BACKGROUND Acupuncture promotes the recovery of gastrointestinal function and provides analgesia after major abdominal surgery.The effects of transcutaneous electrical acupoint stimulation(TEAS)remain unclear.AIM To e...BACKGROUND Acupuncture promotes the recovery of gastrointestinal function and provides analgesia after major abdominal surgery.The effects of transcutaneous electrical acupoint stimulation(TEAS)remain unclear.AIM To explore the potential effects of TEAS on the recovery of gastrointestinal function after gastrectomy and colorectal resection.METHODS Patients scheduled for gastrectomy or colorectal resection were randomized at a 2:3:3:2 ratio to receive:(1)TEAS at maximum tolerable current for 30 min immediately prior to anesthesia induction and for the entire duration of surgery,plus two 30-min daily sessions for 3 consecutive days after surgery(perioperative TEAS group);(2)Preoperative and intraoperative TEAS only;(3)Preoperative and postoperative TEAS only;or(4)Sham stimulation.The primary outcome was the time from the end of surgery to the first bowel sound.RESULTS In total,441 patients were randomized;405 patients(58.4±10.2 years of age;247 males)received the planned surgery.The time to the first bowel sounds did not differ among the four groups(P=0.90;log-rank test).On postoperative day 1,the rest pain scores differed significantly among the four groups(P=0.04;Kruskal–Wallis test).Post hoc comparison using the Bonferroni test showed lower pain scores in the perioperative TEAS group(1.4±1.2)than in the sham sti-mulation group(1.7±1.1;P=0.04).Surgical complications did not differ among the four groups.CONCLUSION TEAS provided analgesic effects in adult patients undergoing major abdominal surgery,and it can be added to clinical practice as a means of accelerating postoperative rehabilitation of these patients.展开更多
High-frequency spinal cord stimulation(HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat ne...High-frequency spinal cord stimulation(HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat neuropathic pain was induced by spinal nerve ligation. Two days after modeling, the rats were subjected to 4 hours of HF-SCS(motor threshold 50%, frequency 10,000 Hz, and pulse width 0.024 ms) in the dorsal horn of the spinal cord. The results revealed that the tactile allodynia of spinal nerve-injured rats was markedly alleviated by HFSCS, and the effects were sustained for 3 hours after the stimulation had ceased. HF-SCS restored lysosomal function, increased the levels of lysosome-associated membrane protein 2(LAMP2) and the mature form of cathepsin D(matu-CTSD), and alleviated the abnormally elevated levels of microtubule-associated protein 1 A/B-light chain 3(LC3)-II and sequestosome 1(P62) in spinal nerve-injured rats. HF-SCS also mostly restored the immunoreactivity of LAMP2, which was localized in neurons in the superficial layers of the spinal dorsal horn in spinal nerve-injured rats. In addition, intraperitoneal administration of 15 mg/kg chloroquine for 60 minutes reversed the expression of the aforementioned proteins and shortened the timing of the analgesic effects of HF-SCS. These findings suggest that HF-SCS may exhibit longlasting analgesic effects on neuropathic pain in rats through improving lysosomal dysfunction and alleviating autophagic flux. This study was approved by the Laboratory Animal Ethics Committee of China Medical University, Shenyang, China(approval No. 2017 PS196 K) on March 1, 2017.展开更多
An accurate detection of the effective values of electric voltage and current from high frequency power generators is a precondition for the development of smart electrotomes. In this light, an energy detection system...An accurate detection of the effective values of electric voltage and current from high frequency power generators is a precondition for the development of smart electrotomes. In this light, an energy detection system based on personal computer (PC) is developed hereby. It senses voltage and current in isolation from generators with transformers, and then the measured values are amplified, filtered, transformed into single-ended signals and converted to RMS. The detected signals are transformed into digital signals through Data Acquisition Card (DAQ) and the data are processed with quadratic fit in Labview. Finally, the controller completes constant power output. The experiment results indicate that the energy detection system can measure the output parameters precisely and the controller can achieve constant power control.展开更多
