To evaluate the clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema.Methods:One hundred and twenty patients with chronic eczema...To evaluate the clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema.Methods:One hundred and twenty patients with chronic eczema were randomly divided into an experimental group(60 cases)and a control group(60 cases).The experimental group was treated with skin acupuncture combined with external washing therapy,and the control group was treated with externally applied mometasone furoate cream.The patients’symptoms and total severity were scored and analyzed before and after the 4-week treatment.The symptoms scored included:erythema,papule/hard swelling,epidermal exfoliation,mossy lesion,exudation/scab,and pruritus.Clinical efficacy and adverse reactions were compared before and after the 4-week treatment.Results:Scores for the different kinds of skin derogation,pruritus symptoms,the eczema area,and severity index(EASI)were all reduced after the treatments.Pruritus symptoms and EASI scores in the experimental group were lower than those of the control group(P<0.05).The total effective rate in the experimental group was 81.03%,which was much higher than the 61.11%in the control group(Z=-2.391,P=0.017).Conclusion:The clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema was better than that of mometasone furoate cream.展开更多
Objective To explore the effect of acupuncture combined with medicated thread moxibustion of Zhuang medicine on insomnia rats. Methods Sixty SPF Wistar rats were randomly divided into four groups, including a normal c...Objective To explore the effect of acupuncture combined with medicated thread moxibustion of Zhuang medicine on insomnia rats. Methods Sixty SPF Wistar rats were randomly divided into four groups, including a normal control group （control group）, a sham operation group, a model group and a treatment group, with 15 rats in each group. In the model group and treatment group, insomnia model were established by injecting orexin into lateral ventricle of rats. In the sham operation group, artificial cerebrospinal fluid was injected into lateral ventricle of rats, and the rats in control group were not treated. On the basis of modeling, the rats in treatment group were treated by acupuncture combined with medicated thread moxibustion of Zhuang medicine which was conducted once a day, and the treatment lasted for 14 days. The expression of orexin mRNA and orexin content were detected, and the changes of associated receptors, including orexin 1 receptor （OX I R） and orexin 2 receptor （OX 2 R） were observed. Results The expression of orexin mRNA in model group （6.54 ± 1.21） significantly increased when compared with control group （0.66±0.12, P〈0.01）, and orexin content in model group [（i 156.35±126.88） pg/mL] significantly increased when compared with control group [（427.12_± 32.54） pg/mL, P〈O.OI]. The expression of orexin mRNA in treatment group （0.87 ± 0.26） significantly reduced when compared with the model group （P〈0.01）, and orexin content in the treatment group [（585.23 ± 89.21） pg/mL] significantly reduced when compared with the model group （P〈O.01）. The percentage of OX I R positive cells in the model group （0.64±0.15） significantly increased when compared with the control group （0.21±0.03, P〈0.01）, and the percentage of OX 2 R positive cells in the model group （0.76±0.18） significantly increased when compared with the control group （0.24±0.01, P〈O.01）. The percentage of OX 1 R positive cells in the treatment group （0.36_±0.08） significantly reduced when compared with the model group （P〈0.01）. The percentage of OX 2 R positive cells in treatment group （0.25_± 0.03） significantly reduced when compared with model group （P〈0.01）. Conclusion It might be an effective link of acupuncture combined with medicated thread moxibustion of Zhuang medicine in treatment of insomnia that the treatment could inhibit the awakening promotion effect of orexin by affecting orexin, OX I R and OX 2 R.展开更多
文摘To evaluate the clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema.Methods:One hundred and twenty patients with chronic eczema were randomly divided into an experimental group(60 cases)and a control group(60 cases).The experimental group was treated with skin acupuncture combined with external washing therapy,and the control group was treated with externally applied mometasone furoate cream.The patients’symptoms and total severity were scored and analyzed before and after the 4-week treatment.The symptoms scored included:erythema,papule/hard swelling,epidermal exfoliation,mossy lesion,exudation/scab,and pruritus.Clinical efficacy and adverse reactions were compared before and after the 4-week treatment.Results:Scores for the different kinds of skin derogation,pruritus symptoms,the eczema area,and severity index(EASI)were all reduced after the treatments.Pruritus symptoms and EASI scores in the experimental group were lower than those of the control group(P<0.05).The total effective rate in the experimental group was 81.03%,which was much higher than the 61.11%in the control group(Z=-2.391,P=0.017).Conclusion:The clinical efficacy of combined skin acupuncture and external washing therapy of Zhuang nationality medicine in the treatment of chronic eczema was better than that of mometasone furoate cream.
基金Supported by National Natural Science Foundation of China:81360579
文摘Objective To explore the effect of acupuncture combined with medicated thread moxibustion of Zhuang medicine on insomnia rats. Methods Sixty SPF Wistar rats were randomly divided into four groups, including a normal control group （control group）, a sham operation group, a model group and a treatment group, with 15 rats in each group. In the model group and treatment group, insomnia model were established by injecting orexin into lateral ventricle of rats. In the sham operation group, artificial cerebrospinal fluid was injected into lateral ventricle of rats, and the rats in control group were not treated. On the basis of modeling, the rats in treatment group were treated by acupuncture combined with medicated thread moxibustion of Zhuang medicine which was conducted once a day, and the treatment lasted for 14 days. The expression of orexin mRNA and orexin content were detected, and the changes of associated receptors, including orexin 1 receptor （OX I R） and orexin 2 receptor （OX 2 R） were observed. Results The expression of orexin mRNA in model group （6.54 ± 1.21） significantly increased when compared with control group （0.66±0.12, P〈0.01）, and orexin content in model group [（i 156.35±126.88） pg/mL] significantly increased when compared with control group [（427.12_± 32.54） pg/mL, P〈O.OI]. The expression of orexin mRNA in treatment group （0.87 ± 0.26） significantly reduced when compared with the model group （P〈0.01）, and orexin content in the treatment group [（585.23 ± 89.21） pg/mL] significantly reduced when compared with the model group （P〈O.01）. The percentage of OX I R positive cells in the model group （0.64±0.15） significantly increased when compared with the control group （0.21±0.03, P〈0.01）, and the percentage of OX 2 R positive cells in the model group （0.76±0.18） significantly increased when compared with the control group （0.24±0.01, P〈O.01）. The percentage of OX 1 R positive cells in the treatment group （0.36_±0.08） significantly reduced when compared with the model group （P〈0.01）. The percentage of OX 2 R positive cells in treatment group （0.25_± 0.03） significantly reduced when compared with model group （P〈0.01）. Conclusion It might be an effective link of acupuncture combined with medicated thread moxibustion of Zhuang medicine in treatment of insomnia that the treatment could inhibit the awakening promotion effect of orexin by affecting orexin, OX I R and OX 2 R.
