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Overview and Comparison to Words of Antiquity Through Homeric Epics
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作者 Sema SANDALCI Berna CACAN 《Journal of Literature and Art Studies》 2017年第12期1567-1573,共7页
This study aims to examine the relations between languages of antiquity and some words in Homer's epics, Iliad and Odyssey, that are considered the first written texts and important in terms of the richness of Greek ... This study aims to examine the relations between languages of antiquity and some words in Homer's epics, Iliad and Odyssey, that are considered the first written texts and important in terms of the richness of Greek vocabulary. Although the words in Homeric epics carry a value for ancient Anatolia, there are no studies in this field in our eotmtry. For this purpose, with the help of words we have, we will focus on: (a) bond of these words with Hittite, partially (b) some archaic qualities for some Latin words, developed later and also continued of some ground and phrases in the everyday life in the same region for centuries on the language of the people depending on the oral transmission. At the end of the study, we will discuss the changes of the words in philological level as well as in terms of the letter, sounds and meaning by used words in Homer's epics as will be explained in this study. 展开更多
关键词 HOMER WORDS linguistic bonds archaic marks today marks
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Homer1b/c通过内质网功能调节由谷氨酸兴奋性毒性损伤诱发的小鼠海马神经元HT22细胞自噬
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作者 张敏敏 朱宣 +4 位作者 沈红健 吕楠 吴雄枫 徐小龙 吴涛 《海军军医大学学报》 CAS CSCD 北大核心 2024年第3期277-283,共7页
目的研究Homer1b/c蛋白在谷氨酸兴奋性毒性损伤诱发的细胞自噬中的作用及机制。方法选用小鼠海马神经元HT22细胞,通过500μmol/L L-谷氨酸处理建立细胞损伤模型。用siRNA慢病毒转染方式下调Homer1b/c表达,用10μmol/L钙离子螯合剂BAPTA... 目的研究Homer1b/c蛋白在谷氨酸兴奋性毒性损伤诱发的细胞自噬中的作用及机制。方法选用小鼠海马神经元HT22细胞,通过500μmol/L L-谷氨酸处理建立细胞损伤模型。用siRNA慢病毒转染方式下调Homer1b/c表达,用10μmol/L钙离子螯合剂BAPTA-AM、10 mmol/L内质网应激抑制剂4-PBA分别抑制细胞内钙离子释放和内质网应激后,使用蛋白质印迹法检测细胞中Homer1b/c蛋白,自噬效应蛋白[beclin-1、微管相关蛋白1轻链3(LC3)]及内质网应激标志蛋白[C/EBP同源蛋白(CHOP)、葡萄糖调节蛋白78(GRP 78)]的表达水平。结果L-谷氨酸处理HT22细胞12 h后,细胞中beclin-1表达和LC3-Ⅱ/LC3-Ⅰ比值均较对照组升高(均P<0.05);与转染对照组相比,下调Homer1b/c表达可降低细胞中beclin-1表达和LC3-Ⅱ/LC3-Ⅰ比值(均P<0.05);抑制细胞内钙离子释放和内质网应激均能降低细胞中beclin-1表达和LC3-Ⅱ/LC3-Ⅰ比值(均P<0.05);下调Homer1b/c表达后,抑制细胞内钙离子释放和内质网应激未能进一步降低细胞中beclin-1表达和LC3-Ⅱ/LC3-Ⅰ比值。结论Homer1b/c能够调节谷氨酸兴奋性毒性损伤诱发的细胞自噬,其调节作用可能与内质网功能有关。 展开更多
关键词 海马神经元 自噬 HOMER 钙稳态 内质网应激 兴奋性损伤 谷氨酸
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基于HOMER Pro的孤岛微电网优化设计与研究
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作者 田拥军 刘阳京 《科技与创新》 2024年第14期39-42,共4页
多能互补的孤岛微电网通常用来解决偏僻地区的用电问题,以南海某海岛的微电网系统优化设计为例,采用HOMER Pro电力系统仿真软件为辅助设计平台,根据当地的太阳能、风能资源丰富的特点选择风、光、油、储多能互补方式为微电网提供电力,... 多能互补的孤岛微电网通常用来解决偏僻地区的用电问题,以南海某海岛的微电网系统优化设计为例,采用HOMER Pro电力系统仿真软件为辅助设计平台,根据当地的太阳能、风能资源丰富的特点选择风、光、油、储多能互补方式为微电网提供电力,给出了HOMER Pro的仿真结果,仿真显示所设计的系统具有较好的经济效益、环保效益及供电稳定性。 展开更多
关键词 孤岛微电网 优化 HOMER Pro 多能互补
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Homer1a reduces inflammatory response after retinal ischemia/reperfusion injury 被引量:1
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作者 Yanan Dou Xiaowei Fei +7 位作者 Xin He Yu Huan Jialiang Wei Xiuquan Wu Weihao Lyu Zhou Fei Xia Li Fei Fei 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第7期1608-1617,共10页
Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in ... Elevated intraocular pressure(IOP)is one of the causes of retinal ischemia/reperfusion injury,which results in NRP3 inflammasome activation and leads to visual damage.Homerla is repo rted to play a protective role in neuroinflammation in the cerebrum.However,the effects of Homerla on NLRP3inflammasomes in retinal ischemia/reperfusion injury caused by elevated IOP remain unknown.In our study,animal models we re constructed using C57BL/6J and Homer1^(flox/-)/Homerla^(+/-)/Nestin-Cre^(+/-)mice with elevated IOP-induced retinal ischemia/repe rfusion injury.For in vitro expe riments,the oxygen-glucose deprivation/repe rfusion injury model was constructed with M uller cells.We found that Homerla ove rexpression amelio rated the decreases in retinal thickness and Muller cell viability after ischemia/reperfusion injury.Furthermore,Homerla knockdown promoted NF-κB P65^(Ser536)activation via caspase-8,NF-κB P65 nuclear translocation,NLRP3 inflammasome formation,and the production and processing of interleukin-1βand inte rleukin-18.The opposite results we re observed with Homerla ove rexpression.Finally,the combined administration of Homerla protein and JSH-23 significantly inhibited the reduction in retinal thickness in Homer1^(flox/-)Homer1a^(+/-)/Nestin-Cre^(+/-)mice and apoptosis in M uller cells after ischemia/reperfusion injury.Taken together,these studies demonstrate that Homer1a exerts protective effects on retinal tissue and M uller cells via the caspase-8/NF-KB P65/NLRP3 pathway after I/R injury. 展开更多
关键词 CASPASE-8 Homer1a INTERLEUKIN-18 INTERLEUKIN-1Β intraocular pressure ischemia/reperfusion injury JSH-23 Müller cells NLRP3 nuclear factor-kB p65 RETINA
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Homer1b/c“支架”在CTNND2-/-自闭症模型鼠中的作用研究
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作者 张翰鸿 王岩 +4 位作者 吕明其 聂应 蔡锦雯 王楚萱 李英博 《重庆医科大学学报》 CAS CSCD 北大核心 2024年第4期409-414,共6页
目的:观察CTNND2-/-自闭症模型鼠前额叶皮层中支架蛋白荷马1b/c(homer protein homolog 1b and 1c,Homer1b/c)与三磷酸肌醇受体(inositol 1,4,5-trisphosphate receptor,IP3R)、代谢型谷氨酸受体5(metabotropic glutamate receptor 5,mG... 目的:观察CTNND2-/-自闭症模型鼠前额叶皮层中支架蛋白荷马1b/c(homer protein homolog 1b and 1c,Homer1b/c)与三磷酸肌醇受体(inositol 1,4,5-trisphosphate receptor,IP3R)、代谢型谷氨酸受体5(metabotropic glutamate receptor 5,mGluR5)和香克3蛋白(sh3 and multiple ankyrin repeat domains 3,Shank3)蛋白相关复合体的变化;前额叶皮层中常见氨基酸的变化,发现自闭症模型鼠中可能参与疾病发生的关键靶点。方法:蛋白免疫印迹法(Western blot,WB)法检测CTNND2-/-自闭症模型鼠前额叶皮层中支架蛋白Homer1b/c、突触后密度蛋白-95(postsynaptic density protein 95,PSD-95)、突触素蛋白(synaptophysin,SYP)、囊泡谷氨酸转运体1(vesicular glutamate transporter 1,vGluT1)的表达的变化;通过免疫荧光(immunofluorescence,IF)观察Homer1b/c与IP3R、mGluR5和Shank3蛋白的表达与共定位;免疫共沉淀(co-immunoprecipitation,CO-IP)技术分别观察Homer1b/c与IP3R、mGluR5或Shank3结合的变化;使用液相色谱(liquid chromatography,LC)观察前额叶皮层中常见氨基酸的变化。结果:与对照组相比,CTNND2-/-模型鼠前额叶皮层中Homer1b/c(P=0.003)、PSD-95(P=0.003)以及SYP蛋白(P=0.046)的表达均明显降低;同时,Homer1b/c与IP3R、mGluR5、Shank3蛋白相互之间结合减少;前额叶皮层中常见的兴奋性神经递质谷氨酸(glutamate,Glu)和抑制性神经递质γ-氨基丁酸(γ-aminobutyric acid,GABA)的表达无明显变化(P=0.366,P=0.355),组氨酸(histidine,His)(P=0.036),酪氨酸(tyrosine,Tyr)(P=0.030)表达则明显增高。结论:CTNND2-/-自闭症模型鼠中Homer1b/c蛋白低表达,同时Homer1b/c与IP3R、Shank3、mGluR5蛋白复合物的形成减少,并推测低表达的Homer1b/c可能是导致自闭症神经元突触异常发育的关键靶点。 展开更多
关键词 Homer1b/c 自闭症谱系障碍 CTNND2基因敲除鼠
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考虑风光融合的多稳态合成氨经济优化研究
