To achieve high microwave permeability in wide-band for the micron-thick magnetic films,[Fe-Fe_(20)Ni_(80)/Cr]_(n) multilayer structure was proposed by co-sputtering Fe and FeNi to form the magnetic layers and Cr to f...To achieve high microwave permeability in wide-band for the micron-thick magnetic films,[Fe-Fe_(20)Ni_(80)/Cr]_(n) multilayer structure was proposed by co-sputtering Fe and FeNi to form the magnetic layers and Cr to form the interlayers.The multilayer structure contributes to the high permeability by reducing the coercivity and diminishing out-of-plane magnetization.The maximum imaginary permeability of[Fe-Fe_(20)Ni_(80)/Cr]_(n) multilayer film reaches a large value of 800 at 0.52 GHz even though its overall thickness exceeds 1μm.Besides,the magnetic resonance frequency of the multilayer film can be modulated from 0.52 to 1.35 GHz by adjusting the sputtering power of Fe from 0 to 86 W,and its bandwidth for μ’’>200(Δf) is as large as 2.0 GHz.The desirable broad Δf of magnetic permeability,which can be well fitted by the Landau-Lifshitz-Gilbert equations,is due to dual magnetic resonances originated from double magnetic phases of Fe and FeNi that are of different saturation magnetization.The micron-thick multilayer films with high permeability in extended waveband are promising candidate for electromagnetic noise suppression application.展开更多
In this paper, the feasibility study of chemical flooding is carried out for ultra-high porosity and high permeability heavy oil field with permeability higher than 10 μm<sup>2</sup> and porosity greater ...In this paper, the feasibility study of chemical flooding is carried out for ultra-high porosity and high permeability heavy oil field with permeability higher than 10 μm<sup>2</sup> and porosity greater than 35%. The viscosity-concentration relationship of four kinds of oil flooding systems such as hydrolyzed polyacrylamide, structural polymer A, structural polymer B and gel was studied. The results showed that the viscosity of ordinary polymer and structural polymer B was lower compared with other two types of oil displacement agents, and the viscosity of structural polymer A was higher. The higher the concentration, the higher the viscosity retention rate. The gel system has the highest viscosity and best anti-shear ability. The resistance coefficient and residual resistance coefficient of structural polymer A and gel system were further studied. The results show that permeability, velocity and polymer concentration all affect the resistance coefficient and residual resistance coefficient. From the point of view of resistance establishment ability, it is considered that structural polymer A is not suitable for permeability formation above 10 μm<sup>2</sup>. Gel system has stronger ability to establish resistance coefficient than structural polymer A flooding system, and it is more feasible for formation system with permeability above 10 μm<sup>2</sup>.展开更多
The coupling numerical model of wave interaction with porous medium is used to study wave- induced pore water pressure in high permeability seabed. In the model, the wave field solver is based on the two dimensional R...The coupling numerical model of wave interaction with porous medium is used to study wave- induced pore water pressure in high permeability seabed. In the model, the wave field solver is based on the two dimensional Reynolds-averaged Navier-Stokes (RANS) equations with a k-s closure, and Forchheimer equations are adopted for flow within the porous media. By introducing a Velocity-Pressure Correction equation for the wave flow and porous flow, a highly efficient coupling between the two flows is implemented. The numerical tests are conducted to study the effects of seabed thickness, porosity, particle size and intrinsic permeability coefficient on regular wave and solitary wave-induced pore water pressure response. The results indicate that, as compared with regular wave-induced, solitary wave-induced pore water pressure has larger values and stronger action on seabed with different parameters. The results also clearly show the flow characteristics of pore water flow within seabed and water wave flow on seabed. The maximum pore water flow velocities within seabed under solitary wave action are higher than those under regular wave action.展开更多
