Heat-sensitive moxibustion attenuates the inflammation after focal cerebral ischemia/ reperfusion injury

Heat-sensitive moxibustion has neuroprotective effects against focal cerebral ischemia/reperfusion injury, however its mechanism of action remains unclear. In this study, rat models of focal cerebral ischemia/reperfusion injury were treated with suspended moxibustion at acupoint Dazhui （DU14） for 35 minutes. Results showed that suspended moxibustion decreased infarct volume, reduced cortical myeloperoxidase activity, and suppressed serum levels of proinflammatory cytokines in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings indicated that heat-sensitive moxibustion can attenuate inflammation and promote repair after focal cerebral ischemia/reperfusion injury.

Anti-inflammatory Effect of Heat-sensitive Moxibustion via the NF-κB Signaling Pathway on Cerebral Ischemia/Reperfusion Injury in Rats

Ischemic stroke is universally acknowledged as a common cause of long-term disability or even death. Suspended moxibustion, an indirect form of moxibustion, is when moxibustion is placed superficially over the skin without being in contact with it. Some researchers have used this method to treat stroke patients, but strong evidence of its therapeutic effectiveness is lacking. However, the effect of traditional suspended moxibustion has recently been improved with the development of heat-sensitive suspended moxibustion. Our previous studies showed that moxibustion for 35 min provided a more effective treatment strategy than moxibustion for 15 min, and moxibustion by 35 min with tail temperature increase had a better outcome than that without, however, the mechanism underlying the effect is not clear. In this study, we treated the stroke rats with moxibustion by 35min and divided them into non-heat sensitive moxibustion(NHSM) group and heat sensitive moxibustion (HSM) group according to difference in the tail temperature increase, then we compared the effect and investigated the mechanisms between NHSM and HSM. We found that HSM significantly decreased tail-flick latency, increased neurological function score, decreased infarct volume, reduced inflammatory cells, decreased the expression of inflammatory factor ICAM-1 and reduced the expression of NF-κB p65 and p-IKKα/β in rats with focal cerebral ischemia/reperfusion injury. Our experimental findings revealed that HSM exerted its anti-inflammatory and neuroprotective effects from MCAO-induced injury by decreasing the expression of the NF-κB signaling pathway.

The molecular mechanism of meridian qi sensory transmission by heat-sensitive moxibustion in the treatment of cerebral infarction

Background:To explore the potential mechanism of thermal moxibustion in the treatment of i schemic strok e by using the method of network pharmacology and to partially explain the mechanism of acupoint meridian qi sense transmission.Methods:In this project,a training set was formed by researching the intersection of the reported components of M ugwort leaves that entered the blood after combustion and obtained the targets of heat-sensitive moxibustion meridian qi sensing and thermal effect by querying the literature.The Encyclopedia of Tr ad itional Chinese Medicine is used to search and screen the highly active chemical constituents of Artemisia argyi to predict potential targets;search i schemic strok e-related targets through GeneCards,O nline Mendelian Inheritance in Man,Drugbank databases.Gene Oncology functional analysis and Kyoto Encyclopedia of Genes and Genomes signaling pathway enrichment analysis were performed on the potential targets of the blood components of Artemisia argyi and molecular docking simulated the binding activity of key candidate active components and core genes.Results:192 ischemic stroke disease targets with r elevance score greater than 10 were screened out for analysis.Through the database Encyclopedia of Tr ad itional Chinese Medicine query of the action targets(243)of Mugwort leaves and the intersection of heat-sensitive moxibustion effect targets and ischemic stroke-related targets,a Venn diagram was drawn and a total of 17 were obtained.Finally,the effective components of Mugwort leaves into the blood were screened out.Five main volatile components were molecularly docked with 17 targets and 9 targets of acupoint meridian gas sensing/thermal effect.The docking results showed that the main volatile components showed good affinities for binding to key targets,respectively.Conclusion:Using the characteristics of“multi-component-multi-target-multi-pathway”of traditional Chinese medicine,the potential mechanism of action of Artemisia argyi in the treatment of i schemic strok e is explored,which provides a certain basis for the follow-up scientific research and clinical application of Artemisia argyi in the treatment of IS.