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作者 苏文华 文丽梅 +3 位作者 张晓梦 王博 陶鑫 黄超 《太阳能学报》 EI CAS CSCD 北大核心 2024年第9期210-218,共9页
为研究多稳态合成氨工艺经济性,结合某地区特定风光资源条件和装置规模,对合成氨负荷动态调度生产过程进行模拟。当氢气不足时,为防止对合成氨生产造成影响,采用买电制氢的方式弥补对氢气的需求,并分析买电的限度对整个调度过程的影响... 为研究多稳态合成氨工艺经济性,结合某地区特定风光资源条件和装置规模,对合成氨负荷动态调度生产过程进行模拟。当氢气不足时,为防止对合成氨生产造成影响,采用买电制氢的方式弥补对氢气的需求,并分析买电的限度对整个调度过程的影响。通过多稳态合成氨与稳态制氨的经济性对比分析发现前者经济性更高;与内蒙古某稳态制绿氨项目进行对比,发现该文对绿氨项目的优化是切实有效的。 展开更多
关键词 绿氨 新能源发电 经济优化 HOMER PRO 风光互补 绿氢
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基于HOMER的多场景离网型微电网优化设计
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作者 张一凡 颜世烨 +3 位作者 李斌 柳丹 叶季蕾 刘丽丽 《太阳能学报》 EI CAS CSCD 北大核心 2024年第8期123-134,共12页
基于HOMER软件对武汉某商业园区开展离网型光-柴-储微电网系统优化设计研究。首先,构建多运行策略下离网型光-柴-储微电网系统容量优化配置模型;在此基础上,分析不同运行策略下系统容量配置、光伏渗透比例和电池储能运行状态,并得出离... 基于HOMER软件对武汉某商业园区开展离网型光-柴-储微电网系统优化设计研究。首先,构建多运行策略下离网型光-柴-储微电网系统容量优化配置模型;在此基础上,分析不同运行策略下系统容量配置、光伏渗透比例和电池储能运行状态,并得出离网型光-柴-储微电网系统最优运行策略;然后,基于最优运行策略开展多场景下离网型光-柴-储微电网容量优化配置,对多场景离网型光-柴-储微电网的平准化度电成本本(LCOE)、系统净现值(NPC)和总排放等性能进行比较分析;最后,结合具体案例开展敏感性因素分析。结果表明,所提容量配置模型可实现系统经济性与清洁性的最佳权衡,并降低系统对于储能电池的依赖;通过敏感性分析得出不同机组参数、负荷参数对系统最优配置的影响。 展开更多
关键词 微电网 可再生能源 储能 HOMER仿真 多场景 容量配置
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Modelling and Optimization of Hydroelectric Power Plants in Cameroon for the Development of the Green Energy Market in Neighboring Countries Using Homer Software
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作者 Bachirou Bogno Michel Aillerie +1 位作者 Kitmo   Dieudonné Kidmo Kaoga 《Smart Grid and Renewable Energy》 2024年第10期248-265,共18页
Renewable energy is increasingly in demand for a variety of applications in both urban and rural areas. There are, however, a number of implementation constraints in some countries, even though sunshine, wind and wate... Renewable energy is increasingly in demand for a variety of applications in both urban and rural areas. There are, however, a number of implementation constraints in some countries, even though sunshine, wind and water are abundant and available. As part of this research, we are carrying out a technical and economic study on the availability of renewable energy in Cameroon, with a view to combining several sources of solar, biomass, wind and hydroelectric power to meet energy demand both inside and outside the country, in countries such as Chad, Gabon and Nigeria. In this work, the implementation of the entire system in the HOMER software demonstrates the feasibility and possibility of implementing a multi-source power plant based on renewable energies. Calculation of the levelized cost of energy (LCOE) and the net present cost (NPC) shows that a capacity of 485 GW can meet the energy demand of the countries bordering Cameroon. Furthermore, the calculation of the performance ratio gives a PR = 46.52 and a Capacity factor of CF = 11.64. The system is profitable not only economically but also environmentally, as it reduces greenhouse gas emissions and energy losses. 展开更多
关键词 Wind Plant PV Plant HYDROPOWER HOMER Renewable Energy
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Numerical Modeling and Technico-Economic Analysis of a Hybrid Energy Production System for Self-Consumption: Case of Rural Area in the Comoros
