Extracorporeal shockwave lithotripsy in the management of urinary stones: New concepts and techniques to improve outcomes

Objective: Extracorporeal shockwave lithotripsy (SWL) currently plays an important role in the treatment of urinary tract lithiasis. The purpose of this article was to describe new concepts and procedural strategies that would improve results using SWL as a treatment for urolithiasis, thereby achieving better clinical practice.Methods: A systematic review process was carried in PubMed/PMC from January 2003 to March 2023. A narrative synthesis of the most important aspects has been made.Results: The important recommendations for the adequate selection of the candidate patient for treatment with SWL are summarized, as well as the new strategies for a better application of the technique. Aspects about intraoperative position, stone localization and monitoring, analgesic control, machine and energy settings, and measures aiming at reduced risk of complications are described.Conclusion: To achieve the therapeutic goal of efficient stone disintegration without increasing the risk of complications, it is necessary to make an adequate selection of patients and to pay special attention to several important factors in the application of treatment. Technological development in later generation devices will help to improve current SWL results.

The association of benign prostatic hyperplasia with lower urinary tract stones in adult men: A retrospective multicenter study

Objective:To examine the relationship between benign prostatic hyperplasia(BPH)and the presence of lower urinary tract stones.Methods:We retrospectively reviewed the records of men with lower urinary tract stones who presented to three clinical centers in Korea over a 4-year period.We divided the patients into two groups based on the location of urinary stones:Group 1(bladder calculi)and Group 2(urethral calculi).We compared the characteristics of both groups and performed univariate and multivariate analyses with a logistic regression model to investigate the relationship between BPH and lower urinary tract stones.Results:Of 221 patients,194(87.8%)had bladder calculi and 27(12.2%)had urethral calculi.The mean age of Group 1 was higher than that of Group 2(68.96
12.11 years vs.55.74
14.20 years,p<0.001).The mean prostate volume of Group 1 was higher than that of Group 2(44.47
27.14 mL vs.24.70
6.41 mL,respectively,p<0.001).Multivariate logistic regression showed that age(OR Z 1.075,95%CI:1.023e1.129)and prostate volume(OR Z 1.069,95%CI:1.017e1.123)were independently associated with increased risk for bladder calculi.Upper urinary tract stones and/or hydronephrosis conferred a 3-fold risk for urethral calculi(OR Z 3.468,95%CI:1.093e10.999).Conclusion:Age and prostate volume are independent risk factors for bladder calculi.In addition,men with upper urinary tract disease are at greater risk for urethral calculi,which may migrate from the upper urinary tract rather than from the bladder.

Neodymium:Yttrium Aluminum Garnet Laser for Mini-Percutaneous Treatment of Upper Urinary Tract Stones

To observe the efficacy and safety of mini-percutaneous nephrolithotomy with Neodymium：Yttrium Aluminum Garnet （Nd-YAG） laser in the treatment for upper urinary tract stones, from December 2005 to September 2006, 31 patients with renal stones, 15 patients with ureteral stones and 7 patients with renal and ureteral stones underwent mini-percutaneous nephrolithotomy with Nd-YAG laser by combination of rigid ureteroscope and flexible ureteroscope under B-ultrasound guidance. Clinical data including operation time, lithotripsy time, complications and stone-free rate were analyzed retrospectively. Our study showed that the percutaneous renal access （F14-F18） was successfully established under B-ultrasound guidance in all cases. Immediate phase Ⅰ lithotripsy was performed in 47 cases through single tract, and in one case through two tracts. Delayed phase Ⅱ lithotripsy was done in 5 cases of renal stones. Operation time ranged from 55 to 180 rain with an average time of 100±15 min. Lithotripsy time was from 25 to 135 min and the average lithotripsy time was 65±11 min. No severe complications occurred in our series. Complex renal stones were cleared in 34 of 38 cases （89.5 %）. All ureteral stones were completely removed in 15 cases （100 %）. It was concluded that mini-percutaneous nephrolithotomy with Nd：YAG laser for the treatment of upper urinary tract stones by combination of rigid ureteroscope and flexible ureteroscope has the advantages of effectiveness, mini-invasion, shorter operative time and safety.

