Georgian kings and princes were trying to establish ties and to develop relationships with European monarchies. In times of cultural, religious, demographic crisis, the Catholic missions sent by the Pope, and Russian ...Georgian kings and princes were trying to establish ties and to develop relationships with European monarchies. In times of cultural, religious, demographic crisis, the Catholic missions sent by the Pope, and Russian ambassadors hold out hope to the Bagrations. In such circumstances, Georgians became closer to Europeans. The Capuchins, the Theatines, Jesuit monks were honored guests and members of the royal retinue in the Georgian Kingdoms-Princedoms. Thanks to them, in XVII-XVIII centuries, were brought up such Georgians thinkers as： Vakhushti Batonishvili, Beri Egnatashvili, Sulkhan-Saba Orbeliani, Vakhtang VI, Teimuraz II, daughter of Vaghtang VI, Tamar （mother of King Erekle II）, etc. In addition, at the royal courts of Russia and Persia, it became fashionable to send their Princes to Europe, in order to get an education. The best example of this is Peter the Great and Nader Shah＇s son--known as Baron Semlin. From XVIII century, in the history of Georgian-German relations, there are authentic sources about Georgians＇ stay in Germany. Among the sources, if taking them chronologically, the oldest is about military education of Prince Erekle. The following sources are about visits of other Georgian Princes to Germany. The next sources tell about the military campaign of Georgian Hussars regiment, in whose ranks poet Davit Guramishvili was fighting. Among the above-mentioned sources, in the Georgian historiography, the issue of Davit Guramishvili has been well researched, but the same cannot be said of King Erekle II.展开更多
AIM： TO investigate the correlation of depressed-type （0-IIc） colorectal neoplasm and family history of firstdegree relatives （FDR） with colorectal cancer （CRC）. METHODS： This cross-sectional study was conduct...AIM： TO investigate the correlation of depressed-type （0-IIc） colorectal neoplasm and family history of firstdegree relatives （FDR） with colorectal cancer （CRC）. METHODS： This cross-sectional study was conducted from June 2000 to October 2002 at National Cancer Center Hospital East. Eligible patients undergoing initial total colonoscopy were surveyed regarding family history of CRC among FDR by a questionnaire prior to colonoscopic examinations. All endoscopic findings during colonoscopy were recorded and the macroscopic classification of the early stage neoplasm/cancer was classified into two types （0-IIc vs non 0-IIc）. Odds ratios （OR） and 95% confidence intervals （CI） were calculated by univariate and multivariate logistic regression to estimate the association between macroscopic features and clinicopathological data including gender, age, and family history of FDR with CRC. RESULTS： The OR of an association between family history of FDR with CRC and overall early stage neoplasm adjusted by gender and age was 1.85 （95% CI： 1.31-2.61, P = 0.0004）, that for non 0-IIc neoplasm was 1.71 （95% CI： 1.22-2.41, P = 0.0017） and for 0-IIc colorectal neoplasm was 2.78 （95% CI： 1.49-5.16, P = 0.0031）. CONCLUSION： Our study shows a significant association between a family history of FDR with CRC and 0-IIc colorectal neoplasm. When patients with a family history of FDR with CRC undergo colonoscopy, colonoscopists should check carefully for not only polypoid, but also depressed-type （0-IIc） lesions.展开更多
Sichuan Province,East Western of China,within the area of east longitude 97°21′-108°31′,north latitude 26°03′-34°19′,which is on the Mediterranean seismic zone;with its complicated geological b...Sichuan Province,East Western of China,within the area of east longitude 97°21′-108°31′,north latitude 26°03′-34°19′,which is on the Mediterranean seismic zone;with its complicated geological background,several strong shocks occurred in this district since ancient times.Earthquake catalogue of this area could date back to B.C.26,however,limited by the conditions—technology or funds,lots of minor earthquake have been lost,which could be展开更多
Objective:The spectrum and risk of cancer in relatives of BRCA1/2 pathogenic variant carriers in the Chinese population have not been established.Methods:A family history of cancer in 9903 unselected breast cancer pat...Objective:The spectrum and risk of cancer in relatives of BRCA1/2 pathogenic variant carriers in the Chinese population have not been established.Methods:A family history of cancer in 9903 unselected breast cancer patients was retrospectively analyzed.BRCA1/2 status was determined for all patients and relative risks(RRs)were calculated to evaluate cancer risk in relatives of the patients.Results:The incidences of breast cancer in female relatives of BRCA1 carriers,BRCA2 carriers,and non-carriers were 33.0%,32.2%,and 7.7%,respectively.The corresponding incidences of ovarian cancer were 11.5%,2.4%,and 0.5%,respectively.The incidences of pancreatic cancer in male relatives of BRCA1 carriers,BRCA2 carriers,and non-carriers were 1.4%,2.7%,and 0.6%,respectively.The corresponding incidences of prostate cancer were 1.0%,2.1%,and 0.4%,respectively.The risks of breast and ovarian cancers in female relatives of BRCA1 and BRCA2 carriers were significantly higher than female relatives of non-carriers(BRCA1:RR=4.29,P<0.001 and RR=21.95,P<0.001;BRCA2:RR=4.19,P<0.001 and RR=4.65,P<0.001,respectively).Additionally,higher risks of pancreatic and prostate cancers were noted in male relatives of BRCA2 carriers than non-carriers(RR=4.34,P=0.001 and RR=4.86,P=0.001,respectively).Conclusions:Female relatives of BRCA1 and BRCA2 carriers are at increased risk for breast and ovarian cancers,and male relatives of BRCA2 carriers are at increased risk for pancreatic and prostate cancers.展开更多
