Objective:To investigate the relationship between serum histone Deacetylase 3(HDAC3),High Mobility Group B 1(HMGB-1)and the occurrence,development and structural remodeling of nonvalvular atrial fibrillation.Methods:P...Objective:To investigate the relationship between serum histone Deacetylase 3(HDAC3),High Mobility Group B 1(HMGB-1)and the occurrence,development and structural remodeling of nonvalvular atrial fibrillation.Methods:Patients admitted to non-valvular atrial fibrillation(atrial fibrillation AF group,n=166)were selected and divided into paroxysmal atrial fibrillation group(paroxysmal AF group,n=42),persistent atrial fibrillation group(persistent AF group,n=63),and permanent atrial fibrillation group(permanent AF group,n=61).50 cases of sinus rhythm were selected as the control group,general clinical data,heart color ultrasound,NT-proBNP,and the levels of HDAC 3 and HMGB-1 were determined by enzyme-linked adsorption immunoassay(ELISA).Results:The levels of HDAC3,HMGB-1,LAD,and LVEDD were all higher than those in the control group(P<0.05);The levels of LAD,LVEDD,HDAC3,and HMGB-1 were all higher in the permanent AF groups than in the persistent AF versus paroxysmal AF groups(P<0.05),And the persistent AF group was higher than the paroxysmal AF group(P<0.05);According to the Pearson correlation analysis,HDAC3 vs.LAD(r=0.635,P<0.01),LVEDD(r=0.651,P<0.01),HMGB-1(r=0.757,P<0.01)showed a positive correlation;HMGB-1 was compared with LAD(r=0.658,P<0.01),LVEDD(r=0.569,P<0.01)showed a positive correlation;After a binary logistic regression analysis,HDAC3(OR=1.712,95%CI:1.070-2.739,P<0.05),HMGB-1(OR=1.287,95%CI:1.008-1.634,P<0.05)was associated with whether atrial fibrillation occurred.Conclusion:The levels of HDAC3 and HMGB-1 are correlated to the occurrence and development of AF and are independent risk factors for the occurrence of AF;HDAC3 and HMGB-1 levels are related to the structural remodeling of atrial fibrillation.展开更多
基金National Natural Science Foundation of China(No.81970313)Anhui Province Key Research and Development Plan(No.1804h08020246)。
文摘Objective:To investigate the relationship between serum histone Deacetylase 3(HDAC3),High Mobility Group B 1(HMGB-1)and the occurrence,development and structural remodeling of nonvalvular atrial fibrillation.Methods:Patients admitted to non-valvular atrial fibrillation(atrial fibrillation AF group,n=166)were selected and divided into paroxysmal atrial fibrillation group(paroxysmal AF group,n=42),persistent atrial fibrillation group(persistent AF group,n=63),and permanent atrial fibrillation group(permanent AF group,n=61).50 cases of sinus rhythm were selected as the control group,general clinical data,heart color ultrasound,NT-proBNP,and the levels of HDAC 3 and HMGB-1 were determined by enzyme-linked adsorption immunoassay(ELISA).Results:The levels of HDAC3,HMGB-1,LAD,and LVEDD were all higher than those in the control group(P<0.05);The levels of LAD,LVEDD,HDAC3,and HMGB-1 were all higher in the permanent AF groups than in the persistent AF versus paroxysmal AF groups(P<0.05),And the persistent AF group was higher than the paroxysmal AF group(P<0.05);According to the Pearson correlation analysis,HDAC3 vs.LAD(r=0.635,P<0.01),LVEDD(r=0.651,P<0.01),HMGB-1(r=0.757,P<0.01)showed a positive correlation;HMGB-1 was compared with LAD(r=0.658,P<0.01),LVEDD(r=0.569,P<0.01)showed a positive correlation;After a binary logistic regression analysis,HDAC3(OR=1.712,95%CI:1.070-2.739,P<0.05),HMGB-1(OR=1.287,95%CI:1.008-1.634,P<0.05)was associated with whether atrial fibrillation occurred.Conclusion:The levels of HDAC3 and HMGB-1 are correlated to the occurrence and development of AF and are independent risk factors for the occurrence of AF;HDAC3 and HMGB-1 levels are related to the structural remodeling of atrial fibrillation.
