Analysis of clinical characteristics of leptomeningeal metastasis with band-like high signal in the brainstem

Objective:The aim was to analyse the clinical features of leptomeningeal metastasis with banded high signal in the brainstem.Methods:In this paper,we report two cases of lung adenocarcinoma with soft meningeal metastasis,collected from the First Affiliated Hospital of Hainan Medical College,and searched the databases of CNKI,Wanfang,VIP,PubMed,Web of Science,and other databases which reported the MRI manifestation of"brainstem bandlike high signal",and collected the patients'past medical history,symptoms,signs,genetic findings,cerebrospinal fluid manifestation,treatment,and prognosis.Result:A total of 28 patients were included,of whom 26 had a history of lung adenocarcinoma and 2 were found to have occupational changes in the lungs.Magnetic resonance imaging(MRI)showed a band-like high signal in the ventral part of the brainstem on T2-FLAIR,symmetrical on both sides,which could extend to the cerebellar peduncles,with high signals on diffusion-weighted imaging(DWI),low signals on apparent diffusion coefficient(ADC),and long T1 signals on T1-weighted imaging,long T2 signals on T2 weighted imaging,and no long T2 signals on enhancement scan.T1-weighted imaging was a long T1 signal,T2-weighted imaging was a long T2 signal,and no enhancement was seen on enhanced scanning.Conclusion:It is important to recognize leptomeningeal metastasis of lung cancer,and the non-enhancing band of high signal in the brainstem on T2-FLAIR and DWI is likely to be the characteristic manifestation of leptomeningeal metastasis of non-small cell lung cancer.

Acquisition Practice of High Signal-to-Noise Ratio in YTB Block of Sichuan Basin

YTB block in Sichuan basin is a favorable area to exploit oil and gas in shallow tight rock. 3D seismic project of this zone has two characteristics. Firstly, it has high requirements for the tolerance rate of the construction process and the acquisition of high signal-to-noise ratio seismic data;Second, there are widely obstacles and noises that lead to difficult acquisition construction organization. In acquisition practice, high signal-to-noise ratio seismic data was obtained by reasonable design of construction scheme, optimization of excitation parameters, improvement of receiving conditions and optimization of obstacle crossing observation system. .

Gamma-aminobutyric acid A receptors in Alzheimer＇s disease： highly localized remodeling of a complex and diverse signaling pathway

Alzheimer＇s disease （AD）, the predominant form of dementia, is a chronic, incurable neurodegenerative disorder presenting with symptoms includ- ing progressive memory loss and disturbed emotional state. It has been estimated that dementia affects over 47 million people worldwide （Prince et al., 2015）, and with 60-80% of cases attributable to AD.

Research on Multi-System Ultra-High Speed Optical Signal Access System

In view of the small transmission capacity and single signal modulation format of the existing optical transmission system, this paper proposes an ultra-high-speed optical signal access scheme based on NEL0670, which can realize the transmission of 100 G DP-QPSK, 200 G DP-16QAM and 400 G DP-16QAM signals, and realize flexible and intelligent reception of multi-system optical signals.

Cognitive impairment in cerebral small vessel disease induced by hypertension

Hypertension is a primary risk factor for the progression of cognitive impairment caused by cerebral small vessel disease,the most common cerebrovascular disease.Howeve r,the causal relationship between hypertension and cerebral small vessel disease remains unclear.Hypertension has substantial negative impacts on brain health and is recognized as a risk factor for cerebrovascular disease.Chronic hypertension and lifestyle factors are associated with risks for stro ke and dementia,and cerebral small vessel disease can cause dementia and stroke.Hypertension is the main driver of cerebral small vessel disease,which changes the structure and function of cerebral vessels via various mechanisms and leads to lacunar infarction,leukoaraiosis,white matter lesions,and intracerebral hemorrhage,ultimately res ulting in cognitive decline and demonstrating that the brain is the to rget organ of hypertension.This review updates our understanding of the pathogenesis of hypertensioninduced cerebral small vessel disease and the res ulting changes in brain structure and function and declines in cognitive ability.We also discuss drugs to treat cerebral small vessel disease and cognitive impairment.

