Objective:To use high-frequency ultrasound to evaluate the efficacy ofα-lipoic acid combined with traditional Chinese medicine in the treatment of diabetic peripheral neuropathy(DPN),so as to provide a basis for clin...Objective:To use high-frequency ultrasound to evaluate the efficacy ofα-lipoic acid combined with traditional Chinese medicine in the treatment of diabetic peripheral neuropathy(DPN),so as to provide a basis for clinical medication and evaluation of therapeutic effect.Methods:From December 2018 to December 2019,110 patients with DPN who met the inclusion and exclusion criteria were divided into observation group and control group according to different treatment plans.The control group was treated withα-lipoic acid,and the observation group was treated withα-lipoic acid combined with traditional Chinese medicine encapsulation treatment,and used high-frequency ultrasound,nerve conduction velocity and serological examination to comprehensively evaluate the effectiveness of the two treatment methods.Results:The mean amplitude of glycemic excursions(MAGE)value of the observation group and the control group after treatment was significantly lower than before treatment(P<0.05);After treatment,the SCV of the ulnar nerve,median nerve,and common peroneal nerve in the two groups was significantly faster than before treatment(P<0.05).Similar to SCV,the MCV of the three nerves measured after treatment in the two groups was significantly faster than before treatment(P<0.05).Compared between the groups after treatment,the three kinds of nerve SCV and MCV in the observation group were significantly faster than those in the control group(P<0.05).The cross-sectional area(CSA)value of the ulnar nerve,median nerve and common peroneal nerve in the observation group after treatment was significantly lower than before treatment(P<0.05).Compared with the control group after treatment,the three nerves CSA in the observation group was significantly lower than that in the control group(P<0.05).Abnormal ultrasound performance:The proportion of abnormal ultrasound performances of the ulnar nerve,median nerve,and common peroneal nerve in the observation group after treatment was significantly lower than before treatment(P<0.05).The composition ratio of internal echo reduction and ambiguity in the observation group after three nerve treatments was significantly lower than that in the control group after treatment(P<0.05).In the correlation analysis,the three kinds of nerve CSA before and after treatment were negatively correlated with SCV and amplitude(P<0.05),and positively correlated with latency(P<0.05).Conclusion:The combination ofα-lipoic acid and Chinese medicine encapsulation technology has a good effect on the treatment and repair of DPN nerve damage,and can be routinely applied in clinical treatment.High-frequency ultrasound can intuitively observe changes in peripheral nerves and can be used to evaluate the prognosis of DPN.展开更多
Traumatic facial nerve injuries can result in temporary or permanent loss of function.Restoration of facial expression may occur spontaneously or require surgical intervention.Although thorough examination and history...Traumatic facial nerve injuries can result in temporary or permanent loss of function.Restoration of facial expression may occur spontaneously or require surgical intervention.Although thorough examination and history can localize the site of facial nerve damage,it can be difficult to predict if and when recovery will occur.This is salient because the window for optimal outcomes from surgical re-neurotization can be as short as 1 to 2 years,after which functional loss may be irreversible.It is essential to offer patients the most appropriate treatment plan based on prognosis,and imaging plays an essential role in localizing the site and morphology of nerve injury.Multiple imaging modalities have been used to evaluate the facial nerve,including computed tomography(CT)and,more recently,advanced magnetic resonance imaging(MRI)and ultrasound(US).CT and MRI are more commonly implemented;however,Diffusion tensor tractography,high-resolution US,and functional US are gaining traction for studying cranial nerve pathology.Until recently,the morphology of facial nerve and other cranial nerve injuries could only be inferred using non-invasive diagnostic techniques.With the advent of newer imaging technologies and techniques to examine nerves,more refined assessment and prognostic information is now possible.This article reviews up-to-date cranial nerve imaging techniques from the last ten years and explores future avenues for facial nerve imaging.展开更多
基金National natural science foundation of China(No.81701891)Guided scientific research project of Shiyan science and technology bureau(No.18Y63)。
文摘Objective:To use high-frequency ultrasound to evaluate the efficacy ofα-lipoic acid combined with traditional Chinese medicine in the treatment of diabetic peripheral neuropathy(DPN),so as to provide a basis for clinical medication and evaluation of therapeutic effect.Methods:From December 2018 to December 2019,110 patients with DPN who met the inclusion and exclusion criteria were divided into observation group and control group according to different treatment plans.The control group was treated withα-lipoic acid,and the observation group was treated withα-lipoic acid combined with traditional Chinese medicine encapsulation treatment,and used high-frequency ultrasound,nerve conduction velocity and serological examination to comprehensively evaluate the effectiveness of the two treatment methods.Results:The mean amplitude of glycemic excursions(MAGE)value of the observation group and the control group after treatment was significantly lower than before treatment(P<0.05);After treatment,the SCV of the ulnar nerve,median nerve,and common peroneal nerve in the two groups was significantly faster than before treatment(P<0.05).Similar to SCV,the MCV of the three nerves measured after treatment in the two groups was significantly faster than before treatment(P<0.05).Compared between the groups after treatment,the three kinds of nerve SCV and MCV in the observation group were significantly faster than those in the control group(P<0.05).The cross-sectional area(CSA)value of the ulnar nerve,median nerve and common peroneal nerve in the observation group after treatment was significantly lower than before treatment(P<0.05).Compared with the control group after treatment,the three nerves CSA in the observation group was significantly lower than that in the control group(P<0.05).Abnormal ultrasound performance:The proportion of abnormal ultrasound performances of the ulnar nerve,median nerve,and common peroneal nerve in the observation group after treatment was significantly lower than before treatment(P<0.05).The composition ratio of internal echo reduction and ambiguity in the observation group after three nerve treatments was significantly lower than that in the control group after treatment(P<0.05).In the correlation analysis,the three kinds of nerve CSA before and after treatment were negatively correlated with SCV and amplitude(P<0.05),and positively correlated with latency(P<0.05).Conclusion:The combination ofα-lipoic acid and Chinese medicine encapsulation technology has a good effect on the treatment and repair of DPN nerve damage,and can be routinely applied in clinical treatment.High-frequency ultrasound can intuitively observe changes in peripheral nerves and can be used to evaluate the prognosis of DPN.
文摘Traumatic facial nerve injuries can result in temporary or permanent loss of function.Restoration of facial expression may occur spontaneously or require surgical intervention.Although thorough examination and history can localize the site of facial nerve damage,it can be difficult to predict if and when recovery will occur.This is salient because the window for optimal outcomes from surgical re-neurotization can be as short as 1 to 2 years,after which functional loss may be irreversible.It is essential to offer patients the most appropriate treatment plan based on prognosis,and imaging plays an essential role in localizing the site and morphology of nerve injury.Multiple imaging modalities have been used to evaluate the facial nerve,including computed tomography(CT)and,more recently,advanced magnetic resonance imaging(MRI)and ultrasound(US).CT and MRI are more commonly implemented;however,Diffusion tensor tractography,high-resolution US,and functional US are gaining traction for studying cranial nerve pathology.Until recently,the morphology of facial nerve and other cranial nerve injuries could only be inferred using non-invasive diagnostic techniques.With the advent of newer imaging technologies and techniques to examine nerves,more refined assessment and prognostic information is now possible.This article reviews up-to-date cranial nerve imaging techniques from the last ten years and explores future avenues for facial nerve imaging.
