A systematic review of the efficacy of traditional Chinese medicine retention enema in the treatment of ulcerative colitis

The objective of this study is to summarize the efficacy and safety of traditional Chinese medicine(TCM)enema in the treatment of ulcerative colitis(UC).The randomized controlled trials on TCM enema intervention in the treatment of UC were searched in seven databases:PubMed,Embase,Web of Science,CBM,CNKI,Wanfang Database,and VIP Database from January 1,2013 to June 6,2022,and the data were analyzed using RevMan 5.3 software.A total of 18 studies involving 1514 UC patients were included.Meta analysis results showed that compared with conventional Western medicine,Chinese medicine enema had a significant effect on UC,and the clinical effective rate of the experimental group using Chinese medicine enema was 4.45 times that of the control group using conventional Western medicine(odds ratio=4.45,95%confidence interval[3.27,6.06]).Therefore,Chinese medicine enema is effective in the treatment of UC,and can significantly reduce related symptoms.

A Meta-Analysis of Treating Radiation Proctitis by Retention Enema with Integrated Traditional Chinese and Western Medicine

Objective:To systematically and objectively evaluate clinical efficacy of retention enema with integrated traditional Chinese and western medicine on radiation proctitis(RP).Methods:CNKI,WANFANG,VIP,CMB and foreign language databases like Embase,Central and Medline were searched.Search dates were from establishment of the databases until May 2020.Randomized controlled trials(RCTs)of retention enema with integrated traditional Chinese and western medicine for RP were retrieved.Two system reviewers selected literature materials,extracted literature data,and evaluated the quality of the literatures.RevMan 5.3 software was used for data analysis.Results:A total of 12 studies were included,including 941 patients.Meta-analysis results showed:Clinical efficacy in the retention enema group with integrated traditional Chinese and western medicine was better than that in the simple western medicine enema or blank enema group(OR=5.96,95%CI[5.50,14.29],P<0.00001).Improvement of abdominal pain in the retention enema group with integrated traditional Chinese and western medicine was better than that in the control group(MD=-0.57,95%CI[-0.72,-0.42],P<0.00001).Treatment for hematochezia in the retention enema group with integrated traditional Chinese and western medicine was better than that in the control group(MD=-0.55,95%CI[-0.69,-0.42],P<0.00001).Improvement of diarrhea in the retention enema group with integrated traditional Chinese and western medicine was better than that in the control group(MD=-0.69,95%CI[-0.91,-0.48],P<0.00001).KPS scores in the retention enema group with integrated traditional Chinese and western medicine were better than those in the control group(MD=11.91,95%CI[3.81,20.01],P<0.00001).Conclusion:Clinical efficacy of retention enema with integrated traditional Chinese and western medicine on RP is better than simple western medicine enema or blank enema.Due to the low quality of the included clinical literatures,it is necessary to carry out more deliberate,detailed,high-quality,randomized,double-blind,and multi-center RCTs in order to give more powerful demonstration on its clinical efficacy on RP.

Structural and functional characteristics of microbiota in oropharynx of sub-healthy children with gastrointestinal heat retention syndrome differentiated by traditional Chinese medicine

Objective:To explore the structural and functional characteristics of microbiota in oropharynx of subhealthy children with gastrointestinal heat retention syndrome(GHRS)differentiated by traditional Chinese medicine,and screen the biometric operational taxonomic units(OTUs)to assist the clinical diagnosis.Methods:We recruited children according to the“GHRS diagnostic scale”,collected their oropharyngeal swabs,and sequenced the 16 SrDNA V4 region.We described the bacterial structure with alpha-indexes,beta-distances,and relative abundances;moreover,we screened the differential genera/OTUs with Wilcoxon rank-sum test,Metagenome Seq analysis,and linear discriminant analysis effect size(LEf Se)analysis,in which biometric OTUs were selected to construct the receiver operating characteristic curve to verify the diagnostic value.The bacterial function was predicted with Kyoto Encyclopedia of Genes and Genomes pathways according to 16S rDNA gene by using Phylogenetic Investigation of Communities by Reconstruction of Unobserved States.Results:The study population was composed of 10 children with GHRS and 10 healthy control children.GHRS children were more likely to overeat(gluttony,P=.033).Alpha-indexes,such as Sobs,abundancebased coverage estimator,Bootstrap,and Qstat,were significantly higher in the GHRS group,while betadistances did not exhibit any significant intergroup differences.There were 9 differently distributed nonpredominant genera between the groups in Wilcoxon rank-sum test,as well as 13 non-predominant genera in Metagenome Seq analysis and 3 non-predominant OTUs in LEfSe analysis.OTU44 and OTU196 were used to construct the receiver operating characteristic curve,and the area under curve was 0.92.Predicted functions showed that pathways related to oxidative phosphorylation and carbon metabolism were enriched in healthy control samples,while the pathway related to renin secretion was remarkably enriched in GHRS samples.Conclusion:Unique oropharyngeal microbial structure and function were identified in GHRS children.OTU44 and OTU196 were specific OTUs,which could be used as biomarkers of GHRS to assist clinical diagnosis.