The visualization experiments were carried out to investigate the permeability of the high permeable medium (HPM) and the roles of the peel ply and the HPM in the mold filling.The influence of process parameters on m...The visualization experiments were carried out to investigate the permeability of the high permeable medium (HPM) and the roles of the peel ply and the HPM in the mold filling.The influence of process parameters on mold filling is discussed.Furthermore,the whole vacuum infusion molding process (VIMP) procedure is introduced in detail taking the manufacture of a model boat for example.展开更多
To explore the variation of permeability and deformation behaviors of a fractured rock mass in high water pressure,a high pressure permeability test(HPPT),including measuring sensors of pore water pressure and displ...To explore the variation of permeability and deformation behaviors of a fractured rock mass in high water pressure,a high pressure permeability test(HPPT),including measuring sensors of pore water pressure and displacement of the rock mass,was designed according to the hydrogeological condition of Heimifeng pumped storage power station.With the assumption of radial water flow pattern in the rock mass during the HPPT,a theoretical formula was presented to estimate the coefficient of permeability of the rock mass using water pressures in injection and measuring boreholes.The variation in permeability of the rock mass with the injected water pressure was studied according to the suggested formula.By fitting the relationship between the coefficient of permeability and the injected water pressure,a mathematical expression was obtained and used in the numerical simulations.For a better understanding of the relationship between the pore water pressure and the displacement of the rock mass,a 3D numerical method based on a coupled hydro-mechanical theory was employed to simulate the response of the rock mass during the test.By comparison of the calculated and measured data of pore water pressure and displacement,the deformation behaviors of the rock mass were analyzed.It is shown that the variation of displacement in the fractured rock mass is caused by water flow passing through it under high water pressure,and the rock deformation during the test could be calculated by using the coupled hydro-mechanical model.展开更多
In this paper,a model free volt/var control(VVC)algorithm is developed by using deep reinforcement learning(DRL).We transform the VVC problem of distribution networks into the network framework of PPO algorithm,in ord...In this paper,a model free volt/var control(VVC)algorithm is developed by using deep reinforcement learning(DRL).We transform the VVC problem of distribution networks into the network framework of PPO algorithm,in order to avoid directly solving a large-scale nonlinear optimization problem.We select photovoltaic inverters as agents to adjust system voltage in a distribution network,taking the reactive power output of inverters as action variables.An appropriate reward function is designed to guide the interaction between photovoltaic inverters and the distribution network environment.OPENDSS is used to output system node voltage and network loss.This method realizes the goal of optimal VVC in distribution network.The IEEE 13-bus three phase unbalanced distribution system is used to verify the effectiveness of the proposed algorithm.Simulation results demonstrate that the proposed method has excellent performance in voltage and reactive power regulation of a distribution network.展开更多
The high-performance electromagnetic(EM)wave absorption material Ba(Co Ti)_(x)Fe_(12-2x)O19@Bi Fe O_(3)was prepared by solid-state reaction,and its EM wave absorption properties were deeply studied.The results reveale...The high-performance electromagnetic(EM)wave absorption material Ba(Co Ti)_(x)Fe_(12-2x)O19@Bi Fe O_(3)was prepared by solid-state reaction,and its EM wave absorption properties were deeply studied.The results revealed that Ba(Co Ti)x Fe12-2x O19@Bi Fe O_(3)could obtain excellent absorption properties in hundreds of megahertz by adjusting the Co^(2+)-Ti^(4+)content.The best comprehensive property was obtained for x=1.2,where the optimal reflection loss(RL)value reaches-30.42 d B at about 600 MHz with thickness of 3.5 mm,and the corresponding effective absorption band covers the frequency range of 437 MHz-1 GHz.Moreover,the EM wave absorption mechanism was studied based on the simulation methods.The simulated results showed that the excellent EM wave absorption properties of Ba(Co Ti)_(x)Fe_(12-2x)O19@Bi Fe O_(3)mainly originated from the internal loss caused by natural resonance,and the interface cancelation further improved the absorption properties and resulted in RL peaks.展开更多
