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Drillhole high-pressure packer permeability test for underground powerhouse in Pushihe pumped storage hydro-plant 被引量:1
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作者 TIAN Zuoyin CHEN Li +1 位作者 REN Xiangyu LI Zhanjun 《Global Geology》 2010年第2期85-89,共5页
Usually the water head of the pumped storage hydro-plant is high, generally up to 400-500 m, therefore the rock mass under the high-pressure bifurcation pipe have to bear as high as millions Pascal water pressure, in ... Usually the water head of the pumped storage hydro-plant is high, generally up to 400-500 m, therefore the rock mass under the high-pressure bifurcation pipe have to bear as high as millions Pascal water pressure, in according with the requirements of high water head pumped storage hydro-plant should be 1.2 times of the water head special high-pressure packer permeability test compared with normal to test the permeability of rock and rock cleavage pressure value. The test results on the choice of design options often play a decisive role. Based on the engineering practice, the authors studied the drillhole high-pressure packer permeability test in the pumped storage hydro-plant's underground powerhouse, by the analysis of test results, this article offers a demonstration of the deformation of rock fracture witch under building in the condition of high-pressure water head, it provides a more detailed engineering geological background. 展开更多
关键词 pumped storage high-pressure packer permeability test rock mass deformation PERMEABILITY rock cleavage
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Enhanced bifunctional oxygen electrochemical catalytic performance using La-doped CoFe_(2)O_(4)spinel supported by 3D-G for Zn-air batteries
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作者 Yinggang Sun Tingwei Zhang +5 位作者 Peng Sun Jigang Wang Wenjie Duan Yanqiong Zhuang Likai Wang Zhongfang Li 《Journal of Energy Chemistry》 SCIE EI CAS CSCD 2024年第7期778-788,共11页
The preparation of bifunctional catalysts for oxygen reduction(ORR)and oxygen evolution(OER)is crucial for Zn-air batteries.Here,we report a La doped CoFe_(2)O_(4) spinel catalyst supported on threedimensional graphen... The preparation of bifunctional catalysts for oxygen reduction(ORR)and oxygen evolution(OER)is crucial for Zn-air batteries.Here,we report a La doped CoFe_(2)O_(4) spinel catalyst supported on threedimensional graphene(3D-G),where La can facilitate electron transfer from Co to Fe,leading to increased electron cloud density in Fe and improved catalytic performance.The redshift of the G peak in the Raman spectra indicates the interaction between theπbond of 3D-G and d orbitals in La_(0.2)CoFe_(1.8)O_(4).La_(0.2)CoFe_(1.8)/3D-G exhibits superior ORR performance(E_(1/2)=0.86 V vs.RHE)and OER performance(E_(j=10)=1.55 V vs.RHE)to CoFe_(2)O_(4)/3D-G(E_(1/2)=0.831 V vs.RHE,E_(j=10)=1.603 V vs.RHE).Furthermore,it demonstrates excellent bifunctional oxygen catalytic performance while maintaining high power density and stability in liquid zinc-air batteries(ZABs)and flexible ZABs(F-ZABs).This work presents a viable strategy for utilizing rare earth element doped spinels to enhance oxygen catalyst and ZABs performance. 展开更多