Study on the Flow Injection Micro-Column Pre-Separation System Coupled With High Performance Liquid Chromatography for the Determination of Ecdysterone in Traditional Chinese Medicine

A flow injection (FI) micro-column system coupled with high performance liquid chromatography (HPLC) was proposed for the pre-separation and determination of active organic component (ecdysterone) in traditional Chinese medicine, Loulu. The factors influencing separation performance were investigated and optimized. Under the optimal conditions, the contents of ecdysterone in Loulu were determined by HPLC system using MeOH-H_2O (40: 60,V/V) as the mobile phase at a flow rate of 1. 0 mL/min. The calibration curve was linear in the range of 0. 5~ 100 mg/L of ecdysterone concentrations. The detection limit of the analyte was 0. 11mol/L(3) with a precision of 0. 38% RSD (n=7 f c= 10. 0 mg/L). The average recovery of the method was 98. 7%. The proposed method has been applied to determine ecdysterone in practical samples, and the determined values by both external standard method and standard addition method were in good agreement. Compared to the traditional solid extraction method, the system proposed has the advantages of simple procedure, good reproducibility, minimum volume requirement, reduction of matrix interference and low contamination risk.

Drug discovery from traditional Chinese herbal medicine using high content imaging technology

Traditional Chinese medicine(TCM) has been widely used in China and other Asia countries for thousands of years to treat or prevent human diseases. Chinese herbal medicine, one of the most important components of TCM, has unique diversities in chemical components, and thus results in a wide range of biological activities. However, pharmaceutical industry is facing a major challenge to develop a large population of novel natural products and drugs, and considerable efforts have not resulted in highvolume of novel drug discovery and productivity. At present, increasing attention has been paid to Chinese herb medicine modernization in combination with the cutting-age technologies of drug discovery, especially the high throughput selection. High content imaging is an image-based high throughput screening method by using automated microscopy and image analysis software to capture and analyze phenotypes at a large scale to investigate multiple biological features simultaneously in the biological complex. Here, we described the pipeline of the state-of-the-art high content imaging technology, summarized the applications of the high content imaging technology in drug discovery from traditional Chinese herbal medicine, and finally discussed the current challenges and future perspectives for development of high throughput image-based screening technology in novel drug research and discovery.

Feasibility and simulation model of a pilot scale membrane bioreactor for wastewater treatment and reuse from Chinese traditional medicine

The lack and pollution of water resource make wastewater reuse necessary. The pilot scale long-term tests for submerged membrane bioreactor were conducted to treat the effluents of anaerobic or aerobic treatment process for the high-strength Chinese traditional medicine wastewater. This article was focused on the feasibility of the wastewater treatment and reuse at shorter hydraulic retention time （HRT） of 5.0, 3.2 and 2.13 h. MLSS growth, membrane flux, vacuum values and chemical cleaning periods were also investigated. The experimental results of treating two-phase anaerobic treatment effluent demonstrated that the CODfilt was less than 100 mg/L when the influent COD was between 500-10000 mg/L at HRT of 5.0 h, which could satisfy the normal discharged standard in China. The experimental results to treat cross flow aerobic reactor effluent demonstrated that the average value of CODfilt was 17.28 mg/L when the average value of influent COD was 192.84 mg/L at HRT of 2.13 h during 106 d, which could completely meet the normal standard for water reuse. The maximum MLSS and MLVSS reached 24000 and 14500 mg/L at HRT of 3.2 h respectively. Membrane flux had maximal resume degrees of 94.7% at vacuum value of 0.02 MPa after cleaning. Chemical cleaning periods of membrane module were 150 d. A simulation model of operational parameters was also established based on the theory of back propagation neural network and linear regression of traditional mathematical model. The simulation model showed that the optimum operational parameters were suggested as follows： HRT was 5.0 h, SRT was 100 d, the range of COD loading rate was between 10.664-20.451 kg/（m3.d）, the range of MLSS was between 7543-13694 mg/L.

