This study investigated the impact of simulated microgravity on acute injury induced by low doses of carbon ions in male reproductive organs of mice,and determined alterations in spermatogenic function and expression ...This study investigated the impact of simulated microgravity on acute injury induced by low doses of carbon ions in male reproductive organs of mice,and determined alterations in spermatogenic function and expression levels of apoptotic factors in mice following exposure to acute irradiation after 7 days of simulated microgravity.The results demonstrated that significant reductions in spermatozoa,primary spermatocytes and spermatogonia,and increased globular cells in seminiferous tubule and pro-apoptotic proteins were observed in the group exposed to over0.4 Gy irradiation.Collectively,the data suggest that lesions inflicted by simulated microgravity are not markedly modified by lower doses of irradiation(0.2 Gy)in mouse testis compared to the control group.However,testicular impairments were markedly evident in the group exposed to higher doses of carbon ions plus simulated microgravity,which may be due at least in part to elevated apoptosis initiated by the mitochondrial apoptosis pathway in germ cells.展开更多
目的：采用Meta分析方法评价let-7低表达在肺癌预后中的作用及高迁移率旋蛋白A2（HMGA2）表达与肺癌关系的临床意义。方法：计算机检索PubMed、Web of Science、Medline、Cochrane Library、Google、Scholar、CNKI、CBM、万方和维普等...目的：采用Meta分析方法评价let-7低表达在肺癌预后中的作用及高迁移率旋蛋白A2（HMGA2）表达与肺癌关系的临床意义。方法：计算机检索PubMed、Web of Science、Medline、Cochrane Library、Google、Scholar、CNKI、CBM、万方和维普等数据库,收集关于let-7低表达与肺癌预后及HMGA2与肺癌发生发展的关联性研究,采用StataSE 12.0软件进行Meta分析。结果：共纳入10篇关于let-7低表达与肺癌预后关系的文献用于Meta分析,均为非小细胞肺癌患者。let-7低表达预示着肺癌患者较差的总生存率,风险比（HR）的合并值为1.55（95%CI：1.16～2.09,P〈0.05）。共纳入9篇关于HMGA2表达与非小细胞肺癌发生发展关系的病例对照研究用于Meta分析,肺癌组织中HMGA2表达阳性率明显高于癌旁正常组织（OR=5.92,95%CI：3.96～8.85,P=0.000）。HMGA2在肺癌组织的表达与肺癌TNM分期、有无淋巴结转移有明显关联（OR=0.26,95%CI：0.16～0.41,P〈0.05;OR=0.29,95%CI：0.12～0.71,P〈0.05）。结论：肺癌患者中let-7低表达是肺癌患者预后的危险因素。HMGA2表达阳性率越高,肺癌发生的概率就越高,越具有侵袭性。展开更多
基金Supported by grants from the National Basic Research Program of China(No.2010CB834202)Knowledge Innovation Projection of Chinese Academy of Science(No.KJCX2-YW-L08)The National Natural Science Foundation of China(No.10835011,No.10675151,No.41161058,No.31060065 and No.10805064)
文摘This study investigated the impact of simulated microgravity on acute injury induced by low doses of carbon ions in male reproductive organs of mice,and determined alterations in spermatogenic function and expression levels of apoptotic factors in mice following exposure to acute irradiation after 7 days of simulated microgravity.The results demonstrated that significant reductions in spermatozoa,primary spermatocytes and spermatogonia,and increased globular cells in seminiferous tubule and pro-apoptotic proteins were observed in the group exposed to over0.4 Gy irradiation.Collectively,the data suggest that lesions inflicted by simulated microgravity are not markedly modified by lower doses of irradiation(0.2 Gy)in mouse testis compared to the control group.However,testicular impairments were markedly evident in the group exposed to higher doses of carbon ions plus simulated microgravity,which may be due at least in part to elevated apoptosis initiated by the mitochondrial apoptosis pathway in germ cells.
文摘目的：采用Meta分析方法评价let-7低表达在肺癌预后中的作用及高迁移率旋蛋白A2（HMGA2）表达与肺癌关系的临床意义。方法：计算机检索PubMed、Web of Science、Medline、Cochrane Library、Google、Scholar、CNKI、CBM、万方和维普等数据库,收集关于let-7低表达与肺癌预后及HMGA2与肺癌发生发展的关联性研究,采用StataSE 12.0软件进行Meta分析。结果：共纳入10篇关于let-7低表达与肺癌预后关系的文献用于Meta分析,均为非小细胞肺癌患者。let-7低表达预示着肺癌患者较差的总生存率,风险比（HR）的合并值为1.55（95%CI：1.16～2.09,P〈0.05）。共纳入9篇关于HMGA2表达与非小细胞肺癌发生发展关系的病例对照研究用于Meta分析,肺癌组织中HMGA2表达阳性率明显高于癌旁正常组织（OR=5.92,95%CI：3.96～8.85,P=0.000）。HMGA2在肺癌组织的表达与肺癌TNM分期、有无淋巴结转移有明显关联（OR=0.26,95%CI：0.16～0.41,P〈0.05;OR=0.29,95%CI：0.12～0.71,P〈0.05）。结论：肺癌患者中let-7低表达是肺癌患者预后的危险因素。HMGA2表达阳性率越高,肺癌发生的概率就越高,越具有侵袭性。
