期刊文献+
共找到2,922篇文章
< 1 2 147 >
每页显示 20 50 100
FibroScan-aspartate transaminase:A superior non-invasive model for diagnosing high-risk metabolic dysfunction-associated steatohepatitis 被引量:1
1
作者 Jing-Ya Yin Tian-Yuan Yang +4 位作者 Bing-Qing Yang Chen-Xue Hou Jun-Nan Li Yue Li Qi Wang 《World Journal of Gastroenterology》 SCIE CAS 2024年第18期2440-2453,共14页
BACKGROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NASH).Based on an international conse... BACKGROUND Non-alcoholic fatty liver disease(NAFLD)with hepatic histological NAFLD activity score≥4 and fibrosis stage F≥2 is regarded as“at risk”non-alcoholic steatohepatitis(NASH).Based on an international consensus,NAFLD and NASH were renamed as metabolic dysfunction-associated steatotic liver disease(MASLD)and metabolic dysfunction-associated steatohepatitis(MASH),respectively;hence,we introduced the term“high-risk MASH”.Diagnostic values of seven non-invasive models,including FibroScan-aspartate transaminase(FAST),fibrosis-4(FIB-4),aspartate transaminase to platelet ratio index(APRI),etc.for high-risk MASH have rarely been studied and compared in MASLD.AIM To assess the clinical value of seven non-invasive models as alternatives to liver biopsy for diagnosing high-risk MASH.METHODS A retrospective analysis was conducted on 309 patients diagnosed with NAFLD via liver biopsy at Beijing Ditan Hospital,between January 2012 and December 2020.After screening for MASLD and the exclusion criteria,279 patients wereincluded and categorized into high-risk and non-high-risk MASH groups.Utilizing threshold values of each model,sensitivity,specificity,positive predictive value(PPV),and negative predictive values(NPV),were calculated.Receiver operating characteristic curves were constructed to evaluate their diagnostic efficacy based on the area under the curve(AUROC).RESULTS MASLD diagnostic criteria were met by 99.4%patients with NAFLD.The MASLD population was analyzed in two cohorts:Overall population(279 patients)and the subgroup(117 patients)who underwent liver transient elastography(FibroScan).In the overall population,FIB-4 showed better diagnostic efficacy and higher PPV,with sensitivity,specificity,PPV,NPV,and AUROC of 26.9%,95.2%,73.5%,72.2%,and 0.75.APRI,Forns index,and aspartate transaminase to alanine transaminase ratio(ARR)showed moderate diagnostic efficacy,whereas S index and gamma-glutamyl transpeptidase to platelet ratio(GPR)were relatively weaker.In the subgroup,FAST had the highest diagnostic efficacy,its sensitivity,specificity,PPV,NPV,and AUROC were 44.2%,92.3%,82.1%,67.4%,and 0.82.The FIB-4 AUROC was 0.76.S index and GPR exhibited almost no diagnostic value for high-risk MASH.CONCLUSION FAST and FIB-4 could replace liver biopsy as more effectively diagnostic methods for high-risk MASH compared to APRI,Forns index,ARR,S index,and GPR;FAST is superior to FIB-4. 展开更多
关键词 Metabolic dysfunction-associated steatotic liver disease high-risk metabolic dysfunction-associated steatohepatitis Non-invasive models Liver biopsy Diagnostic value
下载PDF
How Effective Is Cervical Ripening Using the Controlled-Release Dinoprostone Vaginal Delivery System for Primiparas with Unruptured Membranes?
2
作者 Yoshino Kinjyo Yukiko Chinen +2 位作者 Tadatsugu Kinjo Shuko Chinen Keiko Mekaru 《Open Journal of Obstetrics and Gynecology》 2024年第8期1185-1196,共12页
Background: Labor induction has a low success rate, especially in primiparas with unruptured membranes. Previous studies focused on pregnant women with unruptured membranes, but none specifically targeted primiparas. ... Background: Labor induction has a low success rate, especially in primiparas with unruptured membranes. Previous studies focused on pregnant women with unruptured membranes, but none specifically targeted primiparas. Aims: To compare the effectiveness of a controlled-release dinoprostone vaginal delivery system for cervical dilatation (PROPESS) with that of mechanical dilation for labor induction in primiparous women with unruptured membranes. Materials and Methods: We retrospectively analyzed the data of 90 primiparas with unruptured membranes (41 and 49 in the PROPESS and mechanical dilation groups, respectively). The primary outcome was the cesarean section (CS) rate. The secondary outcomes were the prevalence of vaginal delivery within 12 or 24 h after the initial insertion, oxytocin usage rate, chorioamnionitis, additional use of mechanical dilation in the PROPESS group, and neonatal outcomes. Results: The CS rate was significantly lower in the PROPESS group than in the mechanical dilation group (p = 0.02). A total of 13 patients (31.7%) delivered within 24 h with PROPESS alone, indicating a significantly higher rate of delivery within 24 h in the PROPESS group (p = 0.02). Fewer patients required additional oxytocin in the PROPESS group than in the mechanical dilation group (p = 0.001). However, 14 (34%) patients in the PROPESS group required additional mechanical cervical dilation, resulting in a longer time to delivery than mechanical dilation. Conclusions: PROPESS significantly reduced CS rates and increased delivery rates 24 h after the initial insertion in primiparas with unruptured membranes compared to mechanical dilatation. However, failure to respond to PROPESS resulted in an overall longer delivery time than that of the conventional mechanical dilation group;therefore, identifying predictors of response to PROPESS is necessary. 展开更多
关键词 PROPESS Labor Induction primiparas Cervical Ripening Unruptured Membranes
下载PDF