关键词 Zn-air batteries Electrocatalysts La_(0.2)CoFe_(1.8)/3D-G Electron pump Bifunctional oxygen catalytic performance
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Development and Application of a Surface High-pressure Injection Device Using a Submersible Electric Pump
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作者 Li Baoyan Tian Xin +1 位作者 Wang Yong Han Shaoming 《Petroleum Science》 SCIE CAS CSCD 2005年第3期24-27,共4页
Injection recovery is an important measure for increasing the oil recovery rate of an oil field. One way is that centrifugal pumps or plunger pumps are used in an injection station to responsible for injection over a ... Injection recovery is an important measure for increasing the oil recovery rate of an oil field. One way is that centrifugal pumps or plunger pumps are used in an injection station to responsible for injection over a large area under the same pressure. This method is ineffective for low-permeability layers. For the oilfields in dispersed distribution in the marginal areas of Daqing, the low water-absorbing section needs an injection with a high delivery pressure and a low discharge capacity; another way is to install the submersible electric pump upside down, but because the submersible electric pump and the motor are underground, it is difficult for installation and maintenance. Introduced in this paper is the development and application of a surface high-pressure injection device with a submersible electric pump. Bysuccessful resolving some problems, such as the axial force of the submersible electric pump, sealing, level regulation of the pump, coaxiality and vibration, the device has the good points of running smoothly, moving easily, installation and maintains quickly and long period of running. This device can effectively solve the injection of the low water-absorbing section and of oilfields in dispersed locations. The recovery rate of oilfields is also enhanced. 展开更多
关键词 Submersible electric pump surface high-pressure injection axial force SEALING COAXIALITY
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Investigation on pumping oxygen characteristics of (Bi_2O_3)_(0.73)(Y_2O_3)_(0.27) solid electrolyte 被引量:3
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作者 厉英 王常珍 《Journal of Rare Earths》 SCIE EI CAS CSCD 2008年第3期337-340,共4页
(Bi2O3)0.73(Y2O3)0.27 fine powders prepared by wet chemical precipitation method were cold isostatically pressed to form solid electrolyte tubes, and sintered at 900 ℃ for 10 h in the air. Their pumping oxygen ch... (Bi2O3)0.73(Y2O3)0.27 fine powders prepared by wet chemical precipitation method were cold isostatically pressed to form solid electrolyte tubes, and sintered at 900 ℃ for 10 h in the air. Their pumping oxygen characteristics in non-dehydrated Ar gas were investigated, where a ZrO2 (Y2O3 stabilized) oxygen sensor was used to measure the oxygen partial pressure Po2. The results showed that the Po2 value reached magnitudes of 1×10^-2-1×10^-10 Pa at the applied pumping oxygen voltage of 0.5 V, 1×10^-37-1×10^-27 Pa at 1.0 V and 1×10^-53-1×10^47 Pa at 2.0 V within the temperature range from 550 to 650 ℃. Moreover, no cracks were found in the tested solid electrolyte tubes. Thus, the Bi2O3-Y2O3 system might be used in solid electrolyte oxygen pump for purifying gases. 展开更多