Antilithic Effects of Extracts from Urtica dentata Hand on Calcium Oxalate Urinary Stones in Rats

This study examined the potential antilithic effects of a traditional Chinese medicine Urtica dentata Hand （UDH） in experimental rats and screened the optimal extract of UDH as a possible therapeutic agent for kidney stones. The rat model of urinary calcium oxalate stones was induced by intragastric （i.g.） administration of 2 mL of 1.25% ethylene glycol （EG） and 1% ammonium chloride （AC） for 28 days and was confirmed by Color Doppler ultrasound imaging. The rats in different experimental groups were then intragastrically given petroleum ether extract （PEE）, N-butanol extract （NBE）, aqueous extract （AqE） of UDH, Jieshitong （positive control drug）, and saline, respectively. Treatment with NBE significantly reduced the elevated levels of urinary calcium, uric acid, phosphate, as well as increased urinary output. Accordingly, the increased calcium, oxalate levels and the number of calcium oxalate crystals deposits were remarkably reverted in the renal tissue of NBE-treated rats. In addition, NBE also prevented the impairment of renal function to decrease the contents of blood urea nitrogen （BUN） and creatinine. Taken together, these data suggest that NBE of UDH has a beneficial effect on calcium oxalate urinary stones in rats by flushing the stones out and protecting renal function.

Usefulness of hounsfield unit and density in the assessment and treatment of urinary stones

Computed tomography(CT) is widely used to examine stones in the urinary system.In addition to the size and location of the stone and the overall health of the kidney,CT can also assess the density of the stone in Hounsfield units(HU).The HU,or Hounsfield density,measured by CT,is related to the density of the tissue or stone.A number of studies have assessed the use of HU in urology.HUs have been used to predict the type and opacity of stones during diagnosis,and the efficacy has been assessed using methods including extracorporeal shock wave lithotripsy(ESWL),percutaneous nephrolithotomy(PCNL),ureterorenoscopic ureterolithotripsy(URSL),and medical expulsive treatment(MET).Previous studies have focused on the success rate of HU for predicting the type of stone and of ESWL treatment.Understanding the composition of the stone plays a key role in determining the most appropriate treatment modality.The most recent reports have suggested that the HU value and its variants facilitate prediction of stone composition.However,the inclusion of data regarding urine,such as pH and presence of crystals,increases the predictive accuracy.HUs,which now form part of the clinical guidelines,allow us to predict the success of ESWL; therefore,they should be takeninto account when ESWL is considered as a treatment option.However,there are currently insufficient data available regarding the value of HU for assessing the efficacy of PCNL,URSL,and MET.Studies performed to date suggest that these values would make a significant contribution to the diagnosis and treatment of urinary system stones.However,more data are required to assess this further.

Epidemiologic, Diagnostic, and Therapeutic Features of Urinary Stone Disease in Northern Benin from 2018 to 2023

Objective: To determine the epidemiologic, diagnostic, and therapeutic features of urinary in northern Benin from 2018 to 2023. Patients and Method: The study was an observational and descriptive one. We exhaustively and retrospectively collected data from the medical records of the patients that were managed from February 1, 2018 to February 1, 2023 at the Department of Surgery of “Centre Hospitalier Universitaire Départmental Borgou-Alibori or CHUD-BA”. Results: Among the 4522 patients managed, 75% or 1.7% had urinary stone disease. Their mean age was 41 years. The sex ratio was 2.75, the males being predominantly affected. Of the 75 cases of urinary stone disease, 30.7% (n = 23) were renal, 46.7% (n = 35) were ureteral, and 22.7% (n = 17) were vesical. The patients came from variable geographical areas, ethnic groups, and professional sectors. Their main complaints were pain (57.3%), hematuria (14.7%), dysuria (12%), and fever (5.3%). 15 (20%) patients, i.e., 7 renal stone and 8 ureteral stone patients, had an obstructive renal failure. The imaging tools available were ultrasonography, tomography and computed tomographic scan. 11 of the bladder stone cases (64.7%) were associated with a bladder outlet obstruction. Overall, 38.7% of the patients had either diabetes mellitus (6.7%), hypertension or high blood pressure (6.7%), benign prostate hyperplasia (8%), urinary schistosomiasis (6.7%), ureteral pelvic junction obstruction (2.7%), and prostate cancer (1.3%). Of the 19 patients whose dietary behavior was investigated 15 (79%), 11 (57.9%) et 11 (57.9%) demonstrated a diet which was respectively rich in milk, fromage and meat. 100% of bladder stones were removed through cystolithotomy. Renal stones were removed by pyelolithtomy (52.2%) and nephrolithotomy (21.7%). Ureteral stones were removed through ureterolithotomy (40%), expelled by means of alpha-blockers (40%) or managed with ureteral pigtail stent (20%). Conclusion: The hospital prevalence of urinary stone disease was 1.7%. The mean age in urinary stone-affected patients was 41 years. The urinary stone predominantly affected male patients: the sex ratio was 2.75. The stones were mainly removed through open surgery.

