In recent years,rumor spreading has caused widespread public panic and affected the whole social harmony and stability.Consequently,how to control the rumor spreading effectively and reduce its negative influence urge...In recent years,rumor spreading has caused widespread public panic and affected the whole social harmony and stability.Consequently,how to control the rumor spreading effectively and reduce its negative influence urgently needs people to pay much attention.In this paper,we mainly study the near-optimal control of a stochastic rumor spreading model with Holling II functional response function and imprecise parameters.Firstly,the science knowledge propagation and the refutation mechanism as the control strategies are introduced into a stochastic rumor spreading model.Then,some sufficient and necessary conditions for the near-optimal control of the stochastic rumor spreading model are discussed respectively.Finally,through some numerical simulations,the validity and availability of theoretical analysis is verified.Meanwhile,it shows the significance and effectiveness of the proposed control strategies on controlling rumor spreading,and demonstrates the influence of stochastic disturbance and imprecise parameters on the process of rumor spreading.展开更多
Objective:To explore the effect of adjuvant tiotropium bromide therapy on the oxygenation function and inflammatory response in patients with COPD and type Ⅱ respiratory failure. Methods:a total of 58 patients with C...Objective:To explore the effect of adjuvant tiotropium bromide therapy on the oxygenation function and inflammatory response in patients with COPD and type Ⅱ respiratory failure. Methods:a total of 58 patients with COPD and type II respiratory failure treated in our hospital between August 2012 and January 2016 were collected and divided into observation group (n=29) and control group (n=29) according to the single blind randomized control method. Control group of patients received clinical routine treatment, and observation group of patients received adjuvant tiotropium bromide treatment on the basis of routine treatment. Before treatment and 30d after treatment, spirometer was used to determine pulmonary ventilation function;blood gas analyzer was used to test oxygenation function indexes;enzyme-linked immunosorbent assay (ELISA) was used to detect serum inflammatory factor levels.Results: Before treatment, differences in pulmonary ventilation function, oxygenation function and serum inflammatory factor levels were not statistically significant between two groups of patients. 30 d after treatment, FEV1, FEF75%, PEF, PaO2/FiO2, DO2 and O2ER levels of observation group were significantly higher than those of control group while VO2 level was significantly lower than that of control group;serum IL-1β, IL-18, IL-27 and CRP levels were significantly lower than those of control group.Conclusion:Adjuvant tiotropium bromide treatment can optimize the pulmonary ventilation and oxygenation function and reduce systemic inflammatory response in patients with COPD and type II respiratory failure.展开更多
基金Project supported by the Program for Professor of Special Appointment(Eastern Scholar)at Shanghai Institutions of Higher Learningthe Project for the Natural Science Foundation of Shanghai,China(Grant No.21ZR1444100)the Project for the National Natural Science Foundation of China(Grant Nos.72174121,71774111,71871144,and 71804047)。
文摘In recent years,rumor spreading has caused widespread public panic and affected the whole social harmony and stability.Consequently,how to control the rumor spreading effectively and reduce its negative influence urgently needs people to pay much attention.In this paper,we mainly study the near-optimal control of a stochastic rumor spreading model with Holling II functional response function and imprecise parameters.Firstly,the science knowledge propagation and the refutation mechanism as the control strategies are introduced into a stochastic rumor spreading model.Then,some sufficient and necessary conditions for the near-optimal control of the stochastic rumor spreading model are discussed respectively.Finally,through some numerical simulations,the validity and availability of theoretical analysis is verified.Meanwhile,it shows the significance and effectiveness of the proposed control strategies on controlling rumor spreading,and demonstrates the influence of stochastic disturbance and imprecise parameters on the process of rumor spreading.
文摘Objective:To explore the effect of adjuvant tiotropium bromide therapy on the oxygenation function and inflammatory response in patients with COPD and type Ⅱ respiratory failure. Methods:a total of 58 patients with COPD and type II respiratory failure treated in our hospital between August 2012 and January 2016 were collected and divided into observation group (n=29) and control group (n=29) according to the single blind randomized control method. Control group of patients received clinical routine treatment, and observation group of patients received adjuvant tiotropium bromide treatment on the basis of routine treatment. Before treatment and 30d after treatment, spirometer was used to determine pulmonary ventilation function;blood gas analyzer was used to test oxygenation function indexes;enzyme-linked immunosorbent assay (ELISA) was used to detect serum inflammatory factor levels.Results: Before treatment, differences in pulmonary ventilation function, oxygenation function and serum inflammatory factor levels were not statistically significant between two groups of patients. 30 d after treatment, FEV1, FEF75%, PEF, PaO2/FiO2, DO2 and O2ER levels of observation group were significantly higher than those of control group while VO2 level was significantly lower than that of control group;serum IL-1β, IL-18, IL-27 and CRP levels were significantly lower than those of control group.Conclusion:Adjuvant tiotropium bromide treatment can optimize the pulmonary ventilation and oxygenation function and reduce systemic inflammatory response in patients with COPD and type II respiratory failure.
