指标与心肌酶、肌钙蛋白、心脏大小及心功能无明显相关。结论心肌炎患儿的HRV普遍降低,提示自主神经系统的总体功能受损,以迷走神经张力降低为主,交感神经张力相对增强,部分HRV指标与心脏大小及心功能有一定的相关性,部分HRV指标是相对独立的,将HRV指标与常规测量指标结合起来能更好的指导心肌炎的诊断和预后的判断。展开更多
目的:探索大鼠左冠状动脉前降支不同结扎处理后,对心肌形态学及心功能的影响,以建立适合移植干细胞再生修复心肌梗死研究的稳定、可靠和更合乎发病机理的动物模型。方法:雄性W istar大鼠70只,随机分为六组即:假手术组、结扎(15 m in、30...目的:探索大鼠左冠状动脉前降支不同结扎处理后,对心肌形态学及心功能的影响,以建立适合移植干细胞再生修复心肌梗死研究的稳定、可靠和更合乎发病机理的动物模型。方法:雄性W istar大鼠70只,随机分为六组即:假手术组、结扎(15 m in、30 m in、45 m in、60 m in)再灌、结扎非再灌。于处理后1 d、1周、2周或4周动态观察心肌梗死变化,并于处理一月后测量动脉收缩压(ASP)、动脉舒张压(ADP)、左室收缩压(LVSP)、左室舒张末压(LV-EDP)及左室压力上升及下降最大速度(±dp/dtm ax)。结果:引起明显的心肌梗死至少需要结扎30 m in。结扎(45m in、60 m in)再灌、结扎非再灌的心肌梗死明显,并观察到梗死区域心肌已绝大部分纤维化,且梗死面积变化较恒定。同时测定不同结扎时间心功能的变化发现,结扎(45 m in、60 m in)再灌或结扎非再灌各组ASP、ADP、LVSP、±dp/dtm ax显著下降,LVEDP明显升高。并且不同结扎时间处理后,大鼠心功能的变化与心肌梗死后的梗死面积变化密切相关。结论:建立了在实验大鼠左冠状动脉前降支中上1/3处结扎45 m in以上的大鼠心肌梗死模型,不仅合乎临床心肌梗死的发病机理,而且梗死部位、梗死区域面积稳定,适合于移植细胞再生修复心肌梗死的研究。展开更多
为了提高大型无线传感器网络的稳定性,延长网络出现首个节点的死亡时间,提出一种基于簇结构稳定的分环多跳路由算法CBSM(Cluster structure stability based Sub-ring algorithm over multi-hop routing).CBSM算法将监测区域划分为许多...为了提高大型无线传感器网络的稳定性,延长网络出现首个节点的死亡时间,提出一种基于簇结构稳定的分环多跳路由算法CBSM(Cluster structure stability based Sub-ring algorithm over multi-hop routing).CBSM算法将监测区域划分为许多固定小区,采用基于节点剩余能量和节点位置的代价函数选择簇头.仿真结果表明,基于簇结构稳定的多跳路由算法,能有效延长网络出现首个节点死亡的时间,提高整个网络的稳定性.展开更多
文摘Ischemic heart disease (IHD) is the most common cause of death around the world. Nowadays Platelet counts (PC) and volumetric platelet indices are available routinely in most laboratories and reflect the level of mobility and production of platelets. It seems that the excessive flexibility and size of the platelets and their local activation have correlation with extent of ischemic heart disease. So our objective is the study of platelet indices in ischemic heart disease. This non-randomized prospective study was performed on 245 patients with ischemic heart disease, who underwent the coronary angiography. The patients were divided into four groups: stable angina, unstable angina, acute myocardial infarction and control group;and then platelet indices, including the platelet counts (PC), the average platelet volume (MPV), the Platelet Distribution Width (PDW) and plateletcrit (PCT) in each group with the extent of coronary disease were compared based on an Syntax Score system and observational methods. The average ages of the patients were 57 years and 65% of them were male and the rest were female. A significant difference is exists between indices in all three groups compared to the control that this difference was related to gender and the type of the coronary artery involvement. However, only in infarction group, PDW in different disease intensities was significantly different. In this study, unlike many of the previous studies no relationship was found between the MPV with the extent of coronary disease.