关键词 (Bi2O3)0.73(Y2O3)0.27 solid electrolyte oxygen sensor oxygen pump rare earths
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Concurrent implantation of intra-aortic balloon pumping with extracorporeal membrane oxygenation improved survival of patients with postcardiotomy cardiogenic shock 被引量:1
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作者 Kai Chen Hanwei Tang +1 位作者 Jianfeng Hou Shengshou Hu 《中国循环杂志》 CSCD 北大核心 2018年第S01期148-148,共1页
Background Extra-corporeal membranous oxygenation (ECMO)and intra-aortic balloon pumping (IABP) are widely used in patients with severe circulatory failure. The decision to initiate ECMO and IABP on optimal occasion i... Background Extra-corporeal membranous oxygenation (ECMO)and intra-aortic balloon pumping (IABP) are widely used in patients with severe circulatory failure. The decision to initiate ECMO and IABP on optimal occasion in postcardiotomy cardiogenic shock (PCS) remains controversial in the absence of guidelines. 展开更多
关键词 Extra-corporeal MEMBRANOUS oxygenATION intra-aortic BALLOON pumpING postcardiotomy CARDIOGENIC shock
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Effect of ultraviolet blood irradiation and oxygenation on nerve function and function of the red blood cell membrane pump in patients with acute cerebral infarction
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作者 Jiaquan Wang Chun Mao Kaifu Ma Shiqing Wang 《Neural Regeneration Research》 SCIE CAS CSCD 2006年第1期60-63,共4页
BACKGROUND: Ultraviolet blood irradiation and oxygenation (UBIO) has obtained better clinical effect in treating acute cerebral infarction, but the mechanism underlying this effect remains unclear. OBJECTIVE: To o... BACKGROUND: Ultraviolet blood irradiation and oxygenation (UBIO) has obtained better clinical effect in treating acute cerebral infarction, but the mechanism underlying this effect remains unclear. OBJECTIVE: To observe the effect of UBIO on the nerve function and activities of K^+-Na^+-ATPase and Ca2^+-Mg2^+-ATPase activities on the red blood cell (RBC) membrane of patients with acute cerebral infarction. DESIGN: A randomized and controlled study.SETTING: Department of Neurology, Xiangfan Central Hospital.PARTICIPANTS: From January 2000 to December 2001, excluding those above 70 years old, 58 cases of 700 patients with acute cerebral infarction admitted in the Department of Neurology, Xiangfan Central Hospital, were recruited and divided into two groups according to the random number table: UBIO treated group (n=28), including 17 males and 11 females, aged 40-68 years; and control group (n=30), including 20 males and 10 females, aged 44-69 years. All the patients agreed to participate in the therapeutic program and detected items. The general informations were comparable without obvious differences between the two groups (P 〉 0.05).METHODS: ① The patients in both groups received routine treatments, besides, those in the UBIO treated group were given UBIO treatment by using the XL-200 type therapeutic apparatus produced in Shijiazhuang, whose ultraviolet wave was set at 253.7 nm with the energy density of 0.568 J/m^2 per second, UBIO treatment started from the second