Intravitreal conbercept injection with panretinal photocoagulation for high-risk proliferative diabetic retinopathy with vitreous hemorrhage
3
作者 Yao Xu Qing Ye Wei Shen 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2024年第6期1066-1072,共7页
AIM:To assess the clinical efficacy and safety of combining panretinal photocoagulation(PRP)with intravitreal conbercept(IVC)injections for patients with high-risk proliferative diabetic retinopathy(HR-PDR)complicated... AIM:To assess the clinical efficacy and safety of combining panretinal photocoagulation(PRP)with intravitreal conbercept(IVC)injections for patients with high-risk proliferative diabetic retinopathy(HR-PDR)complicated by mild or moderate vitreous hemorrhage(VH),with or without diabetic macular edema(DME).METHODS:Patients diagnosed with VH with/without DME secondary to HR-PDR and received PRP combined with IVC injections were recruited in this retrospective study.Upon establishing the patient’s diagnosis,an initial IVC was performed,followed by prompt administration of PRP.In cases who significant bleeding persisted and impeded the laser operation,IVC was sustained before supplementing with PRP.Following the completion of PRP,patients were meticulously monitored for a minimum of six months.Laser therapy and IVC injections were judiciously adjusted based on fundus fluorescein angiography(FFA)results.Therapeutic effect and the incidence of adverse events were observed.RESULTS:Out of 42 patients(74 eyes),29 were male and 13 were female,with a mean age of 59.17±12.74y(33-84y).The diabetic history was between 1wk and 26y,and the interval between the onset of visual symptoms and diagnosis of HR-PDR was 1wk-1y.The affected eye received 2.59±1.87(1-10)IVC injections and underwent 5.5±1.02(4-8)sessions of PRP.Of these,68 eyes received PRP following 1 IVC injection,5 eyes after 2 IVC injections,and 1 eye after 3 IVC injections.Complete absorption of VH was observed in all 74 eyes 5-50wk after initial treatment,with resolution of DME in 51 eyes 3-48wk after initial treatment.A newly developed epiretinal membrane was noted in one eye.Visual acuity significantly improved in 25 eyes.No complications such as glaucoma,retinal detachment,or endophthalmitis were reported.CONCLUSION:The study suggests that the combination of PRP with IVC injections is an effective and safe modality for treating diabetic VH in patients with HR-PDR. 展开更多
关键词 conbercept panretinal photocoagulation high-risk proliferative diabetic retinopathy vitreous hemorrhage
下载PDF
Prevalence of Precancerous Lesions Based on Digital Cervicography with VIA/VILI among Women Positive for High-Risk Human Papillomavirus Serotypes: A Screening Center-Based Study in Cameroon
4
作者 Jeffrey-Lewis Nzang Cliford Ebontane Ebong +8 位作者 Simon Manga Florence Manjuh Félix Essiben Isidore Tompeen Judith Seungue Serge Robert Nyada Jeanne Hortence Fouedjio Ymele Fouelifack Julius Sama Dohbit 《Open Journal of Obstetrics and Gynecology》 2024年第6期967-978,共12页
Background: Since 2021, high-risk Human Papilloma Virus (HR-HPV) testing has been the recommended screening test for cervical cancer for all settings;either used alone in a “test and treat” strategy, or with a triag... Background: Since 2021, high-risk Human Papilloma Virus (HR-HPV) testing has been the recommended screening test for cervical cancer for all settings;either used alone in a “test and treat” strategy, or with a triage test, with or without biopsy, before treatment. Cameroon has rolled out immunization against HPV 16 and 18, but studies show a higher prevalence of non-16/18 HR-HPV types. Objectives: Determine the prevalence of precancerous lesions, in women with HR-HPV infection and evaluate association of digital cervicography (DC) VIA/VILI positivity with HPV serotype, as a measure of their contribution to precancer and cancer incidence. Methodology: The study was cross-sectional, descriptive, and analytic. It took place at the Etoug-Ebe and Ekoudoum Baptist Hospitals in Yaoundé, during the period April-September 2022. We reviewed the records of women screened for cervical cancer between February 2020 and December 2021 and evaluated the prevalence of lesions on digital cervicography (DC) with VIA/VILI for women positive for HR-HPV serotypes. The data were analyzed using SPSS version 20.0 for Windows. P values Results: We identified 315 cases with a positive HR-HPV deoxyribonucleic acid (DNA) test, 224 (71.1%) had a DC VIA/VILI triage test done. Of these, 30 (13.4%) women had a positive DC VIA/VILI, with five women (2.2%) having lesions suggestive of cancer. Out of 11 cases positive for HPV 16 alone, 05 (45.5%) had a positive DC VIA/VILI test. Of the 14 cases positive for HPV 18 alone, 03 (21.4%) had a positive VIA/VILI, meanwhile only 19 (10.7%) of the 177 cases positive for non-16/18 HPV had a positive VIA/VILI test. Conclusion: A high proportion of women (13.4%) with HR HPV had a positive DC VIA/VILI, with a significant proportion (2.2%) having lesions suggestive of invasive cervical cancer HR-HPV serotype was associated with DC VIA/VILI positivity;HPV 16 had the strongest association (45.5%), followed by HPV 18 (21.4%), and non-16/18 HR-HPV (10.7%), suggesting a decreasing order of oncogenicity. 展开更多
关键词 high-risk Human Papillomavirus PRECANCEROUS Digital Cervicography VIA/VILI SEROTYPE
下载PDF
Effects of Health Education with Problem-Based Learning Approaches on the Knowledge, Attitude, Practice and Coping Skills of Women with High-Risk Pregnancies in Plateau Areas
5
