Background: There is emerging evidence that the increased susceptibility to developing alcohol and substance use dis- orders in those with a family history of Alcohol Dependence (AD) may be related to structural diffe...Background: There is emerging evidence that the increased susceptibility to developing alcohol and substance use dis- orders in those with a family history of Alcohol Dependence (AD) may be related to structural differences in brain circuits that influence the salience of rewards or modify the efficiency of information processing. Externalizing disorders of childhood including Attention Deficit Hyperactivity Disorder, Conduct and Oppositional Disorders are a prominent feature of those with a positive family history. The caudate nuclei have been implicated in both the salience of rewards and in the pathophysiology of alcohol dependence and these often antecedent childhood disorders. Methods: Adolescent/young adult high and low-risk for AD offspring (N = 130) were studied using magnetic resonance imaging. Volumes of the caudate nucleus were obtained using manual tracing with BRAINS2 software and neuropsychological functioning determined. Childhood disorders were assessed as part of a long-term longitudinal follow-up that includes young adult assessment. Dopaminergic variation was assessed using genotypic variation in the catechol-O-methyltransferase (COMT) and DRD2 genes. Results: High-risk subjects showed poorer Working Memory functioning. Caudate volume did not differ between high and low-risk subjects, but those with externalizing disorders of childhood showed reduced caudate volume. Variation in COMT and DRD2 genes was associated with Working Memory performance and caudate volume. Conclusions: Caudate volume is reduced in association with externalizing disorders of childhood/adolescence. Working Memory deficits appear in familial high-risk offspring and those with externalizing disorders of childhood. The dopaminergic system appears to be involved in both working memory performance and externalizing disorders of childhood.展开更多
Crane operators control mobile or stationary cranes to lift, move and place objects at locations such as building and construction sites, wharves and shi<span>pyards. This activity occurs all over the world and ...Crane operators control mobile or stationary cranes to lift, move and place objects at locations such as building and construction sites, wharves and shi<span>pyards. This activity occurs all over the world and is a high risk task with many</span><span> noted examples of serious incidents and accidents. There are identifiable key causes that have been noted through analysis of the well documented cases </span><span>and many of these causes are preventable through effective training programs</span><span>. Internationally, there are not currently consistent approaches to crane operator training program content or duration. Leading causes of crane accidents are firstly discussed and identified as areas for inclusion in training programs. A number of current training approaches from a range of countries are then </span><span>considered and these are used to outline the basis of a generic competency </span><span>standard for crane operation, as it was found that there are not common standards</span><span> in place. The proposed competency standard can be adapted by training regulators, training providers, government agencies, industry bodies and </span><span>enterprises as a benchmark for the development of effective training pr</span><span>ograms.</span>展开更多
文摘Background: There is emerging evidence that the increased susceptibility to developing alcohol and substance use dis- orders in those with a family history of Alcohol Dependence (AD) may be related to structural differences in brain circuits that influence the salience of rewards or modify the efficiency of information processing. Externalizing disorders of childhood including Attention Deficit Hyperactivity Disorder, Conduct and Oppositional Disorders are a prominent feature of those with a positive family history. The caudate nuclei have been implicated in both the salience of rewards and in the pathophysiology of alcohol dependence and these often antecedent childhood disorders. Methods: Adolescent/young adult high and low-risk for AD offspring (N = 130) were studied using magnetic resonance imaging. Volumes of the caudate nucleus were obtained using manual tracing with BRAINS2 software and neuropsychological functioning determined. Childhood disorders were assessed as part of a long-term longitudinal follow-up that includes young adult assessment. Dopaminergic variation was assessed using genotypic variation in the catechol-O-methyltransferase (COMT) and DRD2 genes. Results: High-risk subjects showed poorer Working Memory functioning. Caudate volume did not differ between high and low-risk subjects, but those with externalizing disorders of childhood showed reduced caudate volume. Variation in COMT and DRD2 genes was associated with Working Memory performance and caudate volume. Conclusions: Caudate volume is reduced in association with externalizing disorders of childhood/adolescence. Working Memory deficits appear in familial high-risk offspring and those with externalizing disorders of childhood. The dopaminergic system appears to be involved in both working memory performance and externalizing disorders of childhood.
文摘Crane operators control mobile or stationary cranes to lift, move and place objects at locations such as building and construction sites, wharves and shi<span>pyards. This activity occurs all over the world and is a high risk task with many</span><span> noted examples of serious incidents and accidents. There are identifiable key causes that have been noted through analysis of the well documented cases </span><span>and many of these causes are preventable through effective training programs</span><span>. Internationally, there are not currently consistent approaches to crane operator training program content or duration. Leading causes of crane accidents are firstly discussed and identified as areas for inclusion in training programs. A number of current training approaches from a range of countries are then </span><span>considered and these are used to outline the basis of a generic competency </span><span>standard for crane operation, as it was found that there are not common standards</span><span> in place. The proposed competency standard can be adapted by training regulators, training providers, government agencies, industry bodies and </span><span>enterprises as a benchmark for the development of effective training pr</span><span>ograms.</span>