For a long time,the concept“Nei Wai(内外―center-periphery)”has been used to construct the narrative of the backwarded pre-modern East Asian history.While over emphasizing the effect of the center(Nei),it just simpl...For a long time,the concept“Nei Wai(内外―center-periphery)”has been used to construct the narrative of the backwarded pre-modern East Asian history.While over emphasizing the effect of the center(Nei),it just simply ignored the reactions from the marginal entities(Wai),as ancient China and its neighboring countries’tributary relations could offer us the classic paradigm.In the knowledge world and historical writing records before the establishment of the national states,the period after Vietnam politically independent to China,the most intricate relations between the two countries,or dynasties,we could still find so many similarities of politics and culture in China and Vietnam,which is far beyond the summarized conditions as tributary relations.On the basis of the previous academic construction of Zong Fan relations and applying the research path of decentralization in the view of global history,we can explore and interpret such tributary and diplomatic relations from various perspectives and thus a multi-dimensional,high definition and colorful past of communications between countries is projected to us by the voiceless,motionless,and monotone historical materials.展开更多
Nicholas Bourriaud＇s relational aesthetics is regarded as a new approach to art history and criticism, but has recently been appropriated by many art programs as a pedagogical and productive strategy in the classroom...Nicholas Bourriaud＇s relational aesthetics is regarded as a new approach to art history and criticism, but has recently been appropriated by many art programs as a pedagogical and productive strategy in the classroom. While there is much that is positive in Bourriaud＇s ideas in the first sense, its translation into a studio situation is problematic. Offering a corrective through Lacanian psychoanalysis, with acknowledgement of additional figures with corresponding ideas, it is proposed that Bourriaud＇s ideas are valuable additions to pedagogy generally but are equally in need of modifications that encompass a critical understanding of the desire structures of both students and faculty.展开更多
To study the natural history of dry type of age-related macular degeneration (AMD) and search for a sensitive method for detecting the development of the disease, the fundus fluorescein angiography, visual acuity, ele...To study the natural history of dry type of age-related macular degeneration (AMD) and search for a sensitive method for detecting the development of the disease, the fundus fluorescein angiography, visual acuity, electroretinogram and FM 100-hue test were used to examine 75 eyes, 147 eyes, 73 eyes, and 94 eyes respectively. These examinations were taken at least twice during the follow-up periods. The average age was 63.2 years (50-80 years ). The average follow-up was 29.8 months with a range of 3-74 ...展开更多
AIMTo quantify the risk of gastric cancer in first-degree relatives of patients with the cancer.METHODSA comprehensive literature search was performed. Case-control trials comparing the frequency of a positive family ...AIMTo quantify the risk of gastric cancer in first-degree relatives of patients with the cancer.METHODSA comprehensive literature search was performed. Case-control trials comparing the frequency of a positive family history of gastric cancer in patients with gastric cancer, vs non-gastric cancer controls were retrieved. Studies with missed or non-extractable data, studies in children, abstracts, and duplicate publications were excluded. A meta-analysis of pooled odd ratios was performed using Review Manager 5.0.25. We performed subgroup analysis on Asian studies and a sensitivity analysis based on the quality of the studies, type of the outcome, sample size, and whether studies considered only first-degree relatives.RESULTSThirty-two relevant studies out of 612 potential abstracts (n = 80690 individuals) were included. 19.0% of the patients and 10.9% of the controls had at least one relative with gastric cancer (P < 0.00001). The pooled relative risk for the development of gastric cancer in association with a positive family history was 2.35 (95%CI: 1.96-2.81). The Cochran Q test for heterogeneity was positive (P < 0.00001, I² = 92%). After excluding the three outlier studies with the highest relative risks, heterogeneity remained significant (P < 0.00001, I² = 90%). The result was not different among Asian studies as compared to others and remained robust in several sensitivity analyses. In the 26 studies which exclusively analysed the history of gastric cancer in first-degree relatives, the relative risk was 2.71 (95%CI: 2.08-3.53; P < 0.00001).CONCLUSIONIndividuals with a first-degree relative affected with gastric cancer have a risk of about 2.5-fold for the development of gastric cancer. This could be due to genetic or environmental factors. Screening and preventive strategies should be developed for this high-risk population.展开更多
基金This work was supported by Shota Rustaveli National Science Foundation （SRNSF） [grant numberHE 15-021 ].