作者 Ying Wu Suolang Sezhen +5 位作者 Renqing Yuzhen Hong Wei Zhijuan Zhan Baima Hongying Yuhong Zhang Lihong Liu 《Open Journal of Nursing》 2024年第5期192-199,共8页
Objective: Given the unique cultural background, way of life, and physical environment of the Tibetan Plateau, this study aims to investigate the effects of health education using problem-based learning (PBL) approach... Objective: Given the unique cultural background, way of life, and physical environment of the Tibetan Plateau, this study aims to investigate the effects of health education using problem-based learning (PBL) approaches on the knowledge, attitude, practice, and coping skills of women with high-risk pregnancies in this region. Methods: 76 high-risk pregnancy cases were enrolled at Tibet’s Linzhi People’s Hospital between September 2023 and April 2024. 30 patients admitted between September 2023 and December 2023 were selected as the control group and were performed with regular patient education. 46 patients admitted between January 2024 and April 2024 were selected as the observation group and were performed regular patient education with problem-based learning approaches. Two groups’ performance on their health knowledge, attitude, practice and coping skills before and after interventions were evaluated, and patient satisfaction were measured at the end of the study. Results: There was no statistical significance (P P P Conclusions: Health education with problem-based learning approaches is worth promoting as it can help high-risk pregnant women in plateau areas develop better health knowledge, attitude and practice and healthier coping skills. Also, it can improve patient sanctification. 展开更多
关键词 Plateau Areas Patients with high-risk Pregnancies Problem-Based Learning Health Education Health Knowledge Attitude and Practice Coping Skills
下载PDF
Experimental models of high-risk bowel anastomosis in rats:A systematic review
6
作者 Georgios Ntampakis Manousos-Georgios Pramateftakis +8 位作者 Elissavet Anestiadou Stefanos Bitsianis Orestis Ioannidis Chryssa Bekiari George Koliakos Maria Karakota Anastasia Tsakona Angeliki Cheva Stamatios Angelopoulos Fourth 《World Journal of Experimental Medicine》 2024年第2期114-131,共18页
BACKGROUND Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity,that negatively affect the patients’quality of life.Experimental studies play an imp... BACKGROUND Anastomotic leaks remain one of the most dreaded complications in gastrointestinal surgery causing significant morbidity,that negatively affect the patients’quality of life.Experimental studies play an important role in understanding the pathophysiological background of anastomotic healing and there are still many fields that require further investigation.Knowledge drawn from these studies can lead to interventions or techniques that can reduce the risk of anastomotic leak in patients with high-risk features.Despite the advances in experimental protocols and techniques,designing a high-quality study is still challenging for the investigators as there is a plethora of different models used.AIM To review current state of the art for experimental protocols in high-risk anastomosis in rats.METHODS This systematic review was performed according to The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.To identify eligible studies,a comprehensive literature search was performed in the electronic databases PubMed(MEDLINE)and Scopus,covering the period from conception until 18 October 2023.RESULTS From our search strategy 102 studies were included and were categorized based on the mechanism used to create a high-risk anastomosis.Methods of assessing anastomotic healing were extracted and were individually appraised.CONCLUSION Anastomotic healing studies have evolved over the last decades,but the findings are yet to be translated into human studies.There is a need for high-quality,well-designed studies that will help to the better understanding of the pathophysiology of anastomotic healing and the effects of various interventions. 展开更多
关键词 high-risk anastomosis RATS Experimental models BOWEL COLON Anastomotic leak Colon resection Inflammatory bowel disease Intra-abdominal sepsis Bursting pressure
下载PDF
Effect of Continuous Care on Postpartum Anxiety among Primipara Mothers in China
7
作者 Junyu Wang Xuan Li 《Journal of Clinical and Nursing Research》 2024年第8期129-136,共8页
Objective:The purpose of this study was to evaluate the effect of continuous care on postpartum anxiety in primipara mothers in China.Methods:A quasi-experimental,non-equivalent control group design was employed.The i... Objective:The purpose of this study was to evaluate the effect of continuous care on postpartum anxiety in primipara mothers in China.Methods:A quasi-experimental,non-equivalent control group design was employed.The initial screening involved 120 primipara women from two hospitals in Shandong Province.Based on the inclusion criteria,60 eligible primipara mothers were selected to participate in the study.Results:The findings indicated that continuous care significantly reduced the anxiety levels of primipara mothers,as shown by a marked decrease in the scores on a researcher-developed anxiety scale.Conclusion:Continuous care has been proven to be an effective intervention for alleviating postpartum anxiety in Chinese primipara mothers and has a positive impact on their mental health and postpartum recovery. 展开更多
关键词 Continuous care Postpartum anxiety primipara mothers
下载PDF