BACKGROUND Schwannoma is a benign tumor originating from the peripheral nerve sheath.The clinical symptoms of tracheal schwannoma depend on the location of the tumor,and the most common clinical symptoms are cough and...BACKGROUND Schwannoma is a benign tumor originating from the peripheral nerve sheath.The clinical symptoms of tracheal schwannoma depend on the location of the tumor,and the most common clinical symptoms are cough and hemoptysis.The most effective treatment for benign tumors is complete resection of the primary lesion at an early stage.Our experience has demonstrated that primary tracheal schwannoma can be safely excised with a high-frequency electric knife in a minimally invasive manner.CASE SUMMARY We report a 61-year-old asymptomatic woman who underwent chest computed tomography(CT),which accidentally found an intraluminal tracheal mass without enlarged lymph nodes.Then,the patient underwent bronchoscopy,which found that the tracheal mass originated from the left wall of the upper trachea,was less than 1.5 cm in size,immovable,smooth and 4 cm away from the vocal cord,resulting in partial upper respiratory tract obstruction.Treatment was performed using an endoscopic resection for en bloc removal of the tracheal mass.The diagnosis was primary tracheal schwannoma.A follow-up was performed after endoscopic surgery,and bronchoscopy and thoracic CT were used to monitor whether there was a recurrence.At present,there is no evidence of recurrence,and the patient had a good quality of life.Endoscopic resection may be effective and safe in the treatment of primary tracheal schwannoma.CONCLUSION Primary tracheal schwannoma is a very rare benign tumor.In this case,we cured it by complete endoscopic resection.展开更多
Epilepsy is one of the most common serious neurological disorders. Pharmacoresistant epilepsy patients are poorly controlled or their seizures are refractory to drug treatment. Resective surgery is frequently a promis...Epilepsy is one of the most common serious neurological disorders. Pharmacoresistant epilepsy patients are poorly controlled or their seizures are refractory to drug treatment. Resective surgery is frequently a promising therapy in this population, however, not all the patients meet the eligibility criteria for the surgical treatment. Deep brain stimulation has been investigated in clinical studies and animal studies as an alternative treatment, but the optimal stimulation parameters remain an issue. The present study was designed to investigate the effect of unilateral high-frequency stimulation (HFS) of hippocampus on seizure development by using the hippocampal rapid kindling method (hRK) in rats, and compared the results with those of low-frequency stimulation previously published by our group. We used male Wistar rats implanted with electrodes in the ventral hippocampus. All rats underwent hRK (biphasic square wave pulses, 20 Hz for 10 seconds) during three consecutive days (twelve stimulations per day). The control group (hRK;n = 7) received only RK stimulus, while the treated group (HFS-hRK;n = 9) received also HFS (biphasic square wave pulses, 130 Hz for 30 seconds) immediately before the RK stimulus, during three consecutive days. At the end of behavioral testing 78% (p 0.01) of the animals receiving HFS treatment were still not fully kindled staying in stages 0 -III (p 0.01). HFS group needed a higher number of stimulations to achieve stage III (p 0.05) with respect to control group. However, no significant differences in the cumulative daily afterdischarge duration were observed. HFS did not present significant differences compared with LFS in any of studied parameters. The findings suggest that unilateral HFS applied on hippocampus effectively inhibited the epileptogenic process induced by hippocampal rapid kindling. According to the comparative results about hippocampal rapid kindled animals stimulated with HFS and LFS (5 Hz), we found no conclusive information on which treatment is most efficient.展开更多
