通心络和阿伐他汀对冠心病患者内皮功能的对比研究

目的 探讨盅药通心络对冠心病患者血管内皮功能不全的改善作用。方法 将 6 0例经冠脉造影证实为冠心病的患者随机分为通心络及阿托伐他汀 (商品名 :立普妥 )治疗组各 30例 ,治疗 3个月前后 ,分别利用高分辨率超声测定肱动脉血流介导的内皮依赖性舒张功能及血脂的变化。结果 治疗前两组患者血脂水平、内皮依赖性舒张功能差异均无统计学意义。治疗 3个月后 ,两组患者血流介导的内皮依赖性血管舒张功能均明显改善 ,通心络组由治疗前的 (8.93± 5 .0 2 ) %升至 (12 .0 4± 4 .98) % (P <0 .0 0 1) ,阿托伐他汀治疗组由治疗前的 (8.6 5± 8.6 3) %升至(11.75± 8.87) % (P <0 .0 0 1)。血胆固醇 (TC)通心络组由 (4 .6 8± 1.0 3)mmol/L下降到 (4 .18± 0 .88)mmol/L ,阿托伐他汀组由 (5 .0 1± 0 .84 )mmol/L下降至 (3.84± 0 .4 3)mmol/L、甘油三酯 (TG)通心络组由 (1.74± 0 .86 )mmol/L下降至 (1.37± 0 .4 9)mmol/L(P <0 .0 5 ) ;阿托伐他汀组由 (1.6 3± 0 .37)mmol/L下降至 (1.0 7± 0 .37)mmol/L(P <0 .0 1)、低密度脂蛋白胆固醇 (LDL C)水平通心络组由 (2 .88± 0 .86 )mmol/L下降至 (2 .85± 0 .4 5 )mmol/L(P <0 .0 5 ) ,阿托伐他汀组由 (3.0 3± 0 .6 5 )mmol/L下降至 (2 .4 5± 0 .2 5 )mmol/

Assessment of antifungal activity of herbal and conventional toothpastes against clinical isolates of Candida albicans

Objective:To detect the anticandidal activity of nine toothpastes containing sodium fluoride, sodium monofluorophosphate and herbal extracts as an active ingredients against 45 oral and non oral Candida albicans(C.albicans) isolates.Methods:The antifungal activity of these toothpaste formulations was determined using a standard agar well diffusion method.Statistical analysis was performed using a statistical package,SPSS windows version 15,by applying mean values using one-way ANOVA with post-hoc least square differences(LSD) method.A P value of less than 0.05 was considered significant.Results:All toothpastes studied in our experiments were effective in inhibiting the growth of all C.albicans isolates.The highest anticandidal activity was obtained from toothpaste that containing both herbal extracts and sodium fluoride as active ingredients, while the lowest activity was obtained from toothpaste containing sodium monofluorophosphate as an active ingredient.Antifungal activity of Parodontax toothpaste showed a significant difference(P<0.001) against C.albicans isolates compared to toothpastes containing sodium fluoride or herbal products.Conclusions:In the present study,it has been demonstrated that toothpaste containing both herbal extracts and sodium fluoride as active ingredients are more effective in control of C.albicans,while toothpaste that containing monofluorophosphate as an active ingredient is less effective against C.albicans.Some herbal toothpaste formulations studied in our experiments,appear to be equally effective as the fluoride dental formulations and it can be used as an alternative to conventional formulations for individuals who have an interest in naturally-based products.Our results may provide invaluable information for dental professionals.

ELISA技术检测中草药对HBeAg的作用

使用 ELISA 技术对250种中草药水提取物进行抗 HBeAg 的实验研究,共筛出有效药物7种(占总数的2.8%)。按5种不同剂量(0.3、0.6、1.2、2.5、5.0mg/100μl)的药物,2.种不同浓度(10.92、14.26P/N 比值)的 HBeAg 与3种不同接触时间(立即、1h、2h)的10项 P/N 比值的均数来综合评价药效指数,7种有效药物依次为山渣叶(1.64)、梧桐子(2.41)、天名精(2.76)、龙利叶(2.78)、铁苋菜(3.13)、甘草(3.82)和仙人掌(4.17)。

荷瘤小鼠体内腺苷脱氨酶活性变化及药物影响的研究

本文研究厂荷 S_(180)肉瘤小鼠体内腺苷脱氨酶(Adenosine deaminase,ADA)的活性变化及中药“消癌灵”对 ADA 活性的影响;①小鼠红细胞及腹水癌细胞内 ADA 活性均较正常小鼠增高;而胸腺内 ADA 活性却较正常小鼠降低;②荷瘤小鼠经灌胃给予“消癌灵”后,其红细胞及腹水内 ADA活性明显降低;而胸腺内 ADA 活性却明显增高,表明 ADA 活性变化与肿瘤之间有密切关系。中药“消癌灵”能改变荷瘤小鼠体内 ADA 活性,具有一定的抗癌作用,这对于肿瘤防治的研究具有重要意义。

