As one of the most promising candidates for implementing quantum computers, superconducting qubits(SQs) are adopted for fast generating the Greenberger–Horne–Zeilinger(GHZ) state by using invariants-based shortc...As one of the most promising candidates for implementing quantum computers, superconducting qubits(SQs) are adopted for fast generating the Greenberger–Horne–Zeilinger(GHZ) state by using invariants-based shortcuts. Three SQs are separated and connected by two coplanar waveguide resonators(CPWRs) capacitively. The complicated system is skillfully simplified to a three-state system, and a GHZ state among three SQs is fast generated with a very high fidelity and simple driving pulses. Numerical simulations indicate the scheme is insensitive to parameter deviations. Besides, the robustness of the scheme against decoherence is discussed in detail.展开更多
The Horne deposit with rich Cu and Au in Noranda region of Black River Group in Quebec has high economic significance.Current researches on Horne deposit are mostly based on two-dimensional maps and statistical data.I...The Horne deposit with rich Cu and Au in Noranda region of Black River Group in Quebec has high economic significance.Current researches on Horne deposit are mostly based on two-dimensional maps and statistical data.It is hard to reflect the spatial structure and characteristics of Horne orebody directly.In this paper,GIS was used to digitize the mining plan-view maps at different depths,stope maps,the boundary of the massive sulfide in drilling trajectories as well as the grade data of Au and Cu of Horne deposit.Meanwhile,the authors established the grade attribute database.Subsequently the three-dimensional(3D)geological model and grade attribute model of Horne orebody were established by Geological Object Computer Aided Design(GOCAD).Positions of two vents and directions of hydrothermal alteration in Horne deposit were inferred based on the property of the major fault,characteristics of hydrothermal alteration,the enrichment morphology and spatial distribution of high-grade Cu in the Cu attribute model.展开更多
美国最高法院2015年判决的霍恩诉农业部案(Home v. Dep’t of Agriculture)虽然主要涉及农业领域征收与补偿的宪法问题,但也较好地展示了美国农业产业政策法的全貌。该案及其反映的美国农业法治素材,对于我国农业产业政策的法律化颇有...美国最高法院2015年判决的霍恩诉农业部案(Home v. Dep’t of Agriculture)虽然主要涉及农业领域征收与补偿的宪法问题,但也较好地展示了美国农业产业政策法的全貌。该案及其反映的美国农业法治素材,对于我国农业产业政策的法律化颇有启示。农业产业政策必须以法律文本为载体,最大限度地利用市场机制,强调农业政策的可操作性,并应根据经济与社会发展适时进行评估与调整。展开更多
Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury(SCI).However,this subject has been neglected in part because appropriate tools are ...Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury(SCI).However,this subject has been neglected in part because appropriate tools are lacking.Emerging in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and disease.This review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques,and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to SCI.We then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience examinations.Finally,we identify the challenges and possible solutions for spinal cord neuron imaging.展开更多
Stroke can cause Wallerian degeneration in regions outside of the brain,particularly in the corticospinal tract.To investigate the fate of major glial cells and axons within affected areas of the corticospinal tract f...Stroke can cause Wallerian degeneration in regions outside of the brain,particularly in the corticospinal tract.To investigate the fate of major glial cells and axons within affected areas of the corticospinal tract following stroke,we induced photochemical infarction of the sensorimotor cortex leading to Wallerian degeneration along the full extent of the corticospinal tract.We first used a routine,sensitive marker of axonal injury,amyloid precursor protein,to examine Wallerian degeneration of the corticospinal tract.An antibody to amyloid precursor protein mapped exclusively to proximal axonal segments within the ischemic cortex,with no positive signal in distal parts of the corticospinal tract,at all time points.To improve visualization of Wallerian degeneration,we next utilized an orthograde virus that expresses green fluorescent protein to label the corticospinal tract and then quantitatively evaluated green fluorescent protein-expressing axons.Using this approach,we found that axonal degeneration began on day 3 post-stroke and was almost complete by 7 days after stroke.In addition,microglia mobilized and activated early,from day 7 after stroke,but did not maintain a phagocytic state over time.Meanwhile,astrocytes showed relatively delayed mobilization and a moderate response to Wallerian degeneration.Moreover,no anterograde degeneration of spinal anterior horn cells was observed in response to Wallerian degeneration of the corticospinal tract.In conclusion,our data provide evidence for dynamic,pathogenic spatiotemporal changes in major cellular components of the corticospinal tract during Wallerian degeneration.展开更多