The total electricity consumption(TEC)can accurately reflect the operation of the national economy,and the forecasting of the TEC can help predict the economic development trend,as well as provide insights for the for...The total electricity consumption(TEC)can accurately reflect the operation of the national economy,and the forecasting of the TEC can help predict the economic development trend,as well as provide insights for the formulation of macro policies.Nowadays,high-frequency and massive multi-source data provide a new way to predict the TEC.In this paper,a"seasonal-cumulative temperature index"is constructed based on high-frequency temperature data,and a mixed-frequency prediction model based on multi-source big data(Mixed Data Sampling with Monthly Temperature and Daily Temperature index,MIDAS-MT-DT)is proposed.Experimental results show that the MIDAS-MT-DT model achieves higher prediction accuracy,and the"seasonal-cumulative temperature index"can improve prediction accuracy.展开更多
目的:探讨宫腔镜电切术治疗子宫黏膜下肌瘤患者的临床效果。方法:选取2019年1月—2021年12月在宜春新建医院妇产科接受治疗的子宫黏膜下肌瘤患者80例,按照信封法随机分为对照组与观察组,各40例。对照组给予腹腔镜切除术治疗,观察组给予...目的:探讨宫腔镜电切术治疗子宫黏膜下肌瘤患者的临床效果。方法:选取2019年1月—2021年12月在宜春新建医院妇产科接受治疗的子宫黏膜下肌瘤患者80例,按照信封法随机分为对照组与观察组,各40例。对照组给予腹腔镜切除术治疗,观察组给予宫腔镜电切术治疗。比较两组手术相关情况、卵巢储备功能[窦卵泡计数(antral follicle count,AFC)、卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)]、女性性功能指数(female sexual function index,FSFI)评分、术后并发症发生情况及月经状态。结果:观察组手术时间、术后排气时间、首次下床活动时间及住院时间均短于对照组,术中出血量少于对照组,差异均有统计学意义(P<0.05)。手术前后,两组AFC、FSH及LH水平比较,差异均无统计学意义(P>0.05)。手术后3个月,观察组FSFI各项维度评分均高于对照组,差异均有统计学意义(P<0.05)。手术后3个月,两组月经周期、经期时间、月经量较手术前均有改善,且观察组均优于对照组(P<0.05)。观察组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:宫腔镜电切术治疗子宫黏膜下肌瘤患者创伤小,可促进术后康复,对卵巢储备功能影响小且术后并发症发生率低,有助于改善月经状态,提升性生活质量。展开更多
基金National Basic Research Program of China(Project 973)from The Ministry of Science and Technology of the People's Republic of China,No.2013CB531900。
文摘BACKGROUND Acupuncture promotes the recovery of gastrointestinal function and provides analgesia after major abdominal surgery.The effects of transcutaneous electrical acupoint stimulation(TEAS)remain unclear.AIM To explore the potential effects of TEAS on the recovery of gastrointestinal function after gastrectomy and colorectal resection.METHODS Patients scheduled for gastrectomy or colorectal resection were randomized at a 2:3:3:2 ratio to receive:(1)TEAS at maximum tolerable current for 30 min immediately prior to anesthesia induction and for the entire duration of surgery,plus two 30-min daily sessions for 3 consecutive days after surgery(perioperative TEAS group);(2)Preoperative and intraoperative TEAS only;(3)Preoperative and postoperative TEAS only;or(4)Sham stimulation.The primary outcome was the time from the end of surgery to the first bowel sound.RESULTS In total,441 patients were randomized;405 patients(58.4±10.2 years of age;247 males)received the planned surgery.The time to the first bowel sounds did not differ among the four groups(P=0.90;log-rank test).On postoperative day 1,the rest pain scores differed significantly among the four groups(P=0.04;Kruskal–Wallis test).Post hoc comparison using the Bonferroni test showed lower pain scores in the perioperative TEAS group(1.4±1.2)than in the sham sti-mulation group(1.7±1.1;P=0.04).Surgical complications did not differ among the four groups.CONCLUSION TEAS provided analgesic effects in adult patients undergoing major abdominal surgery,and it can be added to clinical practice as a means of accelerating postoperative rehabilitation of these patients.
