In this editorial I comment on the article,published in the current issue of the World Journal of Clinical Oncology.Primary central nervous system lymphoma(PCNSL)is a disease of elderly and immunocompromised patients....In this editorial I comment on the article,published in the current issue of the World Journal of Clinical Oncology.Primary central nervous system lymphoma(PCNSL)is a disease of elderly and immunocompromised patients.The authors reported clinical results of 19 patients with PCNSL treated with zanubrutinib/high dose methotrexate(HD-MTX)until disease progression.They demonstrated that the combination of zanubrutinib with HD-MTX led to a marked clinical response and tolerability among these patients.They also observed that cerebrospinal fluid liquid biopsy to detect circulating tumor DNA may be a good option for evaluating treatment response and tumor burden in patients with PCNSL.PCNSL is a challenging disease for treatment as these patients present with different neurological states and comorbidities.Treatment has evolved over the years from whole brain radiotherapy to HD-MTX followed by autologous stem cell transplant.Gradually,treatment of patients with PCNSL is going to become individualized.展开更多
A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, s...A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, so that the radial distribution function will characterize the short - range order and long - range disorder of amorphous targets. A simulation example is given.展开更多
目的:探讨大剂量甲氨蝶呤(MTX)治疗原发或继发性中枢神经系统淋巴瘤的疗效及不良反应的防治。方法:对20例行大剂量MTX化疗的原发或继发性中枢神经系统淋巴瘤患者进行临床观察,并对化疗引起的不良反应进行干预,确保治疗的按时进行及疗效...目的:探讨大剂量甲氨蝶呤(MTX)治疗原发或继发性中枢神经系统淋巴瘤的疗效及不良反应的防治。方法:对20例行大剂量MTX化疗的原发或继发性中枢神经系统淋巴瘤患者进行临床观察,并对化疗引起的不良反应进行干预,确保治疗的按时进行及疗效。结果:一线、二线及三线化疗有效率分别为66.7%,66.7%和50.0%。20例患者72 h MTX浓度均降至安全范围。主要不良反应为白细胞和中重度血小板减少、重度血红蛋白降低、轻中度肝功能损害及中度口腔溃疡,经干预均得到缓解。结论:规范治疗、MTX血药浓度监测及延续性护理干预可显著降低大剂量MTX患者的不良反应,提高患者依从性,保障临床疗效。展开更多
目的研究大剂量甲氨蝶呤(HD-MTX)加四氢叶酸钙(CF)解救方案治疗儿童急性淋巴细胞白血病(ALL)的不良反应。方法82例ALL患儿进行139例次的HD-MTX加CF治疗。根据44 h MTX血药质量浓度分为A组(44 h MTX浓度≤1.0 mmol/L),B组(44 h MTX浓度&g...目的研究大剂量甲氨蝶呤(HD-MTX)加四氢叶酸钙(CF)解救方案治疗儿童急性淋巴细胞白血病(ALL)的不良反应。方法82例ALL患儿进行139例次的HD-MTX加CF治疗。根据44 h MTX血药质量浓度分为A组(44 h MTX浓度≤1.0 mmol/L),B组(44 h MTX浓度>1.0 mmol/L)。对用药前后两组患儿不良反应观察,并进行对照研究。结果骨髓抑制、肝功能损害、胃肠道反应、感染发生率两组比较无显著性差异。但随着血药质量浓度增加,皮肤黏膜损害、心电图异常和心肌酶谱异常、神经系统症状发生率均显著增加,两组比较有显著性差异。结论HD-MTX加CF治疗儿童白血病时,不良反应较为常见,个体差异较大,应加强个体化治疗。展开更多
文摘In this editorial I comment on the article,published in the current issue of the World Journal of Clinical Oncology.Primary central nervous system lymphoma(PCNSL)is a disease of elderly and immunocompromised patients.The authors reported clinical results of 19 patients with PCNSL treated with zanubrutinib/high dose methotrexate(HD-MTX)until disease progression.They demonstrated that the combination of zanubrutinib with HD-MTX led to a marked clinical response and tolerability among these patients.They also observed that cerebrospinal fluid liquid biopsy to detect circulating tumor DNA may be a good option for evaluating treatment response and tumor burden in patients with PCNSL.PCNSL is a challenging disease for treatment as these patients present with different neurological states and comorbidities.Treatment has evolved over the years from whole brain radiotherapy to HD-MTX followed by autologous stem cell transplant.Gradually,treatment of patients with PCNSL is going to become individualized.
文摘A computer program MACA was developed for simulating high-dose ion implantation into amorphous solids. The topology of amorphous solids was modelled by adjusting the free flight path distribution between collisions, so that the radial distribution function will characterize the short - range order and long - range disorder of amorphous targets. A simulation example is given.
文摘目的:探讨大剂量甲氨蝶呤(MTX)治疗原发或继发性中枢神经系统淋巴瘤的疗效及不良反应的防治。方法:对20例行大剂量MTX化疗的原发或继发性中枢神经系统淋巴瘤患者进行临床观察,并对化疗引起的不良反应进行干预,确保治疗的按时进行及疗效。结果:一线、二线及三线化疗有效率分别为66.7%,66.7%和50.0%。20例患者72 h MTX浓度均降至安全范围。主要不良反应为白细胞和中重度血小板减少、重度血红蛋白降低、轻中度肝功能损害及中度口腔溃疡,经干预均得到缓解。结论:规范治疗、MTX血药浓度监测及延续性护理干预可显著降低大剂量MTX患者的不良反应,提高患者依从性,保障临床疗效。
文摘目的研究大剂量甲氨蝶呤(HD-MTX)加四氢叶酸钙(CF)解救方案治疗儿童急性淋巴细胞白血病(ALL)的不良反应。方法82例ALL患儿进行139例次的HD-MTX加CF治疗。根据44 h MTX血药质量浓度分为A组(44 h MTX浓度≤1.0 mmol/L),B组(44 h MTX浓度>1.0 mmol/L)。对用药前后两组患儿不良反应观察,并进行对照研究。结果骨髓抑制、肝功能损害、胃肠道反应、感染发生率两组比较无显著性差异。但随着血药质量浓度增加,皮肤黏膜损害、心电图异常和心肌酶谱异常、神经系统症状发生率均显著增加,两组比较有显著性差异。结论HD-MTX加CF治疗儿童白血病时,不良反应较为常见,个体差异较大,应加强个体化治疗。