AIM: To examine the expression of high mobility group box-1(HMGB-1) and intercellular adhesion molecule-1(ICAM-1) in the retina and the hippocampal tissues; and further to evaluate the association of these two mo...AIM: To examine the expression of high mobility group box-1(HMGB-1) and intercellular adhesion molecule-1(ICAM-1) in the retina and the hippocampal tissues; and further to evaluate the association of these two molecules with the alterations of blood-retinal barrier(BRB) and blood-brain barrier(BBB) in a rat model of type 2 diabetes.METHODS: The type-2 diabetes mellitus(DM) model was established with a high-fat and high-glucose diet combined with streptozotocin(STZ). Sixteen weeks after DM induction, morphological changes of retina and hippocampus were observed with hematoxylin-eosin staining, and alternations of BRB and BBB permeability were measured using Evans blue method. Levels of HMGB-1 and ICAM-1 in retina and hippocampus were detected by Western blot. Serum HMGB-1 levels were determined by enzyme-linked immunosorbent assay(ELISA).RESULTS: A significantly higher serum fasting blood glucose level in DM rats was observed 2wk after STZ injection(P 〈0.01). The serum levels of fasting insulin,Insulin resistance homeostatic model assessment(IRHOMA),total cholesterol(TC), total triglycerides(TG) and low density lipoprotein cholesterol(LDL-C) in the DM rats significantly higher than those in the controls(all P 〈0.01).HMGB-1(0.96±0.03, P 〈0.01) and ICAM-1(0.76±0.12, P 〈0.05) levels in the retina in the DM rats were significantly higher than those in the controls. HMGB-1(0.83±0.13, P 〈0.01) and ICAM-1(1.15 ±0.08, P 〈0.01) levels in the hippocampal tissues in the DM rats were alsosignificantly higher than those in the controls. Sixteen weeks after induction of DM, the BRB permeability to albumin-bound Evans blue dye in the DM rats was significantly higher than that in the controls(P 〈0.01).However, there was no difference of BBB permeability between the DM rats and controls. When compared to the controls, hematoxylin and eosin staining showed obvious irregularities in the DM rats.CONCLUSION: BRB permeability increases significantly in rats with type-2 DM, which may be associated with the up-regulated retinal expression of HMGB-1 and ICAM-1.展开更多
In the present work, a series of [FesoNi20-O/SiO2]n multilayer thin films is fabricated using a reactive magnetron sputtering equipment. The thickness of SiO2 interlayer is fixed at 3 nm, while the thickness values of...In the present work, a series of [FesoNi20-O/SiO2]n multilayer thin films is fabricated using a reactive magnetron sputtering equipment. The thickness of SiO2 interlayer is fixed at 3 nm, while the thickness values of FesoNi20-O magnetic films range from 10 nm to 30 nm. All films present obvious in-plane uniaxial magnetic anisotropy. With increasing the FesoNi20-O layer thickness, the saturation magnetization increases slightly and the coercivity becomes larger due to the enlarged grain size, which could weaken the soft magnetic property. The results of high frequency magnetic permeability characterization show that films with thin magnetic layer are more suitable for practical applications. When the thickness of FesoNi20-O layer is 10 nm, the multilayer film exhibits the most comprehensive high-frequency magnetic property with a real permeability of 300 in gigahertz range.展开更多