ACUPUNCTURE ANAESTHESIA IN TREATING URINARY TRACT STONE WITH EXTRACORPOREAL SHOCK WAVE LITHOTRIPSY

The anaesthetic effect of acupuncture on 40 patients during extracorporeal shockwave lithotripsy was observed in this study.The anaesthetic rate in 20 eases under manual acupunc-ture was 85％,and that in the other 20 patients under electro-acupuncture anaesthesia was 90％.Under the anaesthesia the patients were conscious and in normal physical conditions.The observationsindicate that the electro-acupuncture anaesthesia is safe,economical and effective.Additionally.it lib-erates acupuncturists from heavy needling manipulation.The relationship between the analgesic ef-fects antI the ages is analysed as well.

Effect of urinary stone disease and its treatment on renal function

Urolithiasis is a common disease that affects urinary tract in all age groups. Both in adults and in children, stone size, location, renal anatomy, and other factors, can infuence the success of treatment modalities. Recently, there has been a great advancement in technology for minimally invasive management of urinary stones.The epoch of open treatment modalities has passed and currently there are much less invasive treatment approaches, such as percutaneous nephrolithotomy, ureteroscopy, shockwave lithotripsy, and retrograde internal Surgery. Furthermore, advancement in imaging technics ensures substantial knowledge that permit physician to decide the most convenient treatment method for the patient. Thus, effective and rapid treatment of urinary tract stones is substantial for the preservation of the renal function. In this review, the effects of the treatment options for urinary stones on renal function have been reviewed.

Urinary stone disease and obesity: Different pathologies sharing common biochemical mechanisms

The prevalence of urolithiasis is increasing in parallel with the escalating rate of obesity worldwide. It has previously been speculated that obesity is a potential risk factor for urinary stone disease. The possibility that common biochemical mechanisms underlie both obesity and urolithiasis is remarkable. Better understanding of possible common mechanisms of these diseases could potentially lead to a better management of urinary stone prevention. The prevention of urinary stone for-mation gives clinicians an acceptable reason to encour-age lifestyle modification and weight loss through a regular diet. In this review, the association of obesity with urinary stone disease, possible common biochemi-cal mechanisms, effects of dietary habits and weight loss on stone formation, as well as diffculties in surgi-cal management of obese individuals with urolithiasis are discussed.

Determination of components in traditional Chinese medicines associated with promoting or inhibiting urinary stone formation

Objective:To measure oxalate,calcium,and sodium contents of traditional Chinese medicines(TCMs)that are commonly used to prevent and dissolve urinary stones to exclude the possibility that long-term use of such medicines promotes stone formation.The second objective was to measure citrate,potassium,and magnesium contents in the same medicines to provide possible clues about the mechanisms of prevention and dissolution of urinary stones by TCMs.Methods:Ten of the most commonly-used TCMs for preventing and dissolving urinary stones were chosen and subjected to ion chromatography(IC)to measure water-soluble and total oxalate and citrate contents.Inductively coupled plasma atomic emission spectrometry(ICPAES)was used to measure calcium,potassium,magnesium,and sodium contents in a water extract and in digestion liquid.Results:Average contents of water-soluble oxalate,calcium,and sodium in the water extract were 41.92,84.32,and 22.82 mg/100 g,respectively,far below the normal dietary intake of adults in China.The average contents of citrate and magnesium in water extracts were 268.99 and 66.65 mg/100 g,respectively,below the recommended intake for adults.These ion contents are therefore insufficient to inhibit the formation of urinary stones.The average content of potassium in the water extract was 867.71 mg/100 g,which was relatively abundant,so taking the prescription used in this experimental protocol can increase the body’s potassium content to some extent.Conclusions:Long-term use of TCMs would not increase the risk of urinary stone formation.The potassium content in TCMs is high,which is one possible reason for the prevention of urinary stones by TCMs.