This article showcases a clinical case of ectopic pregnancy lodged in the cornual. A pregnancy implanted in this location is a rarity, making it difficult to diagnose. By describing this case and screening of the lite...This article showcases a clinical case of ectopic pregnancy lodged in the cornual. A pregnancy implanted in this location is a rarity, making it difficult to diagnose. By describing this case and screening of the literature, we explain the various diagnostic and therapeutic methods, both medical and surgical. Highlighting the importance of conservative treatment flush with the uterine horn, and conclude with some practical recommendations.展开更多
Salvaged cow horns from slaughterhouses have been transformed into fine particles for a physical characterization that has led us to determine the humidity rate (2.34% ± 0.054%), the actual density situated betwe...Salvaged cow horns from slaughterhouses have been transformed into fine particles for a physical characterization that has led us to determine the humidity rate (2.34% ± 0.054%), the actual density situated between 0.586 g/cm<sup>3</sup> and 0.732 g/cm<sup>3</sup>, the swelling rate (12%), and one chemical characterization that permitted us to determine the rate of dry matters (97.05%), of mineral matters (2.5%), of protein matters (94.52%). From these weak values, it can easily be seen that cow horn case doesn’t absorb much water and improve the mechanical characteristics of the composite;the high rate of protein shows that keratin which is the structural molecule favors its gripping as reinforcing element in the manufacturing of composite materials.展开更多
A pathogenic fungus Colletorichum gloeosporioides(Penz.) Sacc isolated from horned gallnut,a Chinese gallnut from Yunnan Province,was reported for the first time.Its morphological and molecular biological characterist...A pathogenic fungus Colletorichum gloeosporioides(Penz.) Sacc isolated from horned gallnut,a Chinese gallnut from Yunnan Province,was reported for the first time.Its morphological and molecular biological characteristics were identified, and its damage status and mycelium characters on gall and mydium were described.The pathogenic fungi C.gloeosporioides Sacc belongs to Melanconiales(Deuteromycotina:Coelomycetes).展开更多
Dendrites play irreplaceable roles in the nerve conduction pathway and are vulnerable to various insults.Peripheral axotomy of motor neurons results in the retraction of dendritic arbors,and the dendritic arbor can be...Dendrites play irreplaceable roles in the nerve conduction pathway and are vulnerable to various insults.Peripheral axotomy of motor neurons results in the retraction of dendritic arbors,and the dendritic arbor can be re-expanded when reinnervation is allowed.RhoA is a target that regulates the cytoskeleton and promotes neuronal survival and axon regeneration.However,the role of RhoA in dendrite degeneration and regeneration is unknown.In this study,we explored the potential role of RhoA in dendrites.A line of motor neuronal conditional knockout mice was developed by crossbreeding HB9~(Cre+)mice with RhoA~(flox/flox)mice.We established two models for assaying dendrite degeneration and regeneration,in which the brachial plexus was transection or crush injured,respectively.We found that at 28 days after brachial plexus transection,the density,complexity,and structural integrity of dendrites in the ventral horn of the spinal cord of RhoA conditional knockout mice were slightly decreased compared with that in Cre mice.Dendrites underwent degeneration at 7 and 14 days after brachial plexus transection and recovered at 28–56 days.The density,complexity,and structural integrity of dendrites in the ventral horn of the spinal cord of RhoA conditional knockout mice recovered compared with results in Cre mice.These findings suggest that RhoA knockout in motor neurons attenuates dendrite degeneration and promotes dendrite regeneration after peripheral nerve injury.展开更多
The dynamic physical characteristics of a DC arc on an arcing horn for a high voltage direct current(HVDC)grounding electrode line are significantly different from those of the switching device arc,secondary arc,AC fa...The dynamic physical characteristics of a DC arc on an arcing horn for a high voltage direct current(HVDC)grounding electrode line are significantly different from those of the switching device arc,secondary arc,AC fault arc and pantograph-catenary arc.In this work,an experimental platform for the DC arc on the arcing horn was built,and mechanisms of the arc column short circuit and arc root movement were studied.This work further analyzes the characteristics and mechanisms of the arc motion when wind speed and direction,magnetic field and the expansion angle of the electrode are varied.Arc root movement is more likely to occur at the upper electrode.There is a competitive relationship between arc expansion and the transferring effect.The effect of wind on the arc column is greater than the effect on the arc root.The magnetic field has a significant driving effect on both the arc column and the arc root.The research results provide a comprehensive experimental basis for forther probing the method of DC arc suppression,and the improvement of the arcing horn.展开更多
