Aiming at the prior medical knowledge that hepatic ascites only occurs in the severe period of liver cirrhosis, and the severe rupture of the liver capsule curve, when ascites occurs visually, can easily lead to the w...Aiming at the prior medical knowledge that hepatic ascites only occurs in the severe period of liver cirrhosis, and the severe rupture of the liver capsule curve, when ascites occurs visually, can easily lead to the wrong location of the liver capsule, a transposed grayscale statistical threshold method is proposed to solve the problem. Realize the identification of liver ascites. By analyzing the visual characteristics of the liver image, the gray value of the upper half of the ultrasound image is counted column by column from a mathematical point of view, the gray distribution curve is drawn, and the relevant threshold is set for corresponding judgment. At the same time, the gray value above the ascites detection boundary is set to zero. The ablation experiment proved that the ascites detection method and post-processing operation proposed in this paper provide effective support for the precise positioning of the liver capsule curve, quantitative analysis and diagnosis of liver cirrhosis in the later stage. The Hessian matrix is sensitive to linear structure to achieve image enhancement. In view of the low accuracy of the existing liver envelope curve detection method and the incomplete quantitative evaluation of liver cirrhosis, it is proposed to use drift iteration under the synergistic effect of multiple filters. A search algorithm extracts the liver capsule.展开更多
BACKGROUND Autotaxin(ATX)has been reported as a direct biomarker for estimating the evaluation of liver fibrosis.But available data on ATX as a useful biomarker for the complications of liver cirrhosis(LC)are scant.AI...BACKGROUND Autotaxin(ATX)has been reported as a direct biomarker for estimating the evaluation of liver fibrosis.But available data on ATX as a useful biomarker for the complications of liver cirrhosis(LC)are scant.AIM To assess the clinical usefulness of ATX for assessing the complications of LC.METHODS This multicenter,retrospective study was conducted at six locations in Japan.We include patients with LC,n=400.The ATX level was evaluated separately in men and women because of its high level in female patients.To assess the clinical usefulness of ATX for the complications of LC,the area under the curve(AUC)of ATX assessing for the severe complications was analyzed in comparison with the model for end-stage liver disease score,albumin-bilirubin(ALBI)score,fibrosis-4 index,and aspartate aminotransferase-to-platelet ratio index.RESULTS The mean age was 68.4±11.4 years,240 patients(60.0%)were male.A total of 213(53.3%)and 187(46.8%)patients were compensated and decompensated,respectively.The numbers of patients with varix rupture,hepatic ascites,and hepatic encephalopathy were 35(8.8%),131(32.8%),and 103(25.8%),respectively.The AUCs of ATX in men for hepatic encephalopathy,hepatic ascites,and varix ruptures were 0.853,0.816,and 0.706,respectively.The AUCs of ATX in women for hepatic encephalopathy,hepatic ascites,and varix rupture were 0.759,0.717,and 0.697,respectively.The AUCs of ATX in men were higher than those in women,as were all the other biomarkers used to detect encephalopathy and varix ruptures.However,for detecting ascites,the AUC of ALBI in men was more effective than using ATX.CONCLUSION ATX in men was more effective than any other biomarkers for detecting hepatic encephalopathy and varix ruptures.展开更多
文摘Aiming at the prior medical knowledge that hepatic ascites only occurs in the severe period of liver cirrhosis, and the severe rupture of the liver capsule curve, when ascites occurs visually, can easily lead to the wrong location of the liver capsule, a transposed grayscale statistical threshold method is proposed to solve the problem. Realize the identification of liver ascites. By analyzing the visual characteristics of the liver image, the gray value of the upper half of the ultrasound image is counted column by column from a mathematical point of view, the gray distribution curve is drawn, and the relevant threshold is set for corresponding judgment. At the same time, the gray value above the ascites detection boundary is set to zero. The ablation experiment proved that the ascites detection method and post-processing operation proposed in this paper provide effective support for the precise positioning of the liver capsule curve, quantitative analysis and diagnosis of liver cirrhosis in the later stage. The Hessian matrix is sensitive to linear structure to achieve image enhancement. In view of the low accuracy of the existing liver envelope curve detection method and the incomplete quantitative evaluation of liver cirrhosis, it is proposed to use drift iteration under the synergistic effect of multiple filters. A search algorithm extracts the liver capsule.
文摘BACKGROUND Autotaxin(ATX)has been reported as a direct biomarker for estimating the evaluation of liver fibrosis.But available data on ATX as a useful biomarker for the complications of liver cirrhosis(LC)are scant.AIM To assess the clinical usefulness of ATX for assessing the complications of LC.METHODS This multicenter,retrospective study was conducted at six locations in Japan.We include patients with LC,n=400.The ATX level was evaluated separately in men and women because of its high level in female patients.To assess the clinical usefulness of ATX for the complications of LC,the area under the curve(AUC)of ATX assessing for the severe complications was analyzed in comparison with the model for end-stage liver disease score,albumin-bilirubin(ALBI)score,fibrosis-4 index,and aspartate aminotransferase-to-platelet ratio index.RESULTS The mean age was 68.4±11.4 years,240 patients(60.0%)were male.A total of 213(53.3%)and 187(46.8%)patients were compensated and decompensated,respectively.The numbers of patients with varix rupture,hepatic ascites,and hepatic encephalopathy were 35(8.8%),131(32.8%),and 103(25.8%),respectively.The AUCs of ATX in men for hepatic encephalopathy,hepatic ascites,and varix ruptures were 0.853,0.816,and 0.706,respectively.The AUCs of ATX in women for hepatic encephalopathy,hepatic ascites,and varix rupture were 0.759,0.717,and 0.697,respectively.The AUCs of ATX in men were higher than those in women,as were all the other biomarkers used to detect encephalopathy and varix ruptures.However,for detecting ascites,the AUC of ALBI in men was more effective than using ATX.CONCLUSION ATX in men was more effective than any other biomarkers for detecting hepatic encephalopathy and varix ruptures.