Application Value of NLR,PLR,LMR,HEART score,and POCT in Early Warning and Accurate Graded Diagnosis of High-Risk Chest Pain in Emergency Medicine
8
作者 Shaochang Ma Chunhua Lin +2 位作者 Yanmei Li Yan Chen Guohui Zhang 《Journal of Clinical and Nursing Research》 2024年第4期93-98,共6页
Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and p... Objective: To evaluate the application value of neutrophils/lymphocytes (NLR), platelets/lymphocytes (PLR), lymphocytes/monocytes (LMR), HEART (history, electrocardiogram, age, risk factors, and troponin) score, and point-of- care testing (POCT) in the early warning and precise diagnosis of high-risk chest pain in emergency medicine. Methods: A total of 157 patients with acute chest pain who were admitted to the emergency department and chest pain treatment unit of our hospital between August 2022 and September 2023 were selected. Rapid testing of bedside myocardial markers (ultrasensitive troponin (hs-cTnI), myoglobin (MYO), creatine kinase isoenzyme (CK-MB), D-dimer (D-Dimer), and N-terminal B-type natriuretic peptide precursor (NT-proBNP)) was performed on the patients using a POCT device (ThermoKing BioMQ60proB). A HEART score was used to classify the patients into low (n = 53), intermediate (n = 59), and high-risk (n = 45) groups, and the NLR, PLR, and LMR were calculated. The NLR, PLR, and LMR values were compared among the three groups of patients, and the optimal cutoff values as well as sensitivity and specificity were determined based on receiver operating characteristic (ROC) analysis. Results: The HEART scores of patients in the low-risk, intermediate-risk, and high-risk groups were (2.72 ± 0.24), (4.75 ± 0.56), and (5.32 ± 0.73) respectively, and the differences were statistically significant (P < 0.05). Compared with the low-risk group, the intermediate-risk group and high-risk group had a significantly higher NLR and PLR, and a significantly lower LMR;the high-risk group had higher NLR and PLR and lower values of LMR as compared to the other two groups, and the difference was statistically significant (P < 0.05). The ROC curves suggested that the area under the curve, sensitivity, and specificity of the combined diagnosis of NLR, PLR, LMR, HEART score, and POCT were greater than those of LR, PLR, and LMR with HEART score and POCT alone. Conclusion: The combined application of NLR, PLR, LMR, HEART score, and POCT has significant application value in the early warning and precise diagnosis of emergency high-risk chest pain. It provides a more simple, easy-to-access, and efficient assessment index for the clinical prediction and treatment of emergency high- risk chest pain. 展开更多
关键词 NLR PLR LMR POCT myocardial markers HEART score Emergency high-risk chest pain
下载PDF
Mediating effect of mindfulness level on the relationship between marital quality and postpartum depression among primiparas 被引量:1
9
作者 Jian Yang Xin-Zhu Lin +4 位作者 Qian-Wen Guo Cheng-Ling Wang Ren-Yan Yang Jun-Wen Zhang Yan Zeng 《World Journal of Clinical Cases》 SCIE 2023年第12期2729-2739,共11页
BACKGROUND Postpartum depression refers to a depressive episode or depressive symptoms up to 12 mo after delivery.Trait mindfulness has presented a protective factor for postpartum depressive symptoms and proved effic... BACKGROUND Postpartum depression refers to a depressive episode or depressive symptoms up to 12 mo after delivery.Trait mindfulness has presented a protective factor for postpartum depressive symptoms and proved efficient in improving relationship satisfaction among couples.AIM To investigate the correlations among mindfulness,marital quality,anxiety,and depression in a large city in western China during the post-corona virus infectious disease-2019 era and determine whether trait mindfulness mediates the relationship between marital quality and postpartum anxiety and depression among primiparas.METHODS A cross-sectional study was conducted.The self-administered questionnaire was submitted online through smartphones.The levels of mindfulness,anxiety,depression,and marital quality were respectively investigated by the mindful attention awareness scale(MAAS),the self-rating anxiety scale(SAS),the selfrating depression scale(SDS),and the marriage perception scale(MPS)in these enrolled Han and Tujia primiparas.RESULTS No statistical significance was observed in the prevalence of postpartum anxiety and depression,nor scores of MAAS and MPS-Total in different regions or ethnicities(P>0.05).However,MPSMarital interaction(P<0.05),MPS-Family relationship(MPS-FR)(P<0.01),and MPS-Marital conflict(MPS-MC)(P<0.01)scores of urban primiparas were higher than those of rural primiparas.The MPS-MC score of Han primiparas was higher than that of Tujia primiparas(P<0.05).Negative correlations were observed between MAAS and SAS(r=-0.457,P<0.01),and MAAS and SDS(r=-0.439,P<0.01).SAS has revealed a highly positive correlation with SDS(r=0.720,P<0.01)and a weak negative correlation with MPS(r=-0.200,P<0.05).Besides,a weak negative correlation was observed between MAAS and MPS-MC(r=-0.184,P<0.05),and a weak positive correlation was noticed between SAS and MPS-MC(r=-0.225,P<0.01).Mediation analysis demonstrated a full mediation effect of mindfulness level on the relationship between MPS-FR and postpartum anxiety(P<0.05,95%CI:-0.384 to 0.033),MPS-MC and postpartum anxiety(P<0.01,95%CI:0.027-0.193),MPS-FR and postpartum depression(P<0.05,95%CI:-0.365 to 0.031),and MPS-MC and postpartum depression(P<0.01,95%CI:0.022-0.206).CONCLUSION Mindfulness demonstrates negative correlations with marital conflict,postpartum anxiety and depression,and it may have cross-ethnic and trans-regional characteristics.Although the mindfulness levels have revealed no significant mediating effect between the total score of marital quality and postpartum depression in this study,it demonstrates a full mediation effect on the relationships between family relationships,marital conflict,and postpartum anxiety and depression. 展开更多