Rudimentary horn of the uterus is a rare congenital malformation that is characterized by significant anatomic variability.We report two cases involving women who presented with a broadly attached rudimentary horn and...Rudimentary horn of the uterus is a rare congenital malformation that is characterized by significant anatomic variability.We report two cases involving women who presented with a broadly attached rudimentary horn and large ovarian endometriomas that were innovatively treated by laparoscopic coring-type dissection of the rudimentary horn of the uterus.This novel surgical approach ensured the integrity of the myometrium of the unicornuate uterus and avoided uterine rupture during pregnancy and ipsilateral ovarian function impairment.展开更多
Amid the background where the rhinoceros horn has been hoarded as a rare commodity,there is never a lack of counterfeits and adulterated products of rhinoceros horns on the market.This article aims to summarize the co...Amid the background where the rhinoceros horn has been hoarded as a rare commodity,there is never a lack of counterfeits and adulterated products of rhinoceros horns on the market.This article aims to summarize the commodity specifications and identification key points of the rhinoceros horn from its medicinal standard,to provide a reference for studying substitutes of rhinoceros horn.展开更多
Background: EVD is a common procedure done in neurosurgery and the residents should master it and this is what exactly means that it should be simple, safe, fast and accurate. EVD can be done through many entry points...Background: EVD is a common procedure done in neurosurgery and the residents should master it and this is what exactly means that it should be simple, safe, fast and accurate. EVD can be done through many entry points to the different part of the lateral ventricle but the famous site is the anterior horn of the lateral ventricle which is commonly approached through Kocher’s point which is a famous point for all neurosurgeon by its measurements of allocation. The commonest problem with EVD insertion into the anterior horn is the navigation of the ventricular cavity with the right trajectory and so the location of the catheter tip in the right place near the foramen of monro to ensure CSF draining. Size of the ventricle plays significant role in the success of the procedure especially free hand technique. The more dilated ventricle, the more chance to hit the ventricular cavity especially from the first trial and vice versa. In case of small ventricle, the procedure with free hand technique seems more complicated and the chance to hit the ventricle from the first trial may reduce especially with non-expert surgeon but may succeed in the following trials with increased risk of complications with more trials. Purpose: Most EVD’s are placed with freehand technique which depends on the operator skills to navigate the ventricle with right trajectory and hit the ventricle from the first trial, because many trials may complicate the procedure and produce undesirable side effects. So the key in this free hand technique is how to ensure the success from the first trial. In case of small anterior horn of the lateral ventricle, the procedure is even more difficult with the free hand technique and the classic Kocher point needs an expert to get the right trajectory to navigate such small ventricle. Our point idea came from this prospective and aimed at raising the success of the procedure especially in the first attempt with simple technique. Method: It is a new entry point for EVD insertion through frontal burr hole gained by the intersection of two lines: the first is running vertically from the ipsilateral medial canthus downward and the second is running horizontal along the coronal suture which is usually palpable as ridge on the scalp extended lateral from the bregma. Burr hole is done just anterior to this intersection and catheter is placed in a perpendicular trajectory toward the ventricular cavity. Result: It has been used in about (n = 50 cases) fulfilling the criteria of radiological small ventricle as defined and they were candidates for EVD insertion by free hand technique. Only 3 cases (6%) out of the 50 cases failed in the first attempt but succeeded in the following trial. So high rate of success in first trial is seen in the most of cases using this technique during a period of one year of our practice without significant side effects seen. Conclusion: Our study is not conclusive and needs further studies for more evaluation. It was a suggested point other than the classic Kocher point in case of free hand EVD insertion in small ventricle. We recommend to try it and report any advantages or disadvantages to the literature.展开更多
基金Project supported by the National Natural Science Foundation of China(Grant No.11464046)
文摘As one of the most promising candidates for implementing quantum computers, superconducting qubits(SQs) are adopted for fast generating the Greenberger–Horne–Zeilinger(GHZ) state by using invariants-based shortcuts. Three SQs are separated and connected by two coplanar waveguide resonators(CPWRs) capacitively. The complicated system is skillfully simplified to a three-state system, and a GHZ state among three SQs is fast generated with a very high fidelity and simple driving pulses. Numerical simulations indicate the scheme is insensitive to parameter deviations. Besides, the robustness of the scheme against decoherence is discussed in detail.