Effect and cerebral mechanism of moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation and myofascial pain syndrome by resting-state functionality magnetic resonance imaging:protocol for an observational study

We want to explore the analgesic brain effect of the moxibustion at heat-sensitized Yaoyangguan(GV3)in patients with lumbar disc herniation(LDH)and myofascial pain syndrome(MPS).In an assessor-blinded observational study,we will include 15 LDH and 15 MPS.They will accept same treatment of heat-sensitive moxibustion at Yaoyangguan(GV3).The resting-state functionality magnetic resonance imaging image data of brain activities before and after treatment will be analyzed by mean fractional amplitude of low-frequency fluctuation,regional homogeneity analysis and brain functional connection.We select seed of first sensory cortex,second sensory cortex,insula cortex,periaqueductal gray and anterior cingulate cortex as the regions of interest to analyse the relationship between brain functional connectivity of pain-related networks and clinical data.Our study could disclose key brain targets and central response characteristics of the analgesic brain effect and the brain functional connection of heat-sensitive moxibustion.

基于CiteSpace可视化分析热敏灸研究热点与发展趋势

目的:通过对热敏灸相关文献进行可视化分析,探讨热敏灸的研究现状、发展趋势、研究热点及前沿。方法:以2006年1月1日至2020年10月25日国家知识基础设施数据库(CNKI)收录的热敏灸相关文献为研究对象,采用CiteSpace5.7.R1软件绘制知识图谱、分析相关数据。结果:共纳入相关文献1387篇,作者合作共现图谱共有431个节点、566条连线,陈日新处于中心地位;机构合作图谱共有348个节点,196条连线,以江西中医药大学及其附属医院形成的合作网络为主。研究热点是颈椎病和膝骨性关节炎,研究前沿是生命质量、失眠和疼痛。结论:知识图谱分析可直观、快速地展现2006年1月1日至2020年10月25日间国内对热敏灸研究领域的总体发展态势、研究热点和前沿内容,为进一步研究提供可参考的数据和发展方向,此次研究结果具有相对参考价值。

热敏灸结合等速肌力训练对中风偏瘫下肢运动功能的影响

目的:探讨热敏灸结合等速肌力训练对脑卒中偏瘫患者下肢运动功能的影响。方法:选择符合标准的100例脑卒中后偏瘫患者,采用随机数字表法分为治疗组和对照组,每组各50例。对照组给予常规康复训练联合等速肌力训练,观察组在对照组的基础上给予热敏灸治疗。观察2组治疗前后Fugl-Meyer评定量表(FMA)下肢部分评分、步态分析、偏瘫侧踝关节主动活动度(AROM)、Barthel指数(BI)。结果:2组治疗后FMA、AROM、BI、步长、步频和步速与治疗前相比较均显著升高,差异均有统计学意义(P<0.05);观察组治疗后FMA、AROM、BI、步长、步频和步速与同期对照组相比较均显著升高,差异均有统计学意义(P<0.05)。结论:热敏灸结合等速运动训练可促进脑卒中后偏瘫患者下肢功能恢复,值得临床推广应用。

中医灸法治疗卵巢损伤的临床疗效和实验研究进展

This review summarizes the clinical efficacy and experimental research of traditional Chinese medicine(TCM)moxibustion in the intervention of ovarian injury.Clinical and experimental research results have shown that as a nonpharmacological treatment method,Chinese medical moxibustion therapy is of great significance in the treatment of ovarian injuries such as diminished ovarian reserve,polycystic ovarian syndrome,premature ovarian failure,and premature ovarian insufficiency.Moxibustion,heat-sensitive moxibustion,and electroacupuncture have significant effects in improving ovarian func-tion,overall treatment efficacy,pregnancy rate,ovulation rate,and sex hormone levels and have higher safety.Their therapeutic mechanisms have also been demonstrated.In conclusion,TCM moxibustion therapy has a significant effect in the treatment of ovarian injury,providing a new option for the treatment of the ovarian injury.

