The reversible process of histone methylation and demethylation plays important roles of epigenetic regulation1. For example, Truncating mutations in human PHF8 gene
基金Supplementary information is linked to the online version of the paper on the Cell Research website.Acknowledgments We thank Dr Dawei Li （China Agricultural University） for generously providing us with the experimental conditions during the early stages of this project. We thank Dr Ruiming Xu （Institute of Biophysics, Chinese Academy of Sciences） for critical reading of this manuscript and advice. We thank Dr Pinchao Mei （Chinese Academy of Medical Sciences and Peking Union Medical College）, Xinqi Liu （Nankai University） and Jiemin Wong （East China Normal University） for discussions and advice. The synchrotronradiation experiments were performed at Shanghai Synchrotron Radiation Facility （SSRF） and NE3A in the Photon Factory. Z.C. is supported by the National Basic Research Program of China （973 Program, 2009CB825501）, the National Natural Science Foundation of China （30870494 and 90919043）, the New Century Excellent Talents in University （NCET-07-0808） and the Innovative Project of SKLAB. S. H. is supported by the National Key Laboratory Special Fund 2060204. Z. D. is supported by the National Natural Science Foundation of China （J0730639）.
基金supported by the Scientific Research Starting Foundation for Returned Overseas Chinese Scholars, Ministry of Education ,ChinaNational Natural Science Foundation of China (30870494)New Century Excellent Talents in University (NCET-07-0808) and China agricultural university
文摘The reversible process of histone methylation and demethylation plays important roles of epigenetic regulation1. For example, Truncating mutations in human PHF8 gene