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作者 Fahad Maoulida Mohamed Aboudou Kassim +2 位作者 Rabah Djedjig Ahmed Ihlal Mohammed El Ganaoui 《Journal of Power and Energy Engineering》 2024年第5期24-59,共36页
This study aims to provide electricity to a remote village in the Union of Comoros that has been affected by energy problems for over 40 years. The study uses a 50 kW diesel generator, a 10 kW wind turbine, 1500 kW ph... This study aims to provide electricity to a remote village in the Union of Comoros that has been affected by energy problems for over 40 years. The study uses a 50 kW diesel generator, a 10 kW wind turbine, 1500 kW photovoltaic solar panels, a converter, and storage batteries as the proposed sources. The main objective of this study is to conduct a detailed analysis and optimization of a hybrid diesel and renewable energy system to meet the electricity demand of a remote area village of 800 to 1500 inhabitants located in the north of Ngazidja Island in Comoros. The study uses the Hybrid Optimization Model for Electric Renewable (HOMER) Pro to conduct simulations and optimize the analysis using meteorological data from Comoros. The results show that hybrid combination is more profitable in terms of margin on economic cost with a less expensive investment. With a diesel cost of $1/L, an average wind speed of 5.09 m/s and a solar irradiation value of 6.14 kWh/m<sup>2</sup>/day, the system works well with a proportion of renewable energy production of 99.44% with an emission quantity of 1311.407 kg/year. 99.2% of the production comes from renewable sources with an estimated energy surplus of 2,125,344 kWh/year with the cost of electricity (COE) estimated at $0.18/kWh, presenting a cost-effective alternative compared to current market rates. These results present better optimization of the used hybrid energy system, satisfying energy demand and reducing the environmental impact. 展开更多
关键词 Hybrid System Rural Area Electrification COMOROS Techno-Economic Analysis PV-Wind-Diesel-Battery Meteorological Data HOMER Energy Pro
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基于HOMER的海岛型微电网系统容量配置方法研究
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作者 马超 赵严树 孔丹 《电力设备管理》 2024年第12期90-92,共3页
由于海岛孤悬于海洋之中,至今众多岛屿供电依托于柴油发电机,造成了海岛环境污染,且发电经济性较低;为解决海岛用电困难,保护环境,建设离网型微电网系统保证用电可靠性,提高海岛居民的生活质量迫在眉睫,建设离网型微电网系统成为解决海... 由于海岛孤悬于海洋之中,至今众多岛屿供电依托于柴油发电机,造成了海岛环境污染,且发电经济性较低;为解决海岛用电困难,保护环境,建设离网型微电网系统保证用电可靠性,提高海岛居民的生活质量迫在眉睫,建设离网型微电网系统成为解决海岛居民用电难题的有效途径,而微电网系统各微源合理的容量配置,成为控制系统经济性关键性指标。 展开更多
关键词 分布式电源 HOMER 海岛微电网 容量配置
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基于Homer Pro的离网型光储系统容量配置分析
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作者 肖伟超 杨韩 +1 位作者 江期枫 卢淇民 《能源研究与管理》 2024年第3期98-103,111,共7页
为探索离网型光储柴混合发电系统中光储容量配置与月最低光照有效时间和年平均光照有效时间的关系,基于Homer Pro微电网软件对光储柴混合发电系统进行模拟,在用电特性相同的情况下,分析了中国某地、苏里南某地和秘鲁某地3个光照强度不... 为探索离网型光储柴混合发电系统中光储容量配置与月最低光照有效时间和年平均光照有效时间的关系,基于Homer Pro微电网软件对光储柴混合发电系统进行模拟,在用电特性相同的情况下,分析了中国某地、苏里南某地和秘鲁某地3个光照强度不同地区理论计算的光储容量配置和Homer Pro微电网软件衍生优化的净现值最低光储容量配置的关系。结果表明:3个不同光照强度地区采用月最低光照有效时间理论计算的储能容量与Homer Pro微电网软件衍生优化的储能容量比值为1.134、1.052和1.019,光伏容量比值为0.97、1.34和1.30;采用年均光照有效时间理论计算的储能容量与Homer Pro微电网软件衍生优化的储能容量比值为1.134、1.052和1.019,光伏容量比值为1.46、1.48和1.50;采用年均光照时间理论计算的光储容量配置与Homer Pro微电网软件衍生优化的光储容量配置比值较为稳定,所以采用月平均光照时间理论计算的储能容量乘以1.07、光伏容量乘以1.48可以得到趋近于Homer Pro微电网软件衍生优化的净现值最低的光储容量,这对于研究离网型光储柴混合发电系统的光储容量配置具有重要参考意义。 展开更多
关键词 微电网 储能 光伏 Homer Pro微电网软件 优化配置 敏感性分析