day after admission, once every other day, with a single course consisting of 5-7 treatments. ② In the UBIO treated group, the venous blood was sampled before and after the first, third and the completion of the treatment course respectively, the venous blood was taken at each corresponding time point in the control group. After centrifugation of the blood at 10 000 rounds per minute, the RBC membrane was separated and then the activities of K^+-Na^+-ATPase and Ca2^+-Mg2^+-ATPase were detected by means of phosphorus determination.③ The nerve function was scored before and after treatment in both groups with European stroke scale, which included 13 items, the total score was 0-100 points, the higher the score, the better the nerve function. MAIN OUTCOME MEASURES :①Score of European stroke scale before and after treatment in both groups.② Comparison of the activities of K^+-Na^+-ATPase and Ca2^+-Mg2^+-ATPase on RBC membrane between the two groups before treatment and after the first, third and the completion of the treatment. RESULTS: All the 58 patients with cerebral infarction were involved in the analysis of results.① The score of European stroke scale had no obvious difference between the two groups [(49.31±11.48), (50.58±12.63), P 〉 0.05], and it was obviously higher in the UBIO treated group than in the control group after treatment [84.66±13.75), (77.05±11.17), P 〈 0.05].②The activity of K^+-Na^+-ATPase on RBC membrane in the UBIO treated group was significantly increased after the first and third treatment as compared with before treatment [(31.56±19.25), (27.64±15.83), (17.67±13.83), P 〈 0.01], it was still higher after the completion of the treatment than before treatment without obvious difference [(20.86±14.53), P 〉 0.05]. After the first and third treatment, it was obviously higher in the UBIO treated group than in the control group [19.31±11.88), (17.44±10.42), P 〈 0.01]. ③ In the UBIO treated group, Ca2^+-Mg2^+-ATPase activity on RBC membrane significantly increased after the first treatment and remained higher than the pre-treatment level throughout the treatment [(27.49±14.72), (17.41±4.82), P 〈 0.01]. The activity of Ca2^+-Mg2^+-ATPase on RBC membrane was markedly higher in the UBIO treated group than in the control group after after the first, third and the completion of treatment respectively [(24.83±12.88), (17.70±5.69); (28.08±13.44), (16.32±5.29); (17.42±6.04), P〈 0.05-0.01]. CONCLUSION: The effect of UBIO treatment against acute cerebral infarction may be mediated by the increased K^+-Na^+ ATPase and Ca2^+-Mg2^+-ATPase activities on RBC membrane, which enhances the RBC transformation ability so as to lower RBC aggregation and correct high blood viscosity. 展开更多
关键词 Effect of ultraviolet blood irradiation and oxygenation on nerve function and function of the red blood cell membrane pump in patients with acute cerebral infarction BIO ATPase cell
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Correlation of Blood Lactate and Mixed Venous Oxygen Saturation in Off-Pump CABG
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作者 Ganapathy Sambandam Kamalakkannan Ranjith Karthekeyan +4 位作者 Mahesh Vakamudi Sandeep Bangale Rajeshkumar Kodali Hemanand Nayagam Sushma Nandipati 《World Journal of Cardiovascular Surgery》 2014年第7期131-138,共8页