文摘Georgian kings and princes were trying to establish ties and to develop relationships with European monarchies. In times of cultural, religious, demographic crisis, the Catholic missions sent by the Pope, and Russian ambassadors hold out hope to the Bagrations. In such circumstances, Georgians became closer to Europeans. The Capuchins, the Theatines, Jesuit monks were honored guests and members of the royal retinue in the Georgian Kingdoms-Princedoms. Thanks to them, in XVII-XVIII centuries, were brought up such Georgians thinkers as： Vakhushti Batonishvili, Beri Egnatashvili, Sulkhan-Saba Orbeliani, Vakhtang VI, Teimuraz II, daughter of Vaghtang VI, Tamar （mother of King Erekle II）, etc. In addition, at the royal courts of Russia and Persia, it became fashionable to send their Princes to Europe, in order to get an education. The best example of this is Peter the Great and Nader Shah＇s son--known as Baron Semlin. From XVIII century, in the history of Georgian-German relations, there are authentic sources about Georgians＇ stay in Germany. Among the sources, if taking them chronologically, the oldest is about military education of Prince Erekle. The following sources are about visits of other Georgian Princes to Germany. The next sources tell about the military campaign of Georgian Hussars regiment, in whose ranks poet Davit Guramishvili was fighting. Among the above-mentioned sources, in the Georgian historiography, the issue of Davit Guramishvili has been well researched, but the same cannot be said of King Erekle II.
文摘AIM： TO investigate the correlation of depressed-type （0-IIc） colorectal neoplasm and family history of firstdegree relatives （FDR） with colorectal cancer （CRC）. METHODS： This cross-sectional study was conducted from June 2000 to October 2002 at National Cancer Center Hospital East. Eligible patients undergoing initial total colonoscopy were surveyed regarding family history of CRC among FDR by a questionnaire prior to colonoscopic examinations. All endoscopic findings during colonoscopy were recorded and the macroscopic classification of the early stage neoplasm/cancer was classified into two types （0-IIc vs non 0-IIc）. Odds ratios （OR） and 95% confidence intervals （CI） were calculated by univariate and multivariate logistic regression to estimate the association between macroscopic features and clinicopathological data including gender, age, and family history of FDR with CRC. RESULTS： The OR of an association between family history of FDR with CRC and overall early stage neoplasm adjusted by gender and age was 1.85 （95% CI： 1.31-2.61, P = 0.0004）, that for non 0-IIc neoplasm was 1.71 （95% CI： 1.22-2.41, P = 0.0017） and for 0-IIc colorectal neoplasm was 2.78 （95% CI： 1.49-5.16, P = 0.0031）. CONCLUSION： Our study shows a significant association between a family history of FDR with CRC and 0-IIc colorectal neoplasm. When patients with a family history of FDR with CRC undergo colonoscopy, colonoscopists should check carefully for not only polypoid, but also depressed-type （0-IIc） lesions.
