From rhizomes of Hemsleya giganthy collected in Shichuan of China, 16 compounds were isolated. Among them, three compounds (8, 9, 15) are new natural products called Hemslecins G; Hemsgiganosides A and B; respectivel...From rhizomes of Hemsleya giganthy collected in Shichuan of China, 16 compounds were isolated. Among them, three compounds (8, 9, 15) are new natural products called Hemslecins G; Hemsgiganosides A and B; respectively. Their structures were elucidated as 7- hydroxy-23, 24-dihydro-cucurbitacin F-25-O-acetate (8); 3-O-(6-butyl ester-)-b-D-glu- curono- pyranosyl)-oleanolic acid-28-O-a-L-arabinopyranoside(9); 3-O-b-D-glucuropyranosyl oleanolic acid -28-O-b-D-gluco pyranosyl-(16)- b-D-glucopyranoside(15) by spectroscopic and chemical means.展开更多
Two new cucurbitacins,jinfushanencins A(1)and B(2),seven new cucurbitane glycosides,jinfushanosides E-K(3-9),along with nine known analogues,were obtained from the tubers of Hemsleya penxianensis.Their structures were...Two new cucurbitacins,jinfushanencins A(1)and B(2),seven new cucurbitane glycosides,jinfushanosides E-K(3-9),along with nine known analogues,were obtained from the tubers of Hemsleya penxianensis.Their structures were elucidated on the basis of extensive spectroscopic and chemical methods.Selected isolates were tested their anti-HIV-1 activities,and compound 5 showed weak anti-HIV-1 in C8166 cell(EC50=5.9μg/mL)with a selectivity index of 13.5.展开更多
Three new cucurbitacins were isolated from the BuOH extract of the rhizomes of Hemsleya lijiangensis. Their structures were elucidated as 23, 24 -dihydro cucurbitacin F-16, 25-diacetate(1), 23, 24-dihydro cucurbitaci...Three new cucurbitacins were isolated from the BuOH extract of the rhizomes of Hemsleya lijiangensis. Their structures were elucidated as 23, 24 -dihydro cucurbitacin F-16, 25-diacetate(1), 23, 24-dihydro cucurbitacin F-16, 25-diacetate-2-O-β-D glucopyranoside (2), 23, 24-dihydro-cucurbitacin F-16-acetate(3), respectively; by spectral analyses.展开更多
Two new compounds, oleanolic acid 28-O--D-glucopyranosyl-3-O--L-arabinopyrano- syl-(13)-(6-butyl ester)--D-glucuropyranoside 1, oleanolic acid 28-O--D-glucopyranosyl- (16)--D-glucopyranoside 2 have been isolated from ...Two new compounds, oleanolic acid 28-O--D-glucopyranosyl-3-O--L-arabinopyrano- syl-(13)-(6-butyl ester)--D-glucuropyranoside 1, oleanolic acid 28-O--D-glucopyranosyl- (16)--D-glucopyranoside 2 have been isolated from the roots of Hemsleya penxianensis var. gulinensis. Their structures were determined on the bases of the spectral and chemical evidences.展开更多
从采自四川汉源县的古蔺雪胆 (Hemsleyapenxianensisvar.gulinensis)中分到 9个三萜皂苷化合物 ,通过化学反应和光谱方法鉴定了它们的结构。其中 7个为已知化合物 ,分别为齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (1) ,3 O β D 吡喃葡萄糖...从采自四川汉源县的古蔺雪胆 (Hemsleyapenxianensisvar.gulinensis)中分到 9个三萜皂苷化合物 ,通过化学反应和光谱方法鉴定了它们的结构。其中 7个为已知化合物 ,分别为齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (1) ,3 O β D 吡喃葡萄糖醛基齐墩果酸苷 (3) ,3 O β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O α L 吡喃阿拉伯糖苷 (4 ) ,3 O β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (5 ) ,3 O α L 阿拉伯糖基 (1→ 3) β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (6 ) ,3 O (6′ 丁酯 ) β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O α L 阿拉伯糖苷 (7) ,3 O (6′ 丁酯 ) β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (8)。两个新化合物 ,即雪胆皂苷A (2 )和雪胆皂苷B (9)。展开更多
基金The authors are grateful to the financial support of the National Natural Science Foundation of China(Grant No.39970086)Natural Science Foundation of Yunnan(Grant No.98C089M)also thank the members of analytical group in Phytochemistry LaboratoTy,Kunming Institute of Botany for their measuring spectral data.