关键词 Mediating effect MINDFULNESS Marital quality Postpartum depression Postpartum anxiety primiparas
下载PDF
Two-step strategy—conjunctival flap covering surgery combined with secondary deep anterior lamellar keratoplasty for the treatment of high-risk fungal keratitis 被引量:1
10
作者 Yu-Chen Wang Jia-Song Wang +3 位作者 Bei Wang Xi Peng Hua-Tao Xie Ming-Chang Zhang 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第7期1065-1070,共6页
AIM:To investigate whether the two-step strategy[conjunctival flap covering surgery(CFCS)combined with secondary deep anterior lamellar keratoplasty(DALK)]is effective for patients with high-risk fungal keratitis(FK).... AIM:To investigate whether the two-step strategy[conjunctival flap covering surgery(CFCS)combined with secondary deep anterior lamellar keratoplasty(DALK)]is effective for patients with high-risk fungal keratitis(FK).METHODS:In this noncomparative,retrospective case series,10 subjects(6 males,4 females)with a mean age of 56.5±7.1(range 47-72)y with high-risk FK undergone the two-step strategy were included.Reported outcome measures were healing of the corneal ulcer,recurrence of FK,reject reaction,improvement in best corrected visual acuity(BCVA)and relevant complications.RESULTS:The average diameter of corneal infiltrates was 7.50±0.39 mm,ranging from 6.94 to 8.13 mm.The mean depth of corneal infiltrates was 422.4±77.1μm,ranging from 350 to 535μm.The mean corneal thickness was 597.4±117.3μm,ranging from 458 to 851μm.Hypopyon and endothelial plaques were presented in all patients.The period between the two steps was 3.65±0.9(ranging from 3 to 5)mo.The graft diameter was 7.75±0.39 mm.At the last follow-up(average 9.25±3.39,ranging from 5.5 to 17mo),no fungal recurrence or graft rejection appeared,and all patients showed improvement of BCVA.One patient suffered from liver function impairment due to oral voriconazole for 4wk and recovered spontaneously after 1wk of drug withdrawal.CONCLUSION:The two-step strategy is safe and effective in the treatment of high-risk FK by transforming intentional therapeutic penetrating keratoplasty during acute infection to later optical DALK.It is a practical strategy,especially in areas lacking fresh donor corneas and eye bank services. 展开更多
关键词 high-risk fungal keratitis conjunctival flap deep anterior lamellar keratoplasty two-step strategy
下载PDF
Non-invasive model for predicting high-risk esophageal varices based on liver and spleen stiffness 被引量:1
11
作者 Long-Bao Yang Xin Gao +7 位作者 Hong Li Xin-Xing Tantai Fen-Rong Chen Lei Dong Xu-Sheng Dang Zhong-Cao Wei Chen-Yu Liu Yan Wang 《World Journal of Gastroenterology》 SCIE CAS 2023年第25期4072-4084,共13页
BACKGROUND Acute bleeding due to esophageal varices(EVs)is a life-threatening complication in patients with cirrhosis.The diagnosis of EVs is mainly through upper gastrointestinal endoscopy,but the discomfort,contrain... BACKGROUND Acute bleeding due to esophageal varices(EVs)is a life-threatening complication in patients with cirrhosis.The diagnosis of EVs is mainly through upper gastrointestinal endoscopy,but the discomfort,contraindications and complications of gastrointestinal endoscopic screening reduce patient compliance.According to the bleeding risk of EVs,the Baveno VI consensus divides varices into high bleeding risk EVs(HEVs)and low bleeding risk EVs(LEVs).We sought to identify a non-invasive prediction model based on spleen stiffness measurement(SSM)and liver stiffness measurement(LSM)as an alternative to EVs screening.AIM To develop a safe,simple and non-invasive model to predict HEVs in patients with viral cirrhosis and identify patients who can be exempted from upper gastrointestinal endoscopy.METHODS Data from 200 patients with viral cirrhosis were included in this study,with 140 patients as the modelling group and 60 patients as the external validation group,and the EVs types of patients were determined by upper gastrointestinal endoscopy and the Baveno Ⅵ consensus.Those patients were divided into the HEVs group(66 patients)and the LEVs group(74 patients).The effect of each parameter on HEVs was analyzed by univariate and multivariate analyses,and a noninvasive prediction model was established.Finally,the discrimination ability,calibration ability and clinical efficacy of the new model were verified in the modelling group and the external validation group.RESULTS Univariate and multivariate analyses showed that SSM and LSM were associated with the occurrence of HEVs in patients with viral cirrhosis.On this basis,logistic regression analysis was used to construct a prediction model:Ln[P/(1-P)]=-8.184-0.228×SSM+0.642×LSM.The area under the curve of the new model was 0.965.When the cut-off value was 0.27,the sensitivity,specificity,positive predictive value and negative predictive value of the model for predicting HEVs were 100.00%,82.43%,83.52%,and 100%,respectively.Compared with the four prediction models of liver stiffness-spleen diameter to platelet ratio score,variceal risk index,aspartate aminotransferase to alanine aminotransferase ratio,and Baveno VI,the established model can better predict HEVs in patients with viral cirrhosis.CONCLUSION Based on the SSM and LSM measured by transient elastography,we established a non-invasive prediction model for HEVs.The new model is reliable in predicting HEVs and can be used as an alternative to routine upper gastrointestinal endoscopy screening,which is helpful for clinical decision making. 展开更多