文摘Sichuan Province,East Western of China,within the area of east longitude 97°21′-108°31′,north latitude 26°03′-34°19′,which is on the Mediterranean seismic zone;with its complicated geological background,several strong shocks occurred in this district since ancient times.Earthquake catalogue of this area could date back to B.C.26,however,limited by the conditions—technology or funds,lots of minor earthquake have been lost,which could be
基金supported by grants from National Natural Science Foundation of China(Grant Nos.81974422,81772824,and 81802635)。
文摘Objective:The spectrum and risk of cancer in relatives of BRCA1/2 pathogenic variant carriers in the Chinese population have not been established.Methods:A family history of cancer in 9903 unselected breast cancer patients was retrospectively analyzed.BRCA1/2 status was determined for all patients and relative risks(RRs)were calculated to evaluate cancer risk in relatives of the patients.Results:The incidences of breast cancer in female relatives of BRCA1 carriers,BRCA2 carriers,and non-carriers were 33.0%,32.2%,and 7.7%,respectively.The corresponding incidences of ovarian cancer were 11.5%,2.4%,and 0.5%,respectively.The incidences of pancreatic cancer in male relatives of BRCA1 carriers,BRCA2 carriers,and non-carriers were 1.4%,2.7%,and 0.6%,respectively.The corresponding incidences of prostate cancer were 1.0%,2.1%,and 0.4%,respectively.The risks of breast and ovarian cancers in female relatives of BRCA1 and BRCA2 carriers were significantly higher than female relatives of non-carriers(BRCA1:RR=4.29,P<0.001 and RR=21.95,P<0.001;BRCA2:RR=4.19,P<0.001 and RR=4.65,P<0.001,respectively).Additionally,higher risks of pancreatic and prostate cancers were noted in male relatives of BRCA2 carriers than non-carriers(RR=4.34,P=0.001 and RR=4.86,P=0.001,respectively).Conclusions:Female relatives of BRCA1 and BRCA2 carriers are at increased risk for breast and ovarian cancers,and male relatives of BRCA2 carriers are at increased risk for pancreatic and prostate cancers.
文摘For a long time,the concept“Nei Wai(内外―center-periphery)”has been used to construct the narrative of the backwarded pre-modern East Asian history.While over emphasizing the effect of the center(Nei),it just simply ignored the reactions from the marginal entities(Wai),as ancient China and its neighboring countries’tributary relations could offer us the classic paradigm.In the knowledge world and historical writing records before the establishment of the national states,the period after Vietnam politically independent to China,the most intricate relations between the two countries,or dynasties,we could still find so many similarities of politics and culture in China and Vietnam,which is far beyond the summarized conditions as tributary relations.On the basis of the previous academic construction of Zong Fan relations and applying the research path of decentralization in the view of global history,we can explore and interpret such tributary and diplomatic relations from various perspectives and thus a multi-dimensional,high definition and colorful past of communications between countries is projected to us by the voiceless,motionless,and monotone historical materials.
文摘Nicholas Bourriaud＇s relational aesthetics is regarded as a new approach to art history and criticism, but has recently been appropriated by many art programs as a pedagogical and productive strategy in the classroom. While there is much that is positive in Bourriaud＇s ideas in the first sense, its translation into a studio situation is problematic. Offering a corrective through Lacanian psychoanalysis, with acknowledgement of additional figures with corresponding ideas, it is proposed that Bourriaud＇s ideas are valuable additions to pedagogy generally but are equally in need of modifications that encompass a critical understanding of the desire structures of both students and faculty.
文摘To study the natural history of dry type of age-related macular degeneration (AMD) and search for a sensitive method for detecting the development of the disease, the fundus fluorescein angiography, visual acuity, electroretinogram and FM 100-hue test were used to examine 75 eyes, 147 eyes, 73 eyes, and 94 eyes respectively. These examinations were taken at least twice during the follow-up periods. The average age was 63.2 years (50-80 years ). The average follow-up was 29.8 months with a range of 3-74 ...
文摘AIMTo quantify the risk of gastric cancer in first-degree relatives of patients with the cancer.METHODSA comprehensive literature search was performed. Case-control trials comparing the frequency of a positive family history of gastric cancer in patients with gastric cancer, vs non-gastric cancer controls were retrieved. Studies with missed or non-extractable data, studies in children, abstracts, and duplicate publications were excluded. A meta-analysis of pooled odd ratios was performed using Review Manager 5.0.25. We performed subgroup analysis on Asian studies and a sensitivity analysis based on the quality of the studies, type of the outcome, sample size, and whether studies considered only first-degree relatives.RESULTSThirty-two relevant studies out of 612 potential abstracts (n = 80690 individuals) were included. 19.0% of the patients and 10.9% of the controls had at least one relative with gastric cancer (P < 0.00001). The pooled relative risk for the development of gastric cancer in association with a positive family history was 2.35 (95%CI: 1.96-2.81). The Cochran Q test for heterogeneity was positive (P < 0.00001, I² = 92%). After excluding the three outlier studies with the highest relative risks, heterogeneity remained significant (P < 0.00001, I² = 90%). The result was not different among Asian studies as compared to others and remained robust in several sensitivity analyses. In the 26 studies which exclusively analysed the history of gastric cancer in first-degree relatives, the relative risk was 2.71 (95%CI: 2.08-3.53; P < 0.00001).CONCLUSIONIndividuals with a first-degree relative affected with gastric cancer have a risk of about 2.5-fold for the development of gastric cancer. This could be due to genetic or environmental factors. Screening and preventive strategies should be developed for this high-risk population.