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面向低碳村镇的可再生能源热电联供系统仿真与优化 被引量:1
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作者 艾平 彭宇志 +3 位作者 金柯达 康霜 徐文勇 李冰峰 《农业机械学报》 EI CAS CSCD 北大核心 2023年第S02期350-358,399,共10页
为促进中国农村可再生能源转型与绿色低碳发展,实现低碳村镇的新时期建设目标,以湖北省新星村为研究案例,基于农村用能需求及可再生能源资源禀赋分析,提出了一种风、光、生物质互补的可再生能源热电联供系统。以最低成本与最低平均电价... 为促进中国农村可再生能源转型与绿色低碳发展,实现低碳村镇的新时期建设目标,以湖北省新星村为研究案例,基于农村用能需求及可再生能源资源禀赋分析,提出了一种风、光、生物质互补的可再生能源热电联供系统。以最低成本与最低平均电价为系统目标函数,以热电覆盖率及生物质利用率为系统评价指标,构建了基于HOMER Pro仿真系统的农村可再生能源热电联供模型,通过仿真分析与容量优化获得了新星村可再生能源系统的构建方案,即由功率674 kW的光伏、功率200 kW的风力发电机和功率500 kW的CHP热电联供机组及外部热源构成最佳系统框架,此时最低系统成本与电价分别为2.30×10^(7)元/a和0.986元/(kW·h)。进一步敏感性分析结果表明,电力负荷提高会导致系统成本及电价上升,名义折现率提高会降低成本但导致电价上涨,生物质日输入量对经济指标无影响。减排评估结果表明,相较于传统供能方式,系统年减排量达410.77 t,相当于新星村传统供能方式下年排放量的28.19%,减排效益明显。该可再生能源供能系统整体经济性与实用性良好,可为农村地区能源转型与低碳村镇的建设提供参考。 展开更多
关键词 农村可再生能源 低碳村镇 热电联供系统 微电网容量优化 HOMER Pro 碳减排
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基于HOMER仿真的风光储互补发电系统容量优化配置研究 被引量:10
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作者 左冲 贾彦 +4 位作者 孟克其劳 刘雪强 邢志泰 包道日娜 赵明智 《内蒙古电力技术》 2023年第1期21-25,共5页
以系统总成本最小为目标函数,基于可再生能源发电混合系统优化仿真软件(Hybrid Optimization Model for Electric Renewables,HOMER),针对某工业园区的风光资源数据和负荷情况,进行了设备成本和参数设定。在获得的配置方案中,对比分析... 以系统总成本最小为目标函数,基于可再生能源发电混合系统优化仿真软件(Hybrid Optimization Model for Electric Renewables,HOMER),针对某工业园区的风光资源数据和负荷情况,进行了设备成本和参数设定。在获得的配置方案中,对比分析了并网型风光储、风光互补以及风储、光储发电系统的优化配置方案,分析其弃电率和经济性,验证了风光储系统的优越性,最终得到并网型风光储互补发电系统总净现成本最小的配置,并对其各设备的年发电量、系统可靠性及经济性进行了分析,可为可再生能源多能互补微电网风光储系统容量优化配置的研究提供参考。 展开更多
关键词 风光储互补发电系统 HOMER仿真 容量优化 多能互补
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基于多指标优化的园区源网荷储系统配置 被引量:3
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作者 郭富强 汪鹏 赵凯明 《科学技术与工程》 北大核心 2023年第14期6018-6026,共9页
为实现双碳目标,构建新型低碳能源体系,针对华北地区某大型工业园区源网荷储一体化系统容量配置优化问题,采用二级优化策略,以新能源发电消纳率最大和系统平准化度电成本LCOE(levelized cost of energy)最小为优化目标进行配置。首先建... 为实现双碳目标,构建新型低碳能源体系,针对华北地区某大型工业园区源网荷储一体化系统容量配置优化问题,采用二级优化策略,以新能源发电消纳率最大和系统平准化度电成本LCOE(levelized cost of energy)最小为优化目标进行配置。首先建立园区源网荷储一体化系统拓扑结构模型,一级优化以源-网-荷-储4个方面的约束为限制,以弃风弃光率小于5%为目标函数进行寻优,然后再将输出结果作为HOMER软件的初始值进行仿真,以平准化度电成本最小为目标函数在一级优化的解集内寻优。通过对二级优化结果进行系统评估,得到兼具经济性、环保性和可靠性的最优配置组合。优化结果证明了二级优化通过枚举法的优化额外考虑了实际工程中会受到土地面积、变压器容量等变量,相较于直接使用HOMER软件更具有合理性。对比不同方案下系统的配置结果,得出最优源网荷储系统配置,为大型工业园区的源网荷储系统的规划提供了参考。 展开更多
关键词 源网荷储 HOMER 风光消纳 容量优化
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冠心病病人血清Homer1及LKB1水平与冠状动脉病变严重程度的相关性
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作者 邱洪 叶加宝 殷莺 《中西医结合心脑血管病杂志》 2023年第21期3988-3991,共4页
目的:探讨冠心病病人血清中Homer1及肝激酶B1(LKB1)水平与冠状动脉病变严重程度的相关性。方法:选取2021年1月—2021年12月在苏州市立医院确诊为冠心病并行冠状动脉造影检查的94例病人为病例组,并选取同期就诊的不明原因胸痛非冠心病病... 目的:探讨冠心病病人血清中Homer1及肝激酶B1(LKB1)水平与冠状动脉病变严重程度的相关性。方法:选取2021年1月—2021年12月在苏州市立医院确诊为冠心病并行冠状动脉造影检查的94例病人为病例组,并选取同期就诊的不明原因胸痛非冠心病病人42例为对照组。收集病人入院后的一般资料,并对血清Homer1及LKB1水平进行检测。根据Gensini积分分为3组,<20分为轻度组,20~55分为中度组,>55分为重度组。结果:病例组94例冠心病根据冠状动脉狭窄程度分为轻度组32例,中度组26例,重度组36例。轻度组、中度组与重度组血清Homer1水平均高于对照组,血清LKB1水平均低于对照组,重度组血清Homer1水平高于中度组、轻度组,血清LKB1水平低于中度组、轻度组,中度组血清Homer1水平高于轻度组,血清LKB1水平低于轻度组,差异均有统计学意义(P<0.05)。相关性分析结果显示,冠心病病人血清Homer1水平与Gensini积分呈正相关(r=0.603,P<0.05);冠心病病人血清LKB1水平与Gensini积分呈负相关(r=-0.659,P<0.05)。受试者工作特征(ROC)曲线分析结果显示,血清Homer1诊断冠心病的截断值为0.39 ng/mL,曲线下面积(AUC)为0.857,敏感度为79.79%,特异度为83.33%。血清LKB1诊断冠心病的截断值为3.81μg/L,AUC为0.694,敏感度为70.21%,特异度为73.80%。结论:冠心病病人血清Homer1水平高于不明原因胸痛非冠心病病人,且随冠状动脉病变程度加重而升高,LKB1水平低于不明原因胸痛非冠心病病人,且随冠状动脉病变程度加重而下降,血清Homer1及LKB1均对冠心病有预测价值。 展开更多
