使用医疗信息系统的数据进行睡眠呼吸暂停低通气综合征(OSAHS)预测和分析过程中,存在不平衡数据问题。为此,在现有临床研究的基础上,提出了一种基于ROSE(Random Over Sampling Examples)和C5.0算法的初筛模型。利用收集到的人体测量学...使用医疗信息系统的数据进行睡眠呼吸暂停低通气综合征(OSAHS)预测和分析过程中,存在不平衡数据问题。为此,在现有临床研究的基础上,提出了一种基于ROSE(Random Over Sampling Examples)和C5.0算法的初筛模型。利用收集到的人体测量学指标数据,通过数据预处理,删除异常值并填补缺失值。然后采用ROSE算法对数据进行平衡,利用C5.0分类器对平衡后的数据构建筛查模型,通过十则交叉验证的方法检验模型的筛查效果。实验结果表明,使用该模型进行打鼾患者的OSAHS筛查,可以有效地提高筛查效率。展开更多
In this paper, we consider the synchronization of chaotic Hindmarsh Rose（HR） neurons via a scalar control input.Chaotic HR neurons coupled with a gap junction are taken into consideration, and an active compensation...In this paper, we consider the synchronization of chaotic Hindmarsh Rose（HR） neurons via a scalar control input.Chaotic HR neurons coupled with a gap junction are taken into consideration, and an active compensation mechanism-based adaptive control is employed to realize the synchronization of two HR neurons. As such an adaptive control is utilized,an accurate model of the system is of no necessity. Asymptotical synchronization of two HR neurons is guaranteed by theoretical results. Numerical results are also provided to confirm the proposed synchronization approach.展开更多
The dynamics and the transition of spiral waves in the coupled Hindmarsh-Rose （H-R） neurons in two-dimensional space are investigated in the paper. It is found that the spiral wave can be induced and developed in th...The dynamics and the transition of spiral waves in the coupled Hindmarsh-Rose （H-R） neurons in two-dimensional space are investigated in the paper. It is found that the spiral wave can be induced and developed in the coupled HR neurons in two-dimensional space, with appropriate initial values and a parameter region given. However, the spiral wave could encounter instability when the intensity of the external current reaches a threshold value of 1.945. The transition of spiral wave is found to be affected by coupling intensity D and bifurcation parameter r. The spiral wave becomes sparse as the coupling intensity increases, while the spiral wave is eliminated and the whole neuronal system becomes homogeneous as the bifurcation parameter increases to a certain threshold value. Then the coupling action of the four sub-adjacent neurons, which is described by coupling coefficient D＇, is also considered, and it is found that the spiral wave begins to breakup due to the introduced coupling action from the sub-adjacent neurons （or sites） and together with the coupling action of the nearest-neighbour neurons, which is described by the coupling intensity D.展开更多
In this paper, we investigate coherence resonance （CR） and noise-induced synchronization in Hindmarsh- Rose （HR） neural network with three different types of topologies： regular, random, and small-world. It is fo...In this paper, we investigate coherence resonance （CR） and noise-induced synchronization in Hindmarsh- Rose （HR） neural network with three different types of topologies： regular, random, and small-world. It is found that the additive noise can induce CR in HR neural network with different topologies and its coherence is optimized by a proper noise level. It is also found that as coupling strength increases the plateau in the measure of coherence curve becomes broadened and the effects of network topology is more pronounced simultaneously. Moreover, we find that increasing the probability p of the network topology leads to an enhancement of noise-induced synchronization in HR neurons network.展开更多
A comb-shaped chaotic region has been simulated in multiple two-dimensional parameter spaces using the Hindmarsh-Rose （HR） neuron model in many recent studies, which can interpret almost all of the previously simula...A comb-shaped chaotic region has been simulated in multiple two-dimensional parameter spaces using the Hindmarsh-Rose （HR） neuron model in many recent studies, which can interpret almost all of the previously simulated bifurcation processes with chaos in neural firing patterns. In the present paper, a comb-shaped chaotic region in a two- dimensional parameter space was reproduced, which presented different processes of period-adding bifurcations with chaos with changing one parameter and fixed the other parameter at different levels. In the biological experiments, different period-adding bifurcation scenarios with chaos by decreasing the extra-cellular calcium concentration were observed from some neural pacemakers at different levels of extra-cellular 4-aminopyridine concentration and from other pacemakers at different levels of extra-cellular caesium concentration. By using the nonlinear time series analysis method, the determin- istic dynamics of the experimental chaotic firings were investigated. The period-adding bifurcations with chaos observed in the experiments resembled those simulated in the comb-shaped chaotic region using the HR model. The experimental results show that period-adding bifurcations with chaos are preserved in different two-dimensional parameter spaces, which provides evidence of the existence of the comb-shaped chaotic region and a demonstration of the simulation results in dif- ferent two-dimensional parameter spaces in the HR neuron model. The results also present relationships between different firing patterns in two-dimensional parameter spaces.展开更多
In this paper, the relationship between external current stimulus and chaotic behaviors of a Hindmarsh–Rose(HR)neuron is considered. In order to find out the range of external current stimulus which will produce chao...In this paper, the relationship between external current stimulus and chaotic behaviors of a Hindmarsh–Rose(HR)neuron is considered. In order to find out the range of external current stimulus which will produce chaotic behaviors of an HR neuron, the Shil’nikov technique is employed. The Cardano formula is taken to obtain the threshold of the chaotic motion, and series solution to a differential equation is utilized to obtain the homoclinic orbit of HR neurons. This analysis establishes mathematically the value of external current input in generating chaotic motion of HR neurons by the Shil’nikov method. The numerical simulations are performed to support the theoretical results.展开更多
文摘使用医疗信息系统的数据进行睡眠呼吸暂停低通气综合征(OSAHS)预测和分析过程中,存在不平衡数据问题。为此,在现有临床研究的基础上,提出了一种基于ROSE(Random Over Sampling Examples)和C5.0算法的初筛模型。利用收集到的人体测量学指标数据,通过数据预处理,删除异常值并填补缺失值。然后采用ROSE算法对数据进行平衡,利用C5.0分类器对平衡后的数据构建筛查模型,通过十则交叉验证的方法检验模型的筛查效果。实验结果表明,使用该模型进行打鼾患者的OSAHS筛查,可以有效地提高筛查效率。
基金Project supported by the Beijing Natural Science Foundation,China(Grant No.4132005)the National Natural Science Foundation of China(Grant No.61403006)+1 种基金the Importation and Development of High-Caliber Talent Project of Beijing Municipal Institutions,China(Grant No.YETP1449)the Project of Scientific and Technological Innovation Platform,China(Grant No.PXM2015 014213 000063)
文摘In this paper, we consider the synchronization of chaotic Hindmarsh Rose（HR） neurons via a scalar control input.Chaotic HR neurons coupled with a gap junction are taken into consideration, and an active compensation mechanism-based adaptive control is employed to realize the synchronization of two HR neurons. As such an adaptive control is utilized,an accurate model of the system is of no necessity. Asymptotical synchronization of two HR neurons is guaranteed by theoretical results. Numerical results are also provided to confirm the proposed synchronization approach.