文摘目的探讨Kringle结构IV型-2亚型结构(KIV-2)拷贝数及载脂蛋白a[Apo(a)]颗粒大小与2型糖尿病和冠心病的相关性。方法回顾性选取2019年6月至2020年6月于复旦大学附属中山医院青浦分院就诊的180例体检者为研究对象,对临床资料进行收集和分析后将其分为3组:正常对照组、冠心病组和糖尿病组,每组各60例。检测3组人群的空腹血糖、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、总胆固醇、甘油三酯、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)和脂蛋白(a)[Lp(a)]含量;通过RT-PCR法测定KIV-2拷贝数,并通过检测KIV-2结构重复数确定Apo(a)颗粒大小;分析Lp(a)拷贝数、Apo(a)颗粒大小分别与2型糖尿病和冠心病的关系。结果冠心病组和糖尿病组空腹血糖、2 h PG、HbA1c、总胆固醇、甘油三酯、LDL-C、Lp(a)水平均高于正常对照组,HDL-C、KIV-2拷贝数低于正常对照组,差异均有统计学意义(P<0.05),而冠心病组与糖尿病组HDL-C水平比较,差异无统计学意义(P>0.05)。2型糖尿病和冠心病分别与KIV-2拷贝数相关性显著,与Apo(a)颗粒大小相关性不显著,且LP(a)浓度与KIV-2拷贝呈负相关。结论Apo(a)颗粒大小与2型糖尿病和冠心病无明显相关性,而KIV-2拷贝数与2型糖尿病和冠心病有明显相关性。检测KIV-2拷贝数可为2型糖尿病和冠心病的诊断与治疗提供依据。
文摘目的:探索大鼠左冠状动脉前降支不同结扎处理后,对心肌形态学及心功能的影响,以建立适合移植干细胞再生修复心肌梗死研究的稳定、可靠和更合乎发病机理的动物模型。方法:雄性W istar大鼠70只,随机分为六组即:假手术组、结扎(15 m in、30 m in、45 m in、60 m in)再灌、结扎非再灌。于处理后1 d、1周、2周或4周动态观察心肌梗死变化,并于处理一月后测量动脉收缩压(ASP)、动脉舒张压(ADP)、左室收缩压(LVSP)、左室舒张末压(LV-EDP)及左室压力上升及下降最大速度(±dp/dtm ax)。结果:引起明显的心肌梗死至少需要结扎30 m in。结扎(45m in、60 m in)再灌、结扎非再灌的心肌梗死明显,并观察到梗死区域心肌已绝大部分纤维化,且梗死面积变化较恒定。同时测定不同结扎时间心功能的变化发现,结扎(45 m in、60 m in)再灌或结扎非再灌各组ASP、ADP、LVSP、±dp/dtm ax显著下降,LVEDP明显升高。并且不同结扎时间处理后,大鼠心功能的变化与心肌梗死后的梗死面积变化密切相关。结论:建立了在实验大鼠左冠状动脉前降支中上1/3处结扎45 m in以上的大鼠心肌梗死模型,不仅合乎临床心肌梗死的发病机理,而且梗死部位、梗死区域面积稳定,适合于移植细胞再生修复心肌梗死的研究。
文摘为了提高大型无线传感器网络的稳定性,延长网络出现首个节点的死亡时间,提出一种基于簇结构稳定的分环多跳路由算法CBSM(Cluster structure stability based Sub-ring algorithm over multi-hop routing).CBSM算法将监测区域划分为许多固定小区,采用基于节点剩余能量和节点位置的代价函数选择簇头.仿真结果表明,基于簇结构稳定的多跳路由算法,能有效延长网络出现首个节点死亡的时间,提高整个网络的稳定性.