关键词 冠心病 Homer1 肝激酶B1 冠状动脉病变 相关性
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东莨菪碱调节SIN3A表达对水杨酸诱导耳鸣大鼠mGluR5/Homer1信号通路的影响
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作者 颜微微 邓可斌 《河北医药》 CAS 2023年第19期2933-2936,共4页
目的探究东莨菪碱(SPL)调节SIN3A表达对水杨酸诱导的耳鸣大鼠mGluR5/Homer1信号通路的影响。方法将50只大鼠分为对照组、模型组、阳性组、SPL低、高剂量组,每组10只。分别对5组大鼠进行惊跳反射前脉冲抑制(PPI)检测和听性脑干反应(ABR)... 目的探究东莨菪碱(SPL)调节SIN3A表达对水杨酸诱导的耳鸣大鼠mGluR5/Homer1信号通路的影响。方法将50只大鼠分为对照组、模型组、阳性组、SPL低、高剂量组,每组10只。分别对5组大鼠进行惊跳反射前脉冲抑制(PPI)检测和听性脑干反应(ABR)检测;RT-qPCR检测大鼠听皮层组织中SIN3A的mRNA水平;Western blot检测大鼠听皮层组织中SIN3A、mGluR5、Homer1蛋白的表达。结果与对照组相比,模型组大鼠的前脉冲抑制率、ABR阈值、mGluR5和Homer1的蛋白表达均显著升高(P<0.05),SIN3A mRNA水平和蛋白表达降低(P<0.05);与模型组相比,阳性组和SPL处理组大鼠的前脉冲抑制率、ABR阈值、mGluR5和Homer1的蛋白表达均显著降低(P<0.05),SIN3A mRNA水平和蛋白表达升高(P<0.05)。结论SPL可以通过促进SIN3A的表达,来抑制水杨酸诱导的耳鸣大鼠mGluR5/Homer1信号通路。 展开更多
关键词 东莨菪碱 SIN3A mGluR5/Homer1信号通路 耳鸣大鼠
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Modelling and Optimization of Clean and Affordable Electricity Solution for Small-Scale Savings and Credit Cooperatives(SACCOs)
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作者 Xiaomei Lin Samuel Bimenyimana +14 位作者 ChenWang Godwin Norense Osarumwensa Asemota Jeanne Paula Ihirwe Aphrodis Nduwamungu Etienne Ntagwirumugara Athanase Gace Changfu Yuan Yaowen Chen Changtai Li Shilpi Bora YiYi Mo Jiyu Lai Mabao Wu Yong Tang Merit M.Huang 《Energy Engineering》 EI 2023年第4期791-810,共20页
Renewable energy exploitation is among the development strategies set by the government of Rwanda on the roadmap to 2023/2024 universal electricity access and theUnitedNations plans by 2030.Numerous previous studies o... Renewable energy exploitation is among the development strategies set by the government of Rwanda on the roadmap to 2023/2024 universal electricity access and theUnitedNations plans by 2030.Numerous previous studies oncleanenergy technologies inRwandahavemostly focusedonhouseholds’usagebut there are currentlynostudies describing the feasibility of clean energy technologies for financial institutions.The skepticism on renewable energy in Africa was previously reported by some personnel.Having realized that most SACCOs(Savings and Credit Co-Operatives)in Rwanda use diesel technology for backup/emergency electricity supply,taking consideration of abundant solar resources in Rwanda,having seen the viability and feasibility studies from other countries of renewable energy for different institutions(financial included);thiswork uses theHOMEREnergy Software and the electricity load profile of a typical SACCO in Rwanda to analyse the affordability and viability of on-site renewable energy generation for SACCO in Rwanda.The results reveal that a solar PV systemwith storage can be the optimal solution(with levelized cost of electricity(LCOE)of 0.713$/kWh which is cheaper than 0.73$/kWh for diesel technology)for SACCOs located in both off-grid areas and grid-connected areas(with 0.041$/kWh LCOE which is lower than the current electricity tariff in Rwanda).The findings in this work can serve as basic tools/materials for policy drafters in Rwanda on how financial institutions can contribute to climate change mitigation through self-renewable energy exploitation. 展开更多
关键词 HOMER energy solar energy SACCO in Rwanda climate change mitigation