基金Project supported by the National Natural Science Foundation of China (Grant Nos 10747005,10572056 and 10774130)the Natural Science Foundation of Lanzhou University,China (Grant No Q200706)
文摘The dynamics and the transition of spiral waves in the coupled Hindmarsh-Rose （H-R） neurons in two-dimensional space are investigated in the paper. It is found that the spiral wave can be induced and developed in the coupled HR neurons in two-dimensional space, with appropriate initial values and a parameter region given. However, the spiral wave could encounter instability when the intensity of the external current reaches a threshold value of 1.945. The transition of spiral wave is found to be affected by coupling intensity D and bifurcation parameter r. The spiral wave becomes sparse as the coupling intensity increases, while the spiral wave is eliminated and the whole neuronal system becomes homogeneous as the bifurcation parameter increases to a certain threshold value. Then the coupling action of the four sub-adjacent neurons, which is described by coupling coefficient D＇, is also considered, and it is found that the spiral wave begins to breakup due to the introduced coupling action from the sub-adjacent neurons （or sites） and together with the coupling action of the nearest-neighbour neurons, which is described by the coupling intensity D.
基金The project supported by National Natural Science Foundation of China under Grant No. 70571017
文摘In this paper, we investigate coherence resonance （CR） and noise-induced synchronization in Hindmarsh- Rose （HR） neural network with three different types of topologies： regular, random, and small-world. It is found that the additive noise can induce CR in HR neural network with different topologies and its coherence is optimized by a proper noise level. It is also found that as coupling strength increases the plateau in the measure of coherence curve becomes broadened and the effects of network topology is more pronounced simultaneously. Moreover, we find that increasing the probability p of the network topology leads to an enhancement of noise-induced synchronization in HR neurons network.
基金Project supported by the National Natural Science Foundation of China(Grant No.11072135)
文摘A comb-shaped chaotic region has been simulated in multiple two-dimensional parameter spaces using the Hindmarsh-Rose （HR） neuron model in many recent studies, which can interpret almost all of the previously simulated bifurcation processes with chaos in neural firing patterns. In the present paper, a comb-shaped chaotic region in a two- dimensional parameter space was reproduced, which presented different processes of period-adding bifurcations with chaos with changing one parameter and fixed the other parameter at different levels. In the biological experiments, different period-adding bifurcation scenarios with chaos by decreasing the extra-cellular calcium concentration were observed from some neural pacemakers at different levels of extra-cellular 4-aminopyridine concentration and from other pacemakers at different levels of extra-cellular caesium concentration. By using the nonlinear time series analysis method, the determin- istic dynamics of the experimental chaotic firings were investigated. The period-adding bifurcations with chaos observed in the experiments resembled those simulated in the comb-shaped chaotic region using the HR model. The experimental results show that period-adding bifurcations with chaos are preserved in different two-dimensional parameter spaces, which provides evidence of the existence of the comb-shaped chaotic region and a demonstration of the simulation results in dif- ferent two-dimensional parameter spaces in the HR neuron model. The results also present relationships between different firing patterns in two-dimensional parameter spaces.
基金supported by the Beijing Natural Science Foundation,China(Grant No.4132005)the National Natural Science Foundation of China(Grant No.61403006)+1 种基金the Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions,China(Grant No.YETP1449)the Project of Scientific and Technological Innovation Platform,China(Grant No.PXM2015 014213 000063)
文摘In this paper, the relationship between external current stimulus and chaotic behaviors of a Hindmarsh–Rose(HR)neuron is considered. In order to find out the range of external current stimulus which will produce chaotic behaviors of an HR neuron, the Shil’nikov technique is employed. The Cardano formula is taken to obtain the threshold of the chaotic motion, and series solution to a differential equation is utilized to obtain the homoclinic orbit of HR neurons. This analysis establishes mathematically the value of external current input in generating chaotic motion of HR neurons by the Shil’nikov method. The numerical simulations are performed to support the theoretical results.
