This paper presents an anomaly detection approach to detect intrusions into computer systems. In this approach, a hierarchical hidden Markov model （HHMM） is used to represent a temporal profile of normal behavior in...This paper presents an anomaly detection approach to detect intrusions into computer systems. In this approach, a hierarchical hidden Markov model （HHMM） is used to represent a temporal profile of normal behavior in a computer system. The HHMM of the norm profile is learned from historic data of the system＇s normal behavior. The observed behavior of the system is analyzed to infer the probability that the HHMM of the norm profile supports the observed behavior. A low probability of support indicates an anomalous behavior that may result from intrusive activities. The model was implemented and tested on the UNIX system call sequences collected by the University of New Mexico group. The testing results showed that the model can clearly identify the anomaly activities and has a better performance than hidden Markov model.展开更多
Protein sequence motifs extraction is an important field of bioinformatics since its relevance to the structural analysis. Two major problems are related to this field：（1） searching the motifs within the same prote...Protein sequence motifs extraction is an important field of bioinformatics since its relevance to the structural analysis. Two major problems are related to this field：（1） searching the motifs within the same protein family; and（2） assuming a window size for the motifs search. This work proposes the Hierarchically Clustered Hidden Markov Model（HC-HMM） approach, which represents the behavior and structure of proteins in terms of a Hidden Markov Model chain and hierarchically clusters each chain by minimizing distance between two given chains＇ structure and behavior. It is well known that HMM can be utilized for clustering, however, methods for clustering on Hidden Markov Models themselves are rarely studied. In this paper, we developed a hierarchical clustering based algorithm for HMMs to discover protein sequence motifs that transcend family boundaries with no assumption on the length of the motif. This paper carefully examines the effectiveness of this approach for motif extraction on 2593 proteins that share no more than 25% sequence identity. Many interesting motifs are generated.Three example motifs generated by the HC-HMM approach are analyzed and visualized with their tertiary structure.We believe the proposed method provides a unique protein sequence motif extraction strategy. The related data mining fields using Hidden Markova Model may also benefit from this clustering on HMM themselves approach.展开更多
基金Supported by the Science and Technology Development Project Foundation of Tianjin (033800611, 05YFGZGX24200)
文摘This paper presents an anomaly detection approach to detect intrusions into computer systems. In this approach, a hierarchical hidden Markov model （HHMM） is used to represent a temporal profile of normal behavior in a computer system. The HHMM of the norm profile is learned from historic data of the system＇s normal behavior. The observed behavior of the system is analyzed to infer the probability that the HHMM of the norm profile supports the observed behavior. A low probability of support indicates an anomalous behavior that may result from intrusive activities. The model was implemented and tested on the UNIX system call sequences collected by the University of New Mexico group. The testing results showed that the model can clearly identify the anomaly activities and has a better performance than hidden Markov model.
文摘Protein sequence motifs extraction is an important field of bioinformatics since its relevance to the structural analysis. Two major problems are related to this field：（1） searching the motifs within the same protein family; and（2） assuming a window size for the motifs search. This work proposes the Hierarchically Clustered Hidden Markov Model（HC-HMM） approach, which represents the behavior and structure of proteins in terms of a Hidden Markov Model chain and hierarchically clusters each chain by minimizing distance between two given chains＇ structure and behavior. It is well known that HMM can be utilized for clustering, however, methods for clustering on Hidden Markov Models themselves are rarely studied. In this paper, we developed a hierarchical clustering based algorithm for HMMs to discover protein sequence motifs that transcend family boundaries with no assumption on the length of the motif. This paper carefully examines the effectiveness of this approach for motif extraction on 2593 proteins that share no more than 25% sequence identity. Many interesting motifs are generated.Three example motifs generated by the HC-HMM approach are analyzed and visualized with their tertiary structure.We believe the proposed method provides a unique protein sequence motif extraction strategy. The related data mining fields using Hidden Markova Model may also benefit from this clustering on HMM themselves approach.