Aim: To evaluate the correlation of blood lactate and mixed venous oxygen saturation to predict outcome in off-pump coronary artery bypass grafting. Method: This is a randomized study including 30 patients. Blood lact... Aim: To evaluate the correlation of blood lactate and mixed venous oxygen saturation to predict outcome in off-pump coronary artery bypass grafting. Method: This is a randomized study including 30 patients. Blood lactate and mixed venous oxygen saturation were measured in 4 groups of patients—number of grafts, presence or absence of left main coronary artery disease, ejection fraction and serum creatinine. Blood samples were taken before induction, after grafting, on intensive care unit admission, 24 hours and 48 hours after surgery. The measured blood lactate and mixed venous oxygen saturation are compared to assess the outcomes in terms of duration of ventilation and intensive care unit stay. Results: The blood lactate and mixed venous oxygen saturation values increased post operatively but no statistically significant difference in three groups— number of grafts, left main coronary artery disease and ejection fraction. In serum creatinine group, the blood lactate value was found to be statistically significant after grafting in patients with creatinine <1.5 mg/dl, however, there was a significant disparity in numbers. Conclusion: Mixed venous oxygen saturation is a better predictor of morbidity than blood lactate in terms of intensive care unit stay in patients undergoing off pump coronary artery bypass grafting. 展开更多
关键词 OFF-pump Coronary Artery BYPASS Grafting Blood LACTATE Mixed VENOUS oxygen Saturation EJECTION Fraction DURATION of Ventilation DURATION of Intensive Care Unit Stay
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急性心肌梗死合并心原性休克患者器械辅助支持下直接经皮冠状动脉介入治疗预后不良的因素分析 被引量:1
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作者 罗明华 陈玉善 +6 位作者 王贺 关怀敏 解金红 邱承杰 宗永华 尚莎莎 王运蔚 《中国介入心脏病学杂志》 CSCD 2024年第4期197-202,共6页
目的本研究旨在考察急性心肌梗死合并心原性休克患者直接经皮冠状动脉介入治疗(PPCI)术后预后不良的影响因素。方法入选2015年1月至2019年12月期间,河南中医药大学第一附属医院胸痛中心收治急性心肌梗死合并心原性休克并且行PPCI的患者... 目的本研究旨在考察急性心肌梗死合并心原性休克患者直接经皮冠状动脉介入治疗(PPCI)术后预后不良的影响因素。方法入选2015年1月至2019年12月期间,河南中医药大学第一附属医院胸痛中心收治急性心肌梗死合并心原性休克并且行PPCI的患者,收集其临床基线特征、冠状动脉造影及PPCI相关参数、器械辅助支持信息等。根据1年内随访生存与否,分为生存组与死亡组,比较两组各项因素。结果共入选40例患者,其中生存组26例,死亡组14例。两组在基线资料、入院诊断、危险因素及合并症等方面差异均无统计学意义(均P>0.05);生存组较死亡组有入院时心率较低、血压较高的趋势;生存组心肌酶显著低于死亡组(肌酸激酶峰值:496.00(198.25,2830.00)U/L比3040.00(405.75,5626.53)U/L,P=0.003;肌酸激酶同工酶MB型峰值:52.65(31.75,219.50)U/L比306.00(27.25,489.63)U/L,P=0.006);两组间在冠状动脉造影及PPCI相关指标方面比较,生存组较对照组有更高的完全血运重建率(53.85%比21.43%,P=0.048);两组器械辅助支持方面比较,生存组较死亡组有更多的体外膜肺氧合(ECMO)联合主动脉内球囊反搏(IABP)支持的比例(38.46%比7.14%,P=0.034)。结论急性心肌梗死合并心原性休克行PPCI的患者的预后与心肌酶水平、ECMO联合IABP支持以及完全血运重建有关。 展开更多
关键词 急性心肌梗死 心原性休克 预后 直接经皮冠状动脉介入治疗 心肌酶 体外膜肺氧合 主动脉内球囊反搏
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诱导轮对高速液氧泵空化流场影响研究 被引量:1
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作者 窦唯 蒋文山 +2 位作者 李超群 高永新 姚程 《振动与冲击》 EI CSCD 北大核心 2024年第8期280-286,共7页
高抗空化诱导轮可以改善液氧泵的空化特性,提高大推力火箭的可靠性。基于计算流体力学方法,建立了高速液氧泵的流动仿真模型,通过三组试验工况验证了模型准确性,研究了诱导轮叶片数对液氧泵性能和空化特性的影响。结果表明:使用诱导轮... 高抗空化诱导轮可以改善液氧泵的空化特性,提高大推力火箭的可靠性。基于计算流体力学方法,建立了高速液氧泵的流动仿真模型,通过三组试验工况验证了模型准确性,研究了诱导轮叶片数对液氧泵性能和空化特性的影响。结果表明:使用诱导轮可以减小离心轮空化面积,代偿离心轮的汽蚀,提高液氧泵扬程;在入口流量和出口压力不变的条件下,增加诱导轮叶片数,液氧泵的效率增加,扬程降低,离心轮空化面积增加,诱导轮代偿离心轮汽蚀能力削弱。综合考虑液氧泵性能参数和空化特性,三叶片诱导轮能够满足大推力液体火箭的高可靠性要求。 展开更多
