BACKGROUND Fourth degree burns damage the full thickness of the skin and affect underlying tissues.Skin grafting after debridement is often used to cover the wounds of salvageable severe burns.A granulation wound can ...BACKGROUND Fourth degree burns damage the full thickness of the skin and affect underlying tissues.Skin grafting after debridement is often used to cover the wounds of salvageable severe burns.A granulation wound can be formed by drilling the skull to the barrier layer to solve the problem of skull exposure.Low oxygen levels present at high altitudes aggravate ischemia and hypoxia which can negatively impact wound healing.The impaired healing in such cases can be ameliorated by hyperbaric oxygen therapy.CASE SUMMARY We describe a patient who presented with fourth degree burns to the left temporal and facial regions upon admission in December 2018.The periosteum of the skull and the deep fascia of the face were exposed.After the first stage of debridement and skin grafting,the temporal skin did not survive well.Granulation was induced by cranial drilling,and then a local flap was transferred to cover the wound.The left temporal and facial wounds were completely covered and the patient recovered well.CONCLUSION Skin grafting and flap transfer after early debridement to cover the wound and control infection were of great significance.In the later stages of the patient's treatment,survival of the skin graft and skin flap was observed.The second stage repair was performed to achieve successful skin grafting by cranial granulation.Granulation was formed by drilling the skull,and then the wound was closed,which is suitable for cases with skull exposure and wounds with poor blood supply.We consider that hyperbaric oxygen treatment and improving tissue oxygen supply were beneficial in this patient.展开更多
Age-related macular degeneration(AMD)is a kind of progressive eye disease that seriously damages vision,and it is one of the important causes of blindness.In recent years,a large number of studies have found that ther...Age-related macular degeneration(AMD)is a kind of progressive eye disease that seriously damages vision,and it is one of the important causes of blindness.In recent years,a large number of studies have found that there is a significant correlation between genetic factors and the occurrence and development of AMD.The study of gene polymorphism provides new ideas and directions for clinical diagnosis and treatment.In this paper,we will make a brief review of the research progress related to complement factor H(CFH),serine protease(HtrA1),age-related macular degeneration susceptibility factor 2(ARMS2)and vascular endothelial growth factor(VEGF)gene single nucleotide polymorphisms(SNP).展开更多
Landscape elements in residential areas can effectively improve the outdoor thermal environment,with different outcomes depending on the climate conditions.This study explores how the ground surface and shading proper...Landscape elements in residential areas can effectively improve the outdoor thermal environment,with different outcomes depending on the climate conditions.This study explores how the ground surface and shading properties affect the outdoor thermal environment in a high-altitude plateau climate where few studies have been conducted.The measurements were conducted during summer and winter in a residential area in Lhasa,Tibet.Without natural shading such as trees,there is a positive correlation between Sky-view factor(SVF)and Physiological equivalent temperature(PET)during winter and a negative correlation during summer.When SVF exceeds 0.65 in summer,it may cause human discomfort.Compared to artificial shading such as a tensioned membrane,deciduous trees are superior at improving human comfort,as they can increase PET by 10.56℃ in winter and decrease it by 9.73℃ in summer.During summer,high-reflection water-permeable bricks can reduce the PET by 1.08℃,and lawns can reduce the mean rachation temperature(Tmrt)by 1.650C;however,the lawns may produce a microclimate with a high air temperature.The results from this paper can be used as a reference for landscape planning and design in residential areas in high-altitude cold-climate regions.展开更多
文摘BACKGROUND Fourth degree burns damage the full thickness of the skin and affect underlying tissues.Skin grafting after debridement is often used to cover the wounds of salvageable severe burns.A granulation wound can be formed by drilling the skull to the barrier layer to solve the problem of skull exposure.Low oxygen levels present at high altitudes aggravate ischemia and hypoxia which can negatively impact wound healing.The impaired healing in such cases can be ameliorated by hyperbaric oxygen therapy.CASE SUMMARY We describe a patient who presented with fourth degree burns to the left temporal and facial regions upon admission in December 2018.The periosteum of the skull and the deep fascia of the face were exposed.After the first stage of debridement and skin grafting,the temporal skin did not survive well.Granulation was induced by cranial drilling,and then a local flap was transferred to cover the wound.The left temporal and facial wounds were completely covered and the patient recovered well.CONCLUSION Skin grafting and flap transfer after early debridement to cover the wound and control infection were of great significance.In the later stages of the patient's treatment,survival of the skin graft and skin flap was observed.The second stage repair was performed to achieve successful skin grafting by cranial granulation.Granulation was formed by drilling the skull,and then the wound was closed,which is suitable for cases with skull exposure and wounds with poor blood supply.We consider that hyperbaric oxygen treatment and improving tissue oxygen supply were beneficial in this patient.
基金Qinghai science and technology department (2017-ZJ-756)
文摘Age-related macular degeneration(AMD)is a kind of progressive eye disease that seriously damages vision,and it is one of the important causes of blindness.In recent years,a large number of studies have found that there is a significant correlation between genetic factors and the occurrence and development of AMD.The study of gene polymorphism provides new ideas and directions for clinical diagnosis and treatment.In this paper,we will make a brief review of the research progress related to complement factor H(CFH),serine protease(HtrA1),age-related macular degeneration susceptibility factor 2(ARMS2)and vascular endothelial growth factor(VEGF)gene single nucleotide polymorphisms(SNP).
文摘Landscape elements in residential areas can effectively improve the outdoor thermal environment,with different outcomes depending on the climate conditions.This study explores how the ground surface and shading properties affect the outdoor thermal environment in a high-altitude plateau climate where few studies have been conducted.The measurements were conducted during summer and winter in a residential area in Lhasa,Tibet.Without natural shading such as trees,there is a positive correlation between Sky-view factor(SVF)and Physiological equivalent temperature(PET)during winter and a negative correlation during summer.When SVF exceeds 0.65 in summer,it may cause human discomfort.Compared to artificial shading such as a tensioned membrane,deciduous trees are superior at improving human comfort,as they can increase PET by 10.56℃ in winter and decrease it by 9.73℃ in summer.During summer,high-reflection water-permeable bricks can reduce the PET by 1.08℃,and lawns can reduce the mean rachation temperature(Tmrt)by 1.650C;however,the lawns may produce a microclimate with a high air temperature.The results from this paper can be used as a reference for landscape planning and design in residential areas in high-altitude cold-climate regions.