The ready-to-use,structure-supporting hydrogel bioink can shorten the time for ink preparation,ensure cell dispersion,and maintain the preset shape/microstructure without additional assistance during printing.Meanwhil...The ready-to-use,structure-supporting hydrogel bioink can shorten the time for ink preparation,ensure cell dispersion,and maintain the preset shape/microstructure without additional assistance during printing.Meanwhile,ink with high permeability might facilitate uniform cell growth in biological constructs,which is beneficial to homogeneous tissue repair.Unfortunately,current bioinks are hard to meet these requirements simultaneously in a simple way.Here,based on the fast dynamic crosslinking of aldehyde hyaluronic acid(AHA)/N-carboxymethyl chitosan(CMC)and the slow stable crosslinking of gelatin(GEL)/4-arm poly(ethylene glycol)succinimidyl glutarate(PEG-SG),we present a time-sharing structure-supporting(TSHSP)hydrogel bioink with high permeability,containing 1%AHA,0.75%CMC,1%GEL and 0.5%PEG-SG.The TSHSP hydrogel can facilitate printing with proper viscoelastic property and self-healing behavior.By crosslinking with 4%PEG-SG for only 3 min,the integrity of the cell-laden construct can last for 21 days due to the stable internal and external GEL/PEG-SG networks,and cells manifested long-term viability and spreading morphology.Nerve-like,muscle-like,and cartilage-like in vitro constructs exhibited homogeneous cell growth and remarkable biological specificities.This work provides not only a convenient and practical bioink for tissue engineering,targeted cell therapy,but also a new direction for hydrogel bioink development.展开更多
当前,高渗透性反渗透膜材料的研究引起了广泛的关注,然而高渗透导致的浓差极化与膜污染加剧等瓶颈问题限制了高性能膜材料的应用发展.本工作采用机器学习结合超级计算提出了针对先进反渗透膜材料的组件进水隔网(亚毫米级)与系统(米级)...当前,高渗透性反渗透膜材料的研究引起了广泛的关注,然而高渗透导致的浓差极化与膜污染加剧等瓶颈问题限制了高性能膜材料的应用发展.本工作采用机器学习结合超级计算提出了针对先进反渗透膜材料的组件进水隔网(亚毫米级)与系统(米级)的多尺度优化设计新方法.在进料含盐度35,000 ppm,回收率50%典型工况下,对标目前国际先进海水反渗透淡化工艺,本文提出的优化方案能使淡水制备比能耗(1.66 k Wh/m^(3))降低27.5%,所需膜面积减少约37.2%,系统最大浓差极化因子控制在工程允许范围以内(<1.20),可有效缓解高渗透膜系统中膜污染问题,为高性能膜材料精准设计提供理论依据、计算工具和大数据支撑,有重要的应用潜力.本文提出的机器学习结合超算的多尺度设计新研究范式,突破了基于“试错法”的传统单一尺度组件设计限制,高通量并行计算规模可扩展至93,120核以上,较串行算法计算效率提升3000倍以上,可大幅度缩短高性能膜组件的设计周期.展开更多
The Heavy Ion Research Facility and Cooling Storage Ring(HIRFL-CSR)accelerator in Lanzhou offers a unique possibility for the generation of high density and short pulse heavy ion beams by non-adiabatic bunch compres...The Heavy Ion Research Facility and Cooling Storage Ring(HIRFL-CSR)accelerator in Lanzhou offers a unique possibility for the generation of high density and short pulse heavy ion beams by non-adiabatic bunch compression longitudinally,which is implemented by a fast jump of the RF-voltage amplitude.For this purpose,an RF cavity with high electric field gradient loaded with Magnetic Alloy cores has been developed.The results show that the resonant frequency range of the single-gap RF cavity is from 1.13 MHz to 1.42 MHz,and a maximum RF voltage of 40 kV with a total length of 100 cm can be obtained,which can be used to compress heavy ion beams of 238U72+ with 250 MeV/u from the initial bunch length of 200 ns to 50 ns with the coaction of the two single-gap RF cavity mentioned above.展开更多
基金Funded by the Young Top-notch Talent Cultivation Program of Hubei Provincethe Fundamental Research Funds for the Central Universities(WUT:2021IVA116 and WUT:2021CG015)。
文摘To achieve high microwave permeability in wide-band for the micron-thick magnetic films,[Fe-Fe_(20)Ni_(80)/Cr]_(n) multilayer structure was proposed by co-sputtering Fe and FeNi to form the magnetic layers and Cr to form the interlayers.The multilayer structure contributes to the high permeability by reducing the coercivity and diminishing out-of-plane magnetization.The maximum imaginary permeability of[Fe-Fe_(20)Ni_(80)/Cr]_(n) multilayer film reaches a large value of 800 at 0.52 GHz even though its overall thickness exceeds 1μm.Besides,the magnetic resonance frequency of the multilayer film can be modulated from 0.52 to 1.35 GHz by adjusting the sputtering power of Fe from 0 to 86 W,and its bandwidth for μ’’>200(Δf) is as large as 2.0 GHz.The desirable broad Δf of magnetic permeability,which can be well fitted by the Landau-Lifshitz-Gilbert equations,is due to dual magnetic resonances originated from double magnetic phases of Fe and FeNi that are of different saturation magnetization.The micron-thick multilayer films with high permeability in extended waveband are promising candidate for electromagnetic noise suppression application.