Association between heat and upper urinary tract stones morbidity and medical costs: A study in the subtropical humid climate zone

Urolithiasis is a heat-specific disease.Exploring heat-related urolithiasis susceptibility subtypes,economic burden,and modifying factors could assist governments in targeting interventions to reduce the heat-related health risks of urolithiasis morbidity.We collected data on 23,492 patients with upper urinary tract stones(main subtypes of urolithiasis)from 2013 to 2017 in Nanjing,China.We adopted generalized additive quasi-Poisson models to examine the associations between daily mean temperatures and morbidity of upper urinary tract stones,while generalized additive Gaussian models were used to explore the relationships between temperatures and log-transformed medical costs.We examined the modification effects of disease subtypes(kidney and ureteral calculus),sex,and age through stratified analyses and the modif-cation effects of other meteorological factors by introducing interaction terms in the models.We found that short-term summer heat exposure has a statistically significant effect on ureteral calculus morbidity but not on kidney calculus morbidity.For ureter calculus,a 1℃ temperature increase was associated with a 4.36%(95%confidence interval[CI]:1.94%,6.83%)increase in daily hospitalization and a 5.44%(95%CI:2.71%,8.25%)increase in daily medical costs.The attributable fraction associated with heat(greater than the median value of daily mean temperature,26.8℃)was 7.85%(95%empirical confidence interval[eCI]:3.64%,11.44%)for hospitalization and 9.36%(95%eCI:4.91%,13.14%)for medical costs.The effects of heat on ureter calculus morbidity were significantly higher among the males and those with high sunshine duration than females and those with low sunshine duration.Short-term summer heat exposure was associated with increased morbidity and medical costs of ureteral calculus.Relevant government organizations should take effective intervention measures,including community health education,to reduce the health hazards and economic losses caused by heat.

A Study on the Interrelationship between Renal Calculi, Hormonal Abnormalities and Urinary Tract Infections in Iraqi Patients

Objective: The main objective of the present study is to assess the interrelationship between renal calculi, selected ions, thyroid and parathyroid hormones and urinary tract infections. Methods: This study was carried out on 150 patients attended Tikrit Teaching Hospital from 2008 to 2009. Stones and serum ions were analyzed utilizing relevant Biolab Company kits (France). Thyroid hormones were determined using ELISA microwells kit (Accuubind, USA) Parathyroid hormone was estimated by active I-PTH ELISA (DSL, USA).Urine cultures were done utilizing cystine-lactose- electrolyte deficient (CLED) medium. Various isolated pathogens were conventionally identified. Results: Urine cultures revealed that 42% of the patients had urinary tract infections particularly with Enterobacteriaceae. 68% of the stones tested were calcium oxalate. Infective and noninfective stones were classified. Calcium ion was more elevated in patients examined. Hypothyroidism was prevalent but parathyroid hormone (PTH) was elevated among 14 patients only. Conclusions: The frequency of UTI was higher among urolithiasis patients and the common causative agents were Gram negative bacteria. Renal stones of calcium origin were predominant. Hormonal abnormalities were seen. 15 patients with hyperthyroidism revealed hypercalcemia and hypercalciuria.

A Review on Kidney Stone and Its Herbal Treatment

Medicinal plants have been valued for millennia as a rich source of therapeutic compounds for the prevention of various ailments all throughout the world.Kidney stones and urinary calculi affect a huge percentage of the population nowadays.Stone sickness has become more prevalent as a result of changes in living conditions,such as industrialization and hunger.The most common stone recorded in India is calcium oxalate kidney stones.Changes in prevalence and incidence,the occurrence of stone kinds and stone position,and stone removal treatment are all discussed.Medicinal herbs have been utilised for centuries because they are safer,more effective,culturally acceptable,and have less adverse effects than manufactured medications.Patients are advised to consume a low-fat diet,as well as fibres from naturally occurring plants and herbal treatments.The current article discusses the steps that should be taken to maximise the potential of medicinal plants for stone dissolving action.Combining herbal remedies with allopathic treatment is an excellent way to eliminate all issues associated with kidney stones.The purpose of this article is to emphasise the use of herbs as a treatment for urinary stones.

Urethral Stone: A Rare Cause of Acute Retention of Urine in Men

Urethral stones are a very rare form of urolithiasis, they most often originate from the upper urinary tract or bladder, and are rarely formed primarily in the urethra, it is formed on a urethral anatomical pathology in the majority of cases. The clinical symptomatology is very variable ranging from simple dysuria with penile pain to acute retention of urine. Smaller stones can be expelled spontaneously without intervention, but larger stones or complicated stones or those developed on an underlying urethral anatomical pathology require surgical treatment. The minimally invasive treatment should be the preferred route for the surgical treatment of this disease when feasible. We report the case of a young man with no particular pathological history who presented to the emergency department for acute retention of urine secondary to a primary fossa navicularis calculus, through this case, we discuss the different clinical aspects, etiology, pathogenesis, diagnosis and therapy of urethral stone in men.