关键词 高速液氧泵 诱导轮 空化特性 数值模拟
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酶标仪法测定离心泵泵头表面肝素涂层生物活性的研究
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作者 徐苏华 刘婧群 +1 位作者 许朝生 黄敏菊 《中国体外循环杂志》 2024年第5期415-419,共5页
目的 建立酶标仪法测定离心泵泵头表面肝素的生物活性。方法 由抗凝血酶(AT)饱和的肝素化表面失活的凝血酶量来量化肝素生物活性:肝素表面与过量的血浆蛋白AT结合,形成AT饱和的肝素化表面(过量的AT通过清洗程序去除),上述肝素化表面又... 目的 建立酶标仪法测定离心泵泵头表面肝素的生物活性。方法 由抗凝血酶(AT)饱和的肝素化表面失活的凝血酶量来量化肝素生物活性:肝素表面与过量的血浆蛋白AT结合,形成AT饱和的肝素化表面(过量的AT通过清洗程序去除),上述肝素化表面又与过量凝血酶Ⅱa结合,残留的凝血酶Ⅱa与显色底物反应,凝血酶肽键H-D-Phe-Pip-Arg-pNa被裂解,释放出生色团,其可以在405 nm下进行测试并定量。结果 应用酶标仪上波长405 nm时的动力学吸光度评估生物活性,生物活性测定表明:对照品(无涂层的离心泵泵头)的结果为-0.01 IU/cm^(2)(≤0.05 IU/cm^(2)),所有3种供试品的结果为0.29 IU/cm^(2)、0.40 IU/cm^(2)和0.32 IU/cm^(2)(均≥0.1 IU/cm^(2)),符合生物活性试验的有效性标准,对照品和供试品的生物活性均被视为通过。结论 通过酶标仪定量测试凝血酶肽键裂解释放生色团的含量,可得到与肝素涂层反应的Ⅱa的量,进一步反推AT的量,最终计算出肝素涂层的生物活性。该方法操作简便,一次可以测定多份样本,检测速度快;具有需要的样本量少、重复性好的特点,适用于对离心泵泵头表面肝素涂层的生物活性定量检测。 展开更多
关键词 酶标仪法 离心泵泵头 肝素生物活性 抗凝血酶 凝血酶 体外膜氧合
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闭腔型氧传感器加热控制策略研究
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作者 钱枫 胡吉康 +5 位作者 祝能 王超 鲍雄 许小伟 舒正昕 王洁 《仪表技术与传感器》 CSCD 北大核心 2024年第10期12-19,共8页
针对目前闭腔型氧传感器温度控制精度低、冷启动热应力大、加热时间长的问题,提出一种加热控制策略和控制电路。首先根据氧传感器的工作原理,分析不同加热电压下温度与泵氧循环的关系,结合加热器温度特性实验,确定了传感器的最佳工作温... 针对目前闭腔型氧传感器温度控制精度低、冷启动热应力大、加热时间长的问题,提出一种加热控制策略和控制电路。首先根据氧传感器的工作原理,分析不同加热电压下温度与泵氧循环的关系,结合加热器温度特性实验,确定了传感器的最佳工作温度和最佳加热功率,然后根据传感器的结构和控制要求,设计了一种加热控制策略以及控制电路,为了进一步验证方案的有效性,最后在不同氧体积分数的实际环境中进行测试验证,并与国外传感器进行对比测试。实验结果表明:设计的加热控制策略和控制电路能够很好地满足传感器的温度控制要求,传感器的最佳工作温度为781℃,最佳加热功率约为9 W,首次到达最佳工作温度时间为41 s,在氧体积分数1%~10%范围,传感器测量误差不大于±0.3%,在氧体积分数10%~25%范围,传感器测量误差不大于±0.5%。 展开更多
关键词 闭腔型氧传感器 泵氧循环 铂加热器
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主动脉内球囊反搏与静脉-动脉体外膜氧合治疗心源性休克的研究进展
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作者 肖婧一 朱佳佳 +1 位作者 陈立颖 刘宝利 《中国医药》 2024年第10期1558-1562,共5页
心源性休克是由于心脏泵血功能受损导致全身灌注不足和组织缺氧的临床综合征,是心脏病患者死亡的重要原因。主动脉内球囊反搏和静脉-动脉体外膜氧合是目前用于心源性休克治疗的两种主要机械循环支持装置,已成为帮助患者度过心功能失代... 心源性休克是由于心脏泵血功能受损导致全身灌注不足和组织缺氧的临床综合征,是心脏病患者死亡的重要原因。主动脉内球囊反搏和静脉-动脉体外膜氧合是目前用于心源性休克治疗的两种主要机械循环支持装置,已成为帮助患者度过心功能失代偿危险期的“桥梁”治疗手段,但其最佳应用时机和临床治疗效果仍存在争议。本文对近年来主动脉内球囊反搏和静脉-动脉体外膜氧合治疗心源性休克的相关研究进行综述。 展开更多
关键词 心源性休克 机械循环支持 主动脉内球囊反搏 静脉-动脉体外膜氧合
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血液吸附对非体外冠状动脉移植术后体外膜氧合患者全身炎症反应的影响
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作者 韩丹诺 张帅 +3 位作者 王红 贾明 侯晓彤 杜中涛 《心肺血管病杂志》 CAS 2024年第8期846-853,共8页
目的:探讨炎症因子及全身炎症反应评分在非体外循环冠状动脉旁路移植术(off-pump coronary artery bypass grafting,OPCABG)后体外膜氧合(extracorporeal membrane oxygenation,ECMO)患者中的变化规律以及血液吸附(hemoperfusion,HP)的... 目的:探讨炎症因子及全身炎症反应评分在非体外循环冠状动脉旁路移植术(off-pump coronary artery bypass grafting,OPCABG)后体外膜氧合(extracorporeal membrane oxygenation,ECMO)患者中的变化规律以及血液吸附(hemoperfusion,HP)的影响。方法:2019年1月至2022年12月,首都医科大学附属北京安贞医院心脏外科重症监护室OPCABG术后进行V-A ECMO辅助的患者42例,分为ECMO组(n=24),ECMO+HP组(n=18)。ECMO组常规辅助;ECMO+HP组为ECMO辅助24h内,联合应用灌流器总治疗时长18h。收集两组患者V-A ECMO开始24h内或血液吸附开始0、6、12、18h、结束后24及48h的炎症因子水平和全身炎症反应评分(systemic inflammatory response syndrome, SIRS);实验室及临床预后相关资料。结果:CRP、IL-6、IL-8、TNF-α和IL-1β的变化率,在ECMO+HP组随时间推移持续下降,且与ECMO组比较,均差异有统计学意义。ECMO+HP组的LAC和全身炎症反应评分明显下降;感染率明显降低(5.6%vs. 33.3%,P=0.030);ECMO辅助时间显著缩短[(132.0±20.1)vs.(155.9±24.2) h,P=0.001],撤机率明显提高(83.3%vs. 41.7%,P=0.001),撤机后24h序贯器官衰竭(sequential organ failure assessment,SOFA)评分[8.0(7.0,9.0) vs. 8.0 (7.8,9.0),P=0.038]和血管活性药物评分(vasoactive-inotropic score,VIS)[8.0(7.0,9.0) vs. 9.0(8.0,10.0),P=0.003]显著低于ECMO组。结论:OPCABG术后VA-ECMO期间,应用血液吸附可能与降低炎症反应和并发症的减少有关,但在ICU住院时间和死亡率方面无明显差异。 展开更多