A MODIFIED HIGH-ORDER CUMULANT MUSIC ALGORITHM FOR SIGNAL DOA ESTIMATION

This paper gives a MUSIC signal DOA estimation algorithm based on the modified high-order cumulant matrix which is constructed by the recieved data and their conjugate rearrangements. When the snapshot number is limited, this algorithm can improve the signal DOA estimation performances obviously, and its computational complexity scarcely increases. Finally, some simulation results to verify the theoretical analyses are presented.

Signal Classification Method Based on Support Vector Machine and High-Order Cumulants

In this paper, a classification method based on Support Vector Machine (SVM) is given in the digital modulation signal classification. The second, fourth and sixth order cumulants of the received signals are used as classification vectors firstly, then the kernel thought is used to map the feature vector to the high dimensional feature space and the optimum separating hyperplane is constructed in space to realize signal recognition. In order to build an effective and robust SVM classifier, the radial basis kernel function is selected, one against one or one against rest of multi-class classifier is designed, and method of parameter selection using cross- validation grid is adopted. Through the experiments it can be concluded that the classifier based on SVM has high performance and is more robust.

神农架地区树轮蓝光强度对气候要素的响应

树轮在过去气候变化研究中发挥着难以替代的作用,在树木生长条件较为适宜地区传统的树轮宽度指标存在短板。树轮蓝光强度作为树轮密度的替代性指标,成为树轮-气候研究的重要载体。然而,树轮蓝光强度这一新兴的指标在亚热带地区的研究仍十分不足。为进一步挖掘树轮蓝光强度在我国亚热带地区树轮气候学研究中的应用潜力,利用神农架地区树轮宽度、树轮早材蓝光强度、树轮晚材蓝光强度、树轮早晚材蓝光强度差以及巴东气象站资料,基于树轮气候学方法,分析了上述树轮指标与月降水量、月平均最低气温、月平均气温和月平均最高气温之间的相关关系,对比了不同树轮指标蕴含气候信号的能力。研究结果表明,与树轮宽度相比,神农架地区树轮蓝光强度蕴含更为丰富的气候信号,其中树轮晚材蓝光强度、树轮早晚材蓝光强度差能够很好反映8月平均气温变化。其中,在原序列上树轮早晚材蓝光强度差与8月气温的关系最为紧密,而在高频上树轮晚材蓝光强度与8月平均气温的关系则更为紧密。树轮蓝光强度与气温之间高频信号一致性的发现,有助于丰富树木生长条件较为适宜地区树轮气候学的研究,为进一步的过去气温重建工作提供参考和依据。

脑小血管病患者膀胱过度活动症的影响因素分析

目的 探讨脑小血管病(CSVD)患者膀胱过度活动症(OAB)的影响因素及其与CSVD影像学标志物的相关性。方法 选取2021年1月至2022年12月于包头医学院第二附属医院就诊的老年CSVD患者163例,依据OAB评分量表评估分为OAB组37例和非OAB组126例。记录并比较2组患者简易智能状态检查量表(MMSE)评分、Fazekas量表评分、CSVD影像学总负荷评分。结果 与非OAB组比较,OAB组年龄、尿频、夜尿、尿急、急迫性尿失禁比例、Fazekas量表评分、脑室旁白质高信号(PWMH)评分、脑深部白质高信号(DWMH)评分、CSVD总负荷评分显著增高,MMSE评分显著降低(P<0.05,P<0.01)。PWMH评分、DWMH评分是OAB发生的危险因素(P<0.01)。CSVD患者OAB评分量表评分与Fazekas量表评分、PWMH评分、DWMH评分呈正相关(r=0.533,P=0.001;r=0.462,P=0.004;r=0.398,P=0.015);CSVD患者急迫性尿失禁的发生与Fazekas量表评分、PWMH评分呈正相关(r=0.352,P=0.033;r=0.346,P=0.036)。结论 PWMH、DWMH是CSVD患者OAB的危险因素。