Urinary Oxalate Excretion Decreased in Androgen Receptor-Knockout Mice by Suppressing Oxalate Synthesis in the Liver

The incidence of calcium oxalate stone in men is higher than that in women. We evaluated the association between the androgen receptor (AR) and urinary oxalate excretion using Crefloxed male androgen receptor-knockout (ARKO) mice (ARL-/Y) and floxed mice (ARL+/Y) as control. Four-teen-week-old ARL-/Y and ARL+/Y mice were fed distilled water. Drinking water was then swapped for 0.5% ethylene glycol (EG). Urinary oxalate was measured on days 0, 14, and 28. Urinary calcium, inorganic phosphorus, citrate, uric acid, and ion-actibity products of calcium oxalate (APCaOx) in mouse, AP (CaOx)-indexMOUSE, were evaluated on days 0 and 15. On day 28, livers were harvested to measure mRNA expression of enzymes. Urinary oxalate excretion was significantly higher in ARL+/Y than in ARL-/Y mice 14 and 28 days after EG treatment (p L-/Y mice exhibited atrophic testes and low serum testosterone, both ARKO and control mice were orchiectomized and implanted DHT pellets (ARL-/Y-ORX-DHT, and ARL+/Y-ORX-DHT), and the same experiments as above were performed. EG loading for 14 and 28 days resulted in significantly higher excretion in ARL+/Y-ORX-DHT mice than ARL-/Y-ORX-DHT mice (p < 0.005). AP(CaOx)-indexMOUSE was significantly higher in ARL+/Y-ORX-DHT mice than in ARL-1/Y-ORX-DHT mice. mRNA expression levels of glycolate oxidase (GO) in liver were lower in ARKO mice than in control ones. AR modulates the excretion of oxalate in urine after EG treatment, which may be associated with increased oxalate synthesis by activated GO in the liver via the AR pathway.

Stone accumulation overlying vaginal mesh exposure:A case report

BACKGROUND Vaginal stones are rare with current literature limited to case reports.Vaginal stones are classified as primary or secondary stones.Primary stones form in the vagina when there is urinary stasis.Secondary stones form in the presence of a vaginal foreign body that acts as a nidus for the deposition of urinary salts.Foreign bodies,such as surgical mesh,make vaginal stone formation more likely,particularly in patients with urinary incontinence and conditions that predispose them to urinary calculi formation.CASE SUMMARY A 71-year-old female with a history of sacrocolpopexy,hyperaldosteronism,and urgency urinary incontinence presented with vaginal stone accumulation overlying two areas of vaginal sacrocolpopexy mesh exposure.The vaginal stones were initially removed to permit examination,but the stones reaccumulated at the site of the exposed mesh,later requiring definitive surgical management.CONCLUSION Patients with vaginal mesh exposure and conditions that predispose them to kidney stones are not ideal candidates for expectant management of mesh exposure,particularly if they have coexisting urinary incontinence.These individuals should be counseled about possible vaginal stone accumulation,and surgical management should be considered.

可控负压吸引下输尿管软镜钬激光碎石术治疗肾结石合并尿路感染的疗效分析

目的 分析肾结石且伴有尿路感染患者应用可控负压吸引下输尿管软镜钬激光碎石术治疗的临床效果。方法 80例肾结石合并尿路感染患者,将样本经随机法分为实验组和对照组,每组40例。对照组患者接受常压输尿管软镜钬激光碎石术治疗,实验组患者接受可控负压吸引下输尿管软镜钬激光碎石术治疗。比较两组患者术后住院时间、术后血尿时间、手术时间、术后结石清除率及术后感染发生情况。结果 实验组患者的术后住院时间(2.55±1.45)d、术后血尿时间(1.13±0.56)d、手术时间(42.30±4.24)min明显短于对照组的(4.00±2.35)d、(2.20±0.65)d、(63.03±6.33)min(P<0.05)。实验组患者的术后感染发生率为12.5%(5/40),相比于对照组的40.0%(16/40)低(P<0.05),手术更安全、可靠。实验组患者的术后结石清除率97.5%(39/40)显著高于对照组的82.5%(33/40)(P<0.05),术后残石率更低。结论 可控负压吸引下输尿管软镜钬激光碎石术应用于肾结石合并尿路感染治疗中,能够有效缩短住院时间及手术时间,提高术后结石清除率,降低患者术后发热发生率,安全有效。

