Protein phosphatase 2A(PP2A)is the pre-dominant serine/threonine phosphatase in eukaryotic cells.In the brains of patients with Alzheimer’s disease(AD),decreased PP2A activities were observed,which is suggested to be...Protein phosphatase 2A(PP2A)is the pre-dominant serine/threonine phosphatase in eukaryotic cells.In the brains of patients with Alzheimer’s disease(AD),decreased PP2A activities were observed,which is suggested to be involved in neurofibrillary tangle(NFT)formation,disturbed amyloid precursor protein(APP)secretion and neurodegeneration in AD brain.Based on our research and other previousfindings,decreased PP2Ac level,decreased PP2A holoenzyme composition,increased level of PP2A inhibitors,increased PP2Ac Leu309 demethylation and Tyr307 phosphorylation underlie PP2A inactivation in AD.β-amyloid(Aβ)over-production,estrogen deficiency and impaired homocys-teine metabolism are the possible up-stream factors that inactivate PP2A in AD neurons.Further studies are required to disclose the role of PP2A in Alzheimer’s disease.展开更多
基金supported partially by the National Natural Science Foundation of China(Grant Nos.30500188,30871035 and 30731160621).
文摘Protein phosphatase 2A(PP2A)is the pre-dominant serine/threonine phosphatase in eukaryotic cells.In the brains of patients with Alzheimer’s disease(AD),decreased PP2A activities were observed,which is suggested to be involved in neurofibrillary tangle(NFT)formation,disturbed amyloid precursor protein(APP)secretion and neurodegeneration in AD brain.Based on our research and other previousfindings,decreased PP2Ac level,decreased PP2A holoenzyme composition,increased level of PP2A inhibitors,increased PP2Ac Leu309 demethylation and Tyr307 phosphorylation underlie PP2A inactivation in AD.β-amyloid(Aβ)over-production,estrogen deficiency and impaired homocys-teine metabolism are the possible up-stream factors that inactivate PP2A in AD neurons.Further studies are required to disclose the role of PP2A in Alzheimer’s disease.