关键词 CIRRHOSIS high-risk esophageal varices Non-invasive prediction model Spleen stiffness measurement Liver stiffness measurement Upper gastrointestinal endoscopy
下载PDF
Nursing model of midwifery and postural and psychological interventions:Impact on maternal and fetal outcomes and negative emotions of primiparas 被引量:1
12
作者 Ping Gao Cai-Qiong Guo +1 位作者 Ma-Yu Chen Hui-Ping Zhuang 《World Journal of Psychiatry》 SCIE 2023年第8期543-550,共8页
BACKGROUND Primiparas are usually at high risk of experiencing perinatal depression,which may cause prolonged labor,increased blood loss,and intensified pain,affecting maternal and fetal outcomes.Therefore,interventio... BACKGROUND Primiparas are usually at high risk of experiencing perinatal depression,which may cause prolonged labor,increased blood loss,and intensified pain,affecting maternal and fetal outcomes.Therefore,interventions are necessary to improve maternal and fetal outcomes and alleviate primiparas’negative emotions(NEs).AIM To discusses the impact of nursing responsibility in midwifery and postural and psychological interventions on maternal and fetal outcomes as well as primiparas’NEs.METHODS As participants,115 primiparas admitted to Quanzhou Maternity and Child Healthcare Hospital between May 2020 and May 2022 were selected.Among them,56 primiparas(control group,Con)were subjected to conventional midwifery and routine nursing.The remaining 59(research group,Res)were subjected to the nursing model of midwifery and postural and psychological interventions.Both groups were comparatively analyzed from the perspectives of delivery mode(cesarean,natural,or forceps-assisted),maternal and fetal outcomes(uterine inertia,postpartum hemorrhage,placental abruption,neonatal pulmonary injury,and neonatal asphyxia),NEs(Hamilton Anxiety/Depressionrating Scale,HAMA/HAMD),labor duration,and nursing satisfaction.RESULTS The Res exhibited a markedly higher natural delivery rate and nursing satisfaction than the Con.Additionally,the Res indicated a lower incidence of adverse events(e.g.,uterine inertia,postpartum hemorrhage,placental abruption,neonatal lung injury,and neonatal asphyxia)and shortened duration of various stages of labor.It also showed statistically lower post-interventional HAMA and HAMD scores than the Con and pre-interventional values.CONCLUSION The nursing model of midwifery and postural and psychological interventions increase the natural delivery rate and reduce the duration of each labor stage.These are also conducive to improving maternal and fetal outcomes and mitigating primiparas’NEs and thus deserve popularity in clinical practice. 展开更多
关键词 Nursing model of midwifery Postural intervention primipara Maternal and fetal outcomes Negative emotions
下载PDF
Features and Patterns of Primipara Delivery in a Cameroon Semi-Rural Area: The Case of Ayos Locality
13
作者 Serge Robert Nyada Cliford E. Ebong +7 位作者 Junie Annick Metogo Ntsama Michelle Mendoua Christiane Nsahlai Véronique Mboua Pascale Mpono Emenguele Isidore Tompeen Etienne Belinga Cyrile Claude Noa Ndoua 《Open Journal of Obstetrics and Gynecology》 CAS 2023年第1期64-73,共10页
Introduction: The delivery of a primipara, a woman giving birth for the first time, is challenging and may lead to complications and influence the obstetrical future of a woman. Materials and Methods: We carried out a... Introduction: The delivery of a primipara, a woman giving birth for the first time, is challenging and may lead to complications and influence the obstetrical future of a woman. Materials and Methods: We carried out a cross-sectional and analytical study at the maternity of the regional hospital annex of Ayos, a semi-rural locality in Cameroon, for the period between January 2012 and December 2020. The objective was to determine the frequency and the determinants of primipara delivery. Results: We recruited 440 cases. The frequency of primipara delivery was 31.8%. The ages of the participants ranged from 12 to 35 years with a mean age of 18.01 ± 3.52 years. Single women contributed to 95.5% of cases while 97.5% were unemployed. The delivery occurred at term in 90.2% and 98.4% of pregnancies were singleton. The delivery was vaginal in 91.6%, while caesarean delivery was done in 8.4% (8% emergency and 0.4% elective). The most frequent maternal complications were genital tract tears (15.7%), post-partum hemorrhage (12.5%) and endometritis (2.7%). The birth weight of newborns ranged from 1070 to 4500 g with a mean of 3024.5 ± 511.4 g. The single marital status, a gestational age between 37 and 42 weeks and a birth weight between 1500 g and 2499 g were significantly associated with vaginal delivery. Conclusion: The frequency of primiparous delivery was relatively high (31.8%) in the Ayos semi-rural health district of Cameroon. Major complications associated with delivery included genital tract tears, post-partum hemorrhage, cesarean section and neo-natal infection. 展开更多
关键词 primipara Delivery COMPLICATION Semi-Rural Cameroon
下载PDF
Efficacy and safety of Lianhuaqingwen capsules in high-risk common type COVID-19 pneumonia:A multicenter retrospective study
14