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A Solar Energy System Design for Green Hydrogen Production in South-Western Nigeria, Lagos State, Using HOMER & ASPEN
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作者 Wilson Fidelis Ekpotu Joseph Taiwo Akintola +1 位作者 Martins Chineme Obialor Philemon Chukwuebuka Udom 《Open Journal of Optimization》 2023年第2期72-97,共26页
Solar system design for green hydrogen production has become the most prominent renewable energy research area, and this has also actively fueled the desire to achieve net-zero emissions. Hydrogen is a promising energ... Solar system design for green hydrogen production has become the most prominent renewable energy research area, and this has also actively fueled the desire to achieve net-zero emissions. Hydrogen is a promising energy carrier because it possesses more energy capacity than fossil fuels and the abundant nature of renewable energy systems can be utilized for green hydrogen production. However, the design of an optimized electrical energy system required for hydrogen production is crucial. Solar energy is indeed beneficial for green hydrogen production and this research designed, discussed, and provided high-level research on HOMER design for green hydrogen production and deployed the energy requirement with ASPEN Plus to optimize the energy system, while also incorporating fuzzy logic and PID control approaches. In addition, a promising technology with a high potential for renewable hydrogen energy is the proton exchange membrane (PEM) electrolyzer. Since its cathode (hydrogen electrode) may be operated over a wide range of pressure, a control process must be added to the system in order for it to work dynamically efficiently. This system can be characterized as an analogous circuit that consists of a resistor, capacitor, and reversible voltage. As a result, this research work also explores the Fuzzy-PID control of the PEM electrolysis system. Both the PID and Fuzzy Logic control systems were simulated using the control simulation program Matlab R2018a, which makes use of Matlab script files and the Simulink environment. Based on the circuit diagram, a transfer function that represents the mathematical model of the plant was created, and the PEM electrolysis control system is determined to be highly significant and applicable to the two control systems. The PI controller, however, has a 30.8% overshoot deficit, but when the fuzzy control system is compared to the PID controller, it is found that the fuzzy control system achieves stability more quickly, demonstrating its benefit over PID. 展开更多
关键词 Homer Solar Design Solar Energy Renewable Energy Green Hydrogen Production Fuzzy Logic HOMER
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Homer in Nietzsche’s Art of Interpretation
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作者 Ellen Caroline Vieira de Paiva 《Journal of Philosophy Study》 2023年第9期387-394,共8页