文摘The Horne deposit with rich Cu and Au in Noranda region of Black River Group in Quebec has high economic significance.Current researches on Horne deposit are mostly based on two-dimensional maps and statistical data.It is hard to reflect the spatial structure and characteristics of Horne orebody directly.In this paper,GIS was used to digitize the mining plan-view maps at different depths,stope maps,the boundary of the massive sulfide in drilling trajectories as well as the grade data of Au and Cu of Horne deposit.Meanwhile,the authors established the grade attribute database.Subsequently the three-dimensional(3D)geological model and grade attribute model of Horne orebody were established by Geological Object Computer Aided Design(GOCAD).Positions of two vents and directions of hydrothermal alteration in Horne deposit were inferred based on the property of the major fault,characteristics of hydrothermal alteration,the enrichment morphology and spatial distribution of high-grade Cu in the Cu attribute model.
文摘美国最高法院2015年判决的霍恩诉农业部案(Home v. Dep’t of Agriculture)虽然主要涉及农业领域征收与补偿的宪法问题,但也较好地展示了美国农业产业政策法的全貌。该案及其反映的美国农业法治素材,对于我国农业产业政策的法律化颇有启示。农业产业政策必须以法律文本为载体,最大限度地利用市场机制,强调农业政策的可操作性,并应根据经济与社会发展适时进行评估与调整。
基金supported by the National Natural Science Foundation of China,No.82272478(to PT)。
文摘Deciphering the neuronal response to injury in the spinal cord is essential for exploring treatment strategies for spinal cord injury(SCI).However,this subject has been neglected in part because appropriate tools are lacking.Emerging in vivo imaging and labeling methods offer great potential for observing dynamic neural processes in the central nervous system in conditions of health and disease.This review first discusses in vivo imaging of the mouse spinal cord with a focus on the latest imaging techniques,and then analyzes the dynamic biological response of spinal cord sensory and motor neurons to SCI.We then summarize and compare the techniques behind these studies and clarify the advantages of in vivo imaging compared with traditional neuroscience examinations.Finally,we identify the challenges and possible solutions for spinal cord neuron imaging.
基金supported by the National Natural Science Foundation of China,Nos.31 730030 (to XL),81941011 (to XL),31 771053 (to HD),82271403 (to XL),82272171 (to ZY),31971279 (to ZY)82201542 (to FH)+1 种基金the Natural Science Foundation of Beijing,No.7222004 (to HD)the Science and Technology Program of Beijing,No.Z181100001818007(to ZY)
文摘Stroke can cause Wallerian degeneration in regions outside of the brain,particularly in the corticospinal tract.To investigate the fate of major glial cells and axons within affected areas of the corticospinal tract following stroke,we induced photochemical infarction of the sensorimotor cortex leading to Wallerian degeneration along the full extent of the corticospinal tract.We first used a routine,sensitive marker of axonal injury,amyloid precursor protein,to examine Wallerian degeneration of the corticospinal tract.An antibody to amyloid precursor protein mapped exclusively to proximal axonal segments within the ischemic cortex,with no positive signal in distal parts of the corticospinal tract,at all time points.To improve visualization of Wallerian degeneration,we next utilized an orthograde virus that expresses green fluorescent protein to label the corticospinal tract and then quantitatively evaluated green fluorescent protein-expressing axons.Using this approach,we found that axonal degeneration began on day 3 post-stroke and was almost complete by 7 days after stroke.In addition,microglia mobilized and activated early,from day 7 after stroke,but did not maintain a phagocytic state over time.Meanwhile,astrocytes showed relatively delayed mobilization and a moderate response to Wallerian degeneration.Moreover,no anterograde degeneration of spinal anterior horn cells was observed in response to Wallerian degeneration of the corticospinal tract.In conclusion,our data provide evidence for dynamic,pathogenic spatiotemporal changes in major cellular components of the corticospinal tract during Wallerian degeneration.