输尿管镜钬激光碎石术治疗糖尿病肾盏结石的效果及对术后尿路炎症的影响

目的探讨输尿管镜钬激光碎石术治疗糖尿病肾盏结石的效果及对术后尿路炎症的影响。方法选取2021-01-01至2023-03-31武警北京总队医院收治的行输尿管镜钬激光碎石术治疗的肾盏结石患者124例,根据是否合并糖尿病分为A组62例(合并糖尿病)和B组62例(不合并糖尿病)。观察两组治疗指标及治疗前后血清、尿液中的炎症因子表达情况。结果两组手术时间[(75.6±8.7)min vs.(73.8±12.8)min]和结石清除率(80.6%vs.82.3%)比较,差异无统计学意义;B组住院时间(4.1±0.8)d,术中出血量(12.4±3.9)ml,显著低于A组[(6.6±1.2)d、(15.2±5.8)ml],差异有统计学意义(P<0.05)。两组手术后12 h血清IL-1β、IL-6和CRP表达量显著高于手术前,且B组明显低于A组,差异有统计学意义(P<0.05)。两组手术后12 h尿液中IL-1β、IL-6和CRP表达量显著高于手术前,且B组显著低于A组,差异具有统计学意义(P<0.05)。结论合并有糖尿病的肾盏结石患者行输尿管镜钬激光碎石术后要积极抗炎治疗,避免影响手术结果。

能谱CT结石成分分析在泌尿系结石体外冲击波碎石中的应用

目的:探讨能谱CT结石成分分析在泌尿系结石体外冲击波碎石(ESWL)中的应用效果。方法:选取2022年5月—2023年8月惠州市中心人民医院门诊治疗的160例泌尿系结石患者,按照随机数表法将其分为两组,各80例。两组均接受ESWL治疗,在此之前,对照组采用常规CT平扫进行结石密度计算,试验组采用能谱CT进行结石成分评估。比较两组手术相关情况、结石清除率及并发症发生率。结果:试验组一次碎石成功率高于对照组,平均体外冲击波次数、最高工作电压平均值低于对照组,平均碎石时间短于对照组,差异有统计学意义(P<0.05)。试验组结石清除率为95.00%,高于对照组的83.75%,差异有统计学意义(P<0.05)。试验组>24 h肉眼血尿发生率均低于对照组,差异有统计学意义(P<0.05);但两组其余并发症发生率比较,差异无统计学意义(P>0.05)。结论:在泌尿系结石ESWL中应用能谱CT结石成分分析能为手术创造有利条件,确保一次碎石成功,提高术后结石清除率,并减少平均体外冲击波次数,缩短手术时间,降低>24 h肉眼血尿发生率。

尿石净丸对尿路结石患者体外冲击波碎石术后促排石效果及复发率的影响

目的:探究尿石净丸对尿路结石患者体外冲击波碎石术(extracorporeal shock wave lithotripsy,ESWL)后促排石效果及复发率的影响。方法:将120例尿路结石患者按随机数字表法分为对照组与研究组,每组各60例。两组均行ESWL治疗,对照组术后给予常规西药治疗,研究组在对照组治疗的基础上给予尿石净丸治疗。比较两组临床疗效、结石排净及复发情况、中医证候积分、尿微量白蛋白(microalbuminuria,mAlb)、血清胱抑素C(cystatin C,Cys C)、术后并发症发生情况。结果:研究组有效率为96.49%,对照组有效率为82.76%,研究组有效率高于对照组,差异有统计学意义(P<0.05)。研究组术后第7天、第14天结石排净率分别为57.89%、87.72%,对照组术后第7天、第14天结石排净率分别为37.93%、70.69%,研究组结石排净率高于对照组,差异有统计学意义(P<0.05);研究组结石复发率为3.51%,对照组结石复发率为15.52%,研究组结石复发率低于对照组,差异有统计学意义(P<0.05)。研究组术后第7天中医证候积分、mAlb、Cys C低于对照组,差异有统计学意义(P<0.05)。研究组术后并发症发生率为10.53%,对照组术后并发症发生率为27.59%,研究组术后并发症发生率低于对照组,差异有统计学意义(P<0.05)。结论:尿石净丸可提升尿路结石患者ESWL术后促排石效果,明显减少术后肾损伤,降低结石复发率及术后并发症发生率。