Hepatobiliary tumor (HBT), one of the leading causes of cancer deaths globally, is more frequent in East Asia including China [1].HBTincludeslivercancer,cholangiocarcinomaandgallbladder cancer.HBTburdenvariesmarkedlyb...Hepatobiliary tumor (HBT), one of the leading causes of cancer deaths globally, is more frequent in East Asia including China [1].HBTincludeslivercancer,cholangiocarcinomaandgallbladder cancer.HBTburdenvariesmarkedlybygenderandgeographic regionduetotheexposureofriskfactors.MajorityofthehepatocellularcarcinomasareassociatedwithhepatitisB-typevirus展开更多
Tumors of the liver and biliary tree,mainly hepatocellular carcinoma and cholangiocarcinoma,are the second leading cause of cancer related death worldwide and the sixth leading cause of cancer related death among men ...Tumors of the liver and biliary tree,mainly hepatocellular carcinoma and cholangiocarcinoma,are the second leading cause of cancer related death worldwide and the sixth leading cause of cancer related death among men in developed countries.Recent developments in biomarkers and imaging modalities have enhanced early detection and accurate diagnosis of these highly fatal malignancies.These advances include serological testing,micro-ribonucleic acids,fluorescence in situ hybridization,contrast-enhanced ultrasound,and hepatobiliary-phase magnetic resonance imaging.In addition,there have been major developments in the surgical and nonsurgical management of these tumors,including expansion of the liver transplantation criteria,new locoregional treatments,and molecularly targeted therapies.In this article,we review various types of hepatobiliary tumors and discuss new developments in their diagnosis and management.展开更多
Hepatobiliary tumors are of high grade of heterogeneity, which is recognized as a key contributor to drug resistance and poor disease prognosis. However, the intrinsic mechanism between heterogeneity and drug response...Hepatobiliary tumors are of high grade of heterogeneity, which is recognized as a key contributor to drug resistance and poor disease prognosis. However, the intrinsic mechanism between heterogeneity and drug response in hepatobiliary tumor is still largely unknown. Using tumor organoid models, Wang and her colleagues have found that cooperation among distinct subpopulations might be a key mechanism for drug resistance in hepatobiliary tumor.展开更多
基金supported by grants from the “919 Tumor Pre-cision Medicine Public Welfare Foundation”the International Sci-ence and Technology Cooperation Projects(2015DFA30650 and 2016YFE0107100)+2 种基金Chinese Academy of Medical Sciences(CAMS) Innovation Fund for Medical Sciences(CIFMS)(2017-I2M-4-003)the Capital Special Research Project for the Clinical Application(Z151100004015170)Beijing Natural Science Foundation Haid-ian Joint Fund Frontier Project(L172055)
文摘Hepatobiliary tumor (HBT), one of the leading causes of cancer deaths globally, is more frequent in East Asia including China [1].HBTincludeslivercancer,cholangiocarcinomaandgallbladder cancer.HBTburdenvariesmarkedlybygenderandgeographic regionduetotheexposureofriskfactors.MajorityofthehepatocellularcarcinomasareassociatedwithhepatitisB-typevirus
文摘Tumors of the liver and biliary tree,mainly hepatocellular carcinoma and cholangiocarcinoma,are the second leading cause of cancer related death worldwide and the sixth leading cause of cancer related death among men in developed countries.Recent developments in biomarkers and imaging modalities have enhanced early detection and accurate diagnosis of these highly fatal malignancies.These advances include serological testing,micro-ribonucleic acids,fluorescence in situ hybridization,contrast-enhanced ultrasound,and hepatobiliary-phase magnetic resonance imaging.In addition,there have been major developments in the surgical and nonsurgical management of these tumors,including expansion of the liver transplantation criteria,new locoregional treatments,and molecularly targeted therapies.In this article,we review various types of hepatobiliary tumors and discuss new developments in their diagnosis and management.
文摘Hepatobiliary tumors are of high grade of heterogeneity, which is recognized as a key contributor to drug resistance and poor disease prognosis. However, the intrinsic mechanism between heterogeneity and drug response in hepatobiliary tumor is still largely unknown. Using tumor organoid models, Wang and her colleagues have found that cooperation among distinct subpopulations might be a key mechanism for drug resistance in hepatobiliary tumor.
基金the National Natural Science Foundation of China(U21A20376,82102871,81988101,81903184,81790633,and 81830054)the Innovation Program of Shanghai Municipal Education Commission(2019-01-07-00-07E00065)+1 种基金the National Science Foundation of Shanghai(21XD1404600,21JC1406600,and 22140901000)the China Postdoctoral Science Foundation(2020M671007).