文摘This article showcases a clinical case of ectopic pregnancy lodged in the cornual. A pregnancy implanted in this location is a rarity, making it difficult to diagnose. By describing this case and screening of the literature, we explain the various diagnostic and therapeutic methods, both medical and surgical. Highlighting the importance of conservative treatment flush with the uterine horn, and conclude with some practical recommendations.
文摘Salvaged cow horns from slaughterhouses have been transformed into fine particles for a physical characterization that has led us to determine the humidity rate (2.34% ± 0.054%), the actual density situated between 0.586 g/cm<sup>3</sup> and 0.732 g/cm<sup>3</sup>, the swelling rate (12%), and one chemical characterization that permitted us to determine the rate of dry matters (97.05%), of mineral matters (2.5%), of protein matters (94.52%). From these weak values, it can easily be seen that cow horn case doesn’t absorb much water and improve the mechanical characteristics of the composite;the high rate of protein shows that keratin which is the structural molecule favors its gripping as reinforcing element in the manufacturing of composite materials.
文摘A pathogenic fungus Colletorichum gloeosporioides(Penz.) Sacc isolated from horned gallnut,a Chinese gallnut from Yunnan Province,was reported for the first time.Its morphological and molecular biological characteristics were identified, and its damage status and mycelium characters on gall and mydium were described.The pathogenic fungi C.gloeosporioides Sacc belongs to Melanconiales(Deuteromycotina:Coelomycetes).
基金the Ministry of Science and Technology China Brain Initiative Grant,No.2022ZD0204701the National Natural Science Foundation of China,Nos.82071386&81870982(all to JG)。
文摘Dendrites play irreplaceable roles in the nerve conduction pathway and are vulnerable to various insults.Peripheral axotomy of motor neurons results in the retraction of dendritic arbors,and the dendritic arbor can be re-expanded when reinnervation is allowed.RhoA is a target that regulates the cytoskeleton and promotes neuronal survival and axon regeneration.However,the role of RhoA in dendrite degeneration and regeneration is unknown.In this study,we explored the potential role of RhoA in dendrites.A line of motor neuronal conditional knockout mice was developed by crossbreeding HB9~(Cre+)mice with RhoA~(flox/flox)mice.We established two models for assaying dendrite degeneration and regeneration,in which the brachial plexus was transection or crush injured,respectively.We found that at 28 days after brachial plexus transection,the density,complexity,and structural integrity of dendrites in the ventral horn of the spinal cord of RhoA conditional knockout mice were slightly decreased compared with that in Cre mice.Dendrites underwent degeneration at 7 and 14 days after brachial plexus transection and recovered at 28–56 days.The density,complexity,and structural integrity of dendrites in the ventral horn of the spinal cord of RhoA conditional knockout mice recovered compared with results in Cre mice.These findings suggest that RhoA knockout in motor neurons attenuates dendrite degeneration and promotes dendrite regeneration after peripheral nerve injury.
基金National Natural Science Foundation of China(No.51907168)funded by Sichuan Science and Technology Program(Outstanding Youth Science and Technology Talents)(No.2020JDJQ0039)。
文摘The dynamic physical characteristics of a DC arc on an arcing horn for a high voltage direct current(HVDC)grounding electrode line are significantly different from those of the switching device arc,secondary arc,AC fault arc and pantograph-catenary arc.In this work,an experimental platform for the DC arc on the arcing horn was built,and mechanisms of the arc column short circuit and arc root movement were studied.This work further analyzes the characteristics and mechanisms of the arc motion when wind speed and direction,magnetic field and the expansion angle of the electrode are varied.Arc root movement is more likely to occur at the upper electrode.There is a competitive relationship between arc expansion and the transferring effect.The effect of wind on the arc column is greater than the effect on the arc root.The magnetic field has a significant driving effect on both the arc column and the arc root.The research results provide a comprehensive experimental basis for forther probing the method of DC arc suppression,and the improvement of the arcing horn.