作者 Bin Liu Liang Li +4 位作者 Lei Liu Min Ye Wei Zhang Xiangdong Zhou Qi Li 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2023年第9期418-424,共7页
Objective:To evaluate the clinical safety and efficacy of Lianhuaqingwen(LHQW)capsules in patients with high-risk common type COVID-19 pneumonia.Methods:A retrospective multicenter study on 383 high-risk common type C... Objective:To evaluate the clinical safety and efficacy of Lianhuaqingwen(LHQW)capsules in patients with high-risk common type COVID-19 pneumonia.Methods:A retrospective multicenter study on 383 high-risk common type COVID-19 pneumonia cases was conducted.Patients were categorized as the standard treatment(SDT)group(n=168)and the LHQW+SDT group(n=215).The primary endpoint was the rate of symptom(fever,fatigue,coughing)recovery and the secondary endpoints included the time to symptom recovery,the proportion of patients with improvement in chest CT images,the proportion of patients with clinical cure,the timing and rate of negative conversion of SARS-CoV-2 RNA assay.Results:The recovery rate was significantly higher in the LHQW+SDT group as compared with the SDT group(89.7%vs.72.0%,P<0.01).The combined use of LHQW+SDT also showed shorter time for symptom recovery,as well as shorter time for individual symptom of fever,fatigue and coughing recovery than use of SDT alone.A higher proportion of patients in the LHQW+SDT group with improvements in chest CT images and clinical cure(77.7%vs.57.1%,P<0.01)but the proportion of patients deteriorating to severe cases(1%vs.25%,P<0.01)in this group was significant lower than those in the SDT group.No significant difference in negative conversion rate of viral assay results was observed(76.8%vs.75.0%,P>0.05).No serious adverse events were reported.Conclusions:LHQW capsules could be recommended to ameliorate clinical symptoms and reduce the rate of deteriorating to severe cases for high-risk common type COVID-19 pneumonia. 展开更多
关键词 Lianhuaqingwen capsules COVID-19 pneumonia high-risk common type Clinical efficacy
下载PDF
Analysis of the relationship between 24-hour sodium and blood pressure and the dietary status based on mobile phone APP in the high-risk population of hypertension in Haikou
15
作者 CHEN Jun-cai YAN You-xuan +2 位作者 LIN Liu-ting ZHAO Chan-juan ZHANG Fan 《Journal of Hainan Medical University》 CAS 2023年第10期35-42,共8页
Objective:To understand the dietary intake of high-risk population with hypertension in Haikou,and to analyze the relationship between dietary intake and blood pressure,especially the relationship between sodium intak... Objective:To understand the dietary intake of high-risk population with hypertension in Haikou,and to analyze the relationship between dietary intake and blood pressure,especially the relationship between sodium intake and blood pressure,so as to provide a scientific basis for salt reduction.Methods:A multi-stage cluster sampling 2021 was used from July to December to collect 3-4 cscs from each of the four districts in Haikou.A total of 15 cscs were collected,295 permanent residents aged 55-74 were recruited from 15 community service centers,with 20 eligible subjects from each community.The subjects underwent general physical examination,laboratory tests,and a dietary survey using the self-developed Android phone APP“Nutrition Assistant”(registration number:2021SR1547832).SPSS 21.0 was used 2 for t test,x^(2) test and multiple Regression analysis.Result:In Haikou,69.4%of the subjects had energy intake above energy requirement,and 44.8%had fat intake above the acceptable range of macronutrients.There were only differences in energy,carbohydrate,vitamin B 6 and sodium intake(t=-2.174,-1.990,2.333,-5.442,P=0.031,0.048,0.021,<0.001,respectively).There were significant differences in BMI,family history of chronic diseases,systolic blood 2 pressure and diastolic blood pressure(f value or x^(2) value were 4.260,19.045,139.916,36.864,P value were 0.015,<0.001,<0.001,<0.001,respectively).Multiple Regression analysis analysis showed that 24h sodium excretion was significantly correlated with systolic and diastolic blood pressure(t=12.964,P<0.001),systolic and diastolic blood pressure increased by 0.135 mmhg and 0.068 mmhg,respectively.Conclusion:The dietary intake of the middle-aged and elderly people at high risk of hypertension in the Haikou community was unbalanced,and the intake of sodium salt was strongly correlated with blood pressure,it is necessary to continue to promote salt reduction as one of the key ways to prevent and control hypertension. 展开更多
关键词 DIET Blood pressure high-risk population Sodium salt
下载PDF
Letter to editor‘Non-invasive model for predicting high-risk esophageal varices based on liver and spleen stiffness’
16
作者 Xin Gao Xiao-Yan Guo +6 位作者 Long-Bao Yang Zhong-Cao Wei Pan Zhang Ya-Tao Wang Chen-Yu Liu Dan-Yang Zhang Yan Wang 《World Journal of Hepatology》 2023年第11期1250-1252,共3页
predicting high-risk esophageal varices based on liver and spleen stiffness".Acute bleeding caused by esophageal varices is a life-threatening complication in patients with liver cirrhosis.Due to the discomfort,c... predicting high-risk esophageal varices based on liver and spleen stiffness".Acute bleeding caused by esophageal varices is a life-threatening complication in patients with liver cirrhosis.Due to the discomfort,contraindications,and associated complications of upper gastrointestinal endoscopy screening,it is crucial to identify an imaging-based non-invasive model for predicting high-risk esophageal varices in patients with cirrhosis. 展开更多