基金supported by the National Nature Science Foundation of China,No.81870838Liaoning Province Distinguished Professor Support Program of China,No.XLYC1802096+1 种基金Shenyang Clinical Medicine Research Center of Anesthesiology of China,Nos.19-110-4-24,20-204-4-44the Outstanding Scientific Foundation of Shengjing Hospital of China,No.201708(all to PZ)。
文摘High-frequency spinal cord stimulation(HF-SCS) has been established as an effective therapy for neuropathic pain. However, the analgesic mechanisms involved in HF-SCS remain to be clarified. In our study, adult rat neuropathic pain was induced by spinal nerve ligation. Two days after modeling, the rats were subjected to 4 hours of HF-SCS(motor threshold 50%, frequency 10,000 Hz, and pulse width 0.024 ms) in the dorsal horn of the spinal cord. The results revealed that the tactile allodynia of spinal nerve-injured rats was markedly alleviated by HFSCS, and the effects were sustained for 3 hours after the stimulation had ceased. HF-SCS restored lysosomal function, increased the levels of lysosome-associated membrane protein 2(LAMP2) and the mature form of cathepsin D(matu-CTSD), and alleviated the abnormally elevated levels of microtubule-associated protein 1 A/B-light chain 3(LC3)-II and sequestosome 1(P62) in spinal nerve-injured rats. HF-SCS also mostly restored the immunoreactivity of LAMP2, which was localized in neurons in the superficial layers of the spinal dorsal horn in spinal nerve-injured rats. In addition, intraperitoneal administration of 15 mg/kg chloroquine for 60 minutes reversed the expression of the aforementioned proteins and shortened the timing of the analgesic effects of HF-SCS. These findings suggest that HF-SCS may exhibit longlasting analgesic effects on neuropathic pain in rats through improving lysosomal dysfunction and alleviating autophagic flux. This study was approved by the Laboratory Animal Ethics Committee of China Medical University, Shenyang, China(approval No. 2017 PS196 K) on March 1, 2017.
文摘An accurate detection of the effective values of electric voltage and current from high frequency power generators is a precondition for the development of smart electrotomes. In this light, an energy detection system based on personal computer (PC) is developed hereby. It senses voltage and current in isolation from generators with transformers, and then the measured values are amplified, filtered, transformed into single-ended signals and converted to RMS. The detected signals are transformed into digital signals through Data Acquisition Card (DAQ) and the data are processed with quadratic fit in Labview. Finally, the controller completes constant power output. The experiment results indicate that the energy detection system can measure the output parameters precisely and the controller can achieve constant power control.
文摘BACKGROUND Schwannoma is a benign tumor originating from the peripheral nerve sheath.The clinical symptoms of tracheal schwannoma depend on the location of the tumor,and the most common clinical symptoms are cough and hemoptysis.The most effective treatment for benign tumors is complete resection of the primary lesion at an early stage.Our experience has demonstrated that primary tracheal schwannoma can be safely excised with a high-frequency electric knife in a minimally invasive manner.CASE SUMMARY We report a 61-year-old asymptomatic woman who underwent chest computed tomography(CT),which accidentally found an intraluminal tracheal mass without enlarged lymph nodes.Then,the patient underwent bronchoscopy,which found that the tracheal mass originated from the left wall of the upper trachea,was less than 1.5 cm in size,immovable,smooth and 4 cm away from the vocal cord,resulting in partial upper respiratory tract obstruction.Treatment was performed using an endoscopic resection for en bloc removal of the tracheal mass.The diagnosis was primary tracheal schwannoma.A follow-up was performed after endoscopic surgery,and bronchoscopy and thoracic CT were used to monitor whether there was a recurrence.At present,there is no evidence of recurrence,and the patient had a good quality of life.Endoscopic resection may be effective and safe in the treatment of primary tracheal schwannoma.CONCLUSION Primary tracheal schwannoma is a very rare benign tumor.In this case,we cured it by complete endoscopic resection.