基于谐波分解恢复弱势信号的高分辨率处理技术

地震资料高分辨率处理是预测薄储集层的有效手段,高分辨率处理的主要目的是有效恢复地震高、低频信息和拓宽频带,同时保持资料的信噪比和保真度。基于谐波分解恢复弱势信号的高分辨率处理技术,以压缩小波变换为基础,根据信号谐波分量对地震高、低频弱势信号进行恢复。首先,基于有效频带内的地震信号,采用压缩小波变换将其分解为各基频信号,然后计算各基频信号的高次谐波与低次谐波,将计算出的高次谐波与低次谐波加入小波变换系数中,最后进行小波逆变换,即可恢复高、低频弱势信号。在实现过程中,仅仅在有效频带内估算基频信号,能较好地保持信号的信噪比。地震信号的小波变换系数与地层反射系数具有一致性,因此该技术具有较高的保真度,可以较好保持相对振幅关系。实际应用表明,在保持资料信噪比的同时,该技术能大幅拓宽地震资料的频带,处理后的地震剖面断点更清楚,分辨能力改善明显,能较好地识别6 000 m以深约40 m的薄储集层。

高速低载频比传感信号下的逆变器有源阻尼自适应控制

逆变器工作在高频运行和控制载波比低的情况下,存在谐振尖峰抑制,提出了高速低载频比传感信号下的逆变器有源阻尼自适应控制技术。在高速低载频比传感信号下,构建逆变器数学模型。输出电流到电容电压与定子电流之间的传递函数,将逆变器的有源阻尼等效成一个控制电压环。调整有源阻尼自适应控制回路的参数,制定逆变器有源阻尼自适应控制策略。实验结果表明:文中技术的稳定裕度由2.46 dB下降至1.18 dB,可以保证逆变器的稳定运行;在不同采样频率下,可以控制逆变器输出与电网电压相同相位和频率的并网电流,其中在采样频率为5.9f时,输出并网电流和电压均表现为正弦状态,波动范围分别为[35 A,58 A]和[185 V,225 V],具有较好的控制效果。

高阶伪随机信号在对地通讯中的应用

对地通讯(Through-The-Earth Communication,TTEC)以大地为传播介质,使用低频电磁波来传输信息,在地下工程建设调度、预警、救援中有着重要作用.高阶伪随机信号可同时包含数十个频率,其具有易于实现、频率可控、抗干扰能力强的特点,有应用于对地通讯的潜力和价值.鉴于此,本文提出一种基于高阶伪随机信号的对地通讯新方法.通过在高阶伪随机信号中设置静态频组和动态频组,利用静态频组保证多个主频的平均幅值以维持发射稳定性,利用动态频组对通讯信息编码,传输有效信息.在实际工作时,发射端将通讯信息编码转换为高阶伪随机信号,利用长导线源向大地发射,接收端利用电极或者线圈接收电磁信号,经模式识别、时频变换、反向解码转换为有效通讯信息.通过仿真测试和在济南市某煤矿井下试验,完成有效通讯信息的发射、传输、解译等过程,实现了基于高阶伪随机信号的对地通讯方法,验证了方法在地下工程通讯的可行性和可靠性.

基于脑电信号特征的高铁调度员疲劳状态识别

为增强铁路行车的稳定性与安全性,有效识别调度员的疲劳状态对行车组织的影响,基于脑电(EEG)信号特征,提出一种调度员疲劳状态识别方法,根据作业时间段划分调度员的疲劳状态,设计高铁调度模拟试验获取脑电信号数据,通过小波级数展开和傅里叶变换提取高铁调度被试的3种脑电波频域幅值作为特征值,结合调度员作业特征和脑电信号特征,验证疲劳状态的划分结果,通过Python语言环境搭建ResNet18+SoftMax和MobileNet V2+SoftMax这2种模型,基于深度学习方法,将输入特征转换为三维立体矩形模型,并优化调整权重,获得最优模型,从而判断高铁调度员的疲劳状态。研究结果表明:ResNet18+SoftMax和MobileNet V2+SoftMax神经网络模型对高铁调度试验参与人员的疲劳状态识别准确率分别为92.78%和99.17%;相较于支持向量机(SVM)模型,这2种模型可提升清醒状态和疲劳状态的识别精度,并降低运算时间,其中,MobileNet V2+SoftMax模型的识别准确率和运行速度最优。以MobileNet V2+SoftMax模型原理为内核,可以更快速准确地识别高铁调度员在长时间作业条件下的潜在疲劳风险。