关键词 CIRRHOSIS high-risk esophageal varices Non-invasive prediction model Spleen stiffness measurement Liver stiffness measurement Upper gastrointestinal endoscopy
下载PDF
Distribution of High-Risk Human Papillomavirus Genotypes among Women with Colposcopic Diagnosis of Cervical Intraepithelial Neoplasia in Bangladesh
17
作者 Siddika Mosammat Shahida Mina Chowdhury +4 位作者 Fatima Shajahan Jannat Ara Rifat Alfi Sharin Lubaba S. M. Shamsuzzaman Annekathryn Goodman 《Journal of Cancer Therapy》 2023年第6期277-290,共14页
Background: The incidence of cervical cancer is high in Bangladesh and there is a high prevalence of preinvasive lower genital tract disease among women of reproductive age. Persistent high-risk Human Papilloma Virus ... Background: The incidence of cervical cancer is high in Bangladesh and there is a high prevalence of preinvasive lower genital tract disease among women of reproductive age. Persistent high-risk Human Papilloma Virus (HPV) infection is the main underlying cause of cervical cancer and its precursor, cervical intraepithelial neoplasia (CIN). Objective: The aim of the study was to identify the subtypes of high-risk HPV infection among women with the colposcopic diagnosis of cervical intraepithelial neoplasia in Bangladesh. Methods: This cross-sectional observational study was conducted in the colposcopy clinic of Dhaka Medical College Hospital over a six-month period. A total of 100 participants were enrolled. Married women, between 30 - 60 years of age with colposcopically diagnosed cervical intra epithelial neoplasia were enrolled. Women with chronic illness, pregnancy, and women unable to consent were excluded from this study. After counselling, colposcopically directed punch biopsies were taken from each CIN case concurrently with high-risk HPV testing by polymerase chain reaction (PCR). Results: The mean age of the patients was 38.69 (SD ±7.76) years. CIN 1 was diagnosed in 57% of participants, while 24% had CIN II and 19% had CIN III lesions. High-risk HPV was present in 52 patients. HPV 16 was the most common identified in 28 (53.84%) and HPV 18 was the second most common with 20 (38.46%) either singly or in combination with other high-risk subtypes. The other HPV strains, HPV 31, 33, 35, 52, 56 and 58, were also detected either as mono or co-infections. Out of the 52 HPV positive cases, 29 (55.8%) had mono infection and 23 (44.2%) had co-infection with several subtypes. The highest incidence (50%) of oncogenic HPV infections was present among women aged 35 - 45 years. Risk factors associated with HPV positive cases were high parity (P 0.05), early age at marriage (P = 0.754) and early age of first child. Conclusion: This study identified a high prevalence of HPV 16 and 18 genotypes. HPV vaccination with the current 9-valent HPV vaccine, which contains HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58. Will be an effective public health measure to eradicate cervical cancer in Bangladesh. 展开更多
关键词 BANGLADESH Cervical Cancer Cervical Intraepithelial Neoplasia Human Papillomavirus Infection high-risk HPV
下载PDF
以家庭为中心的赋能健康教育模式在剖宫产初产妇早期母乳喂养中的应用 被引量:1
18
作者 金微 曾铁英 +5 位作者 刘莉 杨凌艳 王颖 邢翠 董娜娜 张帆 《护士进修杂志》 2024年第8期838-843,853,共7页
目的探讨以家庭为中心的赋能健康教育模式在剖宫产初产妇早期母乳喂养中的应用效果。方法选取2021年11月-2022年1月在我院计划行剖宫产的初产妇及其照顾者93例作为对照组,采用常规健康教育宣教方法,宣教对象主要为初产妇本人;选取2022年... 目的探讨以家庭为中心的赋能健康教育模式在剖宫产初产妇早期母乳喂养中的应用效果。方法选取2021年11月-2022年1月在我院计划行剖宫产的初产妇及其照顾者93例作为对照组,采用常规健康教育宣教方法,宣教对象主要为初产妇本人;选取2022年3-7月在我院计划行剖宫产的初产妇及其照顾者98例作为观察组,在对照组基础上实施以家庭为中心的赋能健康教育模式。比较2组初产妇及其照顾者干预前后母乳喂养知识情况;干预前后初产妇婴儿喂养态度、母乳喂养家庭支持;干预后初产妇泌乳Ⅱ期启动时间和出院时纯母乳喂养率。结果干预前2组初产妇及照顾者各指标比较,差异均无统计学意义(P>0.05);干预后,观察组初产妇及其照顾者母乳喂养知识,以及初产妇婴儿喂养态度、母乳喂养家庭支持、泌乳Ⅱ期启动时间和出院时纯母乳喂养率方面均优于对照组(P<0.05)。结论以家庭为中心的赋能健康教育模式能提高产妇及照顾者的母乳喂养知识,提升婴儿喂养态度及母乳喂养家庭支持,缩短泌乳Ⅱ期启动时间,提高产妇出院时纯母乳喂养率。 展开更多
关键词 以家庭为中心的赋能健康教育模式 剖宫产 初产妇 早期母乳喂养 围产期护理
下载PDF
产房家庭协同护理对初产妇心理状况、分娩自我效能及母婴结局的影响 被引量:2
19
作者 曹慧 丁巧巧 +1 位作者 马明月 汪亚君 《中国计划生育学杂志》 2024年第1期241-245,共5页
目的:探讨产房家庭协同护理对初产妇心理状况、分娩自我效能及母婴结局影响.方法:选取2020年5月-2021年12月在本院产检并分娩的初产妇为研究对象,按随机数字表法分为观察组和对照组各60例.对照组临产进入产房后常规护理与指导,观察组在... 目的:探讨产房家庭协同护理对初产妇心理状况、分娩自我效能及母婴结局影响.方法:选取2020年5月-2021年12月在本院产检并分娩的初产妇为研究对象,按随机数字表法分为观察组和对照组各60例.对照组临产进入产房后常规护理与指导,观察组在对照组的基础上实施家庭成员协同护理.对比分析两组产妇干预前后SAS、SDS评分,分娩自我效能评分,分娩方式,产时VAS评分、产程时间及母婴结局之间的差异.结果:干预后观察组对象SAS评分、SDS评分下降显著,且低于对照组(P<0.05);结果效能、期望效能、自我效能总分提高,且高于对照组(均P<0.05);阴道分娩率显著高于对照组(91.7%比73.3%),中转剖宫产率低于对照组(8.3%比26.7%),差异有统计学意义(P<0.05).观察组经阴道分娩对象产时VAS评分、第一、二产程时间、产后2h出血量及新生儿Apgar评分均明显好于对照组(P<0.05).结论:产房家庭成员协同护理干预可有效改善初产妇心理状况,提高分娩自我效能,降低产时疼痛水平,缩短产程时间,促进阴道分娩,改善母婴结局. 展开更多
关键词 初产妇 家庭协同护理 心理状况 分娩自我效能 母婴结局
下载PDF
生物反馈电刺激治疗膀胱脱垂产妇的盆底肌弹性变化
20
作者 穆靓 郝睿 +5 位作者 南淑良 李良红 陈浩 刘莉 胡盈 管湘平 《山西医药杂志》 CAS 2024年第13期963-967,共5页
目的探讨生物反馈电刺激治疗对膀胱脱垂初产妇盆底肌弹性及盆底解剖功能的影响。方法纳入产后40~45 d常规检查的足月顺产、单胎妊娠、有膀胱脱垂的初产妇66例,随机分为2组,规律接受生物反馈电刺激治疗女性为治疗组32例,同期未接受生物... 目的探讨生物反馈电刺激治疗对膀胱脱垂初产妇盆底肌弹性及盆底解剖功能的影响。方法纳入产后40~45 d常规检查的足月顺产、单胎妊娠、有膀胱脱垂的初产妇66例,随机分为2组,规律接受生物反馈电刺激治疗女性为治疗组32例,同期未接受生物反馈电刺激治疗为对照组34例。采用实时剪切波弹性成像(SWE)技术对2组女性耻骨直肠肌静息状态下弹性模量值进行测量,采用经会阴盆底四维超声检查测量静息状态、缩肛动作及Valsalva动作下肛提肌裂孔大小,并比较前后2次组间及组内的数值差异。结果治疗前首次检查:①SWE检查结果:治疗组与对照组女性双侧耻骨直肠肌弹性模量数值差异无统计学意义(P>0.05);②四维超声肛提肌裂孔面积:治疗组与对照组组内肛提肌裂孔面积在缩肛动作时较静息状态缩小,Valsalva动作面积最大(P<0.05);治疗组与对照组3种状态下分别比较,肛提肌裂孔面积测量值差异无统计学意义(P>0.05)。治疗后再次复查:①SWE检查结果:治疗组女性的经生物反馈电刺激3个月规律治疗后,盆底肌弹性模量测值较治疗前增大、弹性值增高,且在2组女性前后2次检查中测值最大(P<0.05);对照组弹性模量测值较首次检查差异无统计学意义(P>0.05);②四维超声肛提肌裂孔面积:治疗组女性3种状态下,肛提肌裂孔面积测值均较治疗前缩小,且在2组女性前后2次检查中分别在3种状态下测值均最小(P<0.05);对照组女性复查,肛提肌裂孔面积测值较治疗前比较差异无统计学意义(P>0.05)。结论SWE结合盆底四维超声动态检查相结合,表明膀胱脱垂初产妇经过规律生物反馈电刺激治疗后,耻骨直肠肌弹性增大,肛提肌裂孔面积缩小,盆底肌松弛状况得以改善。 展开更多
关键词 电刺激疗法 膀胱膨出 生物反馈 初产妇
下载PDF
上一页 1 2 147 下一页 到第
使用帮助 返回顶部