Pathogenic Mycoplasma Infections in Chronic Illnesses: General Considerations in Selecting Conventional and Integrative Treatments

The presence of pathogenic mycoplasmas in various chronic illnesses and their successful suppression using conventional and integrative medicine approaches are reviewed. Evidence gathered over the last three decades has demonstrated the presence of pathogenic mycoplasma species in the blood, body fluids and tissues from patients with a variety of chronic clinical conditions: atypical pneumonia, asthma and other respiratory conditions;oral cavity infections;urogenital conditions;neurodegenerative and neurobehavioral diseases;autoimmune diseases;immunosuppressive diseases;inflammatory diseases;and illnesses and syndromes of unknown origin, such as fatiguing illnesses. Only recently have these small intracellular bacteria received attention as possible causative agents, cofactors or opportunistic infections or co-infections in these and other conditions. Their clinical management is often inadequate, primarily because of missed diagnosis, under- and inadequate treatment and the presence of persister or dormant microorganisms due to biofilm, resistence and other mechanisms. Pathogenic Mycoplasma species infections have been suppressed slowly by anti-microbial and integrative treatments, resulting in gradual reductions in morbidity, but not in every patient. Even if mycoplasmas are not a cause or an initial trigger for many chronic illnesses, they appear to play important roles in the inception, progression, morbidity and relapse of chronic illnesses in rather large patient subsets. Ignoring such infections can result in failure to achieve eventual patient recovery, even with application of potentially curative treatments.

夏枯草抗Ⅰ型单纯疱疹病毒的实验研究

使用人胚肌皮单层细胞培养技术对中药夏枯草提取物抗Ⅰ型单纯疱疹病毒作用进行了研究。结果:夏枯草提取物的无毒界限为≤1000μg/ml;四种给药途经中,同时给药途经、治疗给药途径、管外给药途径的最低有效量分别为50μg/ml、100μg/ml、250μg/ml;预防给药途经无效。

中药乐脉颗粒治疗冠心病的临床研究

用乐脉颗粒对54例冠心病患者进行为期4周的观察治疗，结果表明：稳定型和不稳定型心绞痛发作频率、持续时间均减少（P＜0．001）。TG、LDL-C降低分别达28．92％、20．91％（P＜0．05）．而HDL-C升高19．44％（P＜0．05）。血液流变学指标ηp和EPT分别降低10．30％和14．26％（P＜0.01）；ηb和Fibg降低为4．32％和6．54％（P＜0．05）．用药后未见明显毒副作用．

上消化道出血152例中西结合治疗小结

目的上消化道出血152例中西结合治疗小结．方法治疗组采用西咪替丁0．8＋肝太乐0．6加入10％葡萄糖中静滴，1次／d，连续3d～6d．po：美蓝20mg～60mg，2次／d，凝血酶3000U～6000U+生理盐水20mL，2次／d，白芨15．0，旱莲草10．0煎汁凉饮50mL，每4h～6h一次．对照组，Vit．K120mg+安咯血20mg，im，2次／d；止血敏4．0，止血芳酸0．2加入10％葡萄糖500mL静滴．必要时，给垂体后叶素10U加入10％葡萄糖250mL．静滴，1次／d，连续3d～6d，可重复进行．结果治疗组总有效率为96．71％＞对照组78．57％，（P＜0．01），有极显著性意义．治疗组医疗费明显低于对照组，在社会、经济效益两方面均有实际意义．结论美蓝、凝血酶、白芨、旱莲草和西咪替丁合用，治疗上消化道出血，优于常规止血药；效果极显著．

光疗法联合中药治疗寻常痤疮的疗效观察

目的探讨痤疮灵颗粒联合蓝-红光照射治疗寻常痤疮的疗效。方法采用蓝-红光照射加口服痤疮灵冲剂治疗寻常痤疮，单独口服痤疮灵冲剂作为对照组。共治疗42例患者，其中治疗组25例，对照组17例。检测治疗前后痤疮患者面部皮肤的油脂分泌量、pH值及水分。结果治疗组总有效率为84％，对照组为71％。对总皮损的清除率和炎性皮损的清除率治疗组都高于对照组。治疗组患者表皮角质层含水量平均值由治疗前的210．47提高到治疗后的294．70，差异有统计学意义。皮肤酸碱度和皮肤油脂分泌量治疗前后未见明显变化。结论光疗法联合中药对Ⅱ-Ⅲ度寻常痤疮有良好疗效，治疗后皮肤角质层含水量有所提高。