Research of Quality Standards for Stachydrine Hydrochloride in Chinese Medicine TJF Granule

A high-performance liquid chromatographic method was applied to the determination of stachydrine hydrochloride concentration in TJF granule (Chinese name: Tiao-Jing-Fang), using a mobile phase of methanol-acetonitrile (50:50, v/v) by the Agilent Kromasi NH2 column (250 mm × 4.6 mm, 5 μm, S/N: 22N25110). Detection wavelength was 201 nm. The result revealed good linearity of stachydrine hydrochloride and was obtained within the range of 0.20 - 1.98 μg/mL (R = 0.9995). The average recovery was 97.01%;the relative standard deviation (RSD) was 0.19%. To the best of our knowledge, this is the first report dedicated to the determination of stachydrine hydrochloride by the evaporative light scattering detector-high-performance liquid chromatographic (ELSD-HPLC) method.

基于子午流注的气交灸法在脑卒中后气虚型尿潴留病人中的应用

目的:探讨基于子午流注的气交灸法治疗脑卒中后气虚型尿潴留病人的临床效果。方法:选取2022年1月—2023年1月在我院住院治疗的60例脑卒中后气虚型尿潴留病人,采用随机数字表法将其分为治疗组和对照组,各30例,对照组给予脑卒中后尿潴留护理常规护理,治疗组在对照组的基础上实施基于子午流注的气交灸法,比较两组治疗前、治疗2周后膀胱残余尿量、治疗后的临床疗效和满意度。结果:治疗2周后,治疗组膀胱残余尿量、临床疗效和满意度均优于对照组,差异有统计学意义(P<0.05)。结论:基于子午流注的气交灸法能有效减少脑卒中后气虚型尿潴留病人的残余尿量,改善临床疗效,提高病人满意度。

中西医结合治疗1例高龄顽固性便秘患者的护理体会

本文总结1例高龄顽固性便秘患者的中西结合治疗和护理经验。在常规治疗的同时,依据知识转化模型(KTA),将循证指南推荐的便秘管理最佳证据进行临床实践,并依据相关中西医结合诊疗专家共识,形成基于循证的个体化中西医协同护理方案,采用中药保留灌肠软化粪石、中药离子导入促进肠蠕动、子午流注经皮穴位电刺激治疗促进气血运行,并配合营养、运动、排便等多维度护理,有效改善患者便秘症状。

“大思政”视域下中医类高校思政育人的建设路径

高等中医药院校专业课程的思政融入是当前“大思政”理念下专业人才培养的重要内容,也是高等中医药院校课程建设发展的刚需。中医学专业作为高等中医药院校的主要专业,在中医药薪火相传的道路上,其专业课程思政建设仍面临诸多难题,培养高水平的新时代中医药人才队伍对高等中医药院校任重而道远。本文以此为切入点,分析中医类高校思政育人的现实需求和阻碍,提出“环境-课程-方法-理念”四协同的育人路径,以期为中医药高素质人才培养提供建设思路。

双高建设背景下中医类专业产教融合培育模式的探索

百年大计,教育为本。中医类专业实践性和综合性都极强,产教融合培育模式是培育中医类人才、发展中医类专业的重要模式。基于此,以“双高”建设背景下中医类专业产教融合培育模式为切入点,从其现存问题、模式内涵和探索途径三方面探究双高背景下中医类专业产教融合培育模式,以期为各界针对双高背景下中医类专业产教融合培育模式的探索发展的理论研究和教学实践提供一定参考。

中药保留灌肠联合芒硝外敷的辨证施护治疗急性胰腺炎的效果

目的探讨中药保留灌肠联合芒硝外敷的中医辨证施护在急性胰腺炎患者中的应用效果。方法将80例急性胰腺炎患者随机分为观察组与对照组,对照组给予常规治疗护理,观察组在对照组基础上给予中药保留灌肠联合芒硝外敷的中医辨证施护治疗,观察两组的治疗效果及临床症状改善时间。结果观察组总有效率为97.5%(39/40),高于对照组的70.0%(28/40)(P<0.05)。经治疗,观察组临床症状改善时间均短于对照组(P<0.05)。结论中药保留灌肠联合芒硝外敷的中医辨证施护在急性胰腺炎患者中的应用效果显著,预后良好,患者乐意接受此项操作,可行推广。

