Purpose To review the efficacy and safety of pegylated interferons (peginterferons) in the treatment of chronic hepatitis C Data sources An English language literature search (MEDLINE 1988-2001) was performed and a...Purpose To review the efficacy and safety of pegylated interferons (peginterferons) in the treatment of chronic hepatitis C Data sources An English language literature search (MEDLINE 1988-2001) was performed and a total of 19 original articles related to the issue were selected Data extraction After careful review of the selected papers, the meaningful results and conclusions were extracted using scientific criteria The papers reviewed pertained mainly to the efficacy and safety profiles of peginterferons in the treatment of chronic hepatitis C Results Peginterferon can effectively prolong the half-life of interferon and can be effectively administered conveniently as a once-a-week dose The antiviral effect using peginterferon was enhanced compared with that of standard interferon, but the frequency and severity of adverse events were typical of those associated with interferon-α Conclusions Based on its efficacy, safety and convenient dosing, peginterferon is more favorable than standard interferon in the treatment of chronic hepatitis C展开更多
Background It has been known that intra-cellualr immunity is important for defense against viral infections and this function lies with interferon gamma (INF-γ). Here we evaluated the role of IFN-γ system in the p...Background It has been known that intra-cellualr immunity is important for defense against viral infections and this function lies with interferon gamma (INF-γ). Here we evaluated the role of IFN-γ system in the pathogenesis of chronic hepatitis C (CHC). Methods The levels of interferon gamma receptor alpha (IFNGRα) on the peripheral lymphocyte membrane were assayed with flow cytometry. The plasma concentrations of the cytokines IFN-γ and IL-10 in CHC patients and normal controls were assayed by enzume-linked-immunosorbent assay (ELISA). The samples were collected randomly from Xinjiang Autonomous Region,Zhejiang and the northern regions of Jiangsu Province in China. Results The levels of IFNGRα in CHC patients were significantly lower than that of normal controls (NC),especially among patients during the stable stage ( P <0.001),whereas there were no significant differences between CHC in active and stable stages. Among the patients of the three regions,there were no significant differences between patients from Xinjiang and Zhejiang provinces,but both had statistically significant difference compared with the patients from Jiangsu Province ( P <0.001). Plasma IFN-γ and IL-10 concentrations in CHC patients decreased significantly,IFN-γ in particular,but there were no significant differences in these levels between various stages of the disease. The IFN-γ/IL-10 (Th1/Th2 ) ratio in patients was reversed. Conclusion There may be defects in the IFN-γ system in chronic HCV infected subjects and a low immune response,which may play an important role in the persistence of HCV infection.展开更多
文摘Purpose To review the efficacy and safety of pegylated interferons (peginterferons) in the treatment of chronic hepatitis C Data sources An English language literature search (MEDLINE 1988-2001) was performed and a total of 19 original articles related to the issue were selected Data extraction After careful review of the selected papers, the meaningful results and conclusions were extracted using scientific criteria The papers reviewed pertained mainly to the efficacy and safety profiles of peginterferons in the treatment of chronic hepatitis C Results Peginterferon can effectively prolong the half-life of interferon and can be effectively administered conveniently as a once-a-week dose The antiviral effect using peginterferon was enhanced compared with that of standard interferon, but the frequency and severity of adverse events were typical of those associated with interferon-α Conclusions Based on its efficacy, safety and convenient dosing, peginterferon is more favorable than standard interferon in the treatment of chronic hepatitis C
文摘Background It has been known that intra-cellualr immunity is important for defense against viral infections and this function lies with interferon gamma (INF-γ). Here we evaluated the role of IFN-γ system in the pathogenesis of chronic hepatitis C (CHC). Methods The levels of interferon gamma receptor alpha (IFNGRα) on the peripheral lymphocyte membrane were assayed with flow cytometry. The plasma concentrations of the cytokines IFN-γ and IL-10 in CHC patients and normal controls were assayed by enzume-linked-immunosorbent assay (ELISA). The samples were collected randomly from Xinjiang Autonomous Region,Zhejiang and the northern regions of Jiangsu Province in China. Results The levels of IFNGRα in CHC patients were significantly lower than that of normal controls (NC),especially among patients during the stable stage ( P <0.001),whereas there were no significant differences between CHC in active and stable stages. Among the patients of the three regions,there were no significant differences between patients from Xinjiang and Zhejiang provinces,but both had statistically significant difference compared with the patients from Jiangsu Province ( P <0.001). Plasma IFN-γ and IL-10 concentrations in CHC patients decreased significantly,IFN-γ in particular,but there were no significant differences in these levels between various stages of the disease. The IFN-γ/IL-10 (Th1/Th2 ) ratio in patients was reversed. Conclusion There may be defects in the IFN-γ system in chronic HCV infected subjects and a low immune response,which may play an important role in the persistence of HCV infection.