文摘From rhizomes of Hemsleya giganthy collected in Shichuan of China, 16 compounds were isolated. Among them, three compounds (8, 9, 15) are new natural products called Hemslecins G; Hemsgiganosides A and B; respectively. Their structures were elucidated as 7- hydroxy-23, 24-dihydro-cucurbitacin F-25-O-acetate (8); 3-O-(6-butyl ester-)-b-D-glu- curono- pyranosyl)-oleanolic acid-28-O-a-L-arabinopyranoside(9); 3-O-b-D-glucuropyranosyl oleanolic acid -28-O-b-D-gluco pyranosyl-(16)- b-D-glucopyranoside(15) by spectroscopic and chemical means.
基金supported by the Natural Science Foundation of Yunnan Province(2008CD158)the Western Doctoral Foundation of Chinese Academy of Sciences(J.C.Chen)+1 种基金the Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China,Kunming Institute of Botany,Chinese Academy of Sciences(P2008ZZ23,P2010ZZ14)the Cooperative Project of Guangdong Province and CAS(2009B091300135).
文摘Two new cucurbitacins,jinfushanencins A(1)and B(2),seven new cucurbitane glycosides,jinfushanosides E-K(3-9),along with nine known analogues,were obtained from the tubers of Hemsleya penxianensis.Their structures were elucidated on the basis of extensive spectroscopic and chemical methods.Selected isolates were tested their anti-HIV-1 activities,and compound 5 showed weak anti-HIV-1 in C8166 cell(EC50=5.9μg/mL)with a selectivity index of 13.5.
基金The authors are grateful to the financial support of the National Natural Sciences Foundation of China (Grant No.39970086) and the Natural Science Foundation of Yunnan (Grant No.98C089M) also thank the members of analytical group in Phytochemistry Labo
文摘Three new cucurbitacins were isolated from the BuOH extract of the rhizomes of Hemsleya lijiangensis. Their structures were elucidated as 23, 24 -dihydro cucurbitacin F-16, 25-diacetate(1), 23, 24-dihydro cucurbitacin F-16, 25-diacetate-2-O-β-D glucopyranoside (2), 23, 24-dihydro-cucurbitacin F-16-acetate(3), respectively; by spectral analyses.
基金supported by Natural Science Foundation of Yunnan and National Natural Science Foundation of China (Grant No.98C089M and No.39970086). The authors were grateful to the Departmental of Instrument Analysis Kunming Institute of Botany Chinese Academy o
文摘Two new compounds, oleanolic acid 28-O--D-glucopyranosyl-3-O--L-arabinopyrano- syl-(13)-(6-butyl ester)--D-glucuropyranoside 1, oleanolic acid 28-O--D-glucopyranosyl- (16)--D-glucopyranoside 2 have been isolated from the roots of Hemsleya penxianensis var. gulinensis. Their structures were determined on the bases of the spectral and chemical evidences.
基金ProgramgrantedbytheNaturalSciencesFoundationofChina (No .39970 0 86 )andYunnanProvince(No .98C0 89M)
文摘从采自四川汉源县的古蔺雪胆 (Hemsleyapenxianensisvar.gulinensis)中分到 9个三萜皂苷化合物 ,通过化学反应和光谱方法鉴定了它们的结构。其中 7个为已知化合物 ,分别为齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (1) ,3 O β D 吡喃葡萄糖醛基齐墩果酸苷 (3) ,3 O β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O α L 吡喃阿拉伯糖苷 (4 ) ,3 O β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (5 ) ,3 O α L 阿拉伯糖基 (1→ 3) β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (6 ) ,3 O (6′ 丁酯 ) β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O α L 阿拉伯糖苷 (7) ,3 O (6′ 丁酯 ) β D 吡喃葡萄糖醛基 -齐墩果酸 2 8 O β D 吡喃葡萄糖苷 (8)。两个新化合物 ,即雪胆皂苷A (2 )和雪胆皂苷B (9)。