双黄溃结宁灌肠方治疗轻中度大肠湿热型溃疡性结肠炎临床观察

目的探讨双黄溃结宁灌肠方治疗轻中度溃疡性结肠炎(UC)的临床疗效和安全性。方法选取医院2021年1月至2023年6月收治的轻中度大肠湿热型UC患者57例,随机分为观察组(28例)和对照组(29例)。两组患者均口服美沙拉嗪,在此基础上,对照组患者加用美沙拉嗪直肠栓剂治疗,观察组患者加用双黄溃结宁保留灌肠。两组患者均连续治疗12周。结果两组患者的临床缓解率相当(92.9%比86.2%,P>0.05)。观察组患者的中医证候改善有效率及生活质量评分均显著优于对照组(P<0.05或P<0.01)。两组均未发生不良反应。结论双黄溃结宁灌肠方治疗轻中度大肠湿热型溃疡性结肠炎疗效较好,安全性较高。

基于中药质量标志物的中药产业高质量发展技术策略

中药质量是中药安全有效的保障,中药质量关乎国民生命健康,也关乎中药产业的健康发展。以往中药质量研究与质量控制模式难以满足中药复杂体系的质量控制要求,需要在理论、模式、技术方法和研究路径上实现质的突破。在对中药复杂体系和产业特点客观分析的基础上,针对中药质量研究与质量控制现实问题,提出基于中药质量标志物的中药产业高质量发展技术策略。以此建立与中药临床效用密切关联、特有专属、整体评价和面向中药全产业链的质量标准和质量控制体系,并为行业监管提供科学、有效的“监管工具”,对于提高我国中药质量标准和质量控制水平具有一定的参考意义。

“六一”绩效管理模式赋能中医医院高质量发展实践探索

目的探索构建公立中医医院内部绩效考核管理体系,实现以绩效“国考”推动公立医院高质量发展的目标。方法在分析绩效考核过程中存在的问题与面临的困境的基础上,以三级公立中医医院绩效考核指标为导向,创新“六一”绩效管理策略和手段,即坚持“一盘棋”整体规划、“一条链”融会贯通、“一张网”全面覆盖、“一条龙”全程服务、“一本账”精细管理、“一个螺旋”持续改进,建立医院内部绩效考核管理体系。结果医院内涵建设取得一定成效,中医特色优势持续彰显,质量安全内涵日趋深化,运营管理效率稳步提升,学科建设成果实现突破,人才培养成效显著,医患双方满意度提升明显。结论构建科学、规范、标准的医院内部绩效考核管理体系,确保国家三级公立中医医院绩效考核工作落实到位,促进公立医院高质量发展。

中医药产业高质量发展的内涵、评价体系与基本路径探析

实现中医药产业高质量发展是构建现代中医药产业体系、推动中医药整体事业高质量发展的基本命题和重要支撑。文章通过梳理中医药产业高质量发展的内涵与评价体系,认为中医药产业高质量发展仍面临着技术升级和科技创新、产业集群打造、产业融合发展、龙头企业带动辐射、国际市场占领、产业服务平台完善等压力。为此,实现中医药产业高质量发展的政策导向和基本路径在于:建设产业基地、产业集群和产业园,完善产业链和产业体系;开发道地品牌中药材优势,打造富民兴业支柱产业;发挥特色脱贫致富模式效应,推进经济社会可持续发展;实施科技创新驱动战略,推动创造性转化创新性发展;构建“中医药+”融合发展新格局,推进现代化产业化;建设服务出口基地,促进对外贸易高速发展;聚焦发展瓶颈,探索产学研医政企协同共建新模式。

基于高分辨质谱的中药学本科实验课程教学探索

中药制剂是由多种中药配伍组成的,是一个复杂的分子体系,其分析鉴定工作存在较大难度。高效液相色谱与高分辨质谱联用系统(HPLC-HRMS)在中药复方的定性研究中发挥着重要作用。本论文通过探索将高分辨液相色谱质谱联用系统应用到中药学本科生实验教学实践中,建立了对中药制剂参松养心胶囊中5种特征性成分进行鉴定的实验教学方法。使学生了解高分辨质谱在中药制剂分析和鉴定中的重要应用,开阔了本校中药学专业本科生的科研视野,提高了学生对仪器分析的理解,对培养高素质高水平的药学本科生起到了积极作用。