轴承转子系统快变过程振动响应的高精度频谱分析

针对高速轴承转子系统的启停过程,研究平稳和非平稳信号的高精度频谱分析方法,利用比例校正法对平稳信号频谱分析后的频率、幅值、相位进行了校正,建立一种将t时空域非平稳信号转变为t~2时空域平稳信号的方法,并基于平稳信号的比例校正法对其进行频谱分析,最后返回到t时空域获得某时刻的频域参数。仿真分析结果表明:该方法可以准确提取平稳信号的谱特征,也能较精确地提取非平稳信号特定时刻的频率、幅值和相位,提取结果精度较好,有效解决轴承转子系统快变过程的谱分析特征提取问题,为动力学特性分析提供了新思路。

溯源弹簧形变过程的断路器振动信号递归量化分析辨识方法

从锁止机构脱扣引起储能弹簧释能,经部件带动动触头运动再到静止的每个动作具有严格阶段特征,伴随断路器动作的机械振动展现了能量传递及设备健康状态。该文提出一种溯源弹簧形变过程的断路器振动信号递归量化分析方法,首先由高速相机捕捉断路器操动时储能弹簧的动作图像,通过计算机视觉跟踪动态提取反映弹簧形变特征帧,再依据特征帧时序划分操动过程;然后将不同阶段振动信号映射至高维相空间,经递归分析得到体现动力系统变化特征的递归图,并递归量化分析其纹理结构特征;最后利用支持向量机模型对正常及故障状态下的断路器振动特征样本进行分析辨识,对比结果证明,由弹簧释能时序细化振动信号特征分析有效提高了分类识别准确率。该文方法在断路器操动机构状态辨识中具有广阔的应用前景。

Treatable focal region modulated by double excitation signal superimposition to realize platform temperature distribution during transcranial brain tumor therapy with high-intensity focused ultrasound

Recently, the phase compensation technique has allowed the ultrasound to propagate through the skull and focus into the brain. However, the temperature evolution during treatment is hard to control to achieve effective treatment and avoid over-high temperature. Proposed in this paper is a method to modulate the temperature distribution in the focal region. It superimposes two signals which focus on two preset different targets with a certain distance. Then the temperature distribution is modulated by changing triggering time delay and amplitudes of the two signals. The simulation model is established based on an 82-element transducer and computed tomography （CT） data of a volunteer＇s head. A finite- difference time-domain （FDTD） method is used to calculate the temperature distributions. The results show that when the distances between the two targets respectively are 7.5-12.5 mm on the acoustic axis and 2.0-3.0 mm in the direction perpendicular to the acoustic axis, a focal region with a uniform temperature distribution （64-65 ℃） can be created. Moreover, the volume of the focal region formed by one irradiation can be adjusted （26.8-266.7 mm3） along with the uniform temperature distribution. This method may ensure the safety and efficacy of HIFU brain tumor therapy.

用数字示波器探究光磁共振实验中反常共振信号的机理

本文根据拟合得到的gF因子大小,确定了光磁共振实验中的反常共振信号;用数字示波器测量了反常共振射频信号的频谱,计算了反常共振射频信号各高次谐波的大小;通过线性拟合,得到了正常共振信号幅度与射频信号幅度的关系。利用此关系,计算了各高次谐波产生的反常共振信号大小,计算结果与测量值基本一致。频率计连接射频信号源后,射频信号波形和频谱发生明显变化,反常共振信号随着射频信号频谱的变化发生相应改变,进一步证明了反常共振信号由射频信号的高次谐波共振所引起。这些结果表明,用数字示波器探究光磁共振实验中反常共振信号的机理不仅可行,还能定量估算和预测射频信号波形对反常共振信号大小的影响。