关键词 血液吸附 体外膜氧合 非体外循环冠状动脉旁路移植术 炎症因子 全身炎症反应评分
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经皮穿刺股静脉-动脉体外膜肺氧合患者发生下肢并发症的危险因素
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作者 尹礼义 胡聪龙 +3 位作者 徐静 展锦 黄明君 曹彦 《中国急救医学》 CAS CSCD 2024年第11期955-959,共5页
目的分析经皮穿刺股静脉-动脉体外膜肺氧合(venoarterial extracorporeal membrane oxygenation,VA-ECMO)患者发生下肢并发症的危险因素。方法收集2020年1月至2022年12月在郑州大学第一附属医院因循环衰竭行VA-ECMO治疗的304例患者临床... 目的分析经皮穿刺股静脉-动脉体外膜肺氧合(venoarterial extracorporeal membrane oxygenation,VA-ECMO)患者发生下肢并发症的危险因素。方法收集2020年1月至2022年12月在郑州大学第一附属医院因循环衰竭行VA-ECMO治疗的304例患者临床资料。根据患者临床事件分为下肢并发症组和无下肢并发症组,比较两组临床资料的差异,采用Logistic多因素回归分析探讨患者发生下肢并发症的危险因素。结果经过纳排标准筛选后,共有209例患者纳入本研究。下肢并发症发生率27.8%(n=58),下肢并发症组主动脉球囊反搏(intra-aortic balloon pump,IABP)治疗、机械通气、ECMO运行后4 h及24 h乳酸、24 h ECMO流量、ECMO操作并发症、神经系统并发症、高胆红素血症、急性肾功能不全进行连续肾脏替代治疗(continuous renal replacement therapy,CRRT)、感染并发症及病死率与无下肢并发症组相比差异有统计学意义(P<0.05)。Logistic多因素回归分析显示,IABP治疗和ECMO后24 h乳酸是VA-ECMO患者发生下肢并发症的独立危险因素。通过Generalized Additive Models分析得出拟合曲线显示,ECMO后24 h乳酸越高,下肢并发症发生率越高。结论IABP治疗和ECMO后24 h乳酸是VA-ECMO患者发生下肢并发症的独立危险因素。在VA-ECMO患者的治疗过程中,应密切关注这些因素,以便早期预防和干预下肢并发症的发生。 展开更多
关键词 体外膜肺氧合 下肢并发症 危险因素 主动脉球囊反搏 乳酸 连续肾脏替代治疗
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体外膜肺氧合辅助治疗高危复杂冠心病患者行PCI的临床效果
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作者 胡聪龙 尹礼义 +2 位作者 黄明君 曹彦 韩小彤 《中国急救医学》 CAS CSCD 2024年第11期943-947,共5页
目的评估体外膜肺氧合(ECMO)辅助治疗接受经皮冠状动脉介入(PCI)的高危复杂冠心病患者(complex high-risk and indicated patients,CHIPs)的临床效果。方法回顾性分析52例CHIPs并接受PCI治疗的患者,按ECMO辅助时机分为术前辅助组(n=24)... 目的评估体外膜肺氧合(ECMO)辅助治疗接受经皮冠状动脉介入(PCI)的高危复杂冠心病患者(complex high-risk and indicated patients,CHIPs)的临床效果。方法回顾性分析52例CHIPs并接受PCI治疗的患者,按ECMO辅助时机分为术前辅助组(n=24)和术中辅助组(n=28)。对比两组患者基线资料、术前状态、院内病死率、冠状动脉造影结果、冠状动脉评分及并发症发生率。结果术前辅助组院内病死率显著低于术中辅助组(12.5%vs.64.3%,P<0.001)。术前辅助组中有5例(20.8%)联合使用主动脉内球囊反搏(intra-aortic balloon pump,IABP),而术中辅助组则为14例(50%)。两组白细胞计数、高密度脂蛋白水平、术中最差乳酸值及总病死率差异有统计学意义(均P<0.05),术前辅助组表现更佳。术前辅助组神经系统、心脏及四肢并发症的发生率也显著低于术中辅助组(均P<0.05),但冠脉评分、冠状动脉造影结果、冠脉血管病变程度、体外膜肺氧合上机操作时间、辅助时间及PCI手术时间等差异无统计学意义(均P>0.05)。结论ECMO辅助CHIPs患者PCI治疗时,术前应用更能有效降低病死率及ECMO相关并发症的发生率,可为CHIPs患者的治疗提供一种更为优化的策略。 展开更多
关键词 体外膜肺氧合 复杂高危冠心病 经皮冠状动脉介入治疗 临床效果 主动脉内球囊反搏 并发症
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复杂高危冠心病患者在体外膜肺氧合联合主动脉内球囊反搏辅助下行择期经皮冠状动脉介入治疗的远期疗效及预后结局分析
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作者 禹天同 赵帅 +10 位作者 陈焱 陈有虎 陈根锐 王欢 张博晖 张玺 朱伯达 韩鹏 高好考 廉坤 李成祥 《中国介入心脏病学杂志》 CSCD 2024年第9期501-508,共8页
目的比较复杂高危冠心病患者在体外膜肺氧合(ECMO)联合主动脉内球囊反搏(IABP)辅助下行经皮冠状动脉介入治疗(PCI)的远期疗效及预后结局,探讨联合应用器械循环支持(MCS)装置在复杂PCI中的价值。方法连续纳入2018年1月至2022年12月于中... 目的比较复杂高危冠心病患者在体外膜肺氧合(ECMO)联合主动脉内球囊反搏(IABP)辅助下行经皮冠状动脉介入治疗(PCI)的远期疗效及预后结局,探讨联合应用器械循环支持(MCS)装置在复杂PCI中的价值。方法连续纳入2018年1月至2022年12月于中国人民解放军空军军医大学第一附属医院心血管内科经冠状动脉造影诊断并符合入选标准的在MCS下行择期PCI的患者,根据术中MCS方式分为ECMO+IABP组和单纯IABP组。收集患者临床特征、造影特征、术中结果及并发症等资料,观察患者术后院内结果和1个月及1年主要不良心血管事件(MACE),分析两组间上述指标的差异并分析独立危险因素。结果共纳入218例行择期PCI的患者,其中ECMO+IABP组66例,单纯IABP组152例。两组患者的基线资料基本相当,ECMO+IABP组患者的病变特征更加复杂,合并心房颤动(6.1%比0.7%,P=0.030)、左主干病变(43.9%比27.0%,P=0.018)、三支病变(90.9%比75.7%,P=0.009)、右冠状动脉(RCA)病变(98.5%比86.8%,P=0.005)及RCA慢性完全闭塞病变(60.6%比35.5%,P<0.001)的比例均高于单纯IABP组,单纯IABP组既往行PCI的比例更高(32.9%比16.7%,P=0.014)。两组患者院内并发症总体发生率的差异无统计学意义(P=0.176),但是ECMO+IABP组术后低血压的发生率更高(19.7%比9.2%,P=0.031)。两组患者术后1个月MACE(4.5%比2.6%,P=0.435)和1年MACE(7.6%比7.9%,P=0.936)的发生率相当。Firth修正的多因素分析显示,院内发生心肺复苏(OR 7.17,95%CI1.27~40.38,P=0.025)和术后低血压(OR3.60,95%CI1.10~11.83,P=0.035)是发生术后1年MACE的独立危险因素。结论联合应用ECMO+IABP支持可使复杂高危冠心病患者获得通过PCI完成血运重建的机会并获得临床获益,远期预后满意。 展开更多