文摘In this paper, the feasibility study of chemical flooding is carried out for ultra-high porosity and high permeability heavy oil field with permeability higher than 10 μm<sup>2</sup> and porosity greater than 35%. The viscosity-concentration relationship of four kinds of oil flooding systems such as hydrolyzed polyacrylamide, structural polymer A, structural polymer B and gel was studied. The results showed that the viscosity of ordinary polymer and structural polymer B was lower compared with other two types of oil displacement agents, and the viscosity of structural polymer A was higher. The higher the concentration, the higher the viscosity retention rate. The gel system has the highest viscosity and best anti-shear ability. The resistance coefficient and residual resistance coefficient of structural polymer A and gel system were further studied. The results show that permeability, velocity and polymer concentration all affect the resistance coefficient and residual resistance coefficient. From the point of view of resistance establishment ability, it is considered that structural polymer A is not suitable for permeability formation above 10 μm<sup>2</sup>. Gel system has stronger ability to establish resistance coefficient than structural polymer A flooding system, and it is more feasible for formation system with permeability above 10 μm<sup>2</sup>.
基金The National Natural Science Foundation of China under contract Nos 50909009,50979008 and 41176072the Open Foundation of the State Key Laboratory of Coastal and Offshore Engineering in Dalian University of Technology of China under contract No. LP1004the Ph.D. Program Foundation of Ministry of Education of China under contract No. 20094316110002
文摘The coupling numerical model of wave interaction with porous medium is used to study wave- induced pore water pressure in high permeability seabed. In the model, the wave field solver is based on the two dimensional Reynolds-averaged Navier-Stokes (RANS) equations with a k-s closure, and Forchheimer equations are adopted for flow within the porous media. By introducing a Velocity-Pressure Correction equation for the wave flow and porous flow, a highly efficient coupling between the two flows is implemented. The numerical tests are conducted to study the effects of seabed thickness, porosity, particle size and intrinsic permeability coefficient on regular wave and solitary wave-induced pore water pressure response. The results indicate that, as compared with regular wave-induced, solitary wave-induced pore water pressure has larger values and stronger action on seabed with different parameters. The results also clearly show the flow characteristics of pore water flow within seabed and water wave flow on seabed. The maximum pore water flow velocities within seabed under solitary wave action are higher than those under regular wave action.
文摘The visualization experiments were carried out to investigate the permeability of the high permeable medium (HPM) and the roles of the peel ply and the HPM in the mold filling.The influence of process parameters on mold filling is discussed.Furthermore,the whole vacuum infusion molding process (VIMP) procedure is introduced in detail taking the manufacture of a model boat for example.
文摘To explore the variation of permeability and deformation behaviors of a fractured rock mass in high water pressure,a high pressure permeability test(HPPT),including measuring sensors of pore water pressure and displacement of the rock mass,was designed according to the hydrogeological condition of Heimifeng pumped storage power station.With the assumption of radial water flow pattern in the rock mass during the HPPT,a theoretical formula was presented to estimate the coefficient of permeability of the rock mass using water pressures in injection and measuring boreholes.The variation in permeability of the rock mass with the injected water pressure was studied according to the suggested formula.By fitting the relationship between the coefficient of permeability and the injected water pressure,a mathematical expression was obtained and used in the numerical simulations.For a better understanding of the relationship between the pore water pressure and the displacement of the rock mass,a 3D numerical method based on a coupled hydro-mechanical theory was employed to simulate the response of the rock mass during the test.By comparison of the calculated and measured data of pore water pressure and displacement,the deformation behaviors of the rock mass were analyzed.It is shown that the variation of displacement in the fractured rock mass is caused by water flow passing through it under high water pressure,and the rock deformation during the test could be calculated by using the coupled hydro-mechanical model.
基金supported by the Science and Technology Project of State Grid Zhejiang Electric Power Co.,Ltd.under Grant B311JY21000A。
文摘In this paper,a model free volt/var control(VVC)algorithm is developed by using deep reinforcement learning(DRL).We transform the VVC problem of distribution networks into the network framework of PPO algorithm,in order to avoid directly solving a large-scale nonlinear optimization problem.We select photovoltaic inverters as agents to adjust system voltage in a distribution network,taking the reactive power output of inverters as action variables.An appropriate reward function is designed to guide the interaction between photovoltaic inverters and the distribution network environment.OPENDSS is used to output system node voltage and network loss.This method realizes the goal of optimal VVC in distribution network.The IEEE 13-bus three phase unbalanced distribution system is used to verify the effectiveness of the proposed algorithm.Simulation results demonstrate that the proposed method has excellent performance in voltage and reactive power regulation of a distribution network.