基金supported by the Medical Science and Technology Project Foundation of Zhejiang Province(2021KY741).
文摘Rudimentary horn of the uterus is a rare congenital malformation that is characterized by significant anatomic variability.We report two cases involving women who presented with a broadly attached rudimentary horn and large ovarian endometriomas that were innovatively treated by laparoscopic coring-type dissection of the rudimentary horn of the uterus.This novel surgical approach ensured the integrity of the myometrium of the unicornuate uterus and avoided uterine rupture during pregnancy and ipsilateral ovarian function impairment.
基金Supported by the Third Batch of TCM Backbone Personnel Training Project of Beijing Administration of Traditional Chinese Medicine。
文摘Amid the background where the rhinoceros horn has been hoarded as a rare commodity,there is never a lack of counterfeits and adulterated products of rhinoceros horns on the market.This article aims to summarize the commodity specifications and identification key points of the rhinoceros horn from its medicinal standard,to provide a reference for studying substitutes of rhinoceros horn.
文摘Background: EVD is a common procedure done in neurosurgery and the residents should master it and this is what exactly means that it should be simple, safe, fast and accurate. EVD can be done through many entry points to the different part of the lateral ventricle but the famous site is the anterior horn of the lateral ventricle which is commonly approached through Kocher’s point which is a famous point for all neurosurgeon by its measurements of allocation. The commonest problem with EVD insertion into the anterior horn is the navigation of the ventricular cavity with the right trajectory and so the location of the catheter tip in the right place near the foramen of monro to ensure CSF draining. Size of the ventricle plays significant role in the success of the procedure especially free hand technique. The more dilated ventricle, the more chance to hit the ventricular cavity especially from the first trial and vice versa. In case of small ventricle, the procedure with free hand technique seems more complicated and the chance to hit the ventricle from the first trial may reduce especially with non-expert surgeon but may succeed in the following trials with increased risk of complications with more trials. Purpose: Most EVD’s are placed with freehand technique which depends on the operator skills to navigate the ventricle with right trajectory and hit the ventricle from the first trial, because many trials may complicate the procedure and produce undesirable side effects. So the key in this free hand technique is how to ensure the success from the first trial. In case of small anterior horn of the lateral ventricle, the procedure is even more difficult with the free hand technique and the classic Kocher point needs an expert to get the right trajectory to navigate such small ventricle. Our point idea came from this prospective and aimed at raising the success of the procedure especially in the first attempt with simple technique. Method: It is a new entry point for EVD insertion through frontal burr hole gained by the intersection of two lines: the first is running vertically from the ipsilateral medial canthus downward and the second is running horizontal along the coronal suture which is usually palpable as ridge on the scalp extended lateral from the bregma. Burr hole is done just anterior to this intersection and catheter is placed in a perpendicular trajectory toward the ventricular cavity. Result: It has been used in about (n = 50 cases) fulfilling the criteria of radiological small ventricle as defined and they were candidates for EVD insertion by free hand technique. Only 3 cases (6%) out of the 50 cases failed in the first attempt but succeeded in the following trial. So high rate of success in first trial is seen in the most of cases using this technique during a period of one year of our practice without significant side effects seen. Conclusion: Our study is not conclusive and needs further studies for more evaluation. It was a suggested point other than the classic Kocher point in case of free hand EVD insertion in small ventricle. We recommend to try it and report any advantages or disadvantages to the literature.
基金Supposed by the National Natural Science Foundaion of China under Grant Nos.6053406060473094(国家自然科学基金)+1 种基金the National High-Tech Research and Development Plan of China under Grant No.2007AA01Z136(国家高技术研究发展计划(863))the National Basic Research Program ofChina under Grant No.2003CB317002(国家重点基础研究发展计划(973))