热敏灸得气灸感量表的研制与初步评价

建立基于热敏灸理论的、广泛适用的、反映艾灸得气的量表。通过文献法和访谈法,对灸感词汇条目进行收集,建立备选条目池;再通过专家问卷、患者问卷以及核心小组专家讨论,采用主观评价法对条目进行筛选并量化,建立热敏灸得气灸感量表初稿。量表初稿对121例患者预调查,通过探索性因子分析(主要成分)检测量表的结构效度,使用克朗巴赫系数评估量表的内部一致性。热敏灸得气灸感量表条目池由最初的36条削减为9条;回收有效调查量表110份进行统计分析,最终热敏灸得气灸感量表V 1.0包含9个条目,4个维度。其中,全身舒适情感体验3个条目,自主神经反应3个条目,热感传2个条目,非热觉1个条目。热敏灸得气灸感量表具有较好的内容和结构效度,符合目前对热敏得气灸感的临床认识,临床操作性强,具有广泛的适应性。

热敏灸辅助治疗普通型新冠肺炎42例

Objective:To observe the clinical therapeutic effect of adjuvant treatment with heat-sensitive moxibustion for coronavirus disease 2019(COVID-19)of the ordinary type.Methods:A total of 42 patients with COVID-19 of the ordinary type were adopted.Shenque(神阙CV8)and Tianshu(天枢ST25)were selected.Heat-sensitive moxibustion was operated according to the required standard,40 min to 60 min each time,once daily.Before and after moxibustion,the improvements in clinical symptoms were evaluated,such as chest oppression,poor appetite,lassitude and negative emotions.Results:(1)The number of cases and the incidence was 21 cases(50.0%),24 cases(57.1%)and 26 cases(61.9%)for chest oppression,poor appetite and lassitude before heat-sensitive moxibustion.The number of cases was reduced to be 10 cases(23.8%),7 cases(16.7%)and 4 cases(9.5%)after the 1 st treatment of heat-sensitive moxibustion for chest oppression,poor appetite,and lassitude.It was reduced to be 11 cases(26.2%),8 cases(19.0%)and 4 cases(9.5%)after the 2 nd treatment of moxibustion and it was reduced to be 18 cases(42.9%),10 cases(23.8%)and 6 cases(14.3%)after the 3 rd treatment of moxibustion.The incidences of the symptoms were all reduced obviously as compared with those before treatment.(2)Before treatment with heat-sensitive moxibustion,there were 24 cases of negative emotions(57.1%).It was reduced to be 16 cases(38.1%),11 cases(26.2%)and 3 cases(7.1%)after the 1 st,2 nd and 3 rd treatment of heat-sensitive moxibustion successively.The incidences were all reduced obviously as compared with those before treatment.(3)After the 1 st treatment,the active acceptance rate of heat-sensitive moxibustion was 100%(42/42)in the patients,higher than 11.9%(5/42)before treatment.Conclusion:Adjuvant treatment with heat-sensitive moxibustion effectively relieves the symptoms of COVID-19 such as chest oppression,poor appetite and lassitude,and alleviates the negative emotions,such as tension and anxiety.This therapy improves the therapeutic effect of COVID-19 and deserves to be promoted in clinical practice.

陈日新教授论灸感

热敏灸感是人体在疾病状态下施灸某一穴位时,被灸者产生远部和深部的热感,甚至热至病所,而非局部与表面的热感。陈日新教授在临床实践中系统研究了热敏灸感现象及其临床规律,阐明了不同的热敏灸感携带着机体不同的生理病理信息,可以反映病情,在临床施灸过程中应重视热敏信息的采集;根据具体的热敏灸感类型、热感强度可以指导临床灸疗选穴与准确定位;根据热敏灸感的产生与消失,可以指导灸疗确立个体化充足灸量,以"热敏灸感消失为度"作为充足灸疗时间,突破了灸疗临床以每穴固定施灸时间的观念,为临床充分发挥灸疗疗效提供了量学标准;提出判断灸疗适应证的标准,即凡是出现热敏灸感的病症就是灸疗的最佳适应证。深入全面认识热敏灸感的产生、变化规律,有利于指导灸疗的规范操作与灸疗疗效的提高。