基金Project supported by the National Natural Science Foundation of China(Grant No.11574122)the Joint Fund of Equipment Pre-Research and Ministry of Education,China(Grant No.6141A02033242)。
文摘The high-performance electromagnetic(EM)wave absorption material Ba(Co Ti)_(x)Fe_(12-2x)O19@Bi Fe O_(3)was prepared by solid-state reaction,and its EM wave absorption properties were deeply studied.The results revealed that Ba(Co Ti)x Fe12-2x O19@Bi Fe O_(3)could obtain excellent absorption properties in hundreds of megahertz by adjusting the Co^(2+)-Ti^(4+)content.The best comprehensive property was obtained for x=1.2,where the optimal reflection loss(RL)value reaches-30.42 d B at about 600 MHz with thickness of 3.5 mm,and the corresponding effective absorption band covers the frequency range of 437 MHz-1 GHz.Moreover,the EM wave absorption mechanism was studied based on the simulation methods.The simulated results showed that the excellent EM wave absorption properties of Ba(Co Ti)_(x)Fe_(12-2x)O19@Bi Fe O_(3)mainly originated from the internal loss caused by natural resonance,and the interface cancelation further improved the absorption properties and resulted in RL peaks.
基金Supported by the Project of Education Bureau Foundation of Hubei Province(No.Q20151901)
文摘AIM: To examine the expression of high mobility group box-1(HMGB-1) and intercellular adhesion molecule-1(ICAM-1) in the retina and the hippocampal tissues; and further to evaluate the association of these two molecules with the alterations of blood-retinal barrier(BRB) and blood-brain barrier(BBB) in a rat model of type 2 diabetes.METHODS: The type-2 diabetes mellitus(DM) model was established with a high-fat and high-glucose diet combined with streptozotocin(STZ). Sixteen weeks after DM induction, morphological changes of retina and hippocampus were observed with hematoxylin-eosin staining, and alternations of BRB and BBB permeability were measured using Evans blue method. Levels of HMGB-1 and ICAM-1 in retina and hippocampus were detected by Western blot. Serum HMGB-1 levels were determined by enzyme-linked immunosorbent assay(ELISA).RESULTS: A significantly higher serum fasting blood glucose level in DM rats was observed 2wk after STZ injection(P 〈0.01). The serum levels of fasting insulin,Insulin resistance homeostatic model assessment(IRHOMA),total cholesterol(TC), total triglycerides(TG) and low density lipoprotein cholesterol(LDL-C) in the DM rats significantly higher than those in the controls(all P 〈0.01).HMGB-1(0.96±0.03, P 〈0.01) and ICAM-1(0.76±0.12, P 〈0.05) levels in the retina in the DM rats were significantly higher than those in the controls. HMGB-1(0.83±0.13, P 〈0.01) and ICAM-1(1.15 ±0.08, P 〈0.01) levels in the hippocampal tissues in the DM rats were alsosignificantly higher than those in the controls. Sixteen weeks after induction of DM, the BRB permeability to albumin-bound Evans blue dye in the DM rats was significantly higher than that in the controls(P 〈0.01).However, there was no difference of BBB permeability between the DM rats and controls. When compared to the controls, hematoxylin and eosin staining showed obvious irregularities in the DM rats.CONCLUSION: BRB permeability increases significantly in rats with type-2 DM, which may be associated with the up-regulated retinal expression of HMGB-1 and ICAM-1.
基金Project supported by the National Basic Research Program of China(Grant No.2012CB933103)the National Natural Science Foundation of China(Grant Nos.51371154,51301145,51171158,and 50825101)the Fundamental Research Funds for the Central Universities of China(Grant No.201212G001)
文摘In the present work, a series of [FesoNi20-O/SiO2]n multilayer thin films is fabricated using a reactive magnetron sputtering equipment. The thickness of SiO2 interlayer is fixed at 3 nm, while the thickness values of FesoNi20-O magnetic films range from 10 nm to 30 nm. All films present obvious in-plane uniaxial magnetic anisotropy. With increasing the FesoNi20-O layer thickness, the saturation magnetization increases slightly and the coercivity becomes larger due to the enlarged grain size, which could weaken the soft magnetic property. The results of high frequency magnetic permeability characterization show that films with thin magnetic layer are more suitable for practical applications. When the thickness of FesoNi20-O layer is 10 nm, the multilayer film exhibits the most comprehensive high-frequency magnetic property with a real permeability of 300 in gigahertz range.