The main purpose of this paper is to demonstrate the relevance of the aesthetic understanding of the Western culture’s development in Nietzsche’s thought based on his artistic conception of interpretation.In order t... The main purpose of this paper is to demonstrate the relevance of the aesthetic understanding of the Western culture’s development in Nietzsche’s thought based on his artistic conception of interpretation.In order to accomplish this,his considerations on the figure of Homer in the production of the classical imaginary of Greek culture are taken as a discursive motif in the comparison between three distinct nuclei of his oeuvres,namely,his methodological discussions on philology,his theoretical analyses on the rhetorical nature of language-both from the time of his academic activity in Basel-and his philosophical reflections on creative interpretation in the 1880s.The fundamental premises raised by such comparison are the following:(a)interpretation as an art is a consequence of language as a pragmatically produced system of references;and(b)language is a practical aspect of the individual’s synthetic organic condition as a body in the world.As such,interpretation would be an aesthetic synthesis in Nietzsche’s philosophy.As a concluding remark,it should be demonstrated how the interpreter conceived as a creator is as worthwhile for understanding the historical processes of cultural transmission as it is for launching prospects for the future of cultural horizons. 展开更多
关键词 NIETZSCHE HOMER HERMENEUTICS philosophical anthropology
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Design and Numerical Analysis of Ultra-High Negative Dispersion, Highly Birefringent Nonlinear Single Mode Core-Tune Photonic Crystal Fiber (CT-PCF) over Communication Bands
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作者 Amit Halder Wahiduzzaman Emon +3 位作者 Md. Shamim Anower Md. Riyad Tanshen Md. Forkan Md. Sharif Uddin Shajib 《Optics and Photonics Journal》 2023年第10期227-242,共16页
This paper presents the development of a highly efficient CT-PCF (Core-Tune Photonic Crystal Fiber) with substantial birefringence, tailored for applications in high-bit-rate communication and sensing while minimizing... This paper presents the development of a highly efficient CT-PCF (Core-Tune Photonic Crystal Fiber) with substantial birefringence, tailored for applications in high-bit-rate communication and sensing while minimizing signal loss. The design incorporates a modified broadband dispersion compensating structure, optimized for operation across the E, S, C, and L communication bands within a wavelength range spanning 1360 nm to 1625 nm. Notably, the CT-PCF demonstrates a remarkable birefringence of 2.372 × 10<sup>-2</sup> at 1550 nm, surpassing traditional PCF structures. Single-mode performance is evaluated using the Higher Order Mode Extinction Ratio (HOMER) method, revealing a peak HOMER value of 10<sup>4</sup> at 1550 nm. Furthermore, at 1550 nm, the CT-PCF exhibits exceptional nonlinear characteristics, featuring a high nonlinearity of 50.74 W<sup>-1</sup>⋅Km<sup>-1</sup> for y polarization. In comparison to existing designs, the proposed CT-PCF exhibits superior performance metrics and optical characteristics. Additionally, the y polarization dispersion coefficient of the CT-PCF at 1550 nm is measured at -3534 ps/(nm⋅km). Overall, the CT-PCF represents a significant advancement, outperforming established systems in terms of performance metrics and optical properties. 展开更多
关键词 Negative Dispersion BIREFRINGENCE Confinement Loss HOMER Method Single-Mode Performance Optical Properties
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