关键词 经皮冠状动脉介入治疗 体外膜肺氧合 主动脉内球囊反搏 主要不良心血管事件
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1例机械循环装置辅助CHIP病人行冠状动脉内旋磨术的围术期护理
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作者 田野 朱平 +6 位作者 王莹 陶通 王羽 潘利飞 董志超 张波 汪正艳 《全科护理》 2024年第2期391-393,共3页
总结1例机械循环装置辅助复杂高危具有介入治疗指征病人(CHIP)行冠状动脉内旋磨术的护理配合经验。护理要点包括导管室仪器设备合理布局,术中密切配合医生完成体外膜肺氧合、主动脉球囊反搏的建立以及冠状动脉内旋磨术的配合,做好手术... 总结1例机械循环装置辅助复杂高危具有介入治疗指征病人(CHIP)行冠状动脉内旋磨术的护理配合经验。护理要点包括导管室仪器设备合理布局,术中密切配合医生完成体外膜肺氧合、主动脉球囊反搏的建立以及冠状动脉内旋磨术的配合,做好手术相关并发症观察与护理、目标导向抗凝管理、精准水化与循环容量管理、清醒镇痛护理。术后体外膜肺氧合脱机并转入心脏重症医学科,术后第1天病人主动脉球囊反搏脱机并转入冠心病病房,术后第4天康复出院。 展开更多
关键词 体外膜肺氧合 主动脉球囊反搏 复杂高危具有介入治疗指征 冠状动脉内旋磨术 围术期护理
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基于全球专利数据的ECMO血液泵技术发展态势研究
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作者 骆静 毛洁 王念念 《中国发明与专利》 2024年第5期41-47,共7页
国内市场上ECMO受制于国外企业的专利壁垒以及先发优势而长期被国外企业所垄断,血液泵构成了“卡脖子”技术,严重阻碍国产化进程,本文从专利角度对ECMO现有技术进行梳理和统计,在分析了各种类型血液泵的基础上进行了技术分解,提出了冷... 国内市场上ECMO受制于国外企业的专利壁垒以及先发优势而长期被国外企业所垄断,血液泵构成了“卡脖子”技术,严重阻碍国产化进程,本文从专利角度对ECMO现有技术进行梳理和统计,在分析了各种类型血液泵的基础上进行了技术分解,提出了冷却液、悬浮、材料、结构和涂层的四级技术分支,从五个维度分析了代表性技术的演进过程,还对国内外主要竞争参与者的类型、地区、研究重点进行了分析,并对国内企业的技术突破方向进行了建议,以助力关键核心技术国产化的实施。 展开更多
关键词 体外膜肺氧合(ECMO) 血液泵 专利壁垒 磁悬浮
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1例体外膜肺氧合联合主动脉球囊反搏辅助下行PCI救治心源性休克患者的护理
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作者 王彦哲 赵静 +4 位作者 杨春晓 闫春林 郝恩刚 孙洪敏 杨岳武 《当代护士(上旬刊)》 2024年第7期103-107,共5页
总结1例体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)联合主动脉内球囊反搏辅助下行冠状动脉介入治疗救治急性心肌梗死伴心源性休克患者的手术护理经验。护理要点如下:采用多学科联合模式,组建“介入+ECMO团队”,规范手术... 总结1例体外膜肺氧合(extracorporeal membrane oxygenation,ECMO)联合主动脉内球囊反搏辅助下行冠状动脉介入治疗救治急性心肌梗死伴心源性休克患者的手术护理经验。护理要点如下:采用多学科联合模式,组建“介入+ECMO团队”,规范手术站位及手术流程,做好冠状动脉介入治疗的术中配合及体外膜肺氧合、主动脉内球囊反搏的护理,术后做好转运及交接。患者手术过程顺利,围手术期无并发症发生,该患者经过专业的治疗与护理,术后第4天撤除主动脉内球囊反搏,术后第8天成功撤除体外膜肺氧合,术后第10天转普通病房治疗,术后第15天出院,随访时患者状态良好。 展开更多
关键词 体外膜肺氧合 主动脉内球囊反搏 冠状动脉支架植入术 急性心肌梗死合并心源性休克
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VA-ECMO联合IABP对心切术后心源性休克患者临床疗效的Meta分析
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作者 刘振江 邵铭心 曲爱君 《中外医疗》 2024年第14期30-33,38,共5页
目的 通过Meta分析方法评价静脉-动脉体外膜肺氧合(Venoarterial Extracorporeal Membrane Oxygenation,VA-ECMO)联合主动脉球囊反搏(Intra-aortic Balloon Pump,IABP)对心切术后心源性休克患者的临床疗效。方法 选择中国知网、维普数... 目的 通过Meta分析方法评价静脉-动脉体外膜肺氧合(Venoarterial Extracorporeal Membrane Oxygenation,VA-ECMO)联合主动脉球囊反搏(Intra-aortic Balloon Pump,IABP)对心切术后心源性休克患者的临床疗效。方法 选择中国知网、维普数据库、万方数据库、PubMed、Cochrane Library等权威数据库,检索关于VA-ECMO联合IABP对心切术后心源性休克患者的中英文文献,时间范围为建库至2024年3月1日,按制订的纳入标准与排除标准筛选文献。对纳入的文献进行质量评价,应用RevMan 5.4对文献进行Meta分析;采用漏斗图分析发表偏倚。结果最终纳入14篇文献,共计2868例患者。Meta结果显示,VA-ECMO联合IABP组可提高VA-ECMO成功脱机率(OR=1.90,95%CI:1.45~2.49,P<0.001),降低心切术后心源性休克患者的院内死亡率(OR=0.83,95%CI:0.69~0.99,P=0.04)。结论 VA-ECMO联合IABP有助于提高心切术后心源性休克患者的VA-ECMO成功脱机率,同时降低院内死亡率。 展开更多
关键词 体外膜肺氧合 主动脉内球囊反搏 成功脱机 院内死亡
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