基金This work was supported by the National Natural Science Foundation of China[grant number 52075285]the Science and Technology Program of Guangzhou,China[grant number 201604040002]+1 种基金the Key-Area Research and Development Program of Guangdong Province,China[grant number 2020B090923003]the Key Research and Development Projects of People’s Liberation Army,China[grant number.BWS17J036].
文摘The ready-to-use,structure-supporting hydrogel bioink can shorten the time for ink preparation,ensure cell dispersion,and maintain the preset shape/microstructure without additional assistance during printing.Meanwhile,ink with high permeability might facilitate uniform cell growth in biological constructs,which is beneficial to homogeneous tissue repair.Unfortunately,current bioinks are hard to meet these requirements simultaneously in a simple way.Here,based on the fast dynamic crosslinking of aldehyde hyaluronic acid(AHA)/N-carboxymethyl chitosan(CMC)and the slow stable crosslinking of gelatin(GEL)/4-arm poly(ethylene glycol)succinimidyl glutarate(PEG-SG),we present a time-sharing structure-supporting(TSHSP)hydrogel bioink with high permeability,containing 1%AHA,0.75%CMC,1%GEL and 0.5%PEG-SG.The TSHSP hydrogel can facilitate printing with proper viscoelastic property and self-healing behavior.By crosslinking with 4%PEG-SG for only 3 min,the integrity of the cell-laden construct can last for 21 days due to the stable internal and external GEL/PEG-SG networks,and cells manifested long-term viability and spreading morphology.Nerve-like,muscle-like,and cartilage-like in vitro constructs exhibited homogeneous cell growth and remarkable biological specificities.This work provides not only a convenient and practical bioink for tissue engineering,targeted cell therapy,but also a new direction for hydrogel bioink development.
基金support provided by Key-Area Research and Development Program of Guangdong Province(2021B0101190003)Zhujiang Talent Program of Guangdong Province(2017GC010576)+3 种基金Natural Science Foundation of Guangdong Province,China(2022A1515011514)financial support from the National Science Foundation(2140946)financial support from the UCLA Sustainable LA Grand Challengefinancial support from China Postdoctoral Science Foundation(2022M723674)。
文摘当前,高渗透性反渗透膜材料的研究引起了广泛的关注,然而高渗透导致的浓差极化与膜污染加剧等瓶颈问题限制了高性能膜材料的应用发展.本工作采用机器学习结合超级计算提出了针对先进反渗透膜材料的组件进水隔网(亚毫米级)与系统(米级)的多尺度优化设计新方法.在进料含盐度35,000 ppm,回收率50%典型工况下,对标目前国际先进海水反渗透淡化工艺,本文提出的优化方案能使淡水制备比能耗(1.66 k Wh/m^(3))降低27.5%,所需膜面积减少约37.2%,系统最大浓差极化因子控制在工程允许范围以内(<1.20),可有效缓解高渗透膜系统中膜污染问题,为高性能膜材料精准设计提供理论依据、计算工具和大数据支撑,有重要的应用潜力.本文提出的机器学习结合超算的多尺度设计新研究范式,突破了基于“试错法”的传统单一尺度组件设计限制,高通量并行计算规模可扩展至93,120核以上,较串行算法计算效率提升3000倍以上,可大幅度缩短高性能膜组件的设计周期.
基金Supported by the National Natural Science Foundation of China (10635090, 10905082)
文摘The Heavy Ion Research Facility and Cooling Storage Ring(HIRFL-CSR)accelerator in Lanzhou offers a unique possibility for the generation of high density and short pulse heavy ion beams by non-adiabatic bunch compression longitudinally,which is implemented by a fast jump of the RF-voltage amplitude.For this purpose,an RF cavity with high electric field gradient loaded with Magnetic Alloy cores has been developed.The results show that the resonant frequency range of the single-gap RF cavity is from 1.13 MHz to 1.42 MHz,and a maximum RF voltage of 40 kV with a total length of 100 cm can be obtained,which can be used to compress heavy ion beams of 238U72+ with 250 MeV/u from the initial bunch length of 200 ns to 50 ns with the coaction of the two single-gap RF cavity mentioned above.