高质量发展视域下中医药院校教师国际化培养模式研究

教师是人才培养的关键所在,是高等教育质量的有力保障。中医药院校教师在国际化建设中面临的问题和挑战主要有:学校顶层设计缺乏、学科间国际化发展不均衡、教师国际化意识不足。面对这些挑战,中医药院校需要建立学校-部门-教师三级联动的“点、线、面”教师国际化培养模式,通过加强顶层设计,完善培养体系,夯实政策保障,扩大国际交流,引进海外人才带动本土教师发展,提升教师国际化意识和跨文化能力,多元协同培养,加快教师队伍的国际化进程,从而推进中医药高等教育高质量发展。

厚朴排气合剂灌肠联合肠梗阻导管在小儿非绞窄性肠梗阻中的应用

目的:探讨肠梗阻导管联合厚朴排气合剂灌肠在小儿非绞窄性肠梗阻的应用。方法:100例非绞窄性肠梗阻患儿随机分为一般灌肠组和厚朴排气组各50例,一般灌肠组给予温盐水灌肠和肥皂水灌肠治疗;厚朴排气组给予肠梗阻导管联合厚朴排气合剂灌肠治疗。观察两组患儿治疗前后血清炎性因子变化情况、腹胀缓解时间、自主排气时间、恢复饮食时间、气-液平面消失时间及临床治疗有效率。结果:厚朴排气组腹胀缓解时间、自主排气时间、恢复饮食时间、气-液平面消失时间均短于一般灌肠组(P<0.05);厚朴排气组治疗后血清肠脂肪酸结合蛋白(intestinal fatty acid binding protein,IFABP)、D-二聚体(D-dimer,D-D)、血小板与淋巴细胞比值(plateletlymphocyte ratio,PLR)、降钙素原(procalcitonin,PCT)水平均低于一般灌肠组(P<0.05);厚朴排气组临床治愈率和有效率均高于一般灌肠组(P<0.05)。结论:肠梗阻导管联合厚朴排气合剂灌肠可以有效缩短小儿非绞窄性肠梗阻腹胀、排气和恢复饮食时间,减轻炎性反应,临床疗效确切。

萆薢渗湿汤合五味消毒饮联合扶利汤熏洗对高位肛瘘术后患者疼痛及创面愈合的影响

目的探讨萆薢渗湿汤合五味消毒饮联合扶利汤熏洗对高位肛瘘术后患者疼痛及创面愈合的影响。方法收集2021年11月—2022年11月在该院肛肠科治疗的104例高位肛瘘患者,随机分为试验组和对照组,各52例,两组均予以高位肛瘘切开挂线引流术,对照组予以复方荆芥熏洗剂坐浴后联合红光治疗,试验组予以萆薢渗湿汤合五味消毒饮口服联合扶利汤熏洗及红光治疗。记录并对比两组治疗后创面愈合时间、不良反应发生,术后不同时间段的创面面积、愈合率、创面渗液量、视觉模拟疼痛评分(VAS)及水肿评分,随访观察术后复发率。结果与对照组比较,试验组创面愈合时间缩短(P<0.05)。治疗后7 d创面面积差异无统计学意义;与对照组比较,试验组14 d、21 d创面面积缩小(P<0.05)。与对照组比较,试验组7 d、14 d、21 d创面愈合率增高(P<0.05)。与对照组比较,试验组7 d、14 d、21 d创面渗液量较低(P<0.05)。与对照组比较,试验组3 d、7 d水肿评分较低(P<0.05);对照组与试验组14 d、21 d水肿情况相比差异无统计学意义(P>0.05)。与对照组比较,试验组3 d、7 d、14 d、21 d疼痛评分较低(P<0.05)。两组复发率及不良反应发生情况相比,差异无统计学意义(P>0.05)。结论萆薢渗湿汤合五味消毒饮联合扶利汤对高位肛瘘患者的临床疗效显著,能够改善疼痛,使水肿减轻、渗出减少,创面愈合快,疗程短,安全性高,适宜临床应用推广。