血必净注射液调控HMGB1/TLR4/NF-κB通路对脓毒症小鼠肺损伤的保护作用

目的 研究血必净注射液调控高迁移率族蛋白1(HMGB1)/Toll样受体4(TLR4)/核因子-κB(NF-κB)通路对脓毒症小鼠肺损伤的保护作用。方法 雄性C57BL/6小鼠随机分为对照组,模型组和低、中、高剂量血必净组,阴性对照(NC)组,NC+模型组,NC+高剂量血必净组,HMGB1+高剂量血必净组。采用盲肠结扎穿孔术建立脓毒症肺损伤模型,造模前给予NC慢病毒或HMGB1慢病毒尾静脉注射,造模当天给予血必净注射液(剂量5、10、15mL/kg)腹腔注射,2次/d,连续3 d,末次给药后24 h进行取材和检测。比较各组间肺组织病理改变,湿重(W)/干重(D)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)、丙二醛(MDA)、超氧化物歧化酶(SOD)含量,裂解型Caspase-3、HMGB1、TLR4、NF-κB表达水平的差异。结果 模型组小鼠肺组织出现肺损伤的病理改变,W/D、TNF-α、IL-1β、IL-6、MDA的含量及裂解型Caspase-3、HMGB1、TLR4、NF-κB的表达水平均高于对照组,SOD的含量低于对照组(P<0.05)。不同剂量血必净组小鼠肺损伤的病理改变减轻,W/D、TNF-α、IL-1β、IL-6、MDA的含量及裂解型Caspase-3、HMGB1、TLR4、NF-κB的表达水平低于模型组,SOD的含量高于模型组(P<0.05)。HMGB1+高剂量血必净组小鼠肺损伤的病理改变加重,W/D、TNF-α、IL-1β、IL-6、MDA的含量及裂解型Caspase-3、HMGB1、TLR4、NF-κB的表达水平均高于NC+高剂量血必净组,SOD的含量低于NC+高剂量血必净组(P<0.05)。结论 血必净注射液对脓毒症小鼠肺损伤具有保护作用,并减轻炎症反应、氧化应激、细胞凋亡,其相关的分子机制为抑制HMGB1/TLR4/NF-κB通路。

一种优化高频注入法PMSM无位置传感器控制

传统高频信号注入法采用带通滤波器分离信号,龙伯格观测器利用所得信号计算出转子位置,考虑到带通滤波器设计复杂且使高频信号幅值产生衰减,同时龙伯格观测器需要电机转矩反馈、转动惯量等多种机械参数,这些因素干扰电机控制系统的动态性能等。采用基于低通滤波器的信号分离方法可在不损失高频信号得到含转子位置信号;利用电机的转速、转子位置角以及其角加速度之间关系构建扩张状态观测器,可以避免测量负载转矩和对不确定扰动的估计。仿真及实验结果表明,该优化策略能够使电机在低速控制时稳定运行,且具有更好的低速动态性能。

高糖培养条件下lncRNA CCAT2调控心肌细胞损伤和凋亡的机制研究

目的 探讨长链非编码RNA(lncRNA)结肠癌相关转录本2(CCAT2)在高糖培养条件下心肌细胞中的表达变化及通过Wnt/β-catenin信号通路调控心肌细胞损伤和凋亡的机制。方法 体外培养人心肌细胞AC16,将细胞分为4组,对照组、高糖组、高糖+干扰RNA阴性对照组、高糖+干扰RNA组(干扰RNA的靶标为lncRNA CCAT2)。采用CCK8法及流式细胞术检测细胞增殖和凋亡率;实时荧光定量PCR(qPCR)检测lncRNA CCAT2、β-catenin、转录因子7类似物2(TCF7L2)、Caspase-3、c-Myc、细胞周期蛋白(Cyclin)D1基因的表达;Western blot检测β-catenin、TCF7L2、CyclinD1蛋白表达;检测细胞培养液中超氧化物歧化酶(SOD)、乳酸脱氢酶(LDH)和天门冬氨酸氨基转移酶(AST)活性。结果 高糖培养条件下的AC16心肌细胞lncRNA CCAT2的基因表达显著高于对照组(P<0.05),同时β-catenin、TCF7L2、Caspase-3、c-Myc、CyclinD1基因表达显著上调(P<0.05),细胞增殖受到抑制(P<0.05),凋亡率增加(P<0.05),细胞培养液中LDH和AST活性显著升高(P<0.05),细胞中SOD活性显著降低(P<0.05)。高糖培养条件下,RNA干扰lncRNA CCAT2表达后,细胞增殖增加(P<0.05),细胞凋亡率显著下降(P<0.05),β-catenin、TCF7L2、Caspase-3、c-Myc、CyclinD1基因的表达下调(P<0.05),β-catenin(细胞核)、TCF7L2、CyclinD1蛋白表达显著下调(P<0.05),β-catenin(细胞质)蛋白表达显著上调(P<0.05)。结论 高糖条件下,lncRNA CCAT2可通过Wnt/β-catenin信号通路调控心肌细胞损伤和凋亡。