文摘Epilepsy is one of the most common serious neurological disorders. Pharmacoresistant epilepsy patients are poorly controlled or their seizures are refractory to drug treatment. Resective surgery is frequently a promising therapy in this population, however, not all the patients meet the eligibility criteria for the surgical treatment. Deep brain stimulation has been investigated in clinical studies and animal studies as an alternative treatment, but the optimal stimulation parameters remain an issue. The present study was designed to investigate the effect of unilateral high-frequency stimulation (HFS) of hippocampus on seizure development by using the hippocampal rapid kindling method (hRK) in rats, and compared the results with those of low-frequency stimulation previously published by our group. We used male Wistar rats implanted with electrodes in the ventral hippocampus. All rats underwent hRK (biphasic square wave pulses, 20 Hz for 10 seconds) during three consecutive days (twelve stimulations per day). The control group (hRK;n = 7) received only RK stimulus, while the treated group (HFS-hRK;n = 9) received also HFS (biphasic square wave pulses, 130 Hz for 30 seconds) immediately before the RK stimulus, during three consecutive days. At the end of behavioral testing 78% (p 0.01) of the animals receiving HFS treatment were still not fully kindled staying in stages 0 -III (p 0.01). HFS group needed a higher number of stimulations to achieve stage III (p 0.05) with respect to control group. However, no significant differences in the cumulative daily afterdischarge duration were observed. HFS did not present significant differences compared with LFS in any of studied parameters. The findings suggest that unilateral HFS applied on hippocampus effectively inhibited the epileptogenic process induced by hippocampal rapid kindling. According to the comparative results about hippocampal rapid kindled animals stimulated with HFS and LFS (5 Hz), we found no conclusive information on which treatment is most efficient.
基金supported by the science and technology project of State Grid Corporation of China(Project Code:1400-202157207A-0-0-00)the National Natural Science Foundation of China[grant numbers 72273137].
文摘The total electricity consumption(TEC)can accurately reflect the operation of the national economy,and the forecasting of the TEC can help predict the economic development trend,as well as provide insights for the formulation of macro policies.Nowadays,high-frequency and massive multi-source data provide a new way to predict the TEC.In this paper,a"seasonal-cumulative temperature index"is constructed based on high-frequency temperature data,and a mixed-frequency prediction model based on multi-source big data(Mixed Data Sampling with Monthly Temperature and Daily Temperature index,MIDAS-MT-DT)is proposed.Experimental results show that the MIDAS-MT-DT model achieves higher prediction accuracy,and the"seasonal-cumulative temperature index"can improve prediction accuracy.
文摘目的:探讨宫腔镜电切术治疗子宫黏膜下肌瘤患者的临床效果。方法:选取2019年1月—2021年12月在宜春新建医院妇产科接受治疗的子宫黏膜下肌瘤患者80例,按照信封法随机分为对照组与观察组,各40例。对照组给予腹腔镜切除术治疗,观察组给予宫腔镜电切术治疗。比较两组手术相关情况、卵巢储备功能[窦卵泡计数(antral follicle count,AFC)、卵泡刺激素(follicle stimulating hormone,FSH)、黄体生成素(luteinizing hormone,LH)]、女性性功能指数(female sexual function index,FSFI)评分、术后并发症发生情况及月经状态。结果:观察组手术时间、术后排气时间、首次下床活动时间及住院时间均短于对照组,术中出血量少于对照组,差异均有统计学意义(P<0.05)。手术前后,两组AFC、FSH及LH水平比较,差异均无统计学意义(P>0.05)。手术后3个月,观察组FSFI各项维度评分均高于对照组,差异均有统计学意义(P<0.05)。手术后3个月,两组月经周期、经期时间、月经量较手术前均有改善,且观察组均优于对照组(P<0.05)。观察组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:宫腔镜电切术治疗子宫黏膜下肌瘤患者创伤小,可促进术后康复,对卵巢储备功能影响小且术后并发症发生率低,有助于改善月经状态,提升性生活质量。
