Laboratory cultures of freshwater cyanobacterium (blue-green alga) Microcystis aeruginosa PCC 7806 was cvaluated for its hepatotoxic effects in rats. The lyophilized cell extract injected intraperitoneally at 1 and 2 ...Laboratory cultures of freshwater cyanobacterium (blue-green alga) Microcystis aeruginosa PCC 7806 was cvaluated for its hepatotoxic effects in rats. The lyophilized cell extract injected intraperitoneally at 1 and 2 LD50 (15.8 and 31.6 mg/kg, respectively) produced significant increase in liver-specific enzymes viz. plasma alkaline phosphatase,γ-glutamyl transferase, lactate dehydrogenase with a concomitant decrease in hepatic glutamic pyruvic transaminase. A corresponding increase in liver body weight index and histopathological changes in liver (degeneration of hepatocytes, congestion and hemorrhage etc.) are indicative of a dose and time dependent hepatotoxic nature of the algal extract展开更多
Drug-induced liver injury(DILI)is one of the leading causes of liver failure and withdrawal of drugs from the market.A poor understanding of the precipitating event aetiology and mechanisms of disease progression has ...Drug-induced liver injury(DILI)is one of the leading causes of liver failure and withdrawal of drugs from the market.A poor understanding of the precipitating event aetiology and mechanisms of disease progression has rendered the prediction and subsequent treatment intractable.Recent literature suggests that some drugs can alter the liver’s repair systems resulting in injury.The pathophysiology of DILI is complex,and immune dysfunction plays an important role in determining the course and severity of the disease.Immune dysfunction is influenced by the host response to drug toxicity.A deeper understanding of these processes may be beneficial in the management of DILI and aid in drug development.This review provides a structured framework presenting DILI in three progressive stages that summarize the interplay between drugs and the host defence networks.展开更多
Porcine peptides have strong antioxidative activities. The porcine peptides at different doses were administered hepatotoxic mice to investigate their in vivo antioxidant capability. After administration, the activity...Porcine peptides have strong antioxidative activities. The porcine peptides at different doses were administered hepatotoxic mice to investigate their in vivo antioxidant capability. After administration, the activity of superoxide dismutase and glutathione peroxidase in liver and serum was enhanced and malonaldehyde content in liver and serum was greatly decreased. Therefore, the porcine peptides can significantly reduce the damage of active oxygen to body, enhance the body＇s antioxidant capability, and thus maintain health.展开更多
Acute-on-chronic liver failure(ACLF)is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan fai...Acute-on-chronic liver failure(ACLF)is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure.Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies.In this context,this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.展开更多
文摘Laboratory cultures of freshwater cyanobacterium (blue-green alga) Microcystis aeruginosa PCC 7806 was cvaluated for its hepatotoxic effects in rats. The lyophilized cell extract injected intraperitoneally at 1 and 2 LD50 (15.8 and 31.6 mg/kg, respectively) produced significant increase in liver-specific enzymes viz. plasma alkaline phosphatase,γ-glutamyl transferase, lactate dehydrogenase with a concomitant decrease in hepatic glutamic pyruvic transaminase. A corresponding increase in liver body weight index and histopathological changes in liver (degeneration of hepatocytes, congestion and hemorrhage etc.) are indicative of a dose and time dependent hepatotoxic nature of the algal extract
文摘Drug-induced liver injury(DILI)is one of the leading causes of liver failure and withdrawal of drugs from the market.A poor understanding of the precipitating event aetiology and mechanisms of disease progression has rendered the prediction and subsequent treatment intractable.Recent literature suggests that some drugs can alter the liver’s repair systems resulting in injury.The pathophysiology of DILI is complex,and immune dysfunction plays an important role in determining the course and severity of the disease.Immune dysfunction is influenced by the host response to drug toxicity.A deeper understanding of these processes may be beneficial in the management of DILI and aid in drug development.This review provides a structured framework presenting DILI in three progressive stages that summarize the interplay between drugs and the host defence networks.
基金supported by National Natural Science Foundation of China (30270976)Major Science and Technology Projects of Hunan Province (2007FJ1003+1 种基金 2007RS40227) Talents Introduction Fund of Hunan Agricultural University(07YJ07)
文摘Porcine peptides have strong antioxidative activities. The porcine peptides at different doses were administered hepatotoxic mice to investigate their in vivo antioxidant capability. After administration, the activity of superoxide dismutase and glutathione peroxidase in liver and serum was enhanced and malonaldehyde content in liver and serum was greatly decreased. Therefore, the porcine peptides can significantly reduce the damage of active oxygen to body, enhance the body＇s antioxidant capability, and thus maintain health.
基金supported by the National S&T Major Project of China(2017ZX10304402 and 2017ZX10203201)the National Natural Science Foundation of China(81830073,81771196,and 81901901)+1 种基金the State’s Key Project of Re-search and Development Plan of China(2016YFC1101303/4)the National and Zhejiang Provincial special support program for high-level personnel recruitment(Ten-thou-sand Talents Program).
文摘Acute-on-chronic liver failure(ACLF)is a clinical syndrome that develops in patients with chronic liver diseases following a precipitating event and associated with a high mortality rate due to systemic multiorgan failure.Establishing a suitable and stable animal model to precisely elucidate the molecular basis of ACLF pathogenesis is essential for the development of effective early diagnostic and treatment strategies.In this context,this article provides a concise and inclusive review of breakthroughs in ACLF animal model development.
