Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder ＆ E. Wilson, known under the pinyin name ＂Houpo＂, has been traditionally used...Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder ＆ E. Wilson, known under the pinyin name ＂Houpo＂, has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.展开更多
为研究厚朴三物汤治疗腹痛的作用机制,通过网络药理学和分子对接技术探究了厚朴三物汤的活性成分、作用靶点及信号通路机制。首先使用相关软件筛选厚朴三物汤的活性成分及腹痛相关靶点,接着利用绘图工具构建“药物成分-靶点”网络图及...为研究厚朴三物汤治疗腹痛的作用机制,通过网络药理学和分子对接技术探究了厚朴三物汤的活性成分、作用靶点及信号通路机制。首先使用相关软件筛选厚朴三物汤的活性成分及腹痛相关靶点,接着利用绘图工具构建“药物成分-靶点”网络图及蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络,然后使用用于注释、可视化和集成发现的数据库(database for annotation,visualization and integrated discovery,DAVID)进行生物信息学富集分析,最后进行蛋白分子对接。结果表明,厚朴三物汤治疗腹痛的核心蛋白为AKT1、表皮生长因子受体(epidermal growth factor receptor,EGFR)、ESR1、BCL2等;有效活性成分为3,4,5,7-四甲氧基黄酮、三甲氧基黄酮、木犀草素、香蜂草苷、异橙黄酮和去氢二松柏醇等;涉及的信号通路包括癌症相关途径、EGFR耐药性、HIF-1信号通路等。分子对接结果揭示了活性成分与靶点之间的高效结合潜力,厚朴三物汤可通过多成分、多靶点、多途径发挥治疗腹痛的作用。该研究为厚朴三物汤的临床应用提供了依据。展开更多
文摘Traditional Chinese herbal drugs have been used for thousands of years in Chinese pharmacopoeia. The bark of Magnolia officinalis Rehder ＆ E. Wilson, known under the pinyin name ＂Houpo＂, has been traditionally used in Chinese and Japanese medicines for the treatment of anxiety, asthma, depression, gastrointestinal disorders, headache, and more. Moreover, Magnolia bark extract is a major constituent of currently marketed dietary supplements and cosmetic products. Much pharmacological activity has been reported for this herb and its major compounds notably antioxidant, anti-inflammatory, antibiotic and antispasmodic effects. However, the mechanisms underlying this have not been elucidated and only a very few clinical trials have been published. In vitro and in vivo toxicity studies have also been published and indicate some intriguing features. The present review aims to summarize the literature on M. officinalis bark composition, utilisation, pharmacology, and safety.
文摘为研究厚朴三物汤治疗腹痛的作用机制,通过网络药理学和分子对接技术探究了厚朴三物汤的活性成分、作用靶点及信号通路机制。首先使用相关软件筛选厚朴三物汤的活性成分及腹痛相关靶点,接着利用绘图工具构建“药物成分-靶点”网络图及蛋白质-蛋白质相互作用(protein-protein interaction,PPI)网络,然后使用用于注释、可视化和集成发现的数据库(database for annotation,visualization and integrated discovery,DAVID)进行生物信息学富集分析,最后进行蛋白分子对接。结果表明,厚朴三物汤治疗腹痛的核心蛋白为AKT1、表皮生长因子受体(epidermal growth factor receptor,EGFR)、ESR1、BCL2等;有效活性成分为3,4,5,7-四甲氧基黄酮、三甲氧基黄酮、木犀草素、香蜂草苷、异橙黄酮和去氢二松柏醇等;涉及的信号通路包括癌症相关途径、EGFR耐药性、HIF-1信号通路等。分子对接结果揭示了活性成分与靶点之间的高效结合潜力,厚朴三物汤可通过多成分、多靶点、多途径发挥治疗腹痛的作用。该研究为厚朴三物汤的临